Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HKL1_LEIBR

TriTrypDb:

LbrM.32.2430 , LBRM2903_320031200

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HKL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.475
CLV_NRD_NRD_1	42	44	PF00675	0.460
CLV_NRD_NRD_1	92	94	PF00675	0.617
CLV_PCSK_KEX2_1	15	17	PF00082	0.475
CLV_PCSK_KEX2_1	42	44	PF00082	0.460
CLV_PCSK_KEX2_1	92	94	PF00082	0.614
CLV_PCSK_PC7_1	38	44	PF00082	0.460
CLV_PCSK_SKI1_1	16	20	PF00082	0.471
CLV_PCSK_SKI1_1	30	34	PF00082	0.471
CLV_PCSK_SKI1_1	45	49	PF00082	0.409
CLV_PCSK_SKI1_1	62	66	PF00082	0.534
DOC_MAPK_DCC_7	19	29	PF00069	0.282
DOC_MAPK_MEF2A_6	23	31	PF00069	0.296
DOC_USP7_MATH_1	196	200	PF00917	0.713
DOC_WW_Pin1_4	146	151	PF00397	0.632
DOC_WW_Pin1_4	182	187	PF00397	0.718
LIG_14-3-3_CanoR_1	162	166	PF00244	0.627
LIG_14-3-3_CanoR_1	177	183	PF00244	0.547
LIG_14-3-3_CanoR_1	45	51	PF00244	0.271
LIG_14-3-3_CanoR_1	71	77	PF00244	0.395
LIG_14-3-3_CanoR_1	92	100	PF00244	0.419
LIG_14-3-3_CterR_2	204	206	PF00244	0.774
LIG_Actin_WH2_2	138	156	PF00022	0.663
LIG_Actin_WH2_2	6	21	PF00022	0.282
LIG_APCC_ABBA_1	120	125	PF00400	0.509
LIG_BIR_II_1	1	5	PF00653	0.417
LIG_CtBP_PxDLS_1	190	194	PF00389	0.629
LIG_eIF4E_1	105	111	PF01652	0.447
LIG_FHA_1	122	128	PF00498	0.655
LIG_FHA_1	19	25	PF00498	0.339
LIG_FHA_1	73	79	PF00498	0.392
LIG_FHA_2	63	69	PF00498	0.283
LIG_LIR_Apic_2	181	186	PF02991	0.678
LIG_LIR_Gen_1	115	123	PF02991	0.227
LIG_LIR_Gen_1	139	147	PF02991	0.583
LIG_LIR_Nem_3	115	121	PF02991	0.227
LIG_PCNA_PIPBox_1	176	185	PF02747	0.661
LIG_Pex14_2	114	118	PF04695	0.358
LIG_SH2_CRK	183	187	PF00017	0.749
LIG_SH2_GRB2like	77	80	PF00017	0.389
LIG_SH2_NCK_1	183	187	PF00017	0.690
LIG_SH2_STAP1	123	127	PF00017	0.634
LIG_SH2_STAT3	202	205	PF00017	0.607
LIG_SH2_STAT5	105	108	PF00017	0.381
LIG_SH2_STAT5	123	126	PF00017	0.630
LIG_SH2_STAT5	17	20	PF00017	0.282
LIG_SH2_STAT5	77	80	PF00017	0.389
LIG_SH3_1	183	189	PF00018	0.690
LIG_SH3_3	183	189	PF00018	0.699
LIG_SUMO_SIM_anti_2	63	70	PF11976	0.419
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.294
LIG_TRAF2_1	149	152	PF00917	0.577
LIG_WRC_WIRS_1	179	184	PF05994	0.618
MOD_CK1_1	46	52	PF00069	0.292
MOD_CK2_1	146	152	PF00069	0.592
MOD_CK2_1	62	68	PF00069	0.205
MOD_GlcNHglycan	1	4	PF01048	0.625
MOD_GlcNHglycan	50	53	PF01048	0.554
MOD_GSK3_1	178	185	PF00069	0.666
MOD_N-GLC_1	25	30	PF02516	0.482
MOD_N-GLC_1	43	48	PF02516	0.507
MOD_NEK2_1	18	23	PF00069	0.362
MOD_NEK2_1	72	77	PF00069	0.383
MOD_NEK2_2	196	201	PF00069	0.750
MOD_NEK2_2	25	30	PF00069	0.282
MOD_PIKK_1	126	132	PF00454	0.531
MOD_PIKK_1	99	105	PF00454	0.398
MOD_PK_1	43	49	PF00069	0.292
MOD_PKA_2	161	167	PF00069	0.641
MOD_PKA_2	70	76	PF00069	0.401
MOD_PKA_2	91	97	PF00069	0.420
MOD_PKB_1	43	51	PF00069	0.311
MOD_Plk_1	25	31	PF00069	0.282
MOD_Plk_1	43	49	PF00069	0.307
MOD_Plk_1	62	68	PF00069	0.351
MOD_Plk_4	101	107	PF00069	0.316
MOD_Plk_4	178	184	PF00069	0.663
MOD_Plk_4	62	68	PF00069	0.292
MOD_ProDKin_1	146	152	PF00069	0.631
MOD_ProDKin_1	182	188	PF00069	0.718
MOD_SUMO_rev_2	146	156	PF00179	0.604
TRG_ENDOCYTIC_2	140	143	PF00928	0.597
TRG_ER_diArg_1	14	16	PF00400	0.275
TRG_ER_diArg_1	41	43	PF00400	0.261
TRG_ER_diArg_1	91	93	PF00400	0.411
TRG_NES_CRM1_1	133	146	PF08389	0.610
TRG_Pf-PMV_PEXEL_1	30	35	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4J0	Leptomonas seymouri	81%	100%
A0A0S4JR38	Bodo saltans	55%	100%
A0A1X0NU58	Trypanosomatidae	71%	100%
A0A3Q8IL84	Leishmania donovani	86%	100%
A4I844	Leishmania infantum	87%	100%
D0AAB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9B302	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q554	Leishmania major	86%	100%
V5BKR8	Trypanosoma cruzi	71%	100%