FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKK1_LEIBR

TriTrypDb:

LbrM.32.2320 , LBRM2903_320029900

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.427
CLV_C14_Caspase3-7	247	251	PF00656	0.595
CLV_C14_Caspase3-7	37	41	PF00656	0.504
CLV_C14_Caspase3-7	634	638	PF00656	0.777
CLV_NRD_NRD_1	395	397	PF00675	0.582
CLV_NRD_NRD_1	441	443	PF00675	0.574
CLV_NRD_NRD_1	491	493	PF00675	0.605
CLV_NRD_NRD_1	515	517	PF00675	0.594
CLV_NRD_NRD_1	631	633	PF00675	0.555
CLV_NRD_NRD_1	677	679	PF00675	0.664
CLV_NRD_NRD_1	75	77	PF00675	0.759
CLV_PCSK_KEX2_1	102	104	PF00082	0.669
CLV_PCSK_KEX2_1	439	441	PF00082	0.604
CLV_PCSK_KEX2_1	491	493	PF00082	0.605
CLV_PCSK_KEX2_1	528	530	PF00082	0.635
CLV_PCSK_KEX2_1	631	633	PF00082	0.555
CLV_PCSK_KEX2_1	677	679	PF00082	0.664
CLV_PCSK_KEX2_1	77	79	PF00082	0.686
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.669
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.447
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.550
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.664
CLV_PCSK_SKI1_1	198	202	PF00082	0.627
CLV_PCSK_SKI1_1	219	223	PF00082	0.606
CLV_PCSK_SKI1_1	260	264	PF00082	0.678
CLV_PCSK_SKI1_1	470	474	PF00082	0.737
CLV_PCSK_SKI1_1	677	681	PF00082	0.681
CLV_PCSK_SKI1_1	721	725	PF00082	0.590
CLV_PCSK_SKI1_1	836	840	PF00082	0.528
DEG_APCC_DBOX_1	143	151	PF00400	0.680
DEG_APCC_DBOX_1	218	226	PF00400	0.441
DEG_Nend_UBRbox_3	1	3	PF02207	0.480
DEG_SPOP_SBC_1	279	283	PF00917	0.574
DEG_SPOP_SBC_1	535	539	PF00917	0.708
DOC_CKS1_1	124	129	PF01111	0.575
DOC_CKS1_1	763	768	PF01111	0.508
DOC_CYCLIN_RxL_1	355	368	PF00134	0.735
DOC_CYCLIN_RxL_1	818	827	PF00134	0.571
DOC_CYCLIN_RxL_1	833	840	PF00134	0.370
DOC_MAPK_gen_1	102	108	PF00069	0.661
DOC_MAPK_gen_1	151	160	PF00069	0.527
DOC_MAPK_gen_1	217	224	PF00069	0.443
DOC_MAPK_gen_1	76	82	PF00069	0.597
DOC_MAPK_JIP1_4	154	160	PF00069	0.577
DOC_MAPK_MEF2A_6	660	669	PF00069	0.566
DOC_PP2B_LxvP_1	131	134	PF13499	0.639
DOC_PP2B_LxvP_1	669	672	PF13499	0.598
DOC_PP4_FxxP_1	211	214	PF00568	0.472
DOC_PP4_FxxP_1	380	383	PF00568	0.614
DOC_PP4_FxxP_1	780	783	PF00568	0.484
DOC_PP4_FxxP_1	825	828	PF00568	0.584
DOC_USP7_MATH_1	134	138	PF00917	0.723
DOC_USP7_MATH_1	17	21	PF00917	0.521
DOC_USP7_MATH_1	193	197	PF00917	0.468
DOC_USP7_MATH_1	248	252	PF00917	0.829
DOC_USP7_MATH_1	29	33	PF00917	0.498
DOC_USP7_MATH_1	342	346	PF00917	0.681
DOC_USP7_MATH_1	375	379	PF00917	0.624
DOC_USP7_MATH_1	405	409	PF00917	0.587
DOC_USP7_MATH_1	504	508	PF00917	0.730
DOC_USP7_MATH_1	515	519	PF00917	0.670
