Serine/threonine-protein kinase CTR1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HKK9_LEIBR

TriTrypDb:

LbrM.32.2410 , LBRM2903_320031000

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.654
CLV_C14_Caspase3-7	149	153	PF00656	0.699
CLV_C14_Caspase3-7	426	430	PF00656	0.604
CLV_NRD_NRD_1	125	127	PF00675	0.830
CLV_NRD_NRD_1	133	135	PF00675	0.746
CLV_NRD_NRD_1	15	17	PF00675	0.701
CLV_NRD_NRD_1	284	286	PF00675	0.587
CLV_NRD_NRD_1	57	59	PF00675	0.615
CLV_NRD_NRD_1	593	595	PF00675	0.524
CLV_PCSK_FUR_1	130	134	PF00082	0.585
CLV_PCSK_KEX2_1	132	134	PF00082	0.773
CLV_PCSK_KEX2_1	284	286	PF00082	0.573
CLV_PCSK_KEX2_1	593	595	PF00082	0.524
CLV_PCSK_SKI1_1	302	306	PF00082	0.739
CLV_PCSK_SKI1_1	576	580	PF00082	0.509
CLV_PCSK_SKI1_1	7	11	PF00082	0.739
DEG_Kelch_Keap1_1	116	121	PF01344	0.609
DEG_SPOP_SBC_1	216	220	PF00917	0.720
DOC_CKS1_1	394	399	PF01111	0.561
DOC_CYCLIN_yCln2_LP_2	574	580	PF00134	0.515
DOC_MAPK_FxFP_2	439	442	PF00069	0.819
DOC_PP4_FxxP_1	377	380	PF00568	0.800
DOC_PP4_FxxP_1	439	442	PF00568	0.819
DOC_USP7_MATH_1	112	116	PF00917	0.809
DOC_USP7_MATH_1	165	169	PF00917	0.708
DOC_USP7_MATH_1	216	220	PF00917	0.745
DOC_USP7_MATH_1	237	241	PF00917	0.590
DOC_USP7_MATH_1	389	393	PF00917	0.743
DOC_USP7_MATH_1	442	446	PF00917	0.664
DOC_USP7_MATH_1	52	56	PF00917	0.809
DOC_USP7_MATH_1	549	553	PF00917	0.585
DOC_WW_Pin1_4	34	39	PF00397	0.603
DOC_WW_Pin1_4	342	347	PF00397	0.810
DOC_WW_Pin1_4	393	398	PF00397	0.565
DOC_WW_Pin1_4	472	477	PF00397	0.681
DOC_WW_Pin1_4	482	487	PF00397	0.643
DOC_WW_Pin1_4	498	503	PF00397	0.793
LIG_14-3-3_CanoR_1	302	310	PF00244	0.573
LIG_14-3-3_CanoR_1	313	317	PF00244	0.513
LIG_APCC_ABBA_1	316	321	PF00400	0.805
LIG_BRCT_BRCA1_1	144	148	PF00533	0.562
LIG_CtBP_PxDLS_1	352	356	PF00389	0.800
LIG_EH_1	50	54	PF12763	0.589
LIG_FHA_1	185	191	PF00498	0.578
LIG_FHA_1	218	224	PF00498	0.762
LIG_FHA_1	394	400	PF00498	0.560
LIG_FHA_1	499	505	PF00498	0.571
LIG_FHA_1	541	547	PF00498	0.568
LIG_FHA_2	120	126	PF00498	0.608
LIG_FHA_2	193	199	PF00498	0.651
LIG_FHA_2	312	318	PF00498	0.622
LIG_FHA_2	388	394	PF00498	0.577
LIG_FHA_2	478	484	PF00498	0.583
LIG_Integrin_isoDGR_2	300	302	PF01839	0.580
LIG_LIR_Apic_2	328	333	PF02991	0.807
LIG_LIR_Apic_2	374	380	PF02991	0.799
LIG_LIR_Apic_2	437	442	PF02991	0.569
LIG_LIR_Apic_2	499	503	PF02991	0.571
LIG_LIR_Gen_1	317	324	PF02991	0.805
LIG_LIR_Gen_1	404	413	PF02991	0.556
LIG_LIR_Gen_1	461	470	PF02991	0.677
