CTP_transf_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytidylyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HKJ7_LEIBR

TriTrypDb:

LbrM.32.2280 , LBRM2903_320029300

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKJ7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0015936	coenzyme A metabolic process	6	1
GO:0015937	coenzyme A biosynthetic process	7	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033866	nucleoside bisphosphate biosynthetic process	6	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004140	dephospho-CoA kinase activity	5	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0016779	nucleotidyltransferase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.394
CLV_NRD_NRD_1	323	325	PF00675	0.460
CLV_PCSK_KEX2_1	221	223	PF00082	0.340
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.201
CLV_PCSK_SKI1_1	194	198	PF00082	0.258
CLV_PCSK_SKI1_1	26	30	PF00082	0.511
CLV_PCSK_SKI1_1	35	39	PF00082	0.668
DEG_APCC_DBOX_1	25	33	PF00400	0.572
DEG_SCF_FBW7_1	28	34	PF00400	0.493
DOC_CKS1_1	28	33	PF01111	0.479
DOC_MAPK_gen_1	111	117	PF00069	0.466
DOC_MAPK_MEF2A_6	245	252	PF00069	0.441
DOC_MAPK_RevD_3	208	222	PF00069	0.498
DOC_USP7_MATH_1	142	146	PF00917	0.544
DOC_USP7_MATH_1	39	43	PF00917	0.697
DOC_USP7_UBL2_3	160	164	PF12436	0.425
DOC_WW_Pin1_4	119	124	PF00397	0.723
DOC_WW_Pin1_4	27	32	PF00397	0.469
DOC_WW_Pin1_4	271	276	PF00397	0.442
DOC_WW_Pin1_4	304	309	PF00397	0.534
LIG_14-3-3_CanoR_1	209	218	PF00244	0.466
LIG_14-3-3_CanoR_1	76	82	PF00244	0.446
LIG_APCC_ABBA_1	146	151	PF00400	0.524
LIG_BIR_III_4	169	173	PF00653	0.487
LIG_deltaCOP1_diTrp_1	158	166	PF00928	0.431
LIG_FHA_1	197	203	PF00498	0.445
LIG_FHA_1	260	266	PF00498	0.544
LIG_FHA_1	307	313	PF00498	0.546
LIG_FHA_2	7	13	PF00498	0.335
LIG_FHA_2	78	84	PF00498	0.485
LIG_GBD_Chelix_1	21	29	PF00786	0.294
LIG_IRF3_LxIS_1	95	102	PF10401	0.472
LIG_LIR_Gen_1	147	156	PF02991	0.389
LIG_LIR_Gen_1	178	186	PF02991	0.212
LIG_LIR_LC3C_4	269	273	PF02991	0.442
LIG_LIR_Nem_3	147	152	PF02991	0.480
LIG_LIR_Nem_3	158	162	PF02991	0.462
LIG_LIR_Nem_3	178	182	PF02991	0.323
LIG_LIR_Nem_3	185	189	PF02991	0.479
LIG_LIR_Nem_3	68	73	PF02991	0.430
LIG_SH2_CRK	177	181	PF00017	0.369
LIG_SH2_CRK	52	56	PF00017	0.323
LIG_SH2_CRK	89	93	PF00017	0.347
LIG_SH2_NCK_1	149	153	PF00017	0.460
LIG_SH2_PTP2	179	182	PF00017	0.440
LIG_SH2_SRC	149	152	PF00017	0.461
LIG_SH2_SRC	87	90	PF00017	0.393
LIG_SH2_STAP1	149	153	PF00017	0.460
LIG_SH2_STAP1	177	181	PF00017	0.285
LIG_SH2_STAP1	89	93	PF00017	0.377
LIG_SH2_STAT3	129	132	PF00017	0.452
LIG_SH2_STAT3	203	206	PF00017	0.384
LIG_SH2_STAT5	177	180	PF00017	0.405
LIG_SH2_STAT5	203	206	PF00017	0.396
