HemK methyltransferase family member 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eRF1 methyltransferase catalytic subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HKJ9_LEIBR

TriTrypDb:

LbrM.32.2300 , LBRM2903_320029500

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0034708	methyltransferase complex	4	1
GO:0035657	eRF1 methyltransferase complex	5	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HKJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKJ9

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0032259	methylation	2	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043414	macromolecule methylation	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.543
CLV_NRD_NRD_1	101	103	PF00675	0.454
CLV_NRD_NRD_1	265	267	PF00675	0.516
CLV_PCSK_KEX2_1	101	103	PF00082	0.654
CLV_PCSK_KEX2_1	265	267	PF00082	0.516
CLV_PCSK_SKI1_1	249	253	PF00082	0.436
CLV_PCSK_SKI1_1	71	75	PF00082	0.485
DEG_APCC_DBOX_1	290	298	PF00400	0.311
DEG_APCC_KENBOX_2	274	278	PF00400	0.434
DOC_CYCLIN_RxL_1	68	79	PF00134	0.522
DOC_MAPK_gen_1	132	142	PF00069	0.327
DOC_MAPK_gen_1	265	273	PF00069	0.494
DOC_MAPK_MEF2A_6	135	142	PF00069	0.474
DOC_PP2B_LxvP_1	257	260	PF13499	0.392
DOC_PP4_FxxP_1	216	219	PF00568	0.350
DOC_PP4_FxxP_1	334	337	PF00568	0.569
DOC_USP7_MATH_1	178	182	PF00917	0.627
DOC_USP7_MATH_1	286	290	PF00917	0.393
DOC_WW_Pin1_4	8	13	PF00397	0.440
LIG_14-3-3_CanoR_1	145	155	PF00244	0.662
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_BRCT_BRCA1_1	207	211	PF00533	0.457
LIG_FHA_1	125	131	PF00498	0.472
LIG_FHA_1	13	19	PF00498	0.495
LIG_FHA_1	135	141	PF00498	0.521
LIG_FHA_1	155	161	PF00498	0.481
LIG_FHA_1	177	183	PF00498	0.645
LIG_FHA_1	185	191	PF00498	0.532
LIG_FHA_1	32	38	PF00498	0.223
LIG_FHA_1	81	87	PF00498	0.679
LIG_FHA_2	123	129	PF00498	0.531
LIG_FHA_2	221	227	PF00498	0.391
LIG_LIR_Apic_2	7	12	PF02991	0.571
LIG_LIR_Gen_1	141	151	PF02991	0.563
LIG_LIR_Gen_1	196	206	PF02991	0.300
LIG_LIR_Gen_1	208	219	PF02991	0.372
LIG_LIR_Gen_1	33	41	PF02991	0.366
LIG_LIR_Nem_3	141	146	PF02991	0.571
LIG_LIR_Nem_3	196	201	PF02991	0.271
LIG_LIR_Nem_3	208	214	PF02991	0.383
LIG_LIR_Nem_3	33	38	PF02991	0.367
LIG_NRBOX	69	75	PF00104	0.449
LIG_PCNA_TLS_4	249	256	PF02747	0.511
LIG_Pex14_1	326	330	PF04695	0.250
LIG_PTB_Apo_2	214	221	PF02174	0.351
LIG_PTB_Phospho_1	214	220	PF10480	0.347
LIG_Rb_LxCxE_1	289	310	PF01857	0.330
LIG_SH2_NCK_1	143	147	PF00017	0.537
LIG_SH2_NCK_1	9	13	PF00017	0.571
LIG_SH2_PTP2	270	273	PF00017	0.437
LIG_SH2_STAP1	14	18	PF00017	0.519
LIG_SH2_STAP1	143	147	PF00017	0.576
LIG_SH2_STAT5	14	17	PF00017	0.395
LIG_SH2_STAT5	220	223	PF00017	0.378
