Importin N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKK5_LEIBR

TriTrypDb:

LbrM.32.2360 , LBRM2903_320030300

Length:

1082

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HKK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKK5

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006913	nucleocytoplasmic transport	5	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0034504	protein localization to nucleus	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051169	nuclear transport	4	12
GO:0051170	import into nucleus	6	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12

Molecular functions
Term	Name	Level	Count
GO:0005048	signal sequence binding	4	1
GO:0005488	binding	1	1
GO:0008139	nuclear localization sequence binding	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1
GO:0061608	nuclear import signal receptor activity	3	1
GO:0140104	molecular carrier activity	1	1
GO:0140142	nucleocytoplasmic carrier activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	466	470	PF00656	0.544
CLV_C14_Caspase3-7	549	553	PF00656	0.396
CLV_C14_Caspase3-7	659	663	PF00656	0.704
CLV_C14_Caspase3-7	832	836	PF00656	0.579
CLV_NRD_NRD_1	1032	1034	PF00675	0.508
CLV_NRD_NRD_1	20	22	PF00675	0.524
CLV_NRD_NRD_1	290	292	PF00675	0.306
CLV_NRD_NRD_1	351	353	PF00675	0.317
CLV_NRD_NRD_1	63	65	PF00675	0.485
CLV_NRD_NRD_1	817	819	PF00675	0.351
CLV_PCSK_KEX2_1	1032	1034	PF00082	0.508
CLV_PCSK_KEX2_1	816	818	PF00082	0.352
CLV_PCSK_KEX2_1	824	826	PF00082	0.350
CLV_PCSK_PC1ET2_1	816	818	PF00082	0.411
CLV_PCSK_PC1ET2_1	824	826	PF00082	0.316
CLV_PCSK_SKI1_1	188	192	PF00082	0.459
CLV_PCSK_SKI1_1	389	393	PF00082	0.518
CLV_PCSK_SKI1_1	455	459	PF00082	0.521
CLV_PCSK_SKI1_1	488	492	PF00082	0.566
CLV_PCSK_SKI1_1	530	534	PF00082	0.421
CLV_PCSK_SKI1_1	576	580	PF00082	0.477
CLV_PCSK_SKI1_1	64	68	PF00082	0.429
CLV_PCSK_SKI1_1	677	681	PF00082	0.477
CLV_PCSK_SKI1_1	824	828	PF00082	0.411
CLV_PCSK_SKI1_1	863	867	PF00082	0.392
DEG_Nend_UBRbox_2	1	3	PF02207	0.523
DEG_SPOP_SBC_1	92	96	PF00917	0.337
DEG_SPOP_SBC_1	924	928	PF00917	0.587
DOC_CYCLIN_RxL_1	61	70	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	101	107	PF00134	0.572
DOC_MAPK_gen_1	1032	1039	PF00069	0.536
DOC_MAPK_gen_1	560	569	PF00069	0.501
DOC_MAPK_HePTP_8	803	815	PF00069	0.592
DOC_MAPK_MEF2A_6	272	280	PF00069	0.570