LIG_LIR_Nem_3	314	319	PF02991	0.768
LIG_LIR_Nem_3	404	408	PF02991	0.698
LIG_LIR_Nem_3	410	415	PF02991	0.731
LIG_LIR_Nem_3	572	578	PF02991	0.534
LIG_LIR_Nem_3	600	606	PF02991	0.542
LIG_LYPXL_S_1	411	415	PF13949	0.801
LIG_LYPXL_S_1	512	516	PF13949	0.579
LIG_LYPXL_yS_3	412	415	PF13949	0.801
LIG_LYPXL_yS_3	441	444	PF13949	0.804
LIG_LYPXL_yS_3	513	516	PF13949	0.579
LIG_MYND_1	292	296	PF01753	0.563
LIG_MYND_1	413	417	PF01753	0.806
LIG_Rb_pABgroove_1	576	584	PF01858	0.759
LIG_SH2_CRK	500	504	PF00017	0.826
LIG_SH2_CRK	575	579	PF00017	0.515
LIG_SH2_CRK	603	607	PF00017	0.529
LIG_SH2_NCK_1	210	214	PF00017	0.612
LIG_SH2_NCK_1	474	478	PF00017	0.831
LIG_SH2_SRC	286	289	PF00017	0.568
LIG_SH2_SRC	330	333	PF00017	0.807
LIG_SH2_STAT3	454	457	PF00017	0.552
LIG_SH2_STAT5	286	289	PF00017	0.568
LIG_SH2_STAT5	309	312	PF00017	0.590
LIG_SH2_STAT5	330	333	PF00017	0.714
LIG_SH2_STAT5	405	408	PF00017	0.529
LIG_SH2_STAT5	44	47	PF00017	0.817
LIG_SH2_STAT5	479	482	PF00017	0.582
LIG_SH2_STAT5	500	503	PF00017	0.558
LIG_SH2_STAT5	573	576	PF00017	0.696
LIG_SH2_STAT5	580	583	PF00017	0.724
LIG_SH3_2	502	507	PF14604	0.568
LIG_SH3_3	340	346	PF00018	0.806
LIG_SH3_3	35	41	PF00018	0.596
LIG_SH3_3	388	394	PF00018	0.577
LIG_SH3_3	410	416	PF00018	0.798
LIG_SH3_3	499	505	PF00018	0.571
LIG_SH3_3	508	514	PF00018	0.570
LIG_TRAF2_1	122	125	PF00917	0.605
LIG_TRAF2_1	73	76	PF00917	0.591
LIG_TRAF2_1	85	88	PF00917	0.547
LIG_WRC_WIRS_1	381	386	PF05994	0.562
LIG_WRC_WIRS_1	408	413	PF05994	0.794
LIG_WW_2	502	505	PF00397	0.568
MOD_CDC14_SPxK_1	345	348	PF00782	0.811
MOD_CDK_SPxK_1	342	348	PF00069	0.811
MOD_CK1_1	115	121	PF00069	0.815
MOD_CK1_1	142	148	PF00069	0.791
MOD_CK1_1	160	166	PF00069	0.657
MOD_CK1_1	181	187	PF00069	0.740
MOD_CK1_1	211	217	PF00069	0.673
MOD_CK1_1	247	253	PF00069	0.705
MOD_CK1_1	308	314	PF00069	0.676
MOD_CK1_1	404	410	PF00069	0.645
MOD_CK1_1	552	558	PF00069	0.626
MOD_CK1_1	560	566	PF00069	0.621
MOD_CK1_1	597	603	PF00069	0.523
MOD_CK1_1	91	97	PF00069	0.729
MOD_CK2_1	115	121	PF00069	0.801
MOD_CK2_1	311	317	PF00069	0.580
MOD_CK2_1	420	426	PF00069	0.758
MOD_CK2_1	472	478	PF00069	0.727
MOD_CK2_1	595	601	PF00069	0.523
MOD_CK2_1	82	88	PF00069	0.684
MOD_GlcNHglycan	141	144	PF01048	0.659
MOD_GlcNHglycan	154	157	PF01048	0.792
MOD_GlcNHglycan	20	25	PF01048	0.556
MOD_GlcNHglycan	255	258	PF01048	0.655
MOD_GlcNHglycan	47	50	PF01048	0.603
MOD_GlcNHglycan	54	57	PF01048	0.590
