Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKK0_LEIBR

TriTrypDb:

LbrM.32.2310 , LBRM2903_320029600

Length:

961

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKK0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.489
CLV_C14_Caspase3-7	62	66	PF00656	0.286
CLV_C14_Caspase3-7	632	636	PF00656	0.677
CLV_C14_Caspase3-7	685	689	PF00656	0.586
CLV_C14_Caspase3-7	954	958	PF00656	0.514
CLV_NRD_NRD_1	338	340	PF00675	0.647
CLV_NRD_NRD_1	545	547	PF00675	0.438
CLV_NRD_NRD_1	552	554	PF00675	0.474
CLV_NRD_NRD_1	616	618	PF00675	0.725
CLV_NRD_NRD_1	772	774	PF00675	0.819
CLV_PCSK_FUR_1	516	520	PF00082	0.553
CLV_PCSK_FUR_1	614	618	PF00082	0.691
CLV_PCSK_KEX2_1	337	339	PF00082	0.619
CLV_PCSK_KEX2_1	435	437	PF00082	0.517
CLV_PCSK_KEX2_1	518	520	PF00082	0.540
CLV_PCSK_KEX2_1	616	618	PF00082	0.730
CLV_PCSK_KEX2_1	682	684	PF00082	0.628
CLV_PCSK_KEX2_1	772	774	PF00082	0.819
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.470
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.555
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.581
CLV_PCSK_PC7_1	334	340	PF00082	0.557
CLV_PCSK_SKI1_1	164	168	PF00082	0.556
CLV_PCSK_SKI1_1	272	276	PF00082	0.419
CLV_PCSK_SKI1_1	512	516	PF00082	0.474
CLV_PCSK_SKI1_1	561	565	PF00082	0.477
CLV_PCSK_SKI1_1	727	731	PF00082	0.485
CLV_PCSK_SKI1_1	900	904	PF00082	0.610
CLV_PCSK_SKI1_1	908	912	PF00082	0.504
DEG_APCC_DBOX_1	163	171	PF00400	0.471
DEG_APCC_DBOX_1	32	40	PF00400	0.433
DEG_APCC_DBOX_1	643	651	PF00400	0.417
DEG_APCC_DBOX_1	899	907	PF00400	0.581
DEG_APCC_KENBOX_2	490	494	PF00400	0.532
DEG_SPOP_SBC_1	112	116	PF00917	0.671
DOC_CKS1_1	267	272	PF01111	0.501
DOC_CKS1_1	380	385	PF01111	0.506
DOC_CYCLIN_RxL_1	298	309	PF00134	0.395
DOC_CYCLIN_yCln2_LP_2	902	905	PF00134	0.566
DOC_MAPK_DCC_7	353	363	PF00069	0.517
DOC_MAPK_gen_1	33	41	PF00069	0.443
DOC_MAPK_gen_1	334	343	PF00069	0.533
DOC_MAPK_gen_1	516	525	PF00069	0.375
DOC_MAPK_gen_1	546	552	PF00069	0.459
DOC_MAPK_gen_1	724	733	PF00069	0.392
DOC_MAPK_MEF2A_6	535	542	PF00069	0.416
DOC_MAPK_NFAT4_5	535	543	PF00069	0.348
DOC_PP1_RVXF_1	300	307	PF00149	0.354
DOC_PP1_RVXF_1	596	603	PF00149	0.523
DOC_PP2B_LxvP_1	288	291	PF13499	0.451
DOC_PP2B_LxvP_1	414	417	PF13499	0.650
DOC_PP2B_LxvP_1	73	76	PF13499	0.253
DOC_PP2B_LxvP_1	902	905	PF13499	0.570
DOC_PP4_FxxP_1	351	354	PF00568	0.657
DOC_USP7_MATH_1	112	116	PF00917	0.675
DOC_USP7_MATH_1	330	334	PF00917	0.703
DOC_USP7_MATH_1	345	349	PF00917	0.493
DOC_USP7_MATH_1	766	770	PF00917	0.520
DOC_USP7_MATH_1	791	795	PF00917	0.531
DOC_USP7_MATH_1	889	893	PF00917	0.649
DOC_WW_Pin1_4	210	215	PF00397	0.500
