ABC transporter-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter-like protein

Species:

Leishmania braziliensis

UniProt:

A4HKJ6_LEIBR

TriTrypDb:

LbrM.32.2270 , LBRM2903_320029200

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HKJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKJ6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0005215	transporter activity	1	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0015399	primary active transmembrane transporter activity	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0022804	active transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0042626	ATPase-coupled transmembrane transporter activity	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140359	ABC-type transporter activity	3	9
GO:0140657	ATP-dependent activity	1	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	586	590	PF00656	0.514
CLV_NRD_NRD_1	344	346	PF00675	0.236
CLV_NRD_NRD_1	555	557	PF00675	0.339
CLV_NRD_NRD_1	617	619	PF00675	0.283
CLV_PCSK_KEX2_1	344	346	PF00082	0.259
CLV_PCSK_KEX2_1	555	557	PF00082	0.339
CLV_PCSK_KEX2_1	617	619	PF00082	0.270
CLV_PCSK_SKI1_1	133	137	PF00082	0.645
CLV_PCSK_SKI1_1	172	176	PF00082	0.370
CLV_PCSK_SKI1_1	212	216	PF00082	0.223
CLV_PCSK_SKI1_1	344	348	PF00082	0.234
CLV_PCSK_SKI1_1	366	370	PF00082	0.418
CLV_PCSK_SKI1_1	47	51	PF00082	0.469
CLV_PCSK_SKI1_1	556	560	PF00082	0.280
CLV_PCSK_SKI1_1	594	598	PF00082	0.197
CLV_PCSK_SKI1_1	617	621	PF00082	0.377
CLV_PCSK_SKI1_1	655	659	PF00082	0.377
CLV_PCSK_SKI1_1	701	705	PF00082	0.388
DEG_APCC_DBOX_1	171	179	PF00400	0.418
DEG_APCC_DBOX_1	414	422	PF00400	0.651
DEG_APCC_DBOX_1	654	662	PF00400	0.539
DOC_CYCLIN_RxL_1	207	216	PF00134	0.397
DOC_MAPK_DCC_7	130	140	PF00069	0.326
DOC_MAPK_FxFP_2	469	472	PF00069	0.596
DOC_MAPK_gen_1	130	140	PF00069	0.506
DOC_MAPK_MEF2A_6	130	138	PF00069	0.511
DOC_MAPK_MEF2A_6	366	375	PF00069	0.412
DOC_MAPK_MEF2A_6	682	689	PF00069	0.613
DOC_PP1_SILK_1	425	430	PF00149	0.451
DOC_PP4_FxxP_1	469	472	PF00568	0.596
DOC_USP7_MATH_1	15	19	PF00917	0.735
DOC_USP7_MATH_1	359	363	PF00917	0.407
DOC_USP7_MATH_1	501	505	PF00917	0.705
DOC_USP7_MATH_1	590	594	PF00917	0.552
DOC_USP7_MATH_1	623	627	PF00917	0.539
DOC_WW_Pin1_4	16	21	PF00397	0.735
DOC_WW_Pin1_4	160	165	PF00397	0.432
DOC_WW_Pin1_4	444	449	PF00397	0.646
DOC_WW_Pin1_4	602	607	PF00397	0.425
DOC_WW_Pin1_4	631	636	PF00397	0.528
DOC_WW_Pin1_4	8	13	PF00397	0.763
DOC_WW_Pin1_4	96	101	PF00397	0.402
LIG_14-3-3_CanoR_1	212	218	PF00244	0.420
LIG_14-3-3_CanoR_1	221	225	PF00244	0.425
LIG_14-3-3_CanoR_1	239	248	PF00244	0.583
LIG_14-3-3_CanoR_1	301	309	PF00244	0.535
LIG_14-3-3_CanoR_1	319	324	PF00244	0.405
LIG_14-3-3_CanoR_1	345	351	PF00244	0.397
LIG_14-3-3_CanoR_1	415	419	PF00244	0.573
LIG_14-3-3_CanoR_1	420	425	PF00244	0.553