DOC_USP7_MATH_1	535	539	PF00917	0.528
DOC_USP7_MATH_1	644	648	PF00917	0.559
DOC_USP7_UBL2_3	393	397	PF12436	0.600
DOC_USP7_UBL2_3	439	443	PF12436	0.440
DOC_USP7_UBL2_3	656	660	PF12436	0.501
DOC_USP7_UBL2_3	858	862	PF12436	0.373
DOC_WW_Pin1_4	118	123	PF00397	0.647
DOC_WW_Pin1_4	242	247	PF00397	0.665
DOC_WW_Pin1_4	308	313	PF00397	0.508
DOC_WW_Pin1_4	338	343	PF00397	0.764
DOC_WW_Pin1_4	479	484	PF00397	0.572
DOC_WW_Pin1_4	596	601	PF00397	0.743
DOC_WW_Pin1_4	651	656	PF00397	0.692
DOC_WW_Pin1_4	70	75	PF00397	0.736
DOC_WW_Pin1_4	762	767	PF00397	0.552
DOC_WW_Pin1_4	90	95	PF00397	0.742
LIG_14-3-3_CanoR_1	103	109	PF00244	0.658
LIG_14-3-3_CanoR_1	138	147	PF00244	0.805
LIG_14-3-3_CanoR_1	176	181	PF00244	0.589
LIG_14-3-3_CanoR_1	278	285	PF00244	0.600
LIG_14-3-3_CanoR_1	318	323	PF00244	0.682
LIG_14-3-3_CanoR_1	474	484	PF00244	0.560
LIG_14-3-3_CanoR_1	516	520	PF00244	0.575
LIG_14-3-3_CanoR_1	529	536	PF00244	0.589
LIG_14-3-3_CanoR_1	59	64	PF00244	0.596
LIG_14-3-3_CanoR_1	684	693	PF00244	0.713
LIG_14-3-3_CanoR_1	713	720	PF00244	0.595
LIG_14-3-3_CanoR_1	770	775	PF00244	0.465
LIG_Actin_WH2_2	203	221	PF00022	0.458
LIG_APCC_ABBA_1	221	226	PF00400	0.588
LIG_APCC_ABBA_1	822	827	PF00400	0.585
LIG_BRCT_BRCA1_1	31	35	PF00533	0.765
LIG_BRCT_BRCA1_1	344	348	PF00533	0.552
LIG_BRCT_BRCA1_1	377	381	PF00533	0.610
LIG_BRCT_BRCA1_1	411	415	PF00533	0.552
LIG_BRCT_BRCA1_1	621	625	PF00533	0.534
LIG_BRCT_BRCA1_1	731	735	PF00533	0.563
LIG_CtBP_PxDLS_1	105	109	PF00389	0.561
LIG_CtBP_PxDLS_1	849	853	PF00389	0.363
LIG_deltaCOP1_diTrp_1	409	415	PF00928	0.562
LIG_EH_1	781	785	PF12763	0.350
LIG_FHA_1	262	268	PF00498	0.522
LIG_FHA_1	280	286	PF00498	0.537
LIG_FHA_1	312	318	PF00498	0.633
LIG_FHA_1	385	391	PF00498	0.608
LIG_FHA_1	49	55	PF00498	0.710
LIG_FHA_1	546	552	PF00498	0.742
LIG_FHA_1	571	577	PF00498	0.562
LIG_FHA_1	596	602	PF00498	0.734
LIG_FHA_1	829	835	PF00498	0.620
LIG_FHA_2	319	325	PF00498	0.690
LIG_FHA_2	326	332	PF00498	0.558
LIG_FHA_2	35	41	PF00498	0.590
LIG_IRF3_LxIS_1	426	433	PF10401	0.495
LIG_LIR_Apic_2	208	214	PF02991	0.461
LIG_LIR_Apic_2	306	312	PF02991	0.505
LIG_LIR_Apic_2	378	383	PF02991	0.624
LIG_LIR_Gen_1	261	270	PF02991	0.679
LIG_LIR_Gen_1	407	416	PF02991	0.641
LIG_LIR_Gen_1	451	459	PF02991	0.688
LIG_LIR_LC3C_4	598	603	PF02991	0.574
LIG_LIR_Nem_3	261	266	PF02991	0.673
LIG_LIR_Nem_3	407	413	PF02991	0.649
LIG_LIR_Nem_3	451	455	PF02991	0.687
LIG_LIR_Nem_3	673	679	PF02991	0.536
LIG_LIR_Nem_3	717	723	PF02991	0.528
LIG_LIR_Nem_3	732	738	PF02991	0.513