DOC_WW_Pin1_4	266	271	PF00397	0.484
DOC_WW_Pin1_4	341	346	PF00397	0.607
DOC_WW_Pin1_4	354	359	PF00397	0.639
DOC_WW_Pin1_4	363	368	PF00397	0.696
DOC_WW_Pin1_4	373	378	PF00397	0.531
DOC_WW_Pin1_4	379	384	PF00397	0.638
DOC_WW_Pin1_4	407	412	PF00397	0.588
DOC_WW_Pin1_4	43	48	PF00397	0.352
DOC_WW_Pin1_4	609	614	PF00397	0.666
DOC_WW_Pin1_4	745	750	PF00397	0.557
DOC_WW_Pin1_4	761	766	PF00397	0.584
DOC_WW_Pin1_4	779	784	PF00397	0.489
DOC_WW_Pin1_4	785	790	PF00397	0.584
DOC_WW_Pin1_4	81	86	PF00397	0.644
DOC_WW_Pin1_4	848	853	PF00397	0.509
LIG_14-3-3_CanoR_1	174	180	PF00244	0.605
LIG_14-3-3_CanoR_1	189	196	PF00244	0.375
LIG_14-3-3_CanoR_1	298	302	PF00244	0.367
LIG_14-3-3_CanoR_1	35	40	PF00244	0.499
LIG_14-3-3_CanoR_1	473	479	PF00244	0.399
LIG_14-3-3_CanoR_1	505	511	PF00244	0.579
LIG_14-3-3_CanoR_1	584	591	PF00244	0.550
LIG_14-3-3_CanoR_1	598	603	PF00244	0.524
LIG_14-3-3_CanoR_1	644	652	PF00244	0.538
LIG_14-3-3_CanoR_1	672	678	PF00244	0.420
LIG_14-3-3_CanoR_1	732	742	PF00244	0.482
LIG_14-3-3_CanoR_1	908	915	PF00244	0.375
LIG_Actin_WH2_2	430	447	PF00022	0.516
LIG_Actin_WH2_2	48	66	PF00022	0.362
LIG_BIR_II_1	1	5	PF00653	0.442
LIG_BIR_III_2	364	368	PF00653	0.535
LIG_BRCT_BRCA1_1	347	351	PF00533	0.682
LIG_BRCT_BRCA1_1	37	41	PF00533	0.344
LIG_BRCT_BRCA1_1	598	602	PF00533	0.669
LIG_BRCT_BRCA1_1	737	741	PF00533	0.530
LIG_BRCT_BRCA1_1	840	844	PF00533	0.457
LIG_Clathr_ClatBox_1	235	239	PF01394	0.402
LIG_EVH1_1	903	907	PF00568	0.562
LIG_FHA_1	219	225	PF00498	0.426
LIG_FHA_1	249	255	PF00498	0.537
LIG_FHA_1	282	288	PF00498	0.444
LIG_FHA_1	298	304	PF00498	0.312
LIG_FHA_1	3	9	PF00498	0.346
LIG_FHA_1	535	541	PF00498	0.480
LIG_FHA_1	603	609	PF00498	0.651
LIG_FHA_1	68	74	PF00498	0.389
LIG_FHA_1	798	804	PF00498	0.488
LIG_FHA_1	917	923	PF00498	0.391
LIG_FHA_1	944	950	PF00498	0.377
LIG_FHA_2	176	182	PF00498	0.600
LIG_FHA_2	213	219	PF00498	0.524
LIG_FHA_2	487	493	PF00498	0.470
LIG_FHA_2	531	537	PF00498	0.591
LIG_FHA_2	60	66	PF00498	0.427
LIG_FHA_2	630	636	PF00498	0.712
LIG_FHA_2	649	655	PF00498	0.514
LIG_FHA_2	683	689	PF00498	0.603
LIG_FHA_2	909	915	PF00498	0.468
LIG_GBD_Chelix_1	130	138	PF00786	0.391
LIG_LIR_Apic_2	348	354	PF02991	0.644
LIG_LIR_Gen_1	133	143	PF02991	0.388
LIG_LIR_Gen_1	3	13	PF02991	0.405
LIG_LIR_Gen_1	38	48	PF02991	0.361
LIG_LIR_Gen_1	476	485	PF02991	0.483
LIG_LIR_Gen_1	495	504	PF02991	0.309
LIG_LIR_Gen_1	919	926	PF02991	0.490
LIG_LIR_Gen_1	938	945	PF02991	0.261
LIG_LIR_Nem_3	133	138	PF02991	0.363
LIG_LIR_Nem_3	17	23	PF02991	0.356
LIG_LIR_Nem_3	194	199	PF02991	0.426
LIG_LIR_Nem_3	3	9	PF02991	0.400
LIG_LIR_Nem_3	38	44	PF02991	0.363