DOC_MAPK_MEF2A_6	488	497	PF00069	0.565
DOC_MAPK_MEF2A_6	806	815	PF00069	0.592
DOC_PP2B_LxvP_1	548	551	PF13499	0.339
DOC_PP4_FxxP_1	669	672	PF00568	0.666
DOC_PP4_FxxP_1	866	869	PF00568	0.592
DOC_SPAK_OSR1_1	668	672	PF12202	0.660
DOC_USP7_MATH_1	1066	1070	PF00917	0.591
DOC_USP7_MATH_1	107	111	PF00917	0.406
DOC_USP7_MATH_1	44	48	PF00917	0.570
DOC_USP7_MATH_1	924	928	PF00917	0.582
DOC_USP7_UBL2_3	288	292	PF12436	0.517
DOC_USP7_UBL2_3	408	412	PF12436	0.557
DOC_USP7_UBL2_3	558	562	PF12436	0.523
DOC_WW_Pin1_4	100	105	PF00397	0.591
DOC_WW_Pin1_4	427	432	PF00397	0.329
DOC_WW_Pin1_4	67	72	PF00397	0.557
DOC_WW_Pin1_4	793	798	PF00397	0.534
LIG_14-3-3_CanoR_1	21	28	PF00244	0.562
LIG_14-3-3_CanoR_1	415	420	PF00244	0.393
LIG_14-3-3_CanoR_1	455	464	PF00244	0.449
LIG_14-3-3_CanoR_1	610	619	PF00244	0.399
LIG_14-3-3_CanoR_1	786	791	PF00244	0.602
LIG_APCC_ABBA_1	114	119	PF00400	0.580
LIG_APCC_ABBA_1	491	496	PF00400	0.534
LIG_APCC_ABBA_1	533	538	PF00400	0.492
LIG_APCC_ABBA_1	541	546	PF00400	0.398
LIG_BRCT_BRCA1_1	2	6	PF00533	0.375
LIG_BRCT_BRCA1_1	297	301	PF00533	0.534
LIG_BRCT_BRCA1_1	425	429	PF00533	0.409
LIG_deltaCOP1_diTrp_1	121	127	PF00928	0.433
LIG_EH1_1	937	945	PF00400	0.397
LIG_eIF4E_1	973	979	PF01652	0.555
LIG_FHA_1	1002	1008	PF00498	0.435
LIG_FHA_1	1010	1016	PF00498	0.447
LIG_FHA_1	1055	1061	PF00498	0.334
LIG_FHA_1	173	179	PF00498	0.458
LIG_FHA_1	181	187	PF00498	0.547
LIG_FHA_1	192	198	PF00498	0.490
LIG_FHA_1	361	367	PF00498	0.324
LIG_FHA_1	428	434	PF00498	0.313
LIG_FHA_1	55	61	PF00498	0.558
LIG_FHA_1	603	609	PF00498	0.462
LIG_FHA_1	611	617	PF00498	0.365
LIG_FHA_1	681	687	PF00498	0.521
LIG_FHA_1	798	804	PF00498	0.549
LIG_FHA_1	916	922	PF00498	0.469
LIG_FHA_1	951	957	PF00498	0.660
LIG_FHA_2	279	285	PF00498	0.517
LIG_FHA_2	318	324	PF00498	0.541
LIG_FHA_2	40	46	PF00498	0.506
LIG_FHA_2	47	53	PF00498	0.537
LIG_FHA_2	470	476	PF00498	0.696
LIG_FHA_2	597	603	PF00498	0.569
LIG_FHA_2	825	831	PF00498	0.592
LIG_LIR_Apic_2	864	869	PF02991	0.592
LIG_LIR_Gen_1	121	131	PF02991	0.435
LIG_LIR_Gen_1	225	233	PF02991	0.563
LIG_LIR_Gen_1	25	36	PF02991	0.396
LIG_LIR_Gen_1	298	309	PF02991	0.511
LIG_LIR_Gen_1	3	13	PF02991	0.353
LIG_LIR_Gen_1	993	1002	PF02991	0.434
LIG_LIR_Nem_3	121	126	PF02991	0.439
LIG_LIR_Nem_3	225	229	PF02991	0.570
LIG_LIR_Nem_3	298	304	PF02991	0.520
LIG_LIR_Nem_3	3	9	PF02991	0.362
LIG_LIR_Nem_3	485	490	PF02991	0.545
