Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKK7_LEIBR

TriTrypDb:

LbrM.32.2390 , LBRM2903_320030800

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.571
CLV_MEL_PAP_1	339	345	PF00089	0.568
CLV_NRD_NRD_1	219	221	PF00675	0.578
CLV_NRD_NRD_1	228	230	PF00675	0.399
CLV_NRD_NRD_1	436	438	PF00675	0.604
CLV_PCSK_KEX2_1	219	221	PF00082	0.578
CLV_PCSK_KEX2_1	228	230	PF00082	0.399
CLV_PCSK_KEX2_1	436	438	PF00082	0.599
CLV_PCSK_SKI1_1	220	224	PF00082	0.494
CLV_PCSK_SKI1_1	437	441	PF00082	0.626
DEG_APCC_DBOX_1	218	226	PF00400	0.555
DEG_COP1_1	118	127	PF00400	0.549
DEG_Nend_UBRbox_3	1	3	PF02207	0.738
DOC_CKS1_1	124	129	PF01111	0.704
DOC_CKS1_1	455	460	PF01111	0.539
DOC_CYCLIN_yCln2_LP_2	424	427	PF00134	0.535
DOC_PP1_RVXF_1	407	413	PF00149	0.426
DOC_PP2B_LxvP_1	424	427	PF13499	0.535
DOC_PP2B_LxvP_1	498	501	PF13499	0.496
DOC_USP7_MATH_1	132	136	PF00917	0.757
DOC_USP7_MATH_1	145	149	PF00917	0.662
DOC_USP7_MATH_1	172	176	PF00917	0.534
DOC_USP7_MATH_1	24	28	PF00917	0.481
DOC_USP7_MATH_1	240	244	PF00917	0.438
DOC_USP7_MATH_1	341	345	PF00917	0.536
DOC_USP7_MATH_1	414	418	PF00917	0.387
DOC_USP7_MATH_1	487	491	PF00917	0.685
DOC_USP7_UBL2_3	104	108	PF12436	0.708
DOC_WW_Pin1_4	123	128	PF00397	0.705
DOC_WW_Pin1_4	173	178	PF00397	0.644
DOC_WW_Pin1_4	189	194	PF00397	0.555
DOC_WW_Pin1_4	417	422	PF00397	0.485
DOC_WW_Pin1_4	454	459	PF00397	0.600
DOC_WW_Pin1_4	542	547	PF00397	0.475
LIG_14-3-3_CanoR_1	210	214	PF00244	0.541
LIG_14-3-3_CanoR_1	219	225	PF00244	0.349
LIG_14-3-3_CanoR_1	23	31	PF00244	0.539
LIG_14-3-3_CanoR_1	256	264	PF00244	0.426
LIG_14-3-3_CanoR_1	34	42	PF00244	0.395
LIG_14-3-3_CanoR_1	342	350	PF00244	0.503
LIG_14-3-3_CanoR_1	404	409	PF00244	0.489
LIG_14-3-3_CanoR_1	437	447	PF00244	0.594
LIG_14-3-3_CanoR_1	571	576	PF00244	0.594
LIG_BIR_III_4	144	148	PF00653	0.625
LIG_BRCT_BRCA1_1	26	30	PF00533	0.464
LIG_CSL_BTD_1	411	414	PF09270	0.444
LIG_deltaCOP1_diTrp_1	10	18	PF00928	0.573
LIG_eIF4E_1	477	483	PF01652	0.394
LIG_FHA_1	24	30	PF00498	0.592
LIG_FHA_1	297	303	PF00498	0.430
LIG_FHA_1	34	40	PF00498	0.432
LIG_FHA_1	468	474	PF00498	0.493
LIG_FHA_1	493	499	PF00498	0.490
LIG_FHA_2	138	144	PF00498	0.548
LIG_FHA_2	289	295	PF00498	0.479
LIG_FHA_2	333	339	PF00498	0.633
LIG_FHA_2	572	578	PF00498	0.446
LIG_GBD_Chelix_1	43	51	PF00786	0.381
LIG_IRF3_LxIS_1	155	162	PF10401	0.526
LIG_LIR_Apic_2	452	458	PF02991	0.537
LIG_LIR_Gen_1	243	252	PF02991	0.463
LIG_LIR_Gen_1	253	261	PF02991	0.372
LIG_LIR_Gen_1	273	283	PF02991	0.226
LIG_LIR_Gen_1	338	347	PF02991	0.389
LIG_LIR_Gen_1	383	390	PF02991	0.517
LIG_LIR_Gen_1	476	485	PF02991	0.450
LIG_LIR_Gen_1	91	99	PF02991	0.588