LIG_LIR_Nem_3	476	482	PF02991	0.481
LIG_LIR_Nem_3	495	499	PF02991	0.314
LIG_LIR_Nem_3	841	847	PF02991	0.614
LIG_LIR_Nem_3	919	924	PF02991	0.494
LIG_LIR_Nem_3	938	942	PF02991	0.260
LIG_NRBOX	198	204	PF00104	0.341
LIG_Pex14_2	139	143	PF04695	0.412
LIG_Pex14_2	20	24	PF04695	0.368
LIG_Pex14_2	935	939	PF04695	0.372
LIG_SH2_CRK	135	139	PF00017	0.294
LIG_SH2_CRK	232	236	PF00017	0.351
LIG_SH2_CRK	496	500	PF00017	0.423
LIG_SH2_CRK	6	10	PF00017	0.430
LIG_SH2_GRB2like	135	138	PF00017	0.248
LIG_SH2_NCK_1	619	623	PF00017	0.565
LIG_SH2_STAP1	135	139	PF00017	0.384
LIG_SH2_STAP1	496	500	PF00017	0.423
LIG_SH2_STAT5	51	54	PF00017	0.455
LIG_SH2_STAT5	6	9	PF00017	0.430
LIG_SH2_STAT5	715	718	PF00017	0.406
LIG_SH2_STAT5	921	924	PF00017	0.491
LIG_SH3_2	267	272	PF14604	0.501
LIG_SH3_3	264	270	PF00018	0.540
LIG_SH3_3	287	293	PF00018	0.359
LIG_SH3_3	377	383	PF00018	0.596
LIG_SH3_3	41	47	PF00018	0.352
LIG_SH3_3	572	578	PF00018	0.638
LIG_SH3_3	79	85	PF00018	0.549
LIG_SH3_3	89	95	PF00018	0.731
LIG_SH3_3	901	907	PF00018	0.569
LIG_SH3_5	47	51	PF00018	0.434
LIG_SUMO_SIM_par_1	152	158	PF11976	0.324
LIG_SUMO_SIM_par_1	223	228	PF11976	0.421
LIG_SUMO_SIM_par_1	234	239	PF11976	0.357
LIG_SUMO_SIM_par_1	359	364	PF11976	0.525
LIG_SUMO_SIM_par_1	851	857	PF11976	0.471
LIG_TRAF2_1	178	181	PF00917	0.596
LIG_TRAF2_1	209	212	PF00917	0.420
LIG_TRAF2_1	461	464	PF00917	0.424
LIG_TRAF2_1	640	643	PF00917	0.496
LIG_UBA3_1	538	547	PF00899	0.338
LIG_WRC_WIRS_1	674	679	PF05994	0.375
LIG_WRC_WIRS_1	921	926	PF05994	0.395
LIG_WRC_WIRS_1	936	941	PF05994	0.380
LIG_WW_3	334	338	PF00397	0.675
LIG_WW_3	741	745	PF00397	0.501
LIG_WW_3	764	768	PF00397	0.506
MOD_CDC14_SPxK_1	366	369	PF00782	0.772
MOD_CDC14_SPxK_1	764	767	PF00782	0.500
MOD_CDK_SPK_2	609	614	PF00069	0.666
MOD_CDK_SPK_2	81	86	PF00069	0.459
MOD_CDK_SPxK_1	266	272	PF00069	0.514
MOD_CDK_SPxK_1	363	369	PF00069	0.777
MOD_CDK_SPxK_1	761	767	PF00069	0.502
MOD_CDK_SPxxK_3	609	616	PF00069	0.672
MOD_CDK_SPxxK_3	779	786	PF00069	0.530
MOD_CK1_1	114	120	PF00069	0.654
MOD_CK1_1	155	161	PF00069	0.311
MOD_CK1_1	2	8	PF00069	0.449
MOD_CK1_1	213	219	PF00069	0.564
MOD_CK1_1	328	334	PF00069	0.712
MOD_CK1_1	393	399	PF00069	0.608
MOD_CK1_1	477	483	PF00069	0.381
MOD_CK1_1	586	592	PF00069	0.658
MOD_CK1_1	601	607	PF00069	0.761
MOD_CK1_1	629	635	PF00069	0.631
MOD_CK1_1	690	696	PF00069	0.602
MOD_CK1_1	735	741	PF00069	0.510
MOD_CK1_1	784	790	PF00069	0.538
MOD_CK1_1	794	800	PF00069	0.406
MOD_CK1_1	831	837	PF00069	0.495
MOD_CK1_1	84	90	PF00069	0.495
MOD_CK1_1	848	854	PF00069	0.630
MOD_CK1_1	892	898	PF00069	0.638
MOD_CK2_1	157	163	PF00069	0.440