LIG_LIR_Nem_3	577	582	PF02991	0.428
LIG_LIR_Nem_3	993	998	PF02991	0.400
LIG_MLH1_MIPbox_1	297	301	PF16413	0.611
LIG_Pex14_2	296	300	PF04695	0.517
LIG_Pex14_2	301	305	PF04695	0.517
LIG_Pex14_2	866	870	PF04695	0.506
LIG_PTB_Apo_2	307	314	PF02174	0.592
LIG_PTB_Phospho_1	307	313	PF10480	0.592
LIG_Rb_LxCxE_1	739	758	PF01857	0.560
LIG_RPA_C_Fungi	369	381	PF08784	0.288
LIG_SH2_GRB2like	220	223	PF00017	0.562
LIG_SH2_PTP2	494	497	PF00017	0.530
LIG_SH2_PTP2	995	998	PF00017	0.485
LIG_SH2_STAP1	582	586	PF00017	0.404
LIG_SH2_STAP1	962	966	PF00017	0.556
LIG_SH2_STAT3	220	223	PF00017	0.562
LIG_SH2_STAT3	589	592	PF00017	0.565
LIG_SH2_STAT5	1078	1081	PF00017	0.588
LIG_SH2_STAT5	161	164	PF00017	0.451
LIG_SH2_STAT5	220	223	PF00017	0.562
LIG_SH2_STAT5	282	285	PF00017	0.358
LIG_SH2_STAT5	307	310	PF00017	0.374
LIG_SH2_STAT5	413	416	PF00017	0.413
LIG_SH2_STAT5	494	497	PF00017	0.415
LIG_SH2_STAT5	512	515	PF00017	0.401
LIG_SH2_STAT5	536	539	PF00017	0.438
LIG_SH2_STAT5	589	592	PF00017	0.418
LIG_SH2_STAT5	626	629	PF00017	0.524
LIG_SH2_STAT5	710	713	PF00017	0.419
LIG_SH2_STAT5	938	941	PF00017	0.422
LIG_SH2_STAT5	973	976	PF00017	0.485
LIG_SH2_STAT5	984	987	PF00017	0.438
LIG_SH2_STAT5	995	998	PF00017	0.427
LIG_SH3_1	205	211	PF00018	0.572
LIG_SH3_3	205	211	PF00018	0.526
LIG_SH3_3	548	554	PF00018	0.484
LIG_SH3_3	756	762	PF00018	0.374
LIG_SH3_3	908	914	PF00018	0.545
LIG_Sin3_3	377	384	PF02671	0.501
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.496
LIG_SUMO_SIM_anti_2	57	62	PF11976	0.502
LIG_SUMO_SIM_par_1	546	552	PF11976	0.478
LIG_SUMO_SIM_par_1	676	684	PF11976	0.568
LIG_SUMO_SIM_par_1	88	97	PF11976	0.332
LIG_TRAF2_1	23	26	PF00917	0.595
LIG_TRFH_1	307	311	PF08558	0.374
LIG_UBA3_1	133	138	PF00899	0.347
LIG_UBA3_1	737	743	PF00899	0.512
LIG_UBA3_1	854	863	PF00899	0.477
LIG_Vh1_VBS_1	442	460	PF01044	0.291
LIG_WRC_WIRS_1	464	469	PF05994	0.424
MOD_CK1_1	1069	1075	PF00069	0.533
MOD_CK1_1	228	234	PF00069	0.522
MOD_CK1_1	242	248	PF00069	0.518
MOD_CK1_1	47	53	PF00069	0.581
MOD_CK1_1	523	529	PF00069	0.403
MOD_CK1_1	733	739	PF00069	0.448
MOD_CK1_1	772	778	PF00069	0.475
MOD_CK1_1	91	97	PF00069	0.504
MOD_CK1_1	919	925	PF00069	0.567
MOD_CK1_1	949	955	PF00069	0.676
MOD_CK2_1	20	26	PF00069	0.620
MOD_CK2_1	228	234	PF00069	0.547
MOD_CK2_1	278	284	PF00069	0.374
MOD_CK2_1	296	302	PF00069	0.374
MOD_CK2_1	39	45	PF00069	0.288
