Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKI7_LEIBR

TriTrypDb:

LbrM.32.2180 , LBRM2903_320028300

Length:

148

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.569
CLV_NRD_NRD_1	145	147	PF00675	0.544
CLV_NRD_NRD_1	30	32	PF00675	0.507
CLV_NRD_NRD_1	60	62	PF00675	0.566
CLV_PCSK_FUR_1	6	10	PF00082	0.460
CLV_PCSK_KEX2_1	102	104	PF00082	0.586
CLV_PCSK_KEX2_1	144	146	PF00082	0.544
CLV_PCSK_KEX2_1	29	31	PF00082	0.495
CLV_PCSK_KEX2_1	34	36	PF00082	0.546
CLV_PCSK_KEX2_1	59	61	PF00082	0.564
CLV_PCSK_KEX2_1	8	10	PF00082	0.459
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.586
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.525
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.495
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.546
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.564
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.459
CLV_PCSK_PC7_1	30	36	PF00082	0.527
CLV_PCSK_SKI1_1	103	107	PF00082	0.453
CLV_PCSK_SKI1_1	141	145	PF00082	0.527
CLV_PCSK_SKI1_1	30	34	PF00082	0.438
DOC_MAPK_RevD_3	127	141	PF00069	0.473
DOC_USP7_MATH_1	122	126	PF00917	0.640
DOC_USP7_MATH_1	64	68	PF00917	0.742
DOC_USP7_MATH_1	89	93	PF00917	0.637
DOC_USP7_UBL2_3	140	144	PF12436	0.523
DOC_USP7_UBL2_3	4	8	PF12436	0.467
DOC_WW_Pin1_4	82	87	PF00397	0.600
LIG_14-3-3_CanoR_1	91	100	PF00244	0.621
LIG_FHA_2	37	43	PF00498	0.642
LIG_FHA_2	60	66	PF00498	0.590
LIG_FHA_2	71	77	PF00498	0.561
LIG_LIR_Gen_1	108	119	PF02991	0.571
LIG_LIR_Nem_3	108	114	PF02991	0.509
LIG_REV1ctd_RIR_1	103	109	PF16727	0.446
LIG_SH2_STAT5	12	15	PF00017	0.443
LIG_SH2_STAT5	26	29	PF00017	0.453
LIG_TRAF2_1	73	76	PF00917	0.525
MOD_CK1_1	118	124	PF00069	0.459
MOD_CK1_1	36	42	PF00069	0.636
MOD_CK1_1	92	98	PF00069	0.605
MOD_CK2_1	36	42	PF00069	0.661
MOD_CK2_1	70	76	PF00069	0.578
MOD_GlcNHglycan	117	120	PF01048	0.632
MOD_GlcNHglycan	137	140	PF01048	0.571
MOD_GlcNHglycan	91	94	PF01048	0.662
MOD_GSK3_1	118	125	PF00069	0.612
MOD_GSK3_1	135	142	PF00069	0.520
MOD_GSK3_1	81	88	PF00069	0.555
MOD_N-GLC_1	70	75	PF02516	0.534
MOD_NEK2_1	105	110	PF00069	0.459
MOD_NEK2_1	115	120	PF00069	0.506
MOD_NEK2_1	45	50	PF00069	0.514
MOD_NEK2_2	139	144	PF00069	0.525
MOD_PKA_1	59	65	PF00069	0.626
MOD_PKA_2	22	28	PF00069	0.439
MOD_PKA_2	36	42	PF00069	0.559
MOD_PKA_2	59	65	PF00069	0.626
MOD_Plk_4	132	138	PF00069	0.579
MOD_Plk_4	22	28	PF00069	0.439
MOD_ProDKin_1	82	88	PF00069	0.602
TRG_NLS_MonoCore_2	57	62	PF00514	0.569
TRG_NLS_MonoExtC_3	57	63	PF00514	0.569
TRG_NLS_MonoExtN_4	141	148	PF00514	0.526
TRG_NLS_MonoExtN_4	2	7	PF00514	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXV1	Leptomonas seymouri	44%	100%
A0A3Q8IJB3	Leishmania donovani	68%	100%
A4I819	Leishmania infantum	68%	100%
E9B2X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q579	Leishmania major	63%	100%