MOD_CK2_1	175	181	PF00069	0.572
MOD_CK2_1	189	195	PF00069	0.440
MOD_CK2_1	212	218	PF00069	0.539
MOD_CK2_1	486	492	PF00069	0.470
MOD_CK2_1	530	536	PF00069	0.593
MOD_CK2_1	571	577	PF00069	0.500
MOD_CK2_1	620	626	PF00069	0.675
MOD_CK2_1	648	654	PF00069	0.521
MOD_CK2_1	809	815	PF00069	0.337
MOD_GlcNHglycan	123	126	PF01048	0.322
MOD_GlcNHglycan	149	152	PF01048	0.357
MOD_GlcNHglycan	159	162	PF01048	0.338
MOD_GlcNHglycan	191	194	PF01048	0.491
MOD_GlcNHglycan	241	244	PF01048	0.472
MOD_GlcNHglycan	323	328	PF01048	0.728
MOD_GlcNHglycan	605	608	PF01048	0.618
MOD_GlcNHglycan	690	693	PF01048	0.709
MOD_GlcNHglycan	737	740	PF01048	0.459
MOD_GlcNHglycan	750	753	PF01048	0.584
MOD_GlcNHglycan	796	799	PF01048	0.435
MOD_GlcNHglycan	832	836	PF01048	0.586
MOD_GlcNHglycan	89	92	PF01048	0.588
MOD_GSK3_1	121	128	PF00069	0.358
MOD_GSK3_1	155	162	PF00069	0.449
MOD_GSK3_1	185	192	PF00069	0.511
MOD_GSK3_1	293	300	PF00069	0.579
MOD_GSK3_1	341	348	PF00069	0.567
MOD_GSK3_1	35	42	PF00069	0.400
MOD_GSK3_1	391	398	PF00069	0.603
MOD_GSK3_1	473	480	PF00069	0.479
MOD_GSK3_1	530	537	PF00069	0.617
MOD_GSK3_1	596	603	PF00069	0.668
MOD_GSK3_1	622	629	PF00069	0.565
MOD_GSK3_1	673	680	PF00069	0.370
MOD_GSK3_1	683	690	PF00069	0.442
MOD_GSK3_1	733	740	PF00069	0.478
MOD_GSK3_1	761	768	PF00069	0.598
MOD_GSK3_1	781	788	PF00069	0.546
MOD_GSK3_1	806	813	PF00069	0.317
MOD_GSK3_1	81	88	PF00069	0.471
MOD_GSK3_1	888	895	PF00069	0.619
MOD_GSK3_1	916	923	PF00069	0.420
MOD_GSK3_1	943	950	PF00069	0.335
MOD_GSK3_1	953	960	PF00069	0.431
MOD_N-GLC_1	185	190	PF02516	0.323
MOD_N-GLC_1	67	72	PF02516	0.427
MOD_NEK2_1	113	118	PF00069	0.498
MOD_NEK2_1	187	192	PF00069	0.316
MOD_NEK2_1	39	44	PF00069	0.350
MOD_NEK2_1	540	545	PF00069	0.355
MOD_NEK2_1	59	64	PF00069	0.458
MOD_NEK2_1	602	607	PF00069	0.730
MOD_NEK2_1	628	633	PF00069	0.723
MOD_NEK2_1	673	678	PF00069	0.461
MOD_NEK2_1	733	738	PF00069	0.466
MOD_NEK2_1	754	759	PF00069	0.665
MOD_NEK2_1	823	828	PF00069	0.324
MOD_NEK2_1	865	870	PF00069	0.456
MOD_NEK2_2	293	298	PF00069	0.406
MOD_OFUCOSY	820	827	PF10250	0.301
MOD_PIKK_1	114	120	PF00454	0.459
MOD_PIKK_1	584	590	PF00454	0.658
MOD_PIKK_1	845	851	PF00454	0.634
MOD_PIKK_1	94	100	PF00454	0.623
MOD_PKA_1	682	688	PF00069	0.598
MOD_PKA_2	188	194	PF00069	0.478
MOD_PKA_2	297	303	PF00069	0.379
MOD_PKA_2	444	450	PF00069	0.549
MOD_PKA_2	583	589	PF00069	0.588
MOD_PKA_2	620	626	PF00069	0.703
MOD_PKA_2	645	651	PF00069	0.435
MOD_PKA_2	682	688	PF00069	0.598
MOD_PKA_2	743	749	PF00069	0.719
MOD_PKA_2	766	772	PF00069	0.747
MOD_PKA_2	892	898	PF00069	0.433
MOD_PKB_1	33	41	PF00069	0.430
MOD_PKB_1	559	567	PF00069	0.534
