Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKJ4_LEIBR

TriTrypDb:

LbrM.32.2250 , LBRM2903_320029000

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.615
CLV_C14_Caspase3-7	296	300	PF00656	0.555
CLV_C14_Caspase3-7	527	531	PF00656	0.483
CLV_C14_Caspase3-7	787	791	PF00656	0.794
CLV_C14_Caspase3-7	855	859	PF00656	0.593
CLV_NRD_NRD_1	114	116	PF00675	0.595
CLV_NRD_NRD_1	322	324	PF00675	0.559
CLV_NRD_NRD_1	425	427	PF00675	0.359
CLV_NRD_NRD_1	502	504	PF00675	0.613
CLV_NRD_NRD_1	610	612	PF00675	0.587
CLV_NRD_NRD_1	680	682	PF00675	0.614
CLV_NRD_NRD_1	99	101	PF00675	0.577
CLV_PCSK_FUR_1	500	504	PF00082	0.371
CLV_PCSK_KEX2_1	114	116	PF00082	0.593
CLV_PCSK_KEX2_1	322	324	PF00082	0.559
CLV_PCSK_KEX2_1	500	502	PF00082	0.551
CLV_PCSK_KEX2_1	610	612	PF00082	0.601
CLV_PCSK_KEX2_1	98	100	PF00082	0.578
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.411
CLV_PCSK_SKI1_1	105	109	PF00082	0.457
CLV_PCSK_SKI1_1	169	173	PF00082	0.575
CLV_PCSK_SKI1_1	229	233	PF00082	0.452
CLV_PCSK_SKI1_1	284	288	PF00082	0.573
CLV_PCSK_SKI1_1	322	326	PF00082	0.648
CLV_PCSK_SKI1_1	345	349	PF00082	0.570
CLV_PCSK_SKI1_1	514	518	PF00082	0.454
CLV_PCSK_SKI1_1	615	619	PF00082	0.676
CLV_Separin_Metazoa	316	320	PF03568	0.431
DEG_APCC_DBOX_1	321	329	PF00400	0.594
DEG_APCC_DBOX_1	492	500	PF00400	0.394
DEG_APCC_DBOX_1	610	618	PF00400	0.584
DEG_APCC_DBOX_1	778	786	PF00400	0.782
DEG_SCF_FBW7_2	883	890	PF00400	0.503
DEG_SPOP_SBC_1	40	44	PF00917	0.558
DEG_SPOP_SBC_1	635	639	PF00917	0.748
DEG_SPOP_SBC_1	658	662	PF00917	0.581
DEG_SPOP_SBC_1	800	804	PF00917	0.569
DEG_SPOP_SBC_1	845	849	PF00917	0.536
DOC_CKS1_1	541	546	PF01111	0.639
DOC_CKS1_1	605	610	PF01111	0.577
DOC_CKS1_1	641	646	PF01111	0.807
DOC_CKS1_1	884	889	PF01111	0.497
DOC_CYCLIN_yCln2_LP_2	913	916	PF00134	0.526
DOC_MAPK_gen_1	410	418	PF00069	0.602
DOC_MAPK_MEF2A_6	580	589	PF00069	0.543
DOC_MAPK_RevD_3	488	503	PF00069	0.443
DOC_PP1_RVXF_1	584	590	PF00149	0.552
DOC_PP2B_LxvP_1	10	13	PF13499	0.557
DOC_PP2B_LxvP_1	188	191	PF13499	0.569
DOC_PP2B_LxvP_1	913	916	PF13499	0.526
DOC_PP4_FxxP_1	77	80	PF00568	0.548
DOC_PP4_FxxP_1	822	825	PF00568	0.520
DOC_USP7_MATH_1	14	18	PF00917	0.530
DOC_USP7_MATH_1	191	195	PF00917	0.628
DOC_USP7_MATH_1	210	214	PF00917	0.505
DOC_USP7_MATH_1	289	293	PF00917	0.566
DOC_USP7_MATH_1	306	310	PF00917	0.568
