DUF647-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vitamin B6 photo-protection and homoeostasis, putative

Species:

Leishmania braziliensis

UniProt:

A4HKI1_LEIBR

TriTrypDb:

LbrM.32.2110 , LBRM2903_320027600

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HKI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKI1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	224	226	PF00675	0.366
CLV_NRD_NRD_1	326	328	PF00675	0.395
CLV_NRD_NRD_1	378	380	PF00675	0.363
CLV_NRD_NRD_1	381	383	PF00675	0.360
CLV_NRD_NRD_1	398	400	PF00675	0.239
CLV_PCSK_KEX2_1	223	225	PF00082	0.393
CLV_PCSK_KEX2_1	325	327	PF00082	0.464
CLV_PCSK_KEX2_1	378	380	PF00082	0.363
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.354
CLV_PCSK_SKI1_1	213	217	PF00082	0.336
CLV_PCSK_SKI1_1	225	229	PF00082	0.302
CLV_PCSK_SKI1_1	295	299	PF00082	0.379
CLV_PCSK_SKI1_1	342	346	PF00082	0.317
CLV_PCSK_SKI1_1	378	382	PF00082	0.340
CLV_PCSK_SKI1_1	399	403	PF00082	0.337
DEG_Nend_UBRbox_1	1	4	PF02207	0.499
DOC_CDC14_PxL_1	240	248	PF14671	0.467
DOC_CKS1_1	226	231	PF01111	0.524
DOC_MAPK_gen_1	247	255	PF00069	0.650
DOC_MAPK_gen_1	80	89	PF00069	0.443
DOC_MAPK_JIP1_4	295	301	PF00069	0.454
DOC_MAPK_MEF2A_6	197	204	PF00069	0.378
DOC_MAPK_MEF2A_6	247	255	PF00069	0.599
DOC_MAPK_MEF2A_6	295	303	PF00069	0.592
DOC_MAPK_MEF2A_6	82	91	PF00069	0.454
DOC_MAPK_NFAT4_5	248	256	PF00069	0.469
DOC_PP1_RVXF_1	203	210	PF00149	0.445
DOC_PP2B_LxvP_1	241	244	PF13499	0.468
DOC_PP2B_LxvP_1	424	427	PF13499	0.559
DOC_PP4_FxxP_1	4	7	PF00568	0.454
DOC_USP7_MATH_1	131	135	PF00917	0.527
DOC_USP7_UBL2_3	350	354	PF12436	0.599
DOC_WW_Pin1_4	225	230	PF00397	0.493
DOC_WW_Pin1_4	260	265	PF00397	0.473
DOC_WW_Pin1_4	49	54	PF00397	0.234
LIG_14-3-3_CanoR_1	132	137	PF00244	0.515
LIG_14-3-3_CanoR_1	325	334	PF00244	0.641
LIG_14-3-3_CanoR_1	369	377	PF00244	0.444
LIG_14-3-3_CanoR_1	420	428	PF00244	0.537
LIG_Actin_WH2_2	231	249	PF00022	0.622
LIG_Actin_WH2_2	354	371	PF00022	0.408
LIG_BRCT_BRCA1_1	44	48	PF00533	0.370
LIG_Clathr_ClatBox_1	206	210	PF01394	0.489
LIG_CtBP_PxDLS_1	427	431	PF00389	0.551
LIG_deltaCOP1_diTrp_1	305	312	PF00928	0.545
LIG_deltaCOP1_diTrp_1	389	398	PF00928	0.606
LIG_EH1_1	84	92	PF00400	0.468
LIG_FHA_1	115	121	PF00498	0.303
LIG_FHA_1	176	182	PF00498	0.264
LIG_FHA_1	209	215	PF00498	0.450
LIG_FHA_1	255	261	PF00498	0.481
LIG_FHA_1	286	292	PF00498	0.536
LIG_FHA_1	356	362	PF00498	0.453
LIG_FHA_1	363	369	PF00498	0.502
LIG_FHA_2	226	232	PF00498	0.505
LIG_FHA_2	273	279	PF00498	0.610
LIG_FHA_2	300	306	PF00498	0.586
LIG_FHA_2	391	397	PF00498	0.441
LIG_LIR_Apic_2	308	313	PF02991	0.454
LIG_LIR_Gen_1	149	160	PF02991	0.447
LIG_LIR_Gen_1	37	48	PF02991	0.300
LIG_LIR_Nem_3	149	155	PF02991	0.443
LIG_LIR_Nem_3	203	207	PF02991	0.532
LIG_LIR_Nem_3	305	310	PF02991	0.596
LIG_LIR_Nem_3	311	315	PF02991	0.633
LIG_LIR_Nem_3	37	43	PF02991	0.300
LIG_MLH1_MIPbox_1	44	48	PF16413	0.377
LIG_PCNA_PIPBox_1	41	50	PF02747	0.271
LIG_Pex14_1	294	298	PF04695	0.436
LIG_Pex14_2	18	22	PF04695	0.443
LIG_Pex14_2	30	34	PF04695	0.271
LIG_REV1ctd_RIR_1	316	324	PF16727	0.655
