Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKK4_LEIBR

TriTrypDb:

LbrM.32.2350 , LBRM2903_320030200

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HKK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.283
CLV_PCSK_KEX2_1	115	117	PF00082	0.283
CLV_PCSK_SKI1_1	86	90	PF00082	0.369
DOC_CKS1_1	15	20	PF01111	0.335
DOC_CYCLIN_RxL_1	83	91	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	81	87	PF00134	0.529
DOC_PP1_RVXF_1	84	90	PF00149	0.616
DOC_PP2B_LxvP_1	62	65	PF13499	0.481
DOC_PP2B_LxvP_1	81	84	PF13499	0.226
DOC_PP4_FxxP_1	94	97	PF00568	0.468
DOC_WW_Pin1_4	14	19	PF00397	0.335
LIG_Actin_WH2_2	25	40	PF00022	0.482
LIG_BRCT_BRCA1_1	25	29	PF00533	0.355
LIG_BRCT_BRCA1_1	75	79	PF00533	0.408
LIG_BRCT_BRCA1_1	90	94	PF00533	0.596
LIG_CAP-Gly_1	126	133	PF01302	0.714
LIG_eIF4E_1	43	49	PF01652	0.447
LIG_FHA_1	45	51	PF00498	0.430
LIG_FHA_1	72	78	PF00498	0.468
LIG_FHA_1	88	94	PF00498	0.518
LIG_IRF3_LxIS_1	33	40	PF10401	0.678
LIG_LIR_Apic_2	6	12	PF02991	0.460
LIG_LIR_Apic_2	91	97	PF02991	0.476
LIG_LIR_Gen_1	107	114	PF02991	0.603
LIG_LIR_Gen_1	26	37	PF02991	0.455
LIG_LIR_Gen_1	40	51	PF02991	0.458
LIG_LIR_Nem_3	26	32	PF02991	0.351
LIG_LIR_Nem_3	40	46	PF02991	0.463
LIG_LIR_Nem_3	8	13	PF02991	0.454
LIG_NRBOX	47	53	PF00104	0.447
LIG_PCNA_yPIPBox_3	30	38	PF02747	0.487
LIG_PDZ_Class_3	128	133	PF00595	0.720
LIG_Pex14_1	9	13	PF04695	0.455
LIG_SH2_CRK	43	47	PF00017	0.447
LIG_SH2_GRB2like	43	46	PF00017	0.484
LIG_SH2_NCK_1	43	47	PF00017	0.447
LIG_SH2_STAT5	106	109	PF00017	0.581
LIG_SH2_STAT5	120	123	PF00017	0.561
LIG_SH2_STAT5	43	46	PF00017	0.451
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.480
LIG_UBA3_1	77	86	PF00899	0.403
MOD_CK1_1	3	9	PF00069	0.382
MOD_CK2_1	2	8	PF00069	0.538
MOD_GSK3_1	37	44	PF00069	0.468
MOD_GSK3_1	52	59	PF00069	0.355
MOD_GSK3_1	73	80	PF00069	0.406
MOD_N-GLC_1	44	49	PF02516	0.480
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	105	110	PF00069	0.502
MOD_NEK2_1	28	33	PF00069	0.442
MOD_NEK2_1	37	42	PF00069	0.438
MOD_NEK2_1	52	57	PF00069	0.294
MOD_NEK2_1	58	63	PF00069	0.454
MOD_NEK2_1	73	78	PF00069	0.283
MOD_NEK2_1	88	93	PF00069	0.404
MOD_NMyristoyl	1	7	PF02799	0.545
MOD_PKA_2	37	43	PF00069	0.445
MOD_Plk_1	44	50	PF00069	0.480
MOD_Plk_4	28	34	PF00069	0.407
MOD_Plk_4	44	50	PF00069	0.453
MOD_Plk_4	73	79	PF00069	0.430
MOD_ProDKin_1	14	20	PF00069	0.355
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.589
TRG_ENDOCYTIC_2	109	112	PF00928	0.420
TRG_ENDOCYTIC_2	43	46	PF00928	0.355
TRG_ER_diArg_1	114	116	PF00400	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE7	Leptomonas seymouri	57%	100%
A0A0S4IHK1	Bodo saltans	29%	100%
A0A1X0NU87	Trypanosomatidae	57%	100%
A0A3S7X5Q0	Leishmania donovani	87%	100%
A0A422MY14	Trypanosoma rangeli	42%	100%
A4I836	Leishmania infantum	87%	100%
D0AAA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B2Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q562	Leishmania major	88%	100%