CMP/dCMP-type deaminase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cytidine and deoxycytidylate deaminase zinc-binding region, putative

Species:

Leishmania braziliensis

UniProt:

A4HKJ8_LEIBR

TriTrypDb:

LbrM.32.2290 , LBRM2903_320029400

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKJ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.526
CLV_NRD_NRD_1	288	290	PF00675	0.397
CLV_NRD_NRD_1	392	394	PF00675	0.492
CLV_PCSK_KEX2_1	288	290	PF00082	0.377
CLV_PCSK_KEX2_1	392	394	PF00082	0.581
CLV_PCSK_KEX2_1	49	51	PF00082	0.473
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.473
CLV_PCSK_SKI1_1	278	282	PF00082	0.396
CLV_PCSK_SKI1_1	495	499	PF00082	0.275
DEG_Nend_UBRbox_1	1	4	PF02207	0.418
DEG_SCF_FBW7_1	201	206	PF00400	0.548
DEG_SCF_FBW7_1	70	76	PF00400	0.571
DOC_CKS1_1	70	75	PF01111	0.597
DOC_CYCLIN_yClb5_NLxxxL_5	31	40	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	404	410	PF00134	0.371
DOC_MAPK_MEF2A_6	336	345	PF00069	0.308
DOC_PP1_RVXF_1	493	499	PF00149	0.475
DOC_PP2B_LxvP_1	253	256	PF13499	0.506
DOC_USP7_MATH_1	136	140	PF00917	0.692
DOC_USP7_MATH_1	154	158	PF00917	0.379
DOC_USP7_MATH_1	171	175	PF00917	0.427
DOC_USP7_MATH_1	190	194	PF00917	0.518
DOC_USP7_MATH_1	201	205	PF00917	0.539
DOC_USP7_MATH_1	298	302	PF00917	0.466
DOC_USP7_MATH_1	354	358	PF00917	0.436
DOC_USP7_MATH_1	455	459	PF00917	0.649
DOC_USP7_MATH_1	53	57	PF00917	0.448
DOC_USP7_MATH_1	71	75	PF00917	0.429
DOC_USP7_MATH_2	241	247	PF00917	0.520
DOC_WW_Pin1_4	11	16	PF00397	0.510
DOC_WW_Pin1_4	197	202	PF00397	0.584
DOC_WW_Pin1_4	257	262	PF00397	0.430
DOC_WW_Pin1_4	315	320	PF00397	0.705
DOC_WW_Pin1_4	441	446	PF00397	0.535
DOC_WW_Pin1_4	69	74	PF00397	0.633
DOC_WW_Pin1_4	92	97	PF00397	0.511
LIG_14-3-3_CanoR_1	322	329	PF00244	0.550
LIG_14-3-3_CanoR_1	52	62	PF00244	0.602
LIG_Actin_WH2_2	273	290	PF00022	0.313
LIG_BIR_III_4	195	199	PF00653	0.512
LIG_BRCT_BRCA1_1	149	153	PF00533	0.475
LIG_Clathr_ClatBox_1	19	23	PF01394	0.328
LIG_deltaCOP1_diTrp_1	243	251	PF00928	0.489
LIG_FHA_1	12	18	PF00498	0.499
LIG_FHA_1	124	130	PF00498	0.565
LIG_FHA_1	154	160	PF00498	0.488
LIG_FHA_1	322	328	PF00498	0.607
LIG_FHA_1	347	353	PF00498	0.529
LIG_FHA_1	61	67	PF00498	0.521
LIG_Integrin_RGD_1	208	210	PF01839	0.564
LIG_MYND_1	237	241	PF01753	0.368
LIG_MYND_1	445	449	PF01753	0.514
LIG_NRBOX	76	82	PF00104	0.469
LIG_PDZ_Class_1	534	539	PF00595	0.462
LIG_REV1ctd_RIR_1	495	505	PF16727	0.564
LIG_SH2_CRK	373	377	PF00017	0.577
LIG_SH2_SRC	106	109	PF00017	0.534
LIG_SH2_STAT5	373	376	PF00017	0.482
LIG_SH2_STAT5	460	463	PF00017	0.551
LIG_SH2_STAT5	467	470	PF00017	0.389
LIG_SH2_STAT5	475	478	PF00017	0.467
LIG_SH2_STAT5	536	539	PF00017	0.493
LIG_SH3_3	18	24	PF00018	0.328
LIG_SH3_3	252	258	PF00018	0.493
LIG_SH3_3	341	347	PF00018	0.405
LIG_SH3_3	394	400	PF00018	0.530
LIG_SH3_3	439	445	PF00018	0.508
LIG_SH3_CIN85_PxpxPR_1	252	257	PF14604	0.575