LIG_14-3-3_CanoR_1	429	434	PF00244	0.520
LIG_14-3-3_CanoR_1	96	100	PF00244	0.402
LIG_Actin_WH2_2	400	417	PF00022	0.472
LIG_Actin_WH2_2	681	698	PF00022	0.610
LIG_APCC_ABBA_1	215	220	PF00400	0.397
LIG_BIR_II_1	1	5	PF00653	0.762
LIG_BRCT_BRCA1_1	51	55	PF00533	0.418
LIG_Clathr_ClatBox_1	670	674	PF01394	0.505
LIG_deltaCOP1_diTrp_1	30	37	PF00928	0.503
LIG_eIF4E_1	183	189	PF01652	0.418
LIG_FHA_1	1	7	PF00498	0.604
LIG_FHA_1	184	190	PF00498	0.397
LIG_FHA_1	243	249	PF00498	0.511
LIG_FHA_1	272	278	PF00498	0.374
LIG_FHA_1	29	35	PF00498	0.650
LIG_FHA_1	320	326	PF00498	0.489
LIG_FHA_1	345	351	PF00498	0.535
LIG_FHA_1	363	369	PF00498	0.231
LIG_FHA_1	514	520	PF00498	0.505
LIG_FHA_1	546	552	PF00498	0.541
LIG_FHA_1	675	681	PF00498	0.558
LIG_FHA_1	700	706	PF00498	0.538
LIG_FHA_1	722	728	PF00498	0.513
LIG_FHA_1	80	86	PF00498	0.493
LIG_FHA_2	152	158	PF00498	0.345
LIG_FHA_2	242	248	PF00498	0.511
LIG_FHA_2	301	307	PF00498	0.539
LIG_FHA_2	436	442	PF00498	0.720
LIG_FHA_2	568	574	PF00498	0.463
LIG_FHA_2	636	642	PF00498	0.505
LIG_FHA_2	676	682	PF00498	0.591
LIG_FHA_2	89	95	PF00498	0.552
LIG_LIR_Apic_2	468	472	PF02991	0.558
LIG_LIR_Gen_1	117	127	PF02991	0.383
LIG_LIR_Gen_1	30	39	PF02991	0.500
LIG_LIR_Gen_1	514	522	PF02991	0.486
LIG_LIR_Gen_1	634	643	PF02991	0.568
LIG_LIR_Gen_1	665	676	PF02991	0.523
LIG_LIR_LC3C_4	432	437	PF02991	0.521
LIG_LIR_Nem_3	117	122	PF02991	0.455
LIG_LIR_Nem_3	259	265	PF02991	0.306
LIG_LIR_Nem_3	30	35	PF02991	0.582
LIG_LIR_Nem_3	468	474	PF02991	0.572
LIG_LIR_Nem_3	514	518	PF02991	0.486
LIG_LIR_Nem_3	634	639	PF02991	0.504
LIG_LIR_Nem_3	665	671	PF02991	0.523
LIG_LYPXL_yS_3	471	474	PF13949	0.587
LIG_MLH1_MIPbox_1	51	55	PF16413	0.219
LIG_Pex14_1	161	165	PF04695	0.380
LIG_SH2_CRK	357	361	PF00017	0.418
LIG_SH2_CRK	668	672	PF00017	0.523
LIG_SH2_NCK_1	357	361	PF00017	0.418
LIG_SH2_SRC	165	168	PF00017	0.442
LIG_SH2_STAP1	668	672	PF00017	0.523
LIG_SH2_STAT3	378	381	PF00017	0.303
LIG_SH2_STAT5	165	168	PF00017	0.437
LIG_SH2_STAT5	258	261	PF00017	0.392
LIG_SH2_STAT5	312	315	PF00017	0.577
LIG_SH2_STAT5	357	360	PF00017	0.258
LIG_SH2_STAT5	393	396	PF00017	0.338
LIG_SH3_3	131	137	PF00018	0.471
LIG_SH3_3	469	475	PF00018	0.578
LIG_SH3_3	592	598	PF00018	0.577
LIG_SH3_3	600	606	PF00018	0.483
LIG_SH3_3	640	646	PF00018	0.577
LIG_SH3_3	9	15	PF00018	0.728
LIG_SUMO_SIM_anti_2	220	226	PF11976	0.539
LIG_SUMO_SIM_anti_2	274	279	PF11976	0.418
LIG_SUMO_SIM_anti_2	365	371	PF11976	0.418
LIG_SUMO_SIM_anti_2	669	675	PF11976	0.505
LIG_SUMO_SIM_par_1	432	439	PF11976	0.655
LIG_SUMO_SIM_par_1	449	457	PF11976	0.644
LIG_SUMO_SIM_par_1	47	53	PF11976	0.407
LIG_SUMO_SIM_par_1	556	561	PF11976	0.397
LIG_SUMO_SIM_par_1	60	65	PF11976	0.317
LIG_SUMO_SIM_par_1	669	675	PF11976	0.539
LIG_SUMO_SIM_par_1	701	707	PF11976	0.553
LIG_TRAF2_1	24	27	PF00917	0.590
LIG_TRAF2_1	303	306	PF00917	0.539