MOD_CK2_1	469	475	PF00069	0.589
MOD_CK2_1	681	687	PF00069	0.531
MOD_CK2_1	772	778	PF00069	0.522
MOD_CK2_1	882	888	PF00069	0.538
MOD_Cter_Amidation	350	353	PF01082	0.374
MOD_GlcNHglycan	109	112	PF01048	0.330
MOD_GlcNHglycan	14	17	PF01048	0.519
MOD_GlcNHglycan	22	25	PF01048	0.518
MOD_GlcNHglycan	339	342	PF01048	0.374
MOD_GlcNHglycan	45	49	PF01048	0.533
MOD_GlcNHglycan	732	735	PF01048	0.468
MOD_GSK3_1	1009	1016	PF00069	0.437
MOD_GSK3_1	1054	1061	PF00069	0.556
MOD_GSK3_1	125	132	PF00069	0.564
MOD_GSK3_1	161	168	PF00069	0.499
MOD_GSK3_1	191	198	PF00069	0.505
MOD_GSK3_1	238	245	PF00069	0.512
MOD_GSK3_1	387	394	PF00069	0.559
MOD_GSK3_1	423	430	PF00069	0.339
MOD_GSK3_1	451	458	PF00069	0.399
MOD_GSK3_1	463	470	PF00069	0.547
MOD_GSK3_1	520	527	PF00069	0.396
MOD_GSK3_1	677	684	PF00069	0.539
MOD_GSK3_1	74	81	PF00069	0.462
MOD_GSK3_1	793	800	PF00069	0.445
MOD_GSK3_1	88	95	PF00069	0.434
MOD_GSK3_1	889	896	PF00069	0.492
MOD_GSK3_1	905	912	PF00069	0.427
MOD_GSK3_1	915	922	PF00069	0.331
MOD_GSK3_1	946	953	PF00069	0.558
MOD_GSK3_1	990	997	PF00069	0.382
MOD_LATS_1	406	412	PF00433	0.546
MOD_N-GLC_1	366	371	PF02516	0.328
MOD_N-GLC_1	67	72	PF02516	0.568
MOD_N-GLC_2	819	821	PF02516	0.505
MOD_NEK2_1	1	6	PF00069	0.622
MOD_NEK2_1	1001	1006	PF00069	0.436
MOD_NEK2_1	191	196	PF00069	0.492
MOD_NEK2_1	278	283	PF00069	0.467
MOD_NEK2_1	296	301	PF00069	0.221
MOD_NEK2_1	305	310	PF00069	0.339
MOD_NEK2_1	31	36	PF00069	0.600
MOD_NEK2_1	354	359	PF00069	0.534
MOD_NEK2_1	39	44	PF00069	0.497
MOD_NEK2_1	467	472	PF00069	0.593
MOD_NEK2_1	854	859	PF00069	0.441
MOD_NEK2_1	889	894	PF00069	0.486
MOD_NEK2_1	946	951	PF00069	0.531
MOD_NEK2_1	994	999	PF00069	0.398
MOD_NEK2_2	139	144	PF00069	0.322
MOD_NEK2_2	172	177	PF00069	0.519
MOD_NEK2_2	387	392	PF00069	0.522
MOD_PIKK_1	360	366	PF00454	0.319
MOD_PIKK_1	391	397	PF00454	0.560
MOD_PIKK_1	423	429	PF00454	0.422
MOD_PIKK_1	47	53	PF00454	0.603
MOD_PIKK_1	506	512	PF00454	0.544
MOD_PIKK_1	94	100	PF00454	0.607
MOD_PK_1	786	792	PF00069	0.505
MOD_PK_1	893	899	PF00069	0.282
MOD_PKA_1	824	830	PF00069	0.479
MOD_PKA_2	195	201	PF00069	0.483
MOD_PKA_2	20	26	PF00069	0.573
MOD_PKA_2	343	349	PF00069	0.443
MOD_PKA_2	506	512	PF00069	0.587
MOD_PKA_2	730	736	PF00069	0.395
MOD_PKA_2	824	830	PF00069	0.253
MOD_Plk_1	1	7	PF00069	0.625
MOD_Plk_1	139	145	PF00069	0.318
MOD_Plk_1	191	197	PF00069	0.495