MOD_GlcNHglycan	559	562	PF01048	0.674
MOD_GlcNHglycan	67	71	PF01048	0.824
MOD_GlcNHglycan	98	101	PF01048	0.585
MOD_GSK3_1	115	122	PF00069	0.836
MOD_GSK3_1	138	145	PF00069	0.673
MOD_GSK3_1	178	185	PF00069	0.735
MOD_GSK3_1	200	207	PF00069	0.758
MOD_GSK3_1	211	218	PF00069	0.661
MOD_GSK3_1	221	228	PF00069	0.580
MOD_GSK3_1	243	250	PF00069	0.834
MOD_GSK3_1	305	312	PF00069	0.669
MOD_GSK3_1	389	396	PF00069	0.709
MOD_GSK3_1	477	484	PF00069	0.723
MOD_GSK3_1	528	535	PF00069	0.609
MOD_GSK3_1	560	567	PF00069	0.786
MOD_GSK3_1	595	602	PF00069	0.521
MOD_GSK3_1	94	101	PF00069	0.625
MOD_N-GLC_1	138	143	PF02516	0.578
MOD_N-GLC_1	247	252	PF02516	0.792
MOD_N-GLC_1	429	434	PF02516	0.618
MOD_N-GLC_1	481	486	PF02516	0.579
MOD_N-GLC_1	492	497	PF02516	0.503
MOD_NEK2_1	11	16	PF00069	0.505
MOD_NEK2_1	146	151	PF00069	0.582
MOD_NMyristoyl	1	7	PF02799	0.745
MOD_PIKK_1	160	166	PF00454	0.599
MOD_PIKK_1	200	206	PF00454	0.738
MOD_PIKK_1	208	214	PF00454	0.821
MOD_PIKK_1	517	523	PF00454	0.590
MOD_PKA_1	58	64	PF00069	0.606
MOD_PKA_2	158	164	PF00069	0.749
MOD_PKA_2	312	318	PF00069	0.552
MOD_Plk_1	247	253	PF00069	0.577
MOD_Plk_1	305	311	PF00069	0.685
MOD_Plk_1	387	393	PF00069	0.608
MOD_Plk_1	582	588	PF00069	0.747
MOD_Plk_2-3	387	393	PF00069	0.616
MOD_Plk_4	305	311	PF00069	0.790
MOD_Plk_4	401	407	PF00069	0.710
MOD_Plk_4	512	518	PF00069	0.756
MOD_Plk_4	569	575	PF00069	0.699
MOD_Plk_4	576	582	PF00069	0.732
MOD_ProDKin_1	34	40	PF00069	0.601
MOD_ProDKin_1	342	348	PF00069	0.811
MOD_ProDKin_1	393	399	PF00069	0.565
MOD_ProDKin_1	472	478	PF00069	0.683
MOD_ProDKin_1	482	488	PF00069	0.644
MOD_ProDKin_1	498	504	PF00069	0.794
MOD_SUMO_rev_2	168	176	PF00179	0.600
MOD_SUMO_rev_2	55	61	PF00179	0.613
TRG_ENDOCYTIC_2	319	322	PF00928	0.811
TRG_ENDOCYTIC_2	405	408	PF00928	0.694
TRG_ENDOCYTIC_2	412	415	PF00928	0.773
TRG_ENDOCYTIC_2	441	444	PF00928	0.804
TRG_ENDOCYTIC_2	462	465	PF00928	0.817
TRG_ENDOCYTIC_2	513	516	PF00928	0.579
TRG_ENDOCYTIC_2	575	578	PF00928	0.518
TRG_ENDOCYTIC_2	603	606	PF00928	0.534
TRG_ER_diArg_1	130	133	PF00400	0.726
TRG_ER_diArg_1	284	286	PF00400	0.587
TRG_ER_diArg_1	347	350	PF00400	0.539
TRG_ER_diArg_1	593	595	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	584	588	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7S3	Leishmania donovani	46%	95%
A4I842	Leishmania infantum	46%	95%
E9B300	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	95%
Q4Q556	Leishmania major	45%	100%