LIG_MLH1_MIPbox_1	377	381	PF16413	0.610
LIG_MLH1_MIPbox_1	411	415	PF16413	0.552
LIG_MYND_1	824	828	PF01753	0.433
LIG_MYND_3	222	226	PF01753	0.435
LIG_PCNA_PIPBox_1	441	450	PF02747	0.564
LIG_PCNA_yPIPBox_3	198	211	PF02747	0.593
LIG_PCNA_yPIPBox_3	439	448	PF02747	0.582
LIG_Pex14_1	410	414	PF04695	0.553
LIG_Pex14_2	780	784	PF04695	0.531
LIG_PTB_Apo_2	779	786	PF02174	0.373
LIG_SH2_CRK	676	680	PF00017	0.675
LIG_SH2_CRK	720	724	PF00017	0.415
LIG_SH2_CRK	764	768	PF00017	0.510
LIG_SH2_NCK_1	16	20	PF00017	0.570
LIG_SH2_SRC	16	19	PF00017	0.580
LIG_SH2_SRC	43	46	PF00017	0.682
LIG_SH2_STAT3	428	431	PF00017	0.603
LIG_SH2_STAT3	817	820	PF00017	0.541
LIG_SH2_STAT5	309	312	PF00017	0.502
LIG_SH2_STAT5	43	46	PF00017	0.754
LIG_SH2_STAT5	452	455	PF00017	0.566
LIG_SH2_STAT5	764	767	PF00017	0.508
LIG_SH2_STAT5	817	820	PF00017	0.541
LIG_SH2_STAT5	829	832	PF00017	0.417
LIG_SH2_STAT5	842	845	PF00017	0.390
LIG_SH3_1	66	72	PF00018	0.579
LIG_SH3_2	71	76	PF14604	0.712
LIG_SH3_3	121	127	PF00018	0.576
LIG_SH3_3	149	155	PF00018	0.646
LIG_SH3_3	39	45	PF00018	0.697
LIG_SH3_3	565	571	PF00018	0.636
LIG_SH3_3	589	595	PF00018	0.594
LIG_SH3_3	64	70	PF00018	0.843
LIG_SH3_3	649	655	PF00018	0.674
LIG_SH3_3	701	707	PF00018	0.697
LIG_SH3_3	754	760	PF00018	0.598
LIG_SUMO_SIM_anti_2	661	666	PF11976	0.405
LIG_SUMO_SIM_par_1	104	110	PF11976	0.717
LIG_SUMO_SIM_par_1	183	192	PF11976	0.469
LIG_SUMO_SIM_par_1	848	854	PF11976	0.363
LIG_SxIP_EBH_1	507	517	PF03271	0.550
LIG_TRAF2_1	520	523	PF00917	0.553
LIG_TYR_ITIM	762	767	PF00017	0.502
LIG_WRC_WIRS_1	377	382	PF05994	0.632
LIG_WW_3	73	77	PF00397	0.595
MOD_CDC14_SPxK_1	73	76	PF00782	0.717
MOD_CDK_SPK_2	651	656	PF00069	0.559
MOD_CDK_SPK_2	90	95	PF00069	0.580
MOD_CDK_SPxK_1	70	76	PF00069	0.710
MOD_CDK_SPxK_1	762	768	PF00069	0.504
MOD_CDK_SPxxK_3	123	130	PF00069	0.577
MOD_CDK_SPxxK_3	70	77	PF00069	0.682
MOD_CK1_1	170	176	PF00069	0.745
MOD_CK1_1	203	209	PF00069	0.647
MOD_CK1_1	229	235	PF00069	0.557
MOD_CK1_1	261	267	PF00069	0.546
MOD_CK1_1	280	286	PF00069	0.691
MOD_CK1_1	311	317	PF00069	0.467
MOD_CK1_1	326	332	PF00069	0.639
MOD_CK1_1	376	382	PF00069	0.635
MOD_CK1_1	384	390	PF00069	0.487
MOD_CK1_1	507	513	PF00069	0.821
MOD_CK1_1	537	543	PF00069	0.701
MOD_CK1_1	62	68	PF00069	0.615
MOD_CK1_1	627	633	PF00069	0.560
MOD_CK1_1	647	653	PF00069	0.675
MOD_CK1_1	93	99	PF00069	0.736
MOD_CK2_1	104	110	PF00069	0.717
MOD_CK2_1	112	118	PF00069	0.638
MOD_CK2_1	517	523	PF00069	0.758
MOD_CK2_1	558	564	PF00069	0.654
MOD_CK2_1	848	854	PF00069	0.520
MOD_GlcNHglycan	169	172	PF01048	0.721