MOD_Plk_1	233	239	PF00069	0.571
MOD_Plk_1	366	372	PF00069	0.324
MOD_Plk_1	451	457	PF00069	0.300
MOD_Plk_1	772	778	PF00069	0.549
MOD_Plk_2-3	225	231	PF00069	0.566
MOD_Plk_2-3	546	552	PF00069	0.584
MOD_Plk_4	1013	1019	PF00069	0.312
MOD_Plk_4	129	135	PF00069	0.485
MOD_Plk_4	228	234	PF00069	0.483
MOD_Plk_4	296	302	PF00069	0.380
MOD_Plk_4	366	372	PF00069	0.526
MOD_Plk_4	395	401	PF00069	0.491
MOD_Plk_4	463	469	PF00069	0.419
MOD_Plk_4	528	534	PF00069	0.339
MOD_Plk_4	565	571	PF00069	0.425
MOD_Plk_4	626	632	PF00069	0.506
MOD_Plk_4	681	687	PF00069	0.481
MOD_Plk_4	720	726	PF00069	0.541
MOD_Plk_4	733	739	PF00069	0.397
MOD_Plk_4	772	778	PF00069	0.505
MOD_Plk_4	854	860	PF00069	0.439
MOD_Plk_4	88	94	PF00069	0.330
MOD_Plk_4	893	899	PF00069	0.386
MOD_Plk_4	905	911	PF00069	0.495
MOD_Plk_4	994	1000	PF00069	0.389
MOD_ProDKin_1	100	106	PF00069	0.585
MOD_ProDKin_1	427	433	PF00069	0.322
MOD_ProDKin_1	67	73	PF00069	0.550
MOD_ProDKin_1	793	799	PF00069	0.398
MOD_SUMO_for_1	407	410	PF00179	0.560
MOD_SUMO_rev_2	15	24	PF00179	0.632
MOD_SUMO_rev_2	182	189	PF00179	0.537
MOD_SUMO_rev_2	409	414	PF00179	0.434
MOD_SUMO_rev_2	684	691	PF00179	0.508
MOD_SUMO_rev_2	746	751	PF00179	0.619
TRG_DiLeu_BaEn_1	331	336	PF01217	0.479
TRG_DiLeu_BaEn_1	565	570	PF01217	0.377
TRG_DiLeu_BaEn_2	664	670	PF01217	0.631
TRG_ENDOCYTIC_2	28	31	PF00928	0.492
TRG_ENDOCYTIC_2	494	497	PF00928	0.568
TRG_ENDOCYTIC_2	544	547	PF00928	0.566
TRG_ENDOCYTIC_2	745	748	PF00928	0.551
TRG_ENDOCYTIC_2	995	998	PF00928	0.441
TRG_ER_diArg_1	1032	1034	PF00400	0.508
TRG_ER_diArg_1	205	208	PF00400	0.584
TRG_ER_diArg_1	603	606	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	1032	1036	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZF6	Leptomonas seymouri	77%	100%
A0A0S4JKP1	Bodo saltans	37%	100%
A0A1X0NU68	Trypanosomatidae	40%	100%
A0A3Q8ID72	Leishmania donovani	91%	100%
A0A3R7MFW4	Trypanosoma rangeli	42%	100%
A4I837	Leishmania infantum	91%	100%
D0AAA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B2Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O00410	Homo sapiens	21%	99%
O60518	Homo sapiens	21%	98%
O74476	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	99%
P32337	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	99%
Q4Q561	Leishmania major	90%	100%
Q8BIV3	Mus musculus	20%	98%
Q8BKC5	Mus musculus	21%	99%
V5BG77	Trypanosoma cruzi	42%	100%