LIG_WRC_WIRS_1	397	402	PF05994	0.374
LIG_WRC_WIRS_1	51	56	PF05994	0.392
LIG_WRC_WIRS_1	636	641	PF05994	0.577
MOD_CK1_1	18	24	PF00069	0.786
MOD_CK1_1	242	248	PF00069	0.548
MOD_CK1_1	308	314	PF00069	0.545
MOD_CK1_1	362	368	PF00069	0.336
MOD_CK1_1	406	412	PF00069	0.367
MOD_CK1_1	504	510	PF00069	0.673
MOD_CK1_1	511	517	PF00069	0.539
MOD_CK1_1	634	640	PF00069	0.473
MOD_CK1_1	95	101	PF00069	0.569
MOD_CK2_1	151	157	PF00069	0.407
MOD_CK2_1	241	247	PF00069	0.539
MOD_CK2_1	300	306	PF00069	0.539
MOD_CK2_1	435	441	PF00069	0.724
MOD_CK2_1	567	573	PF00069	0.477
MOD_CK2_1	635	641	PF00069	0.539
MOD_CK2_1	688	694	PF00069	0.584
MOD_CK2_1	722	728	PF00069	0.693
MOD_DYRK1A_RPxSP_1	96	100	PF00069	0.389
MOD_GlcNHglycan	111	114	PF01048	0.606
MOD_GlcNHglycan	198	201	PF01048	0.367
MOD_GlcNHglycan	225	228	PF01048	0.288
MOD_GlcNHglycan	236	239	PF01048	0.320
MOD_GlcNHglycan	361	364	PF01048	0.407
MOD_GlcNHglycan	456	459	PF01048	0.387
MOD_GlcNHglycan	499	502	PF01048	0.567
MOD_GlcNHglycan	528	531	PF01048	0.281
MOD_GlcNHglycan	625	628	PF01048	0.339
MOD_GlcNHglycan	648	651	PF01048	0.263
MOD_GlcNHglycan	724	727	PF01048	0.480
MOD_GSK3_1	15	22	PF00069	0.795
MOD_GSK3_1	247	254	PF00069	0.527
MOD_GSK3_1	267	274	PF00069	0.141
MOD_GSK3_1	346	353	PF00069	0.467
MOD_GSK3_1	355	362	PF00069	0.503
MOD_GSK3_1	396	403	PF00069	0.427
MOD_GSK3_1	405	412	PF00069	0.403
MOD_GSK3_1	497	504	PF00069	0.740
MOD_GSK3_1	578	585	PF00069	0.521
MOD_GSK3_1	6	13	PF00069	0.749
MOD_GSK3_1	623	630	PF00069	0.426
MOD_GSK3_1	631	638	PF00069	0.524
MOD_GSK3_1	662	669	PF00069	0.535
MOD_GSK3_1	695	702	PF00069	0.575
MOD_GSK3_1	722	729	PF00069	0.655
MOD_GSK3_1	77	84	PF00069	0.436
MOD_GSK3_1	88	95	PF00069	0.511
MOD_N-GLC_1	350	355	PF02516	0.319
MOD_N-GLC_1	578	583	PF02516	0.294
MOD_NEK2_1	206	211	PF00069	0.486
MOD_NEK2_1	241	246	PF00069	0.517
MOD_NEK2_1	267	272	PF00069	0.360
MOD_NEK2_1	273	278	PF00069	0.370
MOD_NEK2_1	317	322	PF00069	0.535
MOD_NEK2_1	331	336	PF00069	0.411
MOD_NEK2_1	346	351	PF00069	0.511
MOD_NEK2_1	373	378	PF00069	0.355
MOD_NEK2_1	400	405	PF00069	0.402
MOD_NEK2_1	407	412	PF00069	0.179
MOD_NEK2_1	414	419	PF00069	0.577
MOD_NEK2_1	435	440	PF00069	0.737
MOD_NEK2_1	50	55	PF00069	0.316
MOD_NEK2_1	567	572	PF00069	0.505
MOD_NEK2_1	583	588	PF00069	0.505
MOD_NEK2_1	6	11	PF00069	0.682
MOD_NEK2_1	62	67	PF00069	0.426
MOD_NEK2_1	688	693	PF00069	0.527
MOD_NEK2_1	695	700	PF00069	0.532
MOD_NEK2_1	722	727	PF00069	0.653
MOD_OFUCOSY	531	536	PF10250	0.377
MOD_PIKK_1	251	257	PF00454	0.472
MOD_PIKK_1	317	323	PF00454	0.577
MOD_PIKK_1	409	415	PF00454	0.547
MOD_PIKK_1	501	507	PF00454	0.741
MOD_PIKK_1	508	514	PF00454	0.477
MOD_PIKK_1	550	556	PF00454	0.539
MOD_PKA_1	344	350	PF00069	0.459
MOD_PKA_1	617	623	PF00069	0.539
MOD_PKA_2	220	226	PF00069	0.418
MOD_PKA_2	300	306	PF00069	0.515