MOD_GlcNHglycan	191	194	PF01048	0.600
MOD_GlcNHglycan	195	198	PF01048	0.547
MOD_GlcNHglycan	214	217	PF01048	0.436
MOD_GlcNHglycan	228	231	PF01048	0.609
MOD_GlcNHglycan	246	249	PF01048	0.662
MOD_GlcNHglycan	270	273	PF01048	0.678
MOD_GlcNHglycan	298	301	PF01048	0.652
MOD_GlcNHglycan	31	34	PF01048	0.655
MOD_GlcNHglycan	330	334	PF01048	0.778
MOD_GlcNHglycan	457	460	PF01048	0.569
MOD_GlcNHglycan	509	512	PF01048	0.682
MOD_GlcNHglycan	519	522	PF01048	0.614
MOD_GlcNHglycan	531	534	PF01048	0.537
MOD_GlcNHglycan	539	542	PF01048	0.616
MOD_GlcNHglycan	587	590	PF01048	0.604
MOD_GlcNHglycan	634	637	PF01048	0.554
MOD_GlcNHglycan	642	645	PF01048	0.548
MOD_GlcNHglycan	687	690	PF01048	0.733
MOD_GlcNHglycan	802	805	PF01048	0.585
MOD_GlcNHglycan	95	98	PF01048	0.645
MOD_GSK3_1	139	146	PF00069	0.709
MOD_GSK3_1	163	170	PF00069	0.659
MOD_GSK3_1	189	196	PF00069	0.579
MOD_GSK3_1	225	232	PF00069	0.689
MOD_GSK3_1	244	251	PF00069	0.775
MOD_GSK3_1	277	284	PF00069	0.729
MOD_GSK3_1	325	332	PF00069	0.615
MOD_GSK3_1	338	345	PF00069	0.707
MOD_GSK3_1	400	407	PF00069	0.667
MOD_GSK3_1	44	51	PF00069	0.652
MOD_GSK3_1	475	482	PF00069	0.556
MOD_GSK3_1	536	543	PF00069	0.635
MOD_GSK3_1	570	577	PF00069	0.556
MOD_GSK3_1	608	615	PF00069	0.687
MOD_GSK3_1	640	647	PF00069	0.752
MOD_GSK3_1	678	685	PF00069	0.684
MOD_GSK3_1	796	803	PF00069	0.532
MOD_GSK3_1	856	863	PF00069	0.414
MOD_N-GLC_1	118	123	PF02516	0.572
MOD_N-GLC_1	418	423	PF02516	0.572
MOD_N-GLC_1	476	481	PF02516	0.612
MOD_N-GLC_1	507	512	PF02516	0.553
MOD_N-GLC_1	583	588	PF02516	0.576
MOD_N-GLC_1	685	690	PF02516	0.539
MOD_N-GLC_1	80	85	PF02516	0.702
MOD_NEK2_1	139	144	PF00069	0.740
MOD_NEK2_1	167	172	PF00069	0.661
MOD_NEK2_1	189	194	PF00069	0.568
MOD_NEK2_1	200	205	PF00069	0.536
MOD_NEK2_1	225	230	PF00069	0.611
MOD_NEK2_1	249	254	PF00069	0.578
MOD_NEK2_1	335	340	PF00069	0.532
MOD_NEK2_1	454	459	PF00069	0.572
MOD_NEK2_1	527	532	PF00069	0.602
MOD_NEK2_1	536	541	PF00069	0.642
MOD_NEK2_1	54	59	PF00069	0.631
MOD_NEK2_1	61	66	PF00069	0.652
MOD_NEK2_1	621	626	PF00069	0.534
MOD_NEK2_1	640	645	PF00069	0.723
MOD_NEK2_1	796	801	PF00069	0.512
MOD_NEK2_2	48	53	PF00069	0.651
MOD_NEK2_2	730	735	PF00069	0.559
MOD_PIKK_1	200	206	PF00454	0.597
MOD_PIKK_1	335	341	PF00454	0.531
MOD_PIKK_1	83	89	PF00454	0.663
MOD_PK_1	770	776	PF00069	0.468
MOD_PKA_2	139	145	PF00069	0.810
MOD_PKA_2	150	156	PF00069	0.553
MOD_PKA_2	181	187	PF00069	0.614
MOD_PKA_2	226	232	PF00069	0.720
MOD_PKA_2	277	283	PF00069	0.595
MOD_PKA_2	317	323	PF00069	0.516
