Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKK2_LEIBR

TriTrypDb:

LbrM.32.2330 , LBRM2903_320030000

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A4HKK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.518
CLV_C14_Caspase3-7	64	68	PF00656	0.592
CLV_NRD_NRD_1	348	350	PF00675	0.438
CLV_PCSK_KEX2_1	245	247	PF00082	0.404
CLV_PCSK_KEX2_1	348	350	PF00082	0.470
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.429
CLV_PCSK_SKI1_1	245	249	PF00082	0.424
CLV_PCSK_SKI1_1	293	297	PF00082	0.409
DEG_COP1_1	454	462	PF00400	0.222
DEG_Nend_UBRbox_3	1	3	PF02207	0.571
DOC_CKS1_1	285	290	PF01111	0.344
DOC_CYCLIN_RxL_1	355	364	PF00134	0.510
DOC_MAPK_gen_1	125	133	PF00069	0.533
DOC_MAPK_MEF2A_6	126	135	PF00069	0.589
DOC_MAPK_MEF2A_6	219	226	PF00069	0.539
DOC_MAPK_MEF2A_6	418	427	PF00069	0.554
DOC_PP1_RVXF_1	291	298	PF00149	0.233
DOC_PP1_RVXF_1	356	363	PF00149	0.510
DOC_PP1_RVXF_1	92	98	PF00149	0.575
DOC_PP2B_LxvP_1	412	415	PF13499	0.333
DOC_PP4_FxxP_1	168	171	PF00568	0.423
DOC_SPAK_OSR1_1	246	250	PF12202	0.421
DOC_WW_Pin1_4	284	289	PF00397	0.340
DOC_WW_Pin1_4	31	36	PF00397	0.643
LIG_14-3-3_CanoR_1	174	179	PF00244	0.392
LIG_14-3-3_CanoR_1	335	342	PF00244	0.668
LIG_14-3-3_CanoR_1	488	494	PF00244	0.581
LIG_14-3-3_CanoR_1	94	98	PF00244	0.592
LIG_Actin_WH2_2	4	19	PF00022	0.604
LIG_APCC_ABBA_1	38	43	PF00400	0.499
LIG_APCC_ABBA_1	434	439	PF00400	0.202
LIG_BRCT_BRCA1_1	4	8	PF00533	0.591
LIG_Clathr_ClatBox_1	435	439	PF01394	0.176
LIG_FHA_1	155	161	PF00498	0.420
LIG_FHA_1	25	31	PF00498	0.568
LIG_FHA_1	285	291	PF00498	0.423
LIG_FHA_1	341	347	PF00498	0.636
LIG_FHA_1	355	361	PF00498	0.426
LIG_FHA_1	372	378	PF00498	0.420
LIG_FHA_1	395	401	PF00498	0.320
LIG_FHA_1	420	426	PF00498	0.347
LIG_FHA_1	462	468	PF00498	0.333
LIG_FHA_1	90	96	PF00498	0.598
LIG_FHA_2	1	7	PF00498	0.587
LIG_GBD_Chelix_1	472	480	PF00786	0.456
LIG_LIR_Apic_2	266	272	PF02991	0.200
LIG_LIR_Apic_2	454	460	PF02991	0.405
LIG_LIR_Gen_1	106	115	PF02991	0.476
LIG_LIR_Gen_1	153	164	PF02991	0.374
LIG_LIR_Gen_1	177	185	PF02991	0.238
LIG_LIR_Gen_1	232	240	PF02991	0.522
LIG_LIR_Gen_1	26	36	PF02991	0.520
LIG_LIR_Gen_1	278	284	PF02991	0.446
LIG_LIR_Gen_1	389	400	PF02991	0.195
LIG_LIR_Gen_1	464	473	PF02991	0.220
LIG_LIR_Gen_1	474	483	PF02991	0.188
LIG_LIR_Gen_1	495	500	PF02991	0.444
LIG_LIR_Gen_1	5	16	PF02991	0.586
LIG_LIR_Gen_1	82	90	PF02991	0.478
LIG_LIR_Gen_1	96	105	PF02991	0.531
LIG_LIR_LC3C_4	191	194	PF02991	0.290
LIG_LIR_Nem_3	106	111	PF02991	0.510
LIG_LIR_Nem_3	128	132	PF02991	0.577
LIG_LIR_Nem_3	146	150	PF02991	0.265
LIG_LIR_Nem_3	177	182	PF02991	0.309
LIG_LIR_Nem_3	215	221	PF02991	0.612
LIG_LIR_Nem_3	232	236	PF02991	0.417
LIG_LIR_Nem_3	26	31	PF02991	0.625
LIG_LIR_Nem_3	266	271	PF02991	0.304
LIG_LIR_Nem_3	278	284	PF02991	0.391
LIG_LIR_Nem_3	310	315	PF02991	0.209
LIG_LIR_Nem_3	339	345	PF02991	0.648
LIG_LIR_Nem_3	364	369	PF02991	0.337
LIG_LIR_Nem_3	389	395	PF02991	0.219
