RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HKK3_LEIBR

TriTrypDb:

LbrM.32.2340 , LBRM2903_320030100

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HKK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKK3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006379	mRNA cleavage	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.744
CLV_NRD_NRD_1	254	256	PF00675	0.741
CLV_NRD_NRD_1	315	317	PF00675	0.810
CLV_NRD_NRD_1	67	69	PF00675	0.343
CLV_PCSK_KEX2_1	112	114	PF00082	0.645
CLV_PCSK_KEX2_1	219	221	PF00082	0.653
CLV_PCSK_KEX2_1	317	319	PF00082	0.816
CLV_PCSK_KEX2_1	394	396	PF00082	0.584
CLV_PCSK_KEX2_1	67	69	PF00082	0.331
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.645
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.622
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.816
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.626
CLV_PCSK_PC7_1	313	319	PF00082	0.775
CLV_PCSK_SKI1_1	174	178	PF00082	0.399
CLV_PCSK_SKI1_1	219	223	PF00082	0.539
CLV_PCSK_SKI1_1	368	372	PF00082	0.531
CLV_PCSK_SKI1_1	394	398	PF00082	0.611
DEG_APCC_DBOX_1	385	393	PF00400	0.608
DEG_COP1_1	373	383	PF00400	0.637
DEG_Nend_UBRbox_2	1	3	PF02207	0.688
DEG_SCF_FBW7_2	342	348	PF00400	0.737
DEG_SPOP_SBC_1	84	88	PF00917	0.680
DOC_CKS1_1	285	290	PF01111	0.671
DOC_CKS1_1	342	347	PF01111	0.746
DOC_CYCLIN_RxL_1	205	216	PF00134	0.494
DOC_CYCLIN_RxL_1	391	400	PF00134	0.628
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.748
DOC_MAPK_gen_1	164	172	PF00069	0.611
DOC_PP4_FxxP_1	176	179	PF00568	0.473
DOC_PP4_MxPP_1	274	277	PF00568	0.529
DOC_USP7_MATH_1	121	125	PF00917	0.601
DOC_USP7_MATH_1	227	231	PF00917	0.554
DOC_USP7_MATH_1	243	247	PF00917	0.523
DOC_USP7_MATH_1	251	255	PF00917	0.638
DOC_USP7_MATH_1	281	285	PF00917	0.718
DOC_USP7_MATH_1	292	296	PF00917	0.529
DOC_USP7_MATH_1	306	310	PF00917	0.698
DOC_USP7_MATH_1	321	325	PF00917	0.536
DOC_USP7_MATH_1	329	333	PF00917	0.794
DOC_USP7_MATH_1	335	339	PF00917	0.727
DOC_USP7_UBL2_3	297	301	PF12436	0.791
DOC_USP7_UBL2_3	304	308	PF12436	0.703
DOC_WW_Pin1_4	105	110	PF00397	0.587
DOC_WW_Pin1_4	117	122	PF00397	0.652
DOC_WW_Pin1_4	284	289	PF00397	0.613
DOC_WW_Pin1_4	341	346	PF00397	0.759
LIG_14-3-3_CanoR_1	174	179	PF00244	0.622
LIG_14-3-3_CanoR_1	193	201	PF00244	0.347
LIG_14-3-3_CanoR_1	368	373	PF00244	0.532
LIG_14-3-3_CanoR_1	4	8	PF00244	0.653
LIG_14-3-3_CanoR_1	85	90	PF00244	0.715
LIG_BRCT_BRCA1_1	8	12	PF00533	0.457
LIG_FHA_1	175	181	PF00498	0.531
LIG_FHA_1	335	341	PF00498	0.805
LIG_FHA_1	369	375	PF00498	0.431
LIG_FHA_1	84	90	PF00498	0.576
LIG_FHA_2	258	264	PF00498	0.707
LIG_FHA_2	297	303	PF00498	0.547
LIG_FHA_2	345	351	PF00498	0.626
LIG_FHA_2	59	65	PF00498	0.561
LIG_FHA_2	71	77	PF00498	0.561
LIG_LIR_Apic_2	116	121	PF02991	0.695
LIG_LIR_Gen_1	198	209	PF02991	0.479
LIG_LIR_Nem_3	10	16	PF02991	0.437
LIG_LIR_Nem_3	106	110	PF02991	0.572
LIG_LIR_Nem_3	169	175	PF02991	0.638
LIG_LIR_Nem_3	198	204	PF02991	0.470
LIG_MLH1_MIPbox_1	9	13	PF16413	0.434
LIG_Pex14_2	172	176	PF04695	0.402
LIG_SH2_NCK_1	201	205	PF00017	0.475
LIG_SH3_3	124	130	PF00018	0.725