MOD_PKA_2	384	390	PF00069	0.642
MOD_PKA_2	490	496	PF00069	0.720
MOD_PKA_2	515	521	PF00069	0.571
MOD_PKA_2	769	775	PF00069	0.620
MOD_PKB_1	323	331	PF00069	0.535
MOD_PKB_1	768	776	PF00069	0.471
MOD_Plk_1	134	140	PF00069	0.573
MOD_Plk_1	163	169	PF00069	0.621
MOD_Plk_1	17	23	PF00069	0.632
MOD_Plk_1	258	264	PF00069	0.552
MOD_Plk_1	329	335	PF00069	0.694
MOD_Plk_1	563	569	PF00069	0.577
MOD_Plk_1	730	736	PF00069	0.565
MOD_Plk_2-3	574	580	PF00069	0.554
MOD_Plk_4	163	169	PF00069	0.723
MOD_Plk_4	176	182	PF00069	0.619
MOD_Plk_4	18	24	PF00069	0.625
MOD_Plk_4	258	264	PF00069	0.660
MOD_Plk_4	311	317	PF00069	0.624
MOD_Plk_4	376	382	PF00069	0.635
MOD_Plk_4	409	415	PF00069	0.562
MOD_Plk_4	563	569	PF00069	0.634
MOD_Plk_4	621	627	PF00069	0.532
MOD_Plk_4	647	653	PF00069	0.682
MOD_Plk_4	730	736	PF00069	0.565
MOD_ProDKin_1	118	124	PF00069	0.645
MOD_ProDKin_1	242	248	PF00069	0.666
MOD_ProDKin_1	308	314	PF00069	0.497
MOD_ProDKin_1	338	344	PF00069	0.766
MOD_ProDKin_1	479	485	PF00069	0.573
MOD_ProDKin_1	596	602	PF00069	0.742
MOD_ProDKin_1	651	657	PF00069	0.685
MOD_ProDKin_1	70	76	PF00069	0.740
MOD_ProDKin_1	762	768	PF00069	0.555
MOD_ProDKin_1	90	96	PF00069	0.744
MOD_SUMO_rev_2	107	114	PF00179	0.672
MOD_SUMO_rev_2	28	37	PF00179	0.635
MOD_SUMO_rev_2	281	291	PF00179	0.586
MOD_SUMO_rev_2	349	356	PF00179	0.662
MOD_SUMO_rev_2	520	530	PF00179	0.573
MOD_SUMO_rev_2	574	583	PF00179	0.712
TRG_DiLeu_BaEn_2	329	335	PF01217	0.561
TRG_DiLeu_BaEn_4	522	528	PF01217	0.612
TRG_DiLeu_LyEn_5	480	485	PF01217	0.576
TRG_ENDOCYTIC_2	16	19	PF00928	0.628
TRG_ENDOCYTIC_2	395	398	PF00928	0.582
TRG_ENDOCYTIC_2	445	448	PF00928	0.645
TRG_ENDOCYTIC_2	452	455	PF00928	0.615
TRG_ENDOCYTIC_2	676	679	PF00928	0.547
TRG_ENDOCYTIC_2	720	723	PF00928	0.575
TRG_ENDOCYTIC_2	764	767	PF00928	0.508
TRG_ENDOCYTIC_2	781	784	PF00928	0.639
TRG_ENDOCYTIC_2	816	819	PF00928	0.529
TRG_ER_diArg_1	138	141	PF00400	0.760
TRG_ER_diArg_1	631	633	PF00400	0.544
TRG_ER_diArg_1	676	678	PF00400	0.653
TRG_ER_diArg_1	75	78	PF00400	0.690
TRG_ER_diArg_1	767	770	PF00400	0.642
TRG_ER_diLys_1	872	876	PF00400	0.662
TRG_NLS_Bipartite_1	516	532	PF00514	0.549
TRG_NLS_MonoExtC_3	438	443	PF00514	0.434
TRG_NLS_MonoExtN_4	74	80	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	736	740	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	836	840	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IG94	Leishmania donovani	67%	100%
A4I833	Leishmania infantum	67%	100%
E9B2Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q565	Leishmania major	67%	100%