LIG_SH2_STAT5	23	26	PF00017	0.395
LIG_SH2_STAT5	52	55	PF00017	0.422
LIG_SH2_STAT5	70	73	PF00017	0.448
LIG_SH2_STAT5	87	90	PF00017	0.276
LIG_SH3_3	103	109	PF00018	0.295
LIG_SH3_3	25	31	PF00018	0.467
LIG_SH3_3	269	275	PF00018	0.442
LIG_SH3_3	302	308	PF00018	0.506
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.365
LIG_SxIP_EBH_1	97	111	PF03271	0.357
LIG_UBA3_1	103	112	PF00899	0.317
MOD_CK1_1	118	124	PF00069	0.657
MOD_CK1_1	216	222	PF00069	0.543
MOD_CK1_1	226	232	PF00069	0.506
MOD_CK1_1	256	262	PF00069	0.455
MOD_CK1_1	27	33	PF00069	0.511
MOD_CK1_1	274	280	PF00069	0.390
MOD_CK1_1	44	50	PF00069	0.652
MOD_CK2_1	261	267	PF00069	0.524
MOD_CK2_1	6	12	PF00069	0.316
MOD_CK2_1	77	83	PF00069	0.491
MOD_GlcNHglycan	117	120	PF01048	0.575
MOD_GlcNHglycan	135	138	PF01048	0.560
MOD_GlcNHglycan	140	143	PF01048	0.496
MOD_GlcNHglycan	190	193	PF01048	0.337
MOD_GlcNHglycan	257	261	PF01048	0.277
MOD_GlcNHglycan	41	44	PF01048	0.596
MOD_GlcNHglycan	89	92	PF01048	0.469
MOD_GSK3_1	1	8	PF00069	0.337
MOD_GSK3_1	115	122	PF00069	0.677
MOD_GSK3_1	138	145	PF00069	0.417
MOD_GSK3_1	27	34	PF00069	0.586
MOD_GSK3_1	37	44	PF00069	0.507
MOD_LATS_1	74	80	PF00433	0.309
MOD_NEK2_1	115	120	PF00069	0.622
MOD_NEK2_1	138	143	PF00069	0.439
MOD_NEK2_1	162	167	PF00069	0.291
MOD_NEK2_1	196	201	PF00069	0.473
MOD_NEK2_1	223	228	PF00069	0.508
MOD_NEK2_1	24	29	PF00069	0.478
MOD_NEK2_1	312	317	PF00069	0.490
MOD_NEK2_1	6	11	PF00069	0.414
MOD_NEK2_1	82	87	PF00069	0.444
MOD_NEK2_1	99	104	PF00069	0.308
MOD_PIKK_1	123	129	PF00454	0.449
MOD_PKA_2	77	83	PF00069	0.360
MOD_Plk_1	162	168	PF00069	0.297
MOD_Plk_1	213	219	PF00069	0.560
MOD_Plk_1	82	88	PF00069	0.480
MOD_Plk_4	1	7	PF00069	0.418
MOD_Plk_4	16	22	PF00069	0.415
MOD_Plk_4	162	168	PF00069	0.365
MOD_Plk_4	175	181	PF00069	0.357
MOD_Plk_4	213	219	PF00069	0.477
MOD_Plk_4	77	83	PF00069	0.378
MOD_ProDKin_1	119	125	PF00069	0.721
MOD_ProDKin_1	27	33	PF00069	0.480
MOD_ProDKin_1	271	277	PF00069	0.442
MOD_ProDKin_1	304	310	PF00069	0.534
MOD_SUMO_for_1	110	113	PF00179	0.439
TRG_DiLeu_BaEn_1	267	272	PF01217	0.396
TRG_ENDOCYTIC_2	149	152	PF00928	0.304
TRG_ENDOCYTIC_2	177	180	PF00928	0.348
TRG_ENDOCYTIC_2	70	73	PF00928	0.425
TRG_ENDOCYTIC_2	89	92	PF00928	0.543
TRG_NLS_MonoExtC_3	219	225	PF00514	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILA3	Leptomonas seymouri	60%	100%
A0A1X0NU95	Trypanosomatidae	39%	100%
A0A3Q8IFJ1	Leishmania donovani	75%	98%
A0A3R7M2F9	Trypanosoma rangeli	39%	100%
A4I829	Leishmania infantum	75%	98%
D0AA94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B2Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
Q4Q569	Leishmania major	74%	100%
V5DCC0	Trypanosoma cruzi	38%	100%