LIG_LIR_Nem_3	253	257	PF02991	0.433
LIG_LIR_Nem_3	258	264	PF02991	0.402
LIG_LIR_Nem_3	273	278	PF02991	0.230
LIG_LIR_Nem_3	338	343	PF02991	0.438
LIG_LIR_Nem_3	383	388	PF02991	0.517
LIG_LIR_Nem_3	468	474	PF02991	0.493
LIG_LIR_Nem_3	476	480	PF02991	0.377
LIG_LIR_Nem_3	503	507	PF02991	0.428
LIG_LIR_Nem_3	8	14	PF02991	0.678
LIG_LIR_Nem_3	91	97	PF02991	0.594
LIG_LYPXL_SIV_4	226	234	PF13949	0.342
LIG_NRBOX	374	380	PF00104	0.473
LIG_PDZ_Class_3	607	612	PF00595	0.562
LIG_SH2_CRK	185	189	PF00017	0.535
LIG_SH2_CRK	227	231	PF00017	0.350
LIG_SH2_CRK	254	258	PF00017	0.422
LIG_SH2_NCK_1	477	481	PF00017	0.313
LIG_SH2_NCK_1	94	98	PF00017	0.602
LIG_SH2_SRC	477	480	PF00017	0.486
LIG_SH2_STAP1	185	189	PF00017	0.535
LIG_SH2_STAP1	477	481	PF00017	0.481
LIG_SH2_STAT5	244	247	PF00017	0.357
LIG_SH2_STAT5	351	354	PF00017	0.442
LIG_SH2_STAT5	507	510	PF00017	0.486
LIG_SH3_3	121	127	PF00018	0.550
LIG_SH3_3	187	193	PF00018	0.614
LIG_SH3_3	331	337	PF00018	0.670
LIG_SH3_3	392	398	PF00018	0.475
LIG_SH3_3	469	475	PF00018	0.467
LIG_SH3_3	540	546	PF00018	0.500
LIG_SH3_3	589	595	PF00018	0.574
LIG_SH3_3	603	609	PF00018	0.378
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.541
LIG_SUMO_SIM_par_1	129	135	PF11976	0.615
LIG_TRFH_1	471	475	PF08558	0.519
LIG_TYR_ITIM	225	230	PF00017	0.367
LIG_UBA3_1	42	48	PF00899	0.522
LIG_UBA3_1	424	429	PF00899	0.527
LIG_WRPW_2	590	593	PF00400	0.491
MOD_CK1_1	123	129	PF00069	0.751
MOD_CK1_1	168	174	PF00069	0.687
MOD_CK1_1	243	249	PF00069	0.380
MOD_CK1_1	255	261	PF00069	0.371
MOD_CK1_1	274	280	PF00069	0.360
MOD_CK1_1	32	38	PF00069	0.542
MOD_CK1_1	328	334	PF00069	0.584
MOD_CK1_1	402	408	PF00069	0.390
MOD_CK1_1	417	423	PF00069	0.390
MOD_CK1_1	454	460	PF00069	0.571
MOD_CK1_1	514	520	PF00069	0.482
MOD_CK1_1	54	60	PF00069	0.746
MOD_CK1_1	545	551	PF00069	0.391
MOD_CK1_1	72	78	PF00069	0.585
MOD_CK2_1	132	138	PF00069	0.684
MOD_CK2_1	191	197	PF00069	0.531
MOD_CK2_1	247	253	PF00069	0.395
MOD_CK2_1	288	294	PF00069	0.467
MOD_CK2_1	500	506	PF00069	0.429
MOD_CK2_1	571	577	PF00069	0.478
MOD_DYRK1A_RPxSP_1	542	546	PF00069	0.487
MOD_GlcNHglycan	115	118	PF01048	0.688
MOD_GlcNHglycan	170	173	PF01048	0.677
MOD_GlcNHglycan	249	252	PF01048	0.581
MOD_GlcNHglycan	325	328	PF01048	0.649
MOD_GlcNHglycan	331	334	PF01048	0.689
MOD_GlcNHglycan	443	446	PF01048	0.677
MOD_GlcNHglycan	462	465	PF01048	0.477
MOD_GlcNHglycan	53	56	PF01048	0.730
MOD_GlcNHglycan	536	539	PF01048	0.585
MOD_GlcNHglycan	547	550	PF01048	0.477
MOD_GlcNHglycan	71	74	PF01048	0.539
MOD_GSK3_1	1	8	PF00069	0.622
MOD_GSK3_1	104	111	PF00069	0.607
MOD_GSK3_1	132	139	PF00069	0.755
MOD_GSK3_1	155	162	PF00069	0.697
