SBF2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKI4_LEIBR

TriTrypDb:

LbrM.32.2140 , LBRM2903_320027900

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.511
CLV_NRD_NRD_1	176	178	PF00675	0.528
CLV_NRD_NRD_1	403	405	PF00675	0.646
CLV_PCSK_KEX2_1	154	156	PF00082	0.511
CLV_PCSK_KEX2_1	176	178	PF00082	0.528
CLV_PCSK_KEX2_1	403	405	PF00082	0.641
CLV_PCSK_SKI1_1	147	151	PF00082	0.535
CLV_PCSK_SKI1_1	236	240	PF00082	0.485
CLV_Separin_Metazoa	210	214	PF03568	0.533
DEG_APCC_DBOX_1	116	124	PF00400	0.540
DEG_Nend_UBRbox_3	1	3	PF02207	0.632
DOC_MAPK_gen_1	115	124	PF00069	0.544
DOC_MAPK_gen_1	141	150	PF00069	0.517
DOC_MAPK_gen_1	154	164	PF00069	0.465
DOC_MAPK_gen_1	335	343	PF00069	0.546
DOC_MAPK_gen_1	401	409	PF00069	0.582
DOC_MAPK_MEF2A_6	119	127	PF00069	0.595
DOC_MAPK_MEF2A_6	213	221	PF00069	0.432
DOC_USP7_MATH_1	258	262	PF00917	0.537
DOC_USP7_MATH_1	412	416	PF00917	0.583
DOC_USP7_MATH_1	423	427	PF00917	0.547
DOC_USP7_UBL2_3	440	444	PF12436	0.582
DOC_WW_Pin1_4	21	26	PF00397	0.559
DOC_WW_Pin1_4	303	308	PF00397	0.552
DOC_WW_Pin1_4	351	356	PF00397	0.592
DOC_WW_Pin1_4	72	77	PF00397	0.550
LIG_14-3-3_CanoR_1	236	246	PF00244	0.553
LIG_14-3-3_CanoR_1	333	341	PF00244	0.607
LIG_14-3-3_CanoR_1	366	376	PF00244	0.618
LIG_14-3-3_CanoR_1	403	409	PF00244	0.624
LIG_APCC_ABBA_1	283	288	PF00400	0.456
LIG_APCC_ABBA_1	74	79	PF00400	0.546
LIG_APCC_ABBAyCdc20_2	58	64	PF00400	0.570
LIG_Clathr_ClatBox_1	110	114	PF01394	0.481
LIG_FHA_1	329	335	PF00498	0.639
LIG_FHA_1	359	365	PF00498	0.592
LIG_FHA_1	47	53	PF00498	0.576
LIG_FHA_2	116	122	PF00498	0.560
LIG_FHA_2	204	210	PF00498	0.656
LIG_FHA_2	67	73	PF00498	0.563
LIG_FHA_2	96	102	PF00498	0.596
LIG_LIR_Gen_1	181	191	PF02991	0.542
LIG_LIR_Gen_1	288	297	PF02991	0.572
LIG_LIR_Gen_1	75	85	PF02991	0.602
LIG_LIR_LC3C_4	280	285	PF02991	0.445
LIG_LIR_Nem_3	172	178	PF02991	0.546
LIG_LIR_Nem_3	181	186	PF02991	0.624
LIG_LIR_Nem_3	288	294	PF02991	0.564
LIG_LIR_Nem_3	75	80	PF02991	0.667
LIG_LIR_Nem_3	84	90	PF02991	0.604
LIG_NRBOX	119	125	PF00104	0.545
LIG_NRBOX	218	224	PF00104	0.511
LIG_Pex14_1	251	255	PF04695	0.530
LIG_SH2_CRK	253	257	PF00017	0.436
LIG_SH2_GRB2like	20	23	PF00017	0.559
LIG_SH2_NCK_1	87	91	PF00017	0.538
LIG_SH2_PTP2	291	294	PF00017	0.539
LIG_SH2_SRC	77	80	PF00017	0.590
LIG_SH2_STAT5	291	294	PF00017	0.539
LIG_SH2_STAT5	77	80	PF00017	0.576
LIG_SH3_3	352	358	PF00018	0.579
LIG_SH3_3	406	412	PF00018	0.582
LIG_SUMO_SIM_anti_2	214	220	PF11976	0.429
LIG_SUMO_SIM_par_1	108	114	PF11976	0.590
LIG_SUMO_SIM_par_1	373	379	PF11976	0.539
LIG_TRAF2_1	187	190	PF00917	0.462
LIG_TRAF2_1	68	71	PF00917	0.556
LIG_WRC_WIRS_1	183	188	PF05994	0.541
MOD_CDK_SPK_2	351	356	PF00069	0.586
MOD_CDK_SPxK_1	21	27	PF00069	0.560
MOD_CK1_1	109	115	PF00069	0.592
MOD_CK1_1	137	143	PF00069	0.497
MOD_CK1_1	153	159	PF00069	0.481
MOD_CK1_1	182	188	PF00069	0.442
MOD_CK1_1	240	246	PF00069	0.453