LIG_LIR_Nem_3	431	437	PF02991	0.296
LIG_LIR_Nem_3	495	500	PF02991	0.599
LIG_LIR_Nem_3	5	11	PF02991	0.543
LIG_LIR_Nem_3	82	86	PF02991	0.482
LIG_NRBOX	374	380	PF00104	0.295
LIG_NRBOX	475	481	PF00104	0.442
LIG_PCNA_PIPBox_1	273	282	PF02747	0.462
LIG_PCNA_yPIPBox_3	485	498	PF02747	0.632
LIG_PCNA_yPIPBox_3	59	72	PF02747	0.520
LIG_PDZ_Class_2	495	500	PF00595	0.513
LIG_Pex14_1	162	166	PF04695	0.353
LIG_Pex14_2	363	367	PF04695	0.423
LIG_PTB_Apo_2	253	260	PF02174	0.569
LIG_PTB_Apo_2	262	269	PF02174	0.418
LIG_PTB_Phospho_1	253	259	PF10480	0.385
LIG_REV1ctd_RIR_1	245	255	PF16727	0.485
LIG_SH2_CRK	269	273	PF00017	0.404
LIG_SH2_CRK	291	295	PF00017	0.266
LIG_SH2_CRK	396	400	PF00017	0.290
LIG_SH2_GRB2like	206	209	PF00017	0.627
LIG_SH2_GRB2like	411	414	PF00017	0.365
LIG_SH2_NCK_1	269	273	PF00017	0.311
LIG_SH2_PTP2	110	113	PF00017	0.584
LIG_SH2_PTP2	140	143	PF00017	0.457
LIG_SH2_PTP2	233	236	PF00017	0.493
LIG_SH2_PTP2	497	500	PF00017	0.590
LIG_SH2_SRC	238	241	PF00017	0.492
LIG_SH2_SRC	315	318	PF00017	0.405
LIG_SH2_SRC	437	440	PF00017	0.562
LIG_SH2_STAP1	206	210	PF00017	0.535
LIG_SH2_STAP1	227	231	PF00017	0.589
LIG_SH2_STAP1	291	295	PF00017	0.287
LIG_SH2_STAP1	396	400	PF00017	0.335
LIG_SH2_STAT3	206	209	PF00017	0.627
LIG_SH2_STAT5	110	113	PF00017	0.582
LIG_SH2_STAT5	119	122	PF00017	0.560
LIG_SH2_STAT5	132	135	PF00017	0.527
LIG_SH2_STAT5	140	143	PF00017	0.350
LIG_SH2_STAT5	184	187	PF00017	0.306
LIG_SH2_STAT5	188	191	PF00017	0.302
LIG_SH2_STAT5	233	236	PF00017	0.465
LIG_SH2_STAT5	259	262	PF00017	0.225
LIG_SH2_STAT5	342	345	PF00017	0.582
LIG_SH2_STAT5	366	369	PF00017	0.325
LIG_SH2_STAT5	396	399	PF00017	0.457
LIG_SH2_STAT5	411	414	PF00017	0.567
LIG_SH2_STAT5	437	440	PF00017	0.372
LIG_SH2_STAT5	497	500	PF00017	0.556
LIG_SH2_STAT5	83	86	PF00017	0.502
LIG_SH3_1	219	225	PF00018	0.529
LIG_SH3_3	219	225	PF00018	0.519
LIG_Sin3_3	296	303	PF02671	0.176
LIG_SUMO_SIM_anti_2	109	116	PF11976	0.541
LIG_SUMO_SIM_anti_2	374	380	PF11976	0.418
LIG_SUMO_SIM_anti_2	403	409	PF11976	0.347
LIG_SUMO_SIM_par_1	150	155	PF11976	0.381
LIG_SUMO_SIM_par_1	424	431	PF11976	0.292
LIG_TYR_ITIM	138	143	PF00017	0.423
LIG_TYR_ITIM	231	236	PF00017	0.474
LIG_TYR_ITIM	409	414	PF00017	0.239
LIG_TYR_ITSM	362	369	PF00017	0.423
LIG_UBA3_1	12	17	PF00899	0.612
LIG_UBA3_1	120	126	PF00899	0.612
LIG_UBA3_1	448	456	PF00899	0.255
LIG_WRC_WIRS_1	276	281	PF05994	0.396
LIG_WRC_WIRS_1	462	467	PF05994	0.218
MOD_CK1_1	333	339	PF00069	0.604
MOD_CK1_1	394	400	PF00069	0.249
MOD_CK1_1	461	467	PF00069	0.392
MOD_CK1_1	471	477	PF00069	0.162
MOD_CK1_1	93	99	PF00069	0.578
MOD_CK2_1	15	21	PF00069	0.508
MOD_GlcNHglycan	105	108	PF01048	0.303
MOD_GlcNHglycan	31	34	PF01048	0.381
MOD_GlcNHglycan	43	46	PF01048	0.313
MOD_GlcNHglycan	449	452	PF01048	0.485
MOD_GlcNHglycan	76	79	PF01048	0.406
MOD_GSK3_1	12	19	PF00069	0.619
MOD_GSK3_1	139	146	PF00069	0.394
MOD_GSK3_1	150	157	PF00069	0.421