LIG_SH2_CRK	364	368	PF00017	0.478
LIG_SH2_CRK	40	44	PF00017	0.319
LIG_SH2_GRB2like	282	285	PF00017	0.579
LIG_SH2_GRB2like	77	80	PF00017	0.400
LIG_SH2_NCK_1	160	164	PF00017	0.423
LIG_SH2_PTP2	261	264	PF00017	0.420
LIG_SH2_STAP1	364	368	PF00017	0.486
LIG_SH2_STAT5	128	131	PF00017	0.418
LIG_SH2_STAT5	160	163	PF00017	0.284
LIG_SH2_STAT5	170	173	PF00017	0.251
LIG_SH2_STAT5	23	26	PF00017	0.438
LIG_SH2_STAT5	261	264	PF00017	0.420
LIG_SH2_STAT5	282	285	PF00017	0.479
LIG_SH2_STAT5	364	367	PF00017	0.495
LIG_SH3_1	310	316	PF00018	0.641
LIG_SH3_3	310	316	PF00018	0.605
LIG_SH3_3	406	412	PF00018	0.566
LIG_SUMO_SIM_par_1	299	305	PF11976	0.546
LIG_TRAF2_1	228	231	PF00917	0.548
LIG_TRAF2_1	275	278	PF00917	0.552
LIG_TYR_ITIM	362	367	PF00017	0.455
LIG_TYR_ITIM	38	43	PF00017	0.319
LIG_UBA3_1	240	248	PF00899	0.619
LIG_UBA3_1	290	295	PF00899	0.566
LIG_UBA3_1	3	8	PF00899	0.510
LIG_WRC_WIRS_1	152	157	PF05994	0.434
LIG_WRC_WIRS_1	174	179	PF05994	0.385
MOD_CK1_1	25	31	PF00069	0.291
MOD_CK1_1	42	48	PF00069	0.211
MOD_CK2_1	225	231	PF00069	0.512
MOD_CK2_1	272	278	PF00069	0.585
MOD_CK2_1	299	305	PF00069	0.552
MOD_CK2_1	390	396	PF00069	0.531
MOD_GlcNHglycan	123	126	PF01048	0.275
MOD_GlcNHglycan	44	47	PF01048	0.447
MOD_GSK3_1	116	123	PF00069	0.389
MOD_GSK3_1	169	176	PF00069	0.273
MOD_GSK3_1	22	29	PF00069	0.440
MOD_GSK3_1	415	422	PF00069	0.534
MOD_NEK2_1	169	174	PF00069	0.368
MOD_NEK2_1	192	197	PF00069	0.287
MOD_NEK2_1	22	27	PF00069	0.434
MOD_NEK2_1	34	39	PF00069	0.271
MOD_NEK2_1	390	395	PF00069	0.528
MOD_NEK2_1	48	53	PF00069	0.222
MOD_NEK2_1	85	90	PF00069	0.284
MOD_PIKK_1	325	331	PF00454	0.699
MOD_PKA_1	325	331	PF00069	0.647
MOD_PKA_2	131	137	PF00069	0.515
MOD_PKA_2	325	331	PF00069	0.620
MOD_PKA_2	419	425	PF00069	0.503
MOD_Plk_1	285	291	PF00069	0.583
MOD_Plk_4	101	107	PF00069	0.212
MOD_Plk_4	169	175	PF00069	0.303
MOD_Plk_4	26	32	PF00069	0.320
MOD_Plk_4	285	291	PF00069	0.540
MOD_Plk_4	39	45	PF00069	0.212
MOD_Plk_4	85	91	PF00069	0.297
MOD_ProDKin_1	225	231	PF00069	0.495
MOD_ProDKin_1	260	266	PF00069	0.477
MOD_ProDKin_1	49	55	PF00069	0.234
MOD_SUMO_rev_2	330	338	PF00179	0.623
TRG_DiLeu_BaEn_1	231	236	PF01217	0.570
TRG_DiLeu_BaEn_3	396	402	PF01217	0.541
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.542
TRG_ENDOCYTIC_2	23	26	PF00928	0.459
TRG_ENDOCYTIC_2	364	367	PF00928	0.472
TRG_ENDOCYTIC_2	40	43	PF00928	0.257
TRG_ER_diArg_1	224	226	PF00400	0.574
TRG_ER_diArg_1	324	327	PF00400	0.657
TRG_ER_diArg_1	377	379	PF00400	0.559
TRG_NES_CRM1_1	210	222	PF08389	0.489
TRG_Pf-PMV_PEXEL_1	205	210	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I637	Leptomonas seymouri	73%	72%
A0A0N1I7Q2	Leptomonas seymouri	62%	84%
A0A0S4JVE4	Bodo saltans	41%	76%
A0A1X0NUW8	Trypanosomatidae	52%	69%
A0A3Q8IFI0	Leishmania donovani	84%	94%
A0A422NB59	Trypanosoma rangeli	53%	75%
A4I813	Leishmania infantum	84%	94%
D0AA76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	74%
E9B2X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	94%
Q4Q586	Leishmania major	83%	100%
V5ALC0	Trypanosoma cruzi	52%	70%