DOC_USP7_MATH_1	488	492	PF00917	0.644
DOC_USP7_MATH_1	58	62	PF00917	0.554
DOC_USP7_MATH_1	609	613	PF00917	0.642
DOC_USP7_MATH_1	635	639	PF00917	0.669
DOC_USP7_MATH_1	719	723	PF00917	0.649
DOC_USP7_MATH_1	738	742	PF00917	0.615
DOC_USP7_MATH_1	846	850	PF00917	0.543
DOC_USP7_MATH_1	916	920	PF00917	0.760
DOC_USP7_UBL2_3	101	105	PF12436	0.657
DOC_USP7_UBL2_3	169	173	PF12436	0.778
DOC_WW_Pin1_4	201	206	PF00397	0.696
DOC_WW_Pin1_4	331	336	PF00397	0.506
DOC_WW_Pin1_4	46	51	PF00397	0.548
DOC_WW_Pin1_4	540	545	PF00397	0.637
DOC_WW_Pin1_4	604	609	PF00397	0.616
DOC_WW_Pin1_4	619	624	PF00397	0.491
DOC_WW_Pin1_4	640	645	PF00397	0.782
DOC_WW_Pin1_4	659	664	PF00397	0.604
DOC_WW_Pin1_4	76	81	PF00397	0.756
DOC_WW_Pin1_4	802	807	PF00397	0.676
DOC_WW_Pin1_4	883	888	PF00397	0.559
LIG_14-3-3_CanoR_1	156	160	PF00244	0.821
LIG_14-3-3_CanoR_1	349	356	PF00244	0.645
LIG_14-3-3_CanoR_1	410	415	PF00244	0.704
LIG_14-3-3_CanoR_1	580	586	PF00244	0.537
LIG_14-3-3_CanoR_1	610	615	PF00244	0.790
LIG_14-3-3_CanoR_1	634	644	PF00244	0.696
LIG_14-3-3_CanoR_1	659	663	PF00244	0.630
LIG_14-3-3_CanoR_1	670	676	PF00244	0.679
LIG_14-3-3_CanoR_1	747	752	PF00244	0.744
LIG_14-3-3_CanoR_1	758	763	PF00244	0.756
LIG_14-3-3_CanoR_1	779	783	PF00244	0.605
LIG_14-3-3_CanoR_1	801	806	PF00244	0.586
LIG_14-3-3_CanoR_1	904	914	PF00244	0.691
LIG_14-3-3_CanoR_1	99	104	PF00244	0.404
LIG_Actin_WH2_2	308	324	PF00022	0.480
LIG_Actin_WH2_2	457	474	PF00022	0.626
LIG_Actin_WH2_2	828	845	PF00022	0.494
LIG_APCC_ABBA_1	418	423	PF00400	0.645
LIG_APCC_ABBAyCdc20_2	514	520	PF00400	0.674
LIG_BH_BH3_1	378	394	PF00452	0.456
LIG_BRCT_BRCA1_1	721	725	PF00533	0.542
LIG_BRCT_BRCA1_1	848	852	PF00533	0.560
LIG_CtBP_PxDLS_1	415	419	PF00389	0.432
LIG_DLG_GKlike_1	758	766	PF00625	0.538
LIG_FHA_1	332	338	PF00498	0.514
LIG_FHA_1	411	417	PF00498	0.532
LIG_FHA_1	466	472	PF00498	0.410
LIG_FHA_1	576	582	PF00498	0.549
LIG_FHA_1	620	626	PF00498	0.658
LIG_FHA_1	659	665	PF00498	0.514
LIG_FHA_1	764	770	PF00498	0.783
LIG_FHA_1	775	781	PF00498	0.650
LIG_FHA_1	795	801	PF00498	0.785
LIG_FHA_1	908	914	PF00498	0.512
LIG_FHA_2	165	171	PF00498	0.683
LIG_FHA_2	294	300	PF00498	0.659
LIG_FHA_2	474	480	PF00498	0.522
LIG_FHA_2	482	488	PF00498	0.547
LIG_FHA_2	537	543	PF00498	0.552
LIG_FHA_2	591	597	PF00498	0.809
LIG_FHA_2	660	666	PF00498	0.507
