Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKJ1_LEIBR

TriTrypDb:

LbrM.32.2220 , LBRM2903_320028700

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HKJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKJ1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.602
CLV_NRD_NRD_1	253	255	PF00675	0.651
CLV_NRD_NRD_1	86	88	PF00675	0.526
CLV_PCSK_FUR_1	18	22	PF00082	0.492
CLV_PCSK_KEX2_1	20	22	PF00082	0.414
CLV_PCSK_KEX2_1	252	254	PF00082	0.664
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.645
CLV_PCSK_SKI1_1	205	209	PF00082	0.345
CLV_PCSK_SKI1_1	228	232	PF00082	0.354
CLV_PCSK_SKI1_1	283	287	PF00082	0.514
CLV_PCSK_SKI1_1	4	8	PF00082	0.455
CLV_PCSK_SKI1_1	87	91	PF00082	0.495
DEG_ODPH_VHL_1	54	65	PF01847	0.418
DOC_CKS1_1	160	165	PF01111	0.529
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.305
DOC_MAPK_gen_1	205	215	PF00069	0.311
DOC_PP4_FxxP_1	125	128	PF00568	0.574
DOC_PP4_FxxP_1	160	163	PF00568	0.571
DOC_PP4_FxxP_1	65	68	PF00568	0.340
DOC_USP7_MATH_1	223	227	PF00917	0.321
DOC_USP7_MATH_1	274	278	PF00917	0.687
DOC_USP7_MATH_1	289	293	PF00917	0.653
DOC_WW_Pin1_4	159	164	PF00397	0.493
DOC_WW_Pin1_4	176	181	PF00397	0.248
DOC_WW_Pin1_4	285	290	PF00397	0.542
DOC_WW_Pin1_4	47	52	PF00397	0.339
LIG_14-3-3_CanoR_1	109	113	PF00244	0.449
LIG_14-3-3_CanoR_1	172	178	PF00244	0.264
LIG_14-3-3_CanoR_1	216	224	PF00244	0.413
LIG_14-3-3_CanoR_1	245	249	PF00244	0.465
LIG_14-3-3_CanoR_1	283	288	PF00244	0.480
LIG_14-3-3_CanoR_1	87	96	PF00244	0.432
LIG_Actin_WH2_2	212	230	PF00022	0.445
LIG_BIR_III_2	193	197	PF00653	0.534
LIG_deltaCOP1_diTrp_1	261	266	PF00928	0.346
LIG_FHA_1	109	115	PF00498	0.411
LIG_FHA_1	168	174	PF00498	0.564
LIG_FHA_2	143	149	PF00498	0.348
LIG_LIR_Apic_2	122	128	PF02991	0.581
LIG_LIR_Apic_2	158	163	PF02991	0.528
LIG_LIR_Apic_2	176	180	PF02991	0.231
LIG_LIR_Gen_1	229	239	PF02991	0.436
LIG_LIR_Gen_1	261	269	PF02991	0.303
LIG_LIR_Gen_1	60	70	PF02991	0.349
LIG_LIR_Gen_1	76	84	PF02991	0.279
LIG_LIR_Nem_3	229	235	PF02991	0.444
LIG_LIR_Nem_3	261	267	PF02991	0.333
LIG_LIR_Nem_3	60	65	PF02991	0.353
LIG_LIR_Nem_3	76	82	PF02991	0.278
LIG_Pex14_2	231	235	PF04695	0.344
LIG_PTB_Apo_2	192	199	PF02174	0.412
LIG_PTB_Phospho_1	192	198	PF10480	0.412
LIG_SH2_CRK	137	141	PF00017	0.325
LIG_SH2_CRK	66	70	PF00017	0.243
LIG_SH2_STAT5	142	145	PF00017	0.441
LIG_SH2_STAT5	177	180	PF00017	0.398
LIG_SH2_STAT5	287	290	PF00017	0.468
LIG_SH2_STAT5	62	65	PF00017	0.340
LIG_SH3_3	110	116	PF00018	0.335
LIG_SH3_3	53	59	PF00018	0.474
LIG_SUMO_SIM_anti_2	111	116	PF11976	0.363
LIG_TRAF2_1	197	200	PF00917	0.553
MOD_CDK_SPK_2	285	290	PF00069	0.473
MOD_CK1_1	108	114	PF00069	0.431
MOD_CK1_1	167	173	PF00069	0.411
MOD_CK2_1	142	148	PF00069	0.332
MOD_CK2_1	223	229	PF00069	0.442
MOD_GlcNHglycan	183	186	PF01048	0.549
MOD_GlcNHglycan	276	279	PF01048	0.485
MOD_GlcNHglycan	291	294	PF01048	0.682
MOD_GlcNHglycan	33	37	PF01048	0.614
MOD_GSK3_1	104	111	PF00069	0.447
MOD_GSK3_1	155	162	PF00069	0.480
MOD_GSK3_1	244	251	PF00069	0.477
MOD_GSK3_1	274	281	PF00069	0.635
MOD_GSK3_1	285	292	PF00069	0.677
MOD_N-GLC_1	217	222	PF02516	0.362
MOD_NEK2_1	173	178	PF00069	0.519
MOD_NEK2_2	142	147	PF00069	0.385
MOD_NEK2_2	223	228	PF00069	0.453
MOD_NEK2_2	278	283	PF00069	0.490
MOD_PIKK_1	167	173	PF00454	0.443
MOD_PKA_1	87	93	PF00069	0.509
MOD_PKA_2	108	114	PF00069	0.414
MOD_PKA_2	167	173	PF00069	0.443
MOD_PKA_2	244	250	PF00069	0.480
MOD_Plk_1	278	284	PF00069	0.487
MOD_Plk_4	108	114	PF00069	0.432
MOD_Plk_4	173	179	PF00069	0.453
MOD_Plk_4	244	250	PF00069	0.347
MOD_ProDKin_1	159	165	PF00069	0.486
MOD_ProDKin_1	176	182	PF00069	0.248
MOD_ProDKin_1	285	291	PF00069	0.600
MOD_ProDKin_1	47	53	PF00069	0.343
MOD_SUMO_rev_2	81	90	PF00179	0.503
TRG_DiLeu_BaEn_2	150	156	PF01217	0.270
TRG_ENDOCYTIC_2	232	235	PF00928	0.382
TRG_ENDOCYTIC_2	62	65	PF00928	0.340
TRG_ENDOCYTIC_2	66	69	PF00928	0.326
TRG_ER_diArg_1	20	22	PF00400	0.409
TRG_ER_diArg_1	213	216	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B1	Leptomonas seymouri	77%	98%
A0A0S4JVF9	Bodo saltans	32%	100%
A0A1X0NUI0	Trypanosomatidae	59%	100%
A0A3R7MHS5	Trypanosoma rangeli	58%	100%
A0A3S7X5P5	Leishmania donovani	87%	100%
A4I823	Leishmania infantum	87%	100%
D0AA89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	98%
E9B2Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q575	Leishmania major	85%	100%
V5BBL7	Trypanosoma cruzi	56%	100%