LIG_SH2_STAT5	270	273	PF00017	0.344
LIG_SH2_STAT5	318	321	PF00017	0.455
LIG_SH2_STAT5	330	333	PF00017	0.517
LIG_SH3_3	101	107	PF00018	0.607
LIG_SH3_3	216	222	PF00018	0.350
LIG_SH3_3	24	30	PF00018	0.408
LIG_SH3_3	85	91	PF00018	0.638
LIG_SUMO_SIM_par_1	115	120	PF11976	0.365
LIG_SUMO_SIM_par_1	136	141	PF11976	0.334
LIG_SUMO_SIM_par_1	270	276	PF11976	0.382
LIG_TRAF2_1	224	227	PF00917	0.440
LIG_TYR_ITIM	268	273	PF00017	0.483
MOD_CK1_1	177	183	PF00069	0.667
MOD_CK1_1	184	190	PF00069	0.544
MOD_CK1_1	261	267	PF00069	0.449
MOD_CK1_1	76	82	PF00069	0.442
MOD_CK1_1	94	100	PF00069	0.446
MOD_CK2_1	122	128	PF00069	0.529
MOD_CK2_1	199	205	PF00069	0.410
MOD_CK2_1	220	226	PF00069	0.399
MOD_CK2_1	286	292	PF00069	0.448
MOD_CK2_1	7	13	PF00069	0.593
MOD_GlcNHglycan	148	151	PF01048	0.675
MOD_GlcNHglycan	176	179	PF01048	0.700
MOD_GlcNHglycan	183	186	PF01048	0.630
MOD_GlcNHglycan	207	210	PF01048	0.546
MOD_GlcNHglycan	62	65	PF01048	0.350
MOD_GlcNHglycan	97	100	PF01048	0.689
MOD_GSK3_1	122	129	PF00069	0.374
MOD_GSK3_1	151	158	PF00069	0.682
MOD_GSK3_1	174	181	PF00069	0.597
MOD_GSK3_1	4	11	PF00069	0.627
MOD_GSK3_1	65	72	PF00069	0.295
MOD_GSK3_1	76	83	PF00069	0.412
MOD_GSK3_1	91	98	PF00069	0.660
MOD_NEK2_1	119	124	PF00069	0.396
MOD_NEK2_1	134	139	PF00069	0.401
MOD_NEK2_1	155	160	PF00069	0.480
MOD_NEK2_1	183	188	PF00069	0.617
MOD_NEK2_1	73	78	PF00069	0.368
MOD_NEK2_2	286	291	PF00069	0.411
MOD_NEK2_2	91	96	PF00069	0.475
MOD_PIKK_1	167	173	PF00454	0.502
MOD_PIKK_1	80	86	PF00454	0.671
MOD_PKA_2	134	140	PF00069	0.545
MOD_PKA_2	316	322	PF00069	0.441
MOD_PKA_2	95	101	PF00069	0.715
MOD_Plk_1	119	125	PF00069	0.410
MOD_Plk_4	126	132	PF00069	0.495
MOD_Plk_4	134	140	PF00069	0.500
MOD_Plk_4	155	161	PF00069	0.481
MOD_Plk_4	178	184	PF00069	0.624
MOD_Plk_4	258	264	PF00069	0.440
MOD_Plk_4	31	37	PF00069	0.382
MOD_Plk_4	321	327	PF00069	0.461
MOD_Plk_4	62	68	PF00069	0.316
MOD_ProDKin_1	8	14	PF00069	0.433
MOD_SUMO_for_1	302	305	PF00179	0.581
MOD_SUMO_for_1	89	92	PF00179	0.743
TRG_DiLeu_BaEn_2	30	36	PF01217	0.386
TRG_ENDOCYTIC_2	143	146	PF00928	0.570
TRG_ENDOCYTIC_2	270	273	PF00928	0.457
TRG_ER_diArg_1	246	249	PF00400	0.377
TRG_ER_diArg_1	326	329	PF00400	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A8	Leptomonas seymouri	56%	94%
A0A0S4JAA0	Bodo saltans	38%	100%
A0A1X0NUU4	Trypanosomatidae	41%	100%
A0A3Q8IFZ7	Leishmania donovani	81%	100%
A0A3R7LIX6	Trypanosoma rangeli	43%	100%
A4I831	Leishmania infantum	82%	100%
D0AA96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B2Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q567	Leishmania major	80%	100%
V5BBL2	Trypanosoma cruzi	43%	100%