MOD_GSK3_1	170	177	PF00069	0.218
MOD_GSK3_1	180	187	PF00069	0.378
MOD_GSK3_1	188	195	PF00069	0.438
MOD_GSK3_1	330	337	PF00069	0.590
MOD_GSK3_1	350	357	PF00069	0.596
MOD_GSK3_1	447	454	PF00069	0.459
MOD_GSK3_1	89	96	PF00069	0.493
MOD_N-GLC_1	174	179	PF02516	0.437
MOD_N-GLC_1	255	260	PF02516	0.250
MOD_N-GLC_1	386	391	PF02516	0.595
MOD_N-GLC_2	265	267	PF02516	0.290
MOD_N-GLC_2	325	327	PF02516	0.299
MOD_NEK2_1	103	108	PF00069	0.535
MOD_NEK2_1	154	159	PF00069	0.409
MOD_NEK2_1	160	165	PF00069	0.518
MOD_NEK2_1	192	197	PF00069	0.416
MOD_NEK2_1	320	325	PF00069	0.451
MOD_NEK2_1	400	405	PF00069	0.360
MOD_NEK2_1	41	46	PF00069	0.505
MOD_NEK2_1	452	457	PF00069	0.370
MOD_NEK2_1	468	473	PF00069	0.417
MOD_NEK2_1	484	489	PF00069	0.503
MOD_PIKK_1	487	493	PF00454	0.549
MOD_PKA_1	125	131	PF00069	0.453
MOD_PKA_2	103	109	PF00069	0.537
MOD_PKA_2	334	340	PF00069	0.707
MOD_PKA_2	484	490	PF00069	0.606
MOD_PKA_2	90	96	PF00069	0.594
MOD_Plk_1	174	180	PF00069	0.215
MOD_Plk_2-3	24	30	PF00069	0.597
MOD_Plk_4	174	180	PF00069	0.295
MOD_Plk_4	184	190	PF00069	0.305
MOD_Plk_4	229	235	PF00069	0.490
MOD_Plk_4	255	261	PF00069	0.498
MOD_Plk_4	275	281	PF00069	0.193
MOD_Plk_4	307	313	PF00069	0.250
MOD_Plk_4	371	377	PF00069	0.322
MOD_Plk_4	386	392	PF00069	0.284
MOD_Plk_4	468	474	PF00069	0.341
MOD_Plk_4	53	59	PF00069	0.526
MOD_ProDKin_1	284	290	PF00069	0.340
MOD_ProDKin_1	31	37	PF00069	0.641
MOD_SUMO_rev_2	199	203	PF00179	0.622
MOD_SUMO_rev_2	239	247	PF00179	0.512
TRG_DiLeu_BaEn_1	116	121	PF01217	0.490
TRG_DiLeu_BaEn_1	431	436	PF01217	0.454
TRG_ENDOCYTIC_2	105	108	PF00928	0.505
TRG_ENDOCYTIC_2	110	113	PF00928	0.493
TRG_ENDOCYTIC_2	132	135	PF00928	0.570
TRG_ENDOCYTIC_2	140	143	PF00928	0.403
TRG_ENDOCYTIC_2	178	181	PF00928	0.353
TRG_ENDOCYTIC_2	227	230	PF00928	0.480
TRG_ENDOCYTIC_2	233	236	PF00928	0.459
TRG_ENDOCYTIC_2	291	294	PF00928	0.368
TRG_ENDOCYTIC_2	314	317	PF00928	0.312
TRG_ENDOCYTIC_2	342	345	PF00928	0.579
TRG_ENDOCYTIC_2	366	369	PF00928	0.356
TRG_ENDOCYTIC_2	396	399	PF00928	0.414
TRG_ENDOCYTIC_2	411	414	PF00928	0.559
TRG_ENDOCYTIC_2	497	500	PF00928	0.533
TRG_ENDOCYTIC_2	83	86	PF00928	0.478
TRG_ER_diArg_1	347	349	PF00400	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A4	Leptomonas seymouri	53%	71%
A0A1X0NUP0	Trypanosomatidae	33%	79%
A0A1X0P3P0	Trypanosomatidae	22%	73%
A0A3Q8IDV0	Leishmania donovani	22%	77%
A0A3R7R847	Trypanosoma rangeli	24%	75%
A0A3S7X5M8	Leishmania donovani	74%	100%
A0A422MY34	Trypanosoma rangeli	32%	79%
A4HLQ6	Leishmania braziliensis	22%	80%
A4I834	Leishmania infantum	74%	100%
A4I956	Leishmania infantum	22%	77%
D0A6B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	75%
D0AAA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	84%
E9B2Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	74%
Q4Q3Z3	Leishmania major	22%	77%
Q4Q564	Leishmania major	74%	100%
V5B8R5	Trypanosoma cruzi	22%	76%
V5BBK9	Trypanosoma cruzi	30%	80%