LIG_FHA_2	750	756	PF00498	0.566
LIG_FHA_2	768	774	PF00498	0.614
LIG_FHA_2	869	875	PF00498	0.782
LIG_FHA_2	884	890	PF00498	0.615
LIG_IBAR_NPY_1	677	679	PF08397	0.622
LIG_LIR_Apic_2	365	371	PF02991	0.683
LIG_LIR_Apic_2	674	678	PF02991	0.620
LIG_LIR_Apic_2	76	80	PF02991	0.541
LIG_LIR_Gen_1	749	757	PF02991	0.783
LIG_LIR_Gen_1	808	816	PF02991	0.548
LIG_LIR_Nem_3	749	754	PF02991	0.789
LIG_LIR_Nem_3	808	813	PF02991	0.553
LIG_MYND_1	744	748	PF01753	0.552
LIG_NRBOX	837	843	PF00104	0.635
LIG_PCNA_PIPBox_1	71	80	PF02747	0.536
LIG_Pex14_1	675	679	PF04695	0.624
LIG_SH2_CRK	368	372	PF00017	0.641
LIG_SH2_CRK	760	764	PF00017	0.540
LIG_SH2_STAT3	684	687	PF00017	0.614
LIG_SH2_STAT5	388	391	PF00017	0.499
LIG_SH2_STAT5	504	507	PF00017	0.540
LIG_SH2_STAT5	679	682	PF00017	0.619
LIG_SH2_STAT5	684	687	PF00017	0.612
LIG_SH2_STAT5	905	908	PF00017	0.747
LIG_SH2_STAT5	96	99	PF00017	0.541
LIG_SH3_2	32	37	PF14604	0.558
LIG_SH3_3	183	189	PF00018	0.799
LIG_SH3_3	29	35	PF00018	0.556
LIG_SH3_3	367	373	PF00018	0.575
LIG_SH3_3	561	567	PF00018	0.775
LIG_SH3_3	602	608	PF00018	0.584
LIG_SH3_3	629	635	PF00018	0.641
LIG_SH3_3	641	647	PF00018	0.628
LIG_SH3_3	79	85	PF00018	0.750
LIG_SH3_3	869	875	PF00018	0.605
LIG_SH3_3	881	887	PF00018	0.520
LIG_SUMO_SIM_anti_2	450	455	PF11976	0.370
LIG_SUMO_SIM_anti_2	660	668	PF11976	0.499
LIG_SUMO_SIM_par_1	252	259	PF11976	0.699
LIG_SUMO_SIM_par_1	466	474	PF11976	0.411
LIG_SUMO_SIM_par_1	660	668	PF11976	0.499
LIG_SUMO_SIM_par_1	874	880	PF11976	0.551
LIG_TRAF2_1	476	479	PF00917	0.545
LIG_TRAF2_1	484	487	PF00917	0.618
LIG_TRAF2_1	592	595	PF00917	0.760
LIG_TRAF2_1	693	696	PF00917	0.500
LIG_TRAF2_1	887	890	PF00917	0.526
LIG_WRC_WIRS_1	74	79	PF05994	0.540
LIG_WRC_WIRS_1	751	756	PF05994	0.794
LIG_WW_3	607	611	PF00397	0.578
LIG_WW_3	914	918	PF00397	0.539
MOD_CDC14_SPxK_1	204	207	PF00782	0.841
MOD_CDK_SPxK_1	201	207	PF00069	0.847
MOD_CDK_SPxK_1	604	610	PF00069	0.579
MOD_CDK_SPxxK_3	604	611	PF00069	0.581
MOD_CDK_SPxxK_3	619	626	PF00069	0.493
MOD_CK1_1	158	164	PF00069	0.634
MOD_CK1_1	343	349	PF00069	0.598
MOD_CK1_1	41	47	PF00069	0.559
MOD_CK1_1	534	540	PF00069	0.639
MOD_CK1_1	61	67	PF00069	0.524
MOD_CK1_1	624	630	PF00069	0.627
MOD_CK1_1	650	656	PF00069	0.695
MOD_CK1_1	73	79	PF00069	0.691
MOD_CK1_1	750	756	PF00069	0.794
MOD_CK1_1	761	767	PF00069	0.580
MOD_CK1_1	778	784	PF00069	0.520