MOD_PKA_2	344	350	PF00069	0.539
MOD_PKA_2	387	393	PF00069	0.287
MOD_PKA_2	414	420	PF00069	0.615
MOD_PKA_2	617	623	PF00069	0.539
MOD_PKA_2	695	701	PF00069	0.650
MOD_PKA_2	95	101	PF00069	0.401
MOD_PKB_1	545	553	PF00069	0.397
MOD_Plk_1	305	311	PF00069	0.523
MOD_Plk_1	350	356	PF00069	0.508
MOD_Plk_4	184	190	PF00069	0.392
MOD_Plk_4	220	226	PF00069	0.456
MOD_Plk_4	273	279	PF00069	0.371
MOD_Plk_4	308	314	PF00069	0.549
MOD_Plk_4	319	325	PF00069	0.513
MOD_Plk_4	387	393	PF00069	0.311
MOD_Plk_4	396	402	PF00069	0.374
MOD_Plk_4	423	429	PF00069	0.512
MOD_Plk_4	50	56	PF00069	0.397
MOD_Plk_4	57	63	PF00069	0.359
MOD_Plk_4	627	633	PF00069	0.449
MOD_Plk_4	635	641	PF00069	0.507
MOD_Plk_4	666	672	PF00069	0.503
MOD_Plk_4	699	705	PF00069	0.560
MOD_ProDKin_1	16	22	PF00069	0.734
MOD_ProDKin_1	160	166	PF00069	0.429
MOD_ProDKin_1	444	450	PF00069	0.637
MOD_ProDKin_1	602	608	PF00069	0.425
MOD_ProDKin_1	631	637	PF00069	0.528
MOD_ProDKin_1	8	14	PF00069	0.764
MOD_ProDKin_1	96	102	PF00069	0.403
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.509
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.418
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.539
TRG_ENDOCYTIC_2	357	360	PF00928	0.418
TRG_ENDOCYTIC_2	39	42	PF00928	0.667
TRG_ENDOCYTIC_2	471	474	PF00928	0.587
TRG_ENDOCYTIC_2	668	671	PF00928	0.523
TRG_ER_diArg_1	343	345	PF00400	0.462
TRG_ER_diArg_1	544	547	PF00400	0.397
TRG_ER_diArg_1	555	557	PF00400	0.363
TRG_ER_diArg_1	617	619	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	693	697	PF00026	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P4	Leptomonas seymouri	63%	100%
A0A0S4J6G3	Bodo saltans	29%	100%
A0A1X0NU80	Trypanosomatidae	35%	100%
A0A3S5H7S2	Leishmania donovani	78%	99%
A4I828	Leishmania infantum	78%	99%
E9B2Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
G7CBF6	Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316)	23%	100%
P0C529	Brucella abortus biovar 1 (strain 9-941)	23%	100%
P23702	Aggregatibacter actinomycetemcomitans	21%	100%
P26760	Actinobacillus pleuropneumoniae	22%	100%
P44407	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	22%	100%
P63359	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	22%	100%
P63360	Salmonella typhi	22%	100%
Q04473	Actinobacillus pleuropneumoniae	22%	100%
Q2SIN5	Hahella chejuensis (strain KCTC 2396)	21%	100%
Q2YQ73	Brucella abortus (strain 2308)	23%	100%
Q4Q570	Leishmania major	78%	99%
Q57R14	Salmonella choleraesuis (strain SC-B67)	22%	100%
Q5PGH0	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	22%	100%
Q7NZU6	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	22%	100%
Q8G0T8	Brucella suis biovar 1 (strain 1330)	23%	100%
Q8YH20	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	23%	100%
Q9NRK6	Homo sapiens	26%	99%
Q9RCG7	Pasteurella aerogenes	21%	100%