LIG_SH3_3	264	270	PF00018	0.786
LIG_SH3_3	272	278	PF00018	0.655
LIG_SH3_3	339	345	PF00018	0.759
LIG_SH3_3	377	383	PF00018	0.670
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.444
LIG_SUMO_SIM_anti_2	352	359	PF11976	0.552
LIG_SUMO_SIM_par_1	208	213	PF11976	0.493
LIG_TRAF2_1	196	199	PF00917	0.564
LIG_TRAF2_1	61	64	PF00917	0.490
MOD_CDC14_SPxK_1	108	111	PF00782	0.520
MOD_CDK_SPxK_1	105	111	PF00069	0.525
MOD_CDK_SPxxK_3	105	112	PF00069	0.526
MOD_CK1_1	120	126	PF00069	0.800
MOD_CK1_1	284	290	PF00069	0.820
MOD_CK1_1	324	330	PF00069	0.742
MOD_CK1_1	6	12	PF00069	0.504
MOD_CK2_1	199	205	PF00069	0.625
MOD_CK2_1	251	257	PF00069	0.497
MOD_CK2_1	296	302	PF00069	0.553
MOD_CK2_1	344	350	PF00069	0.638
MOD_CK2_1	58	64	PF00069	0.490
MOD_CK2_1	70	76	PF00069	0.490
MOD_GlcNHglycan	101	104	PF01048	0.743
MOD_GlcNHglycan	201	204	PF01048	0.592
MOD_GlcNHglycan	229	232	PF01048	0.559
MOD_GlcNHglycan	304	307	PF01048	0.755
MOD_GlcNHglycan	323	326	PF01048	0.801
MOD_GlcNHglycan	327	330	PF01048	0.753
MOD_GSK3_1	117	124	PF00069	0.798
MOD_GSK3_1	276	283	PF00069	0.755
MOD_GSK3_1	292	299	PF00069	0.577
MOD_GSK3_1	3	10	PF00069	0.535
MOD_GSK3_1	302	309	PF00069	0.791
MOD_GSK3_1	317	324	PF00069	0.681
MOD_GSK3_1	325	332	PF00069	0.723
MOD_GSK3_1	340	347	PF00069	0.620
MOD_GSK3_1	79	86	PF00069	0.540
MOD_N-GLC_1	121	126	PF02516	0.804
MOD_N-GLC_1	359	364	PF02516	0.547
MOD_N-GLC_1	36	41	PF02516	0.238
MOD_NEK2_1	296	301	PF00069	0.557
MOD_NEK2_1	370	375	PF00069	0.559
MOD_NEK2_1	69	74	PF00069	0.500
MOD_NEK2_1	79	84	PF00069	0.481
MOD_NEK2_2	292	297	PF00069	0.638
MOD_PIKK_1	281	287	PF00454	0.650
MOD_PIKK_1	397	403	PF00454	0.567
MOD_PKA_1	317	323	PF00069	0.778
MOD_PKA_2	166	172	PF00069	0.631
MOD_PKA_2	213	219	PF00069	0.495
MOD_PKA_2	3	9	PF00069	0.610
MOD_PKA_2	312	318	PF00069	0.719
MOD_PKA_2	79	85	PF00069	0.593
MOD_Plk_1	36	42	PF00069	0.572
MOD_Plk_2-3	257	263	PF00069	0.652
MOD_Plk_2-3	70	76	PF00069	0.591
MOD_Plk_4	14	20	PF00069	0.369
MOD_Plk_4	183	189	PF00069	0.525
MOD_Plk_4	335	341	PF00069	0.805
MOD_Plk_4	7	13	PF00069	0.455
MOD_ProDKin_1	105	111	PF00069	0.587
MOD_ProDKin_1	117	123	PF00069	0.653
MOD_ProDKin_1	284	290	PF00069	0.614
MOD_ProDKin_1	341	347	PF00069	0.750
MOD_SUMO_rev_2	213	221	PF00179	0.645
TRG_DiLeu_BaEn_1	217	222	PF01217	0.499
TRG_DiLeu_BaEn_1	353	358	PF01217	0.645
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.483
TRG_DiLeu_LyEn_5	217	222	PF01217	0.601
TRG_ENDOCYTIC_2	107	110	PF00928	0.564
TRG_ENDOCYTIC_2	201	204	PF00928	0.468
TRG_ER_diArg_1	110	113	PF00400	0.745
TRG_ER_diArg_1	66	68	PF00400	0.561
TRG_NLS_Bipartite_1	300	320	PF00514	0.553
TRG_NLS_MonoExtC_3	110	115	PF00514	0.786
TRG_NLS_MonoExtN_4	109	115	PF00514	0.529
TRG_NLS_MonoExtN_4	313	320	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4N7	Leptomonas seymouri	56%	100%
A0A1X0NU71	Trypanosomatidae	30%	100%
A0A3Q8ITD1	Leishmania donovani	83%	100%
A0A3R7KNF2	Trypanosoma rangeli	35%	100%
A4I835	Leishmania infantum	83%	100%
E9B2Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q563	Leishmania major	83%	100%
V5BKQ1	Trypanosoma cruzi	36%	100%