MOD_GSK3_1	164	171	PF00069	0.752
MOD_GSK3_1	173	180	PF00069	0.672
MOD_GSK3_1	19	26	PF00069	0.454
MOD_GSK3_1	209	216	PF00069	0.670
MOD_GSK3_1	243	250	PF00069	0.368
MOD_GSK3_1	270	277	PF00069	0.557
MOD_GSK3_1	29	36	PF00069	0.569
MOD_GSK3_1	296	303	PF00069	0.494
MOD_GSK3_1	323	330	PF00069	0.569
MOD_GSK3_1	450	457	PF00069	0.580
MOD_GSK3_1	50	57	PF00069	0.748
MOD_GSK3_1	567	574	PF00069	0.358
MOD_LATS_1	21	27	PF00433	0.576
MOD_N-GLC_1	24	29	PF02516	0.482
MOD_N-GLC_1	534	539	PF02516	0.544
MOD_N-GLC_1	6	11	PF02516	0.523
MOD_NEK2_1	109	114	PF00069	0.556
MOD_NEK2_1	247	252	PF00069	0.473
MOD_NEK2_1	29	34	PF00069	0.471
MOD_NEK2_1	300	305	PF00069	0.489
MOD_NEK2_1	323	328	PF00069	0.529
MOD_NEK2_1	42	47	PF00069	0.428
MOD_NEK2_1	492	497	PF00069	0.482
MOD_NEK2_1	51	56	PF00069	0.566
MOD_NEK2_1	567	572	PF00069	0.348
MOD_NEK2_1	63	68	PF00069	0.566
MOD_PIKK_1	147	153	PF00454	0.557
MOD_PIKK_1	191	197	PF00454	0.544
MOD_PIKK_1	255	261	PF00454	0.426
MOD_PIKK_1	487	493	PF00454	0.487
MOD_PKA_2	209	215	PF00069	0.616
MOD_PKA_2	255	261	PF00069	0.406
MOD_PKA_2	33	39	PF00069	0.507
MOD_PKA_2	341	347	PF00069	0.517
MOD_PKA_2	554	560	PF00069	0.436
MOD_PKA_2	570	576	PF00069	0.457
MOD_PKA_2	79	85	PF00069	0.774
MOD_Plk_1	120	126	PF00069	0.632
MOD_Plk_1	213	219	PF00069	0.471
MOD_Plk_1	252	258	PF00069	0.422
MOD_Plk_1	450	456	PF00069	0.540
MOD_Plk_1	467	473	PF00069	0.398
MOD_Plk_1	92	98	PF00069	0.605
MOD_Plk_4	213	219	PF00069	0.440
MOD_Plk_4	220	226	PF00069	0.435
MOD_Plk_4	240	246	PF00069	0.418
MOD_Plk_4	271	277	PF00069	0.448
MOD_Plk_4	42	48	PF00069	0.458
MOD_Plk_4	420	426	PF00069	0.569
MOD_Plk_4	561	567	PF00069	0.388
MOD_ProDKin_1	123	129	PF00069	0.706
MOD_ProDKin_1	173	179	PF00069	0.636
MOD_ProDKin_1	189	195	PF00069	0.555
MOD_ProDKin_1	417	423	PF00069	0.485
MOD_ProDKin_1	454	460	PF00069	0.598
MOD_ProDKin_1	542	548	PF00069	0.457
TRG_DiLeu_BaEn_3	433	439	PF01217	0.404
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.560
TRG_ENDOCYTIC_2	185	188	PF00928	0.536
TRG_ENDOCYTIC_2	227	230	PF00928	0.361
TRG_ENDOCYTIC_2	244	247	PF00928	0.336
TRG_ENDOCYTIC_2	254	257	PF00928	0.427
TRG_ENDOCYTIC_2	471	474	PF00928	0.443
TRG_ENDOCYTIC_2	477	480	PF00928	0.395
TRG_ENDOCYTIC_2	590	593	PF00928	0.491
TRG_ENDOCYTIC_2	94	97	PF00928	0.604
TRG_ER_diArg_1	218	220	PF00400	0.584
TRG_ER_diArg_1	227	229	PF00400	0.410
TRG_ER_diArg_1	436	438	PF00400	0.431
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W3	Leptomonas seymouri	29%	100%
A0A3S7X5P2	Leishmania donovani	71%	100%
A4I840	Leishmania infantum	71%	100%
E9B2Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q558	Leishmania major	70%	100%