MOD_PKB_1	644	652	PF00069	0.411
MOD_PKB_1	828	836	PF00069	0.445
MOD_Plk_1	125	131	PF00069	0.466
MOD_Plk_1	15	21	PF00069	0.568
MOD_Plk_1	396	402	PF00069	0.489
MOD_Plk_1	561	567	PF00069	0.576
MOD_Plk_1	571	577	PF00069	0.750
MOD_Plk_1	67	73	PF00069	0.425
MOD_Plk_2-3	530	536	PF00069	0.350
MOD_Plk_4	15	21	PF00069	0.499
MOD_Plk_4	152	158	PF00069	0.315
MOD_Plk_4	195	201	PF00069	0.466
MOD_Plk_4	248	254	PF00069	0.387
MOD_Plk_4	35	41	PF00069	0.356
MOD_Plk_4	474	480	PF00069	0.354
MOD_Plk_4	519	525	PF00069	0.373
MOD_Plk_4	534	540	PF00069	0.319
MOD_Plk_4	67	73	PF00069	0.425
MOD_ProDKin_1	210	216	PF00069	0.499
MOD_ProDKin_1	266	272	PF00069	0.479
MOD_ProDKin_1	341	347	PF00069	0.601
MOD_ProDKin_1	354	360	PF00069	0.640
MOD_ProDKin_1	363	369	PF00069	0.697
MOD_ProDKin_1	373	379	PF00069	0.527
MOD_ProDKin_1	407	413	PF00069	0.590
MOD_ProDKin_1	43	49	PF00069	0.357
MOD_ProDKin_1	609	615	PF00069	0.669
MOD_ProDKin_1	745	751	PF00069	0.558
MOD_ProDKin_1	761	767	PF00069	0.588
MOD_ProDKin_1	779	785	PF00069	0.489
MOD_ProDKin_1	81	87	PF00069	0.648
MOD_ProDKin_1	848	854	PF00069	0.503
MOD_SUMO_rev_2	719	729	PF00179	0.497
MOD_SUMO_rev_2	954	960	PF00179	0.388
TRG_DiLeu_BaEn_1	195	200	PF01217	0.339
TRG_DiLeu_BaEn_1	534	539	PF01217	0.352
TRG_DiLeu_BaEn_1	726	731	PF01217	0.485
TRG_DiLeu_BaEn_4	642	648	PF01217	0.432
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.322
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.345
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.525
TRG_ENDOCYTIC_2	135	138	PF00928	0.326
TRG_ENDOCYTIC_2	232	235	PF00928	0.386
TRG_ENDOCYTIC_2	496	499	PF00928	0.423
TRG_ENDOCYTIC_2	6	9	PF00928	0.430
TRG_ENDOCYTIC_2	921	924	PF00928	0.483
TRG_ER_diArg_1	32	35	PF00400	0.456
TRG_ER_diArg_1	336	339	PF00400	0.683
TRG_ER_diArg_1	558	561	PF00400	0.484
TRG_ER_diArg_1	613	616	PF00400	0.679
TRG_ER_diArg_1	644	647	PF00400	0.520
TRG_ER_diArg_1	657	660	PF00400	0.431
TRG_ER_diArg_1	771	773	PF00400	0.540
TRG_NES_CRM1_1	244	259	PF08389	0.479
TRG_NES_CRM1_1	541	555	PF08389	0.501
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	508	513	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	526	530	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	616	620	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	870	874	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ4	Leptomonas seymouri	48%	93%
A0A3Q8IJC8	Leishmania donovani	74%	95%
A0A422MY74	Trypanosoma rangeli	29%	100%
A4I832	Leishmania infantum	74%	95%
E9B2Z0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q566	Leishmania major	74%	100%
V5BG82	Trypanosoma cruzi	31%	100%