CSN8_PSD8_EIF3K domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit k

Species:

Leishmania braziliensis

UniProt:

A4HKK8_LEIBR

TriTrypDb:

LbrM.32.2400 , LBRM2903_320030900

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKK8

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	12
GO:0006446	regulation of translational initiation	7	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0010608	post-transcriptional regulation of gene expression	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0034248	regulation of amide metabolic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0043021	ribonucleoprotein complex binding	3	12
GO:0043022	ribosome binding	4	12
GO:0044877	protein-containing complex binding	2	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.654
CLV_PCSK_KEX2_1	209	211	PF00082	0.780
CLV_PCSK_SKI1_1	137	141	PF00082	0.315
CLV_PCSK_SKI1_1	25	29	PF00082	0.400
CLV_PCSK_SKI1_1	39	43	PF00082	0.331
DEG_MDM2_SWIB_1	97	104	PF02201	0.532
DOC_CYCLIN_yClb5_NLxxxL_5	17	24	PF00134	0.504
DOC_MAPK_FxFP_2	182	185	PF00069	0.562
DOC_MAPK_MEF2A_6	39	47	PF00069	0.359
DOC_PP4_FxxP_1	182	185	PF00568	0.419
DOC_USP7_MATH_1	169	173	PF00917	0.618
DOC_USP7_MATH_1	190	194	PF00917	0.572
DOC_USP7_MATH_1	37	41	PF00917	0.523
DOC_WW_Pin1_4	142	147	PF00397	0.532
DOC_WW_Pin1_4	69	74	PF00397	0.520
LIG_14-3-3_CanoR_1	117	126	PF00244	0.570
LIG_14-3-3_CanoR_1	222	227	PF00244	0.647
LIG_14-3-3_CanoR_1	52	62	PF00244	0.501
LIG_14-3-3_CanoR_1	96	104	PF00244	0.557
LIG_Actin_WH2_2	145	160	PF00022	0.407
LIG_BIR_II_1	1	5	PF00653	0.434
LIG_BRCT_BRCA1_1	110	114	PF00533	0.508
LIG_BRCT_BRCA1_1	173	177	PF00533	0.510
LIG_BRCT_BRCA1_1	192	196	PF00533	0.624
LIG_eIF4E_1	83	89	PF01652	0.568
LIG_FHA_1	118	124	PF00498	0.548
LIG_FHA_1	133	139	PF00498	0.434
LIG_FHA_1	216	222	PF00498	0.555
LIG_FHA_1	5	11	PF00498	0.472
LIG_LIR_Apic_2	15	21	PF02991	0.473
LIG_LIR_Gen_1	140	149	PF02991	0.568
LIG_LIR_Gen_1	193	203	PF02991	0.383
LIG_LIR_Gen_1	225	230	PF02991	0.624
LIG_LIR_Gen_1	99	109	PF02991	0.606
LIG_LIR_Nem_3	140	144	PF02991	0.510
LIG_LIR_Nem_3	193	199	PF02991	0.386
LIG_LIR_Nem_3	99	104	PF02991	0.543
LIG_NRBOX	42	48	PF00104	0.354
LIG_NRBOX	84	90	PF00104	0.568
LIG_Pex14_2	94	98	PF04695	0.465
LIG_SH2_CRK	18	22	PF00017	0.454
LIG_SH2_SRC	81	84	PF00017	0.520
LIG_SH2_STAT5	141	144	PF00017	0.476
LIG_SH2_STAT5	26	29	PF00017	0.426
LIG_SH2_STAT5	81	84	PF00017	0.497
MOD_CK1_1	132	138	PF00069	0.592
MOD_CK1_1	56	62	PF00069	0.492
MOD_CK2_1	100	106	PF00069	0.568
MOD_CK2_1	118	124	PF00069	0.519
MOD_CK2_1	27	33	PF00069	0.526
MOD_CMANNOS	98	101	PF00535	0.265
MOD_GlcNHglycan	171	174	PF01048	0.555
MOD_GSK3_1	118	125	PF00069	0.527
MOD_GSK3_1	190	197	PF00069	0.576
MOD_GSK3_1	52	59	PF00069	0.499
MOD_GSK3_1	96	103	PF00069	0.613
MOD_NEK2_1	27	32	PF00069	0.423
MOD_NEK2_1	46	51	PF00069	0.410
MOD_NEK2_2	190	195	PF00069	0.413
MOD_PIKK_1	4	10	PF00454	0.545
MOD_PIKK_1	96	102	PF00454	0.577
MOD_PKA_2	118	124	PF00069	0.555
MOD_Plk_1	197	203	PF00069	0.529
MOD_Plk_1	37	43	PF00069	0.509
MOD_Plk_2-3	71	77	PF00069	0.524
MOD_Plk_4	118	124	PF00069	0.507
MOD_Plk_4	137	143	PF00069	0.396
MOD_Plk_4	171	177	PF00069	0.451
MOD_Plk_4	198	204	PF00069	0.466
MOD_Plk_4	37	43	PF00069	0.431
MOD_ProDKin_1	142	148	PF00069	0.532
MOD_ProDKin_1	69	75	PF00069	0.520
TRG_ENDOCYTIC_2	141	144	PF00928	0.476
TRG_ER_diArg_1	179	182	PF00400	0.567
TRG_ER_diArg_1	208	210	PF00400	0.649
TRG_ER_diArg_1	221	224	PF00400	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAH2	Leptomonas seymouri	74%	100%
A0A0S4JSL7	Bodo saltans	28%	100%
A0A1X0NU56	Trypanosomatidae	45%	100%
A0A3Q8IGV2	Leishmania donovani	93%	100%
A0A422N8G6	Trypanosoma rangeli	45%	100%
A4I841	Leishmania infantum	93%	100%
D0AAA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B2Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q557	Leishmania major	94%	100%
Q567V6	Danio rerio	26%	100%
Q94HF1	Oryza sativa subsp. japonica	23%	100%
Q9SZA3	Arabidopsis thaliana	22%	100%
V5AW96	Trypanosoma cruzi	44%	100%