MOD_CK1_1	309	315	PF00069	0.550
MOD_CK1_1	31	37	PF00069	0.559
MOD_CK1_1	325	331	PF00069	0.552
MOD_CK1_1	342	348	PF00069	0.568
MOD_CK1_1	359	365	PF00069	0.505
MOD_CK1_1	367	373	PF00069	0.524
MOD_CK1_1	387	393	PF00069	0.604
MOD_CK1_1	402	408	PF00069	0.574
MOD_CK1_1	410	416	PF00069	0.590
MOD_CK1_1	65	71	PF00069	0.574
MOD_CK2_1	115	121	PF00069	0.388
MOD_CK2_1	182	188	PF00069	0.540
MOD_CK2_1	203	209	PF00069	0.480
MOD_CK2_1	51	57	PF00069	0.624
MOD_CK2_1	65	71	PF00069	0.565
MOD_CK2_1	95	101	PF00069	0.595
MOD_GlcNHglycan	136	139	PF01048	0.523
MOD_GlcNHglycan	163	167	PF01048	0.468
MOD_GlcNHglycan	242	245	PF01048	0.477
MOD_GlcNHglycan	308	311	PF01048	0.636
MOD_GlcNHglycan	32	36	PF01048	0.731
MOD_GlcNHglycan	358	361	PF01048	0.571
MOD_GlcNHglycan	386	389	PF01048	0.579
MOD_GlcNHglycan	414	417	PF01048	0.605
MOD_GSK3_1	105	112	PF00069	0.592
MOD_GSK3_1	149	156	PF00069	0.581
MOD_GSK3_1	240	247	PF00069	0.504
MOD_GSK3_1	254	261	PF00069	0.493
MOD_GSK3_1	273	280	PF00069	0.578
MOD_GSK3_1	305	312	PF00069	0.550
MOD_GSK3_1	323	330	PF00069	0.548
MOD_GSK3_1	399	406	PF00069	0.599
MOD_GSK3_1	412	419	PF00069	0.596
MOD_GSK3_1	62	69	PF00069	0.571
MOD_N-GLC_1	21	26	PF02516	0.577
MOD_N-GLC_1	339	344	PF02516	0.540
MOD_NEK2_1	105	110	PF00069	0.595
MOD_NEK2_1	149	154	PF00069	0.520
MOD_NEK2_1	162	167	PF00069	0.433
MOD_NEK2_1	238	243	PF00069	0.557
MOD_NEK2_1	334	339	PF00069	0.626
MOD_NEK2_1	364	369	PF00069	0.548
MOD_NEK2_2	396	401	PF00069	0.580
MOD_PIKK_1	245	251	PF00454	0.508
MOD_PIKK_1	320	326	PF00454	0.616
MOD_PIKK_1	359	365	PF00454	0.553
MOD_PIKK_1	40	46	PF00454	0.592
MOD_PK_1	403	409	PF00069	0.582
MOD_PKA_1	403	409	PF00069	0.582
MOD_PKA_2	153	159	PF00069	0.559
MOD_PKA_2	334	340	PF00069	0.652
MOD_PKA_2	402	408	PF00069	0.627
MOD_PKA_2	410	416	PF00069	0.632
MOD_Plk_1	100	106	PF00069	0.585
MOD_Plk_1	339	345	PF00069	0.538
MOD_Plk_2-3	66	72	PF00069	0.562
MOD_Plk_4	100	106	PF00069	0.487
MOD_Plk_4	387	393	PF00069	0.594
MOD_ProDKin_1	21	27	PF00069	0.560
MOD_ProDKin_1	303	309	PF00069	0.552
MOD_ProDKin_1	351	357	PF00069	0.592
MOD_ProDKin_1	72	78	PF00069	0.549
MOD_SUMO_rev_2	140	149	PF00179	0.515
MOD_SUMO_rev_2	314	323	PF00179	0.549
MOD_SUMO_rev_2	73	82	PF00179	0.538
TRG_DiLeu_BaEn_1	101	106	PF01217	0.586
TRG_DiLeu_BaEn_1	145	150	PF01217	0.523
TRG_DiLeu_BaEn_3	189	195	PF01217	0.462
TRG_ENDOCYTIC_2	253	256	PF00928	0.438
TRG_ENDOCYTIC_2	291	294	PF00928	0.567
TRG_ENDOCYTIC_2	347	350	PF00928	0.556
TRG_ENDOCYTIC_2	77	80	PF00928	0.541
TRG_ENDOCYTIC_2	87	90	PF00928	0.480
TRG_ER_diArg_1	116	119	PF00400	0.588
TRG_ER_diArg_1	154	157	PF00400	0.516
TRG_ER_diArg_1	175	177	PF00400	0.544
TRG_ER_diArg_1	58	61	PF00400	0.572
TRG_ER_diLys_1	446	450	PF00400	0.581
TRG_NES_CRM1_1	114	129	PF08389	0.552
TRG_NLS_MonoExtN_4	437	443	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9B2X3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
Q4Q583	Leishmania major	52%	98%