LeishMANIAdb
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Putative 1-acyl-sn-glycerol-3-phosphateacyltransferase-lik e protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 1-acyl-sn-glycerol-3-phosphateacyltransferase-lik e protein
Gene product:
1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HKI5_LEIBR
TriTrypDb:
LbrM.32.2150 , LBRM2903_320028000
Length:
287

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 36
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 14
GO:0110165 cellular anatomical entity 1 14

Expansion

Sequence features

A4HKI5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKI5

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 1
GO:0006644 phospholipid metabolic process 4 1
GO:0006650 glycerophospholipid metabolic process 5 1
GO:0006654 phosphatidic acid biosynthetic process 6 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0008610 lipid biosynthetic process 4 1
GO:0008654 phospholipid biosynthetic process 5 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0019637 organophosphate metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0045017 glycerolipid biosynthetic process 4 1
GO:0046473 phosphatidic acid metabolic process 6 1
GO:0046474 glycerophospholipid biosynthetic process 5 1
GO:0046486 glycerolipid metabolic process 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0090407 organophosphate biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 7 8
GO:0008374 O-acyltransferase activity 5 8
GO:0016411 acylglycerol O-acyltransferase activity 6 8
GO:0016740 transferase activity 2 16
GO:0016746 acyltransferase activity 3 16
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 8
GO:0042171 lysophosphatidic acid acyltransferase activity 6 8
GO:0071617 lysophospholipid acyltransferase activity 5 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.333
CLV_NRD_NRD_1 164 166 PF00675 0.425
CLV_NRD_NRD_1 167 169 PF00675 0.413
CLV_NRD_NRD_1 273 275 PF00675 0.477
CLV_NRD_NRD_1 58 60 PF00675 0.513
CLV_PCSK_FUR_1 165 169 PF00082 0.458
CLV_PCSK_KEX2_1 163 165 PF00082 0.465
CLV_PCSK_KEX2_1 167 169 PF00082 0.411
CLV_PCSK_KEX2_1 273 275 PF00082 0.682
CLV_PCSK_PC7_1 163 169 PF00082 0.432
CLV_PCSK_SKI1_1 106 110 PF00082 0.389
CLV_PCSK_SKI1_1 241 245 PF00082 0.511
DEG_SPOP_SBC_1 43 47 PF00917 0.368
DOC_CYCLIN_RxL_1 4 16 PF00134 0.506
DOC_CYCLIN_yClb1_LxF_4 190 195 PF00134 0.232
DOC_MAPK_gen_1 163 174 PF00069 0.214
DOC_MAPK_gen_1 261 270 PF00069 0.390
DOC_MAPK_gen_1 87 93 PF00069 0.270
DOC_MAPK_gen_1 9 19 PF00069 0.429
DOC_MAPK_MEF2A_6 12 21 PF00069 0.441
DOC_PP1_RVXF_1 190 196 PF00149 0.219
DOC_PP1_RVXF_1 57 64 PF00149 0.311
DOC_PP4_FxxP_1 122 125 PF00568 0.209
DOC_PP4_FxxP_1 234 237 PF00568 0.289
DOC_USP7_MATH_1 101 105 PF00917 0.291
DOC_USP7_MATH_1 219 223 PF00917 0.338
DOC_USP7_UBL2_3 5 9 PF12436 0.471
DOC_USP7_UBL2_3 83 87 PF12436 0.235
DOC_WW_Pin1_4 278 283 PF00397 0.320
LIG_14-3-3_CanoR_1 12 18 PF00244 0.424
LIG_14-3-3_CanoR_1 241 249 PF00244 0.300
LIG_14-3-3_CanoR_1 59 64 PF00244 0.295
LIG_AP2alpha_2 100 102 PF02296 0.221