MOD_CK1_1	802	808	PF00069	0.716
MOD_CK1_1	814	820	PF00069	0.578
MOD_CK1_1	844	850	PF00069	0.787
MOD_CK2_1	164	170	PF00069	0.574
MOD_CK2_1	209	215	PF00069	0.597
MOD_CK2_1	249	255	PF00069	0.435
MOD_CK2_1	460	466	PF00069	0.459
MOD_CK2_1	473	479	PF00069	0.489
MOD_CK2_1	481	487	PF00069	0.422
MOD_CK2_1	590	596	PF00069	0.811
MOD_CK2_1	659	665	PF00069	0.514
MOD_CK2_1	690	696	PF00069	0.535
MOD_CK2_1	767	773	PF00069	0.550
MOD_CK2_1	883	889	PF00069	0.644
MOD_GlcNHglycan	109	112	PF01048	0.647
MOD_GlcNHglycan	160	163	PF01048	0.702
MOD_GlcNHglycan	193	196	PF01048	0.623
MOD_GlcNHglycan	212	215	PF01048	0.503
MOD_GlcNHglycan	24	27	PF01048	0.554
MOD_GlcNHglycan	340	343	PF01048	0.596
MOD_GlcNHglycan	356	359	PF01048	0.487
MOD_GlcNHglycan	533	536	PF01048	0.726
MOD_GlcNHglycan	560	563	PF01048	0.601
MOD_GlcNHglycan	573	576	PF01048	0.525
MOD_GlcNHglycan	598	601	PF01048	0.691
MOD_GlcNHglycan	628	631	PF01048	0.572
MOD_GlcNHglycan	638	641	PF01048	0.772
MOD_GlcNHglycan	721	724	PF01048	0.681
MOD_GlcNHglycan	725	728	PF01048	0.615
MOD_GlcNHglycan	763	766	PF01048	0.656
MOD_GlcNHglycan	813	816	PF01048	0.651
MOD_GlcNHglycan	817	820	PF01048	0.580
MOD_GSK3_1	154	161	PF00069	0.678
MOD_GSK3_1	289	296	PF00069	0.630
MOD_GSK3_1	345	352	PF00069	0.781
MOD_GSK3_1	40	47	PF00069	0.797
MOD_GSK3_1	404	411	PF00069	0.634
MOD_GSK3_1	536	543	PF00069	0.564
MOD_GSK3_1	571	578	PF00069	0.696
MOD_GSK3_1	58	65	PF00069	0.485
MOD_GSK3_1	581	588	PF00069	0.679
MOD_GSK3_1	596	603	PF00069	0.731
MOD_GSK3_1	626	633	PF00069	0.723
MOD_GSK3_1	636	643	PF00069	0.723
MOD_GSK3_1	719	726	PF00069	0.539
MOD_GSK3_1	738	745	PF00069	0.753
MOD_GSK3_1	746	753	PF00069	0.683
MOD_GSK3_1	763	770	PF00069	0.534
MOD_GSK3_1	774	781	PF00069	0.569
MOD_GSK3_1	801	808	PF00069	0.647
MOD_GSK3_1	811	818	PF00069	0.668
MOD_GSK3_1	837	844	PF00069	0.645
MOD_NEK2_1	22	27	PF00069	0.554
MOD_NEK2_1	249	254	PF00069	0.430
MOD_NEK2_1	328	333	PF00069	0.626
MOD_NEK2_1	389	394	PF00069	0.406
MOD_NEK2_1	471	476	PF00069	0.639
MOD_NEK2_1	573	578	PF00069	0.754
MOD_NEK2_1	587	592	PF00069	0.551
MOD_NEK2_1	62	67	PF00069	0.578
MOD_NEK2_1	636	641	PF00069	0.789
MOD_NEK2_1	811	816	PF00069	0.706
MOD_NEK2_1	837	842	PF00069	0.679
MOD_NEK2_1	877	882	PF00069	0.663
MOD_NEK2_1	907	912	PF00069	0.591
MOD_NEK2_2	488	493	PF00069	0.391
MOD_NEK2_2	647	652	PF00069	0.605
MOD_PIKK_1	128	134	PF00454	0.582
MOD_PIKK_1	41	47	PF00454	0.556
MOD_PIKK_1	691	697	PF00454	0.499
MOD_PIKK_1	700	706	PF00454	0.504
MOD_PKA_1	610	616	PF00069	0.586
MOD_PKA_1	99	105	PF00069	0.406
MOD_PKA_2	155	161	PF00069	0.769
MOD_PKA_2	164	170	PF00069	0.535
MOD_PKA_2	609	615	PF00069	0.795
MOD_PKA_2	658	664	PF00069	0.577
MOD_PKA_2	746	752	PF00069	0.583
MOD_PKA_2	778	784	PF00069	0.654
MOD_PKA_2	800	806	PF00069	0.662
MOD_PKA_2	895	901	PF00069	0.640
MOD_PKA_2	916	922	PF00069	0.765
MOD_PKA_2	99	105	PF00069	0.406
MOD_Plk_1	364	370	PF00069	0.478
MOD_Plk_1	465	471	PF00069	0.408
MOD_Plk_1	868	874	PF00069	0.660
MOD_Plk_2-3	460	466	PF00069	0.516
MOD_Plk_4	249	255	PF00069	0.513
MOD_Plk_4	465	471	PF00069	0.384
MOD_Plk_4	73	79	PF00069	0.550
MOD_Plk_4	758	764	PF00069	0.625
MOD_Plk_4	837	843	PF00069	0.645
MOD_ProDKin_1	201	207	PF00069	0.734
MOD_ProDKin_1	331	337	PF00069	0.509
MOD_ProDKin_1	46	52	PF00069	0.548
MOD_ProDKin_1	540	546	PF00069	0.638
MOD_ProDKin_1	604	610	PF00069	0.618
MOD_ProDKin_1	619	625	PF00069	0.492
MOD_ProDKin_1	640	646	PF00069	0.776
MOD_ProDKin_1	659	665	PF00069	0.602
MOD_ProDKin_1	76	82	PF00069	0.753
MOD_ProDKin_1	802	808	PF00069	0.675
MOD_ProDKin_1	883	889	PF00069	0.554
MOD_SUMO_rev_2	473	482	PF00179	0.503
MOD_SUMO_rev_2	486	491	PF00179	0.447
MOD_SUMO_rev_2	888	893	PF00179	0.661
TRG_DiLeu_BaEn_1	125	130	PF01217	0.574
TRG_DiLeu_BaEn_1	466	471	PF01217	0.530
TRG_DiLeu_BaEn_4	125	131	PF01217	0.578
TRG_DiLeu_BaLyEn_6	568	573	PF01217	0.566
TRG_DiLeu_BaLyEn_6	872	877	PF01217	0.551
TRG_DiLeu_BaLyEn_6	909	914	PF01217	0.609
TRG_DiLeu_LyEn_5	125	130	PF01217	0.643
TRG_ENDOCYTIC_2	760	763	PF00928	0.661
TRG_ER_diArg_1	113	115	PF00400	0.667
TRG_ER_diArg_1	134	137	PF00400	0.591
TRG_ER_diArg_1	321	323	PF00400	0.440
TRG_ER_diArg_1	409	412	PF00400	0.615
TRG_ER_diArg_1	492	495	PF00400	0.472
TRG_ER_diArg_1	499	502	PF00400	0.356
TRG_ER_diArg_1	609	611	PF00400	0.582
TRG_ER_diArg_1	685	688	PF00400	0.490
TRG_ER_FFAT_2	756	768	PF00635	0.540
TRG_NES_CRM1_1	828	839	PF08389	0.528
TRG_NLS_MonoCore_2	97	102	PF00514	0.401
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A7	Leptomonas seymouri	39%	100%
A0A3Q8IH17	Leishmania donovani	60%	100%
A4I826	Leishmania infantum	60%	100%
E9B2Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	98%
Q4Q572	Leishmania major	60%	100%