LIG_SUMO_SIM_anti_2	339	346	PF11976	0.398
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.553
LIG_SUMO_SIM_par_1	143	152	PF11976	0.446
LIG_SUMO_SIM_par_1	17	23	PF11976	0.401
LIG_UBA3_1	19	25	PF00899	0.337
MOD_CDK_SPxxK_3	315	322	PF00069	0.562
MOD_CK1_1	109	115	PF00069	0.604
MOD_CK1_1	174	180	PF00069	0.602
MOD_CK1_1	301	307	PF00069	0.755
MOD_CK1_1	313	319	PF00069	0.595
MOD_CK1_1	451	457	PF00069	0.581
MOD_CK1_1	516	522	PF00069	0.402
MOD_CK2_1	354	360	PF00069	0.346
MOD_CK2_1	72	78	PF00069	0.530
MOD_DYRK1A_RPxSP_1	257	261	PF00069	0.429
MOD_GlcNHglycan	108	111	PF01048	0.717
MOD_GlcNHglycan	115	118	PF01048	0.549
MOD_GlcNHglycan	140	143	PF01048	0.427
MOD_GlcNHglycan	169	172	PF01048	0.523
MOD_GlcNHglycan	173	176	PF01048	0.536
MOD_GlcNHglycan	215	218	PF01048	0.643
MOD_GlcNHglycan	232	235	PF01048	0.359
MOD_GlcNHglycan	245	248	PF01048	0.517
MOD_GlcNHglycan	300	303	PF01048	0.493
MOD_GlcNHglycan	356	359	PF01048	0.452
MOD_GlcNHglycan	431	434	PF01048	0.506
MOD_GlcNHglycan	439	442	PF01048	0.622
MOD_GlcNHglycan	450	453	PF01048	0.567
MOD_GlcNHglycan	55	58	PF01048	0.486
MOD_GlcNHglycan	97	100	PF01048	0.569
MOD_GSK3_1	108	115	PF00069	0.554
MOD_GSK3_1	148	155	PF00069	0.546
MOD_GSK3_1	167	174	PF00069	0.362
MOD_GSK3_1	197	204	PF00069	0.660
MOD_GSK3_1	209	216	PF00069	0.515
MOD_GSK3_1	309	316	PF00069	0.695
MOD_GSK3_1	354	361	PF00069	0.424
MOD_GSK3_1	425	432	PF00069	0.650
MOD_GSK3_1	437	444	PF00069	0.545
MOD_GSK3_1	447	454	PF00069	0.568
MOD_GSK3_1	69	76	PF00069	0.569
MOD_GSK3_1	97	104	PF00069	0.587
MOD_N-GLC_1	113	118	PF02516	0.527
MOD_N-GLC_1	190	195	PF02516	0.493
MOD_NEK2_1	153	158	PF00069	0.531
MOD_NEK2_1	165	170	PF00069	0.316
MOD_NEK2_1	353	358	PF00069	0.337
MOD_NEK2_1	415	420	PF00069	0.351
MOD_NEK2_1	435	440	PF00069	0.472
MOD_NEK2_1	488	493	PF00069	0.312
MOD_NEK2_2	358	363	PF00069	0.427
MOD_NEK2_2	460	465	PF00069	0.444
MOD_PIKK_1	259	265	PF00454	0.423
MOD_PIKK_1	415	421	PF00454	0.358
MOD_PKA_2	321	327	PF00069	0.559
MOD_PKA_2	425	431	PF00069	0.590
MOD_PKA_2	53	59	PF00069	0.465
MOD_Plk_1	113	119	PF00069	0.508
MOD_Plk_1	136	142	PF00069	0.565
MOD_Plk_4	26	32	PF00069	0.413
MOD_ProDKin_1	11	17	PF00069	0.504
MOD_ProDKin_1	197	203	PF00069	0.583
MOD_ProDKin_1	257	263	PF00069	0.431
MOD_ProDKin_1	315	321	PF00069	0.706
MOD_ProDKin_1	441	447	PF00069	0.538
MOD_ProDKin_1	69	75	PF00069	0.623
MOD_ProDKin_1	92	98	PF00069	0.509
TRG_DiLeu_BaEn_1	333	338	PF01217	0.548
TRG_DiLeu_LyEn_5	333	338	PF01217	0.391
TRG_ENDOCYTIC_2	373	376	PF00928	0.558
TRG_ENDOCYTIC_2	536	539	PF00928	0.493
TRG_ER_diArg_1	287	289	PF00400	0.360
TRG_ER_diArg_1	50	53	PF00400	0.481
TRG_NLS_MonoExtC_3	48	53	PF00514	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXU5	Leptomonas seymouri	42%	100%
A0A3Q8IL67	Leishmania donovani	70%	99%
A4I830	Leishmania infantum	70%	99%
E9B2Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
Q4Q568	Leishmania major	68%	100%