LIG_APCC_ABBA_1 172 177 PF00400 0.221
LIG_BRCT_BRCA1_1 40 44 PF00533 0.368
LIG_deltaCOP1_diTrp_1 112 122 PF00928 0.209
LIG_EH_1 188 192 PF12763 0.314
LIG_EH_1 69 73 PF12763 0.252
LIG_EH1_1 17 25 PF00400 0.266
LIG_eIF4E_1 18 24 PF01652 0.386
LIG_FHA_1 14 20 PF00498 0.232
LIG_FHA_1 212 218 PF00498 0.352
LIG_FHA_2 43 49 PF00498 0.335
LIG_LIR_Apic_2 233 237 PF02991 0.285
LIG_LIR_Gen_1 100 110 PF02991 0.254
LIG_LIR_Gen_1 146 155 PF02991 0.313
LIG_LIR_Gen_1 16 25 PF02991 0.283
LIG_LIR_Nem_3 100 105 PF02991 0.262
LIG_LIR_Nem_3 146 151 PF02991 0.313
LIG_LIR_Nem_3 16 21 PF02991 0.285
LIG_LIR_Nem_3 229 234 PF02991 0.330
LIG_Pex14_2 122 126 PF04695 0.240
LIG_Pex14_2 191 195 PF04695 0.209
LIG_SH2_STAT5 18 21 PF00017 0.300
LIG_SH2_STAT5 231 234 PF00017 0.266
LIG_SH3_2 187 192 PF14604 0.314
LIG_SH3_3 181 187 PF00018 0.269
LIG_SH3_3 279 285 PF00018 0.371
LIG_SH3_3 37 43 PF00018 0.362
LIG_SUMO_SIM_par_1 207 212 PF11976 0.259
LIG_TRAF2_1 245 248 PF00917 0.296
LIG_WRC_WIRS_1 231 236 PF05994 0.352
MOD_CK1_1 104 110 PF00069 0.253
MOD_CK1_1 147 153 PF00069 0.323
MOD_CK2_1 209 215 PF00069 0.292
MOD_CK2_1 230 236 PF00069 0.244
MOD_CK2_1 242 248 PF00069 0.302
MOD_CK2_1 42 48 PF00069 0.374
MOD_GlcNHglycan 133 136 PF01048 0.465
MOD_GlcNHglycan 211 214 PF01048 0.438
MOD_GlcNHglycan 221 224 PF01048 0.491
MOD_GlcNHglycan 244 247 PF01048 0.595
MOD_GlcNHglycan 96 99 PF01048 0.419
MOD_GSK3_1 143 150 PF00069 0.218
MOD_GSK3_1 38 45 PF00069 0.460
MOD_NEK2_1 13 18 PF00069 0.306
MOD_NEK2_1 19 24 PF00069 0.308
MOD_NEK2_1 209 214 PF00069 0.331
MOD_NEK2_2 101 106 PF00069 0.288
MOD_NEK2_2 71 76 PF00069 0.262
MOD_PIKK_1 247 253 PF00454 0.316
MOD_PKA_1 144 150 PF00069 0.281
MOD_PKA_1 59 65 PF00069 0.281
MOD_PKA_2 219 225 PF00069 0.386
MOD_PKA_2 272 278 PF00069 0.305
MOD_Plk_4 111 117 PF00069 0.237
MOD_Plk_4 13 19 PF00069 0.313
MOD_Plk_4 202 208 PF00069 0.248
MOD_Plk_4 59 65 PF00069 0.331
MOD_ProDKin_1 278 284 PF00069 0.325
TRG_DiLeu_BaLyEn_6 9 14 PF01217 0.504
TRG_ENDOCYTIC_2 18 21 PF00928 0.296
TRG_ENDOCYTIC_2 231 234 PF00928 0.351
TRG_ER_diArg_1 163 165 PF00400 0.216
TRG_ER_diArg_1 166 168 PF00400 0.207

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6B0 Leptomonas seymouri 84% 99%
A0A0N1I6V1 Leptomonas seymouri 25% 94%
A0A0S4JRB2 Bodo saltans 26% 90%
A0A0S4JRP7 Bodo saltans 50% 100%
A0A1X0NUQ7 Trypanosomatidae 57% 100%
A0A3Q8IFY7 Leishmania donovani 88% 100%
A0A3S5H7L8 Leishmania donovani 22% 89%
A0A3S5IQW0 Trypanosoma rangeli 60% 100%
A0A3S7WNW6 Leishmania donovani 29% 81%
A4H420 Leishmania braziliensis 30% 81%
A4HSA2 Leishmania infantum 29% 81%
A4I4U1 Leishmania infantum 23% 89%
A4I4U2 Leishmania infantum 24% 93%
A4I816 Leishmania infantum 88% 100%
D0AA81 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9AE89 Leishmania major 23% 100%
E9AK86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 93%
E9B2X4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 98%
Q42670 Cocos nucifera 25% 93%
Q4Q582 Leishmania major 86% 100%
Q9LLY4 Brassica napus 27% 83%
Q9NF90 Leishmania major 27% 81%
V5ALB6 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS