Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKI0_LEIBR

TriTrypDb:

LbrM.32.2100 , LBRM2903_320027500

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	321	327	PF00089	0.463
CLV_NRD_NRD_1	133	135	PF00675	0.541
CLV_NRD_NRD_1	31	33	PF00675	0.544
CLV_NRD_NRD_1	316	318	PF00675	0.570
CLV_NRD_NRD_1	36	38	PF00675	0.494
CLV_NRD_NRD_1	73	75	PF00675	0.425
CLV_PCSK_KEX2_1	133	135	PF00082	0.541
CLV_PCSK_KEX2_1	31	33	PF00082	0.544
CLV_PCSK_KEX2_1	316	318	PF00082	0.594
CLV_PCSK_KEX2_1	73	75	PF00082	0.425
CLV_PCSK_SKI1_1	222	226	PF00082	0.520
CLV_PCSK_SKI1_1	37	41	PF00082	0.543
CLV_PCSK_SKI1_1	380	384	PF00082	0.556
CLV_PCSK_SKI1_1	45	49	PF00082	0.449
CLV_Separin_Metazoa	207	211	PF03568	0.484
DEG_APCC_DBOX_1	266	274	PF00400	0.549
DEG_SCF_FBW7_2	201	207	PF00400	0.457
DEG_SPOP_SBC_1	385	389	PF00917	0.544
DOC_CDC14_PxL_1	286	294	PF14671	0.499
DOC_CKS1_1	201	206	PF01111	0.455
DOC_CKS1_1	413	418	PF01111	0.564
DOC_CKS1_1	503	508	PF01111	0.522
DOC_MAPK_gen_1	73	81	PF00069	0.518
DOC_MAPK_gen_1	83	90	PF00069	0.498
DOC_MAPK_RevD_3	25	38	PF00069	0.540
DOC_PP1_RVXF_1	208	215	PF00149	0.542
DOC_USP7_MATH_1	385	389	PF00917	0.568
DOC_USP7_MATH_1	493	497	PF00917	0.588
DOC_WW_Pin1_4	200	205	PF00397	0.437
DOC_WW_Pin1_4	370	375	PF00397	0.673
DOC_WW_Pin1_4	412	417	PF00397	0.684
DOC_WW_Pin1_4	429	434	PF00397	0.573
DOC_WW_Pin1_4	437	442	PF00397	0.572
DOC_WW_Pin1_4	502	507	PF00397	0.530
DOC_WW_Pin1_4	525	530	PF00397	0.514
LIG_14-3-3_CanoR_1	125	130	PF00244	0.370
LIG_14-3-3_CanoR_1	233	237	PF00244	0.379
LIG_14-3-3_CanoR_1	267	271	PF00244	0.485
LIG_14-3-3_CanoR_1	324	328	PF00244	0.614
LIG_14-3-3_CanoR_1	380	385	PF00244	0.554
LIG_AP2alpha_2	523	525	PF02296	0.490
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BRCT_BRCA1_1	388	392	PF00533	0.547
LIG_BRCT_BRCA1_1	86	90	PF00533	0.408
LIG_CSL_BTD_1	526	529	PF09270	0.512
LIG_FHA_1	201	207	PF00498	0.530
LIG_FHA_1	21	27	PF00498	0.531
LIG_FHA_1	316	322	PF00498	0.442
LIG_FHA_1	385	391	PF00498	0.590
LIG_FHA_1	454	460	PF00498	0.495
LIG_FHA_1	499	505	PF00498	0.552
LIG_FHA_2	19	25	PF00498	0.530
LIG_FHA_2	404	410	PF00498	0.734
LIG_FHA_2	416	422	PF00498	0.646
LIG_FHA_2	453	459	PF00498	0.573
LIG_FHA_2	477	483	PF00498	0.547
LIG_FHA_2	513	519	PF00498	0.520
LIG_LIR_Gen_1	146	157	PF02991	0.356
LIG_LIR_Gen_1	172	183	PF02991	0.487
LIG_LIR_Gen_1	21	29	PF02991	0.419
LIG_LIR_Gen_1	211	221	PF02991	0.502
LIG_LIR_Gen_1	235	245	PF02991	0.545
LIG_LIR_Gen_1	515	525	PF02991	0.500
LIG_LIR_Gen_1	87	98	PF02991	0.449
LIG_LIR_Gen_1	9	20	PF02991	0.528
LIG_LIR_Nem_3	144	150	PF02991	0.362
LIG_LIR_Nem_3	172	178	PF02991	0.496
LIG_LIR_Nem_3	189	194	PF02991	0.355
LIG_LIR_Nem_3	21	25	PF02991	0.413
LIG_LIR_Nem_3	211	217	PF02991	0.513
LIG_LIR_Nem_3	235	240	PF02991	0.535
LIG_LIR_Nem_3	269	274	PF02991	0.502
LIG_LIR_Nem_3	280	285	PF02991	0.454
LIG_LIR_Nem_3	515	520	PF02991	0.507
LIG_LIR_Nem_3	87	93	PF02991	0.438
LIG_LIR_Nem_3	9	15	PF02991	0.528
LIG_Pex14_2	282	286	PF04695	0.514
LIG_REV1ctd_RIR_1	180	186	PF16727	0.516
LIG_SH2_GRB2like	514	517	PF00017	0.510
LIG_SH2_NCK_1	480	484	PF00017	0.546
LIG_SH2_SRC	288	291	PF00017	0.330
LIG_SH2_SRC	367	370	PF00017	0.567
LIG_SH2_SRC	480	483	PF00017	0.547
LIG_SH2_STAP1	111	115	PF00017	0.386
LIG_SH2_STAP1	12	16	PF00017	0.539
LIG_SH2_STAP1	22	26	PF00017	0.432
LIG_SH2_STAP1	244	248	PF00017	0.580
LIG_SH2_STAP1	367	371	PF00017	0.567
LIG_SH2_STAT3	244	247	PF00017	0.581
LIG_SH2_STAT5	22	25	PF00017	0.448
LIG_SH2_STAT5	239	242	PF00017	0.540
LIG_SH2_STAT5	288	291	PF00017	0.330
LIG_SH2_STAT5	454	457	PF00017	0.505
LIG_SH2_STAT5	478	481	PF00017	0.548
LIG_SH2_STAT5	514	517	PF00017	0.510
LIG_SH3_1	198	204	PF00018	0.426
LIG_SH3_3	198	204	PF00018	0.426
LIG_SH3_3	371	377	PF00018	0.617
LIG_SH3_3	379	385	PF00018	0.650
LIG_SH3_3	388	394	PF00018	0.678
LIG_SH3_3	419	425	PF00018	0.589
LIG_SH3_3	456	462	PF00018	0.573
LIG_SH3_3	503	509	PF00018	0.552
LIG_SH3_3	518	524	PF00018	0.518
LIG_SH3_3	95	101	PF00018	0.598
LIG_SUMO_SIM_anti_2	432	438	PF11976	0.573
LIG_SUMO_SIM_par_1	432	438	PF11976	0.573
LIG_TRAF2_1	227	230	PF00917	0.448
LIG_TRAF2_1	39	42	PF00917	0.539
LIG_TRAF2_1	406	409	PF00917	0.574
LIG_TRAF2_1	427	430	PF00917	0.673
LIG_TRAF2_1	455	458	PF00917	0.524
LIG_TRAF2_1	479	482	PF00917	0.552
LIG_UBA3_1	460	469	PF00899	0.490
LIG_WW_3	93	97	PF00397	0.622
MOD_CK1_1	232	238	PF00069	0.539
MOD_CK1_1	370	376	PF00069	0.558
MOD_CK1_1	399	405	PF00069	0.572
MOD_CK1_1	496	502	PF00069	0.553
MOD_CK2_1	18	24	PF00069	0.419
MOD_CK2_1	255	261	PF00069	0.485
MOD_CK2_1	399	405	PF00069	0.724
MOD_CK2_1	452	458	PF00069	0.590
MOD_CK2_1	476	482	PF00069	0.542
MOD_CK2_1	492	498	PF00069	0.617
MOD_CK2_1	512	518	PF00069	0.520
MOD_Cter_Amidation	531	534	PF01082	0.535
MOD_GlcNHglycan	400	404	PF01048	0.621
MOD_GSK3_1	14	21	PF00069	0.376
MOD_GSK3_1	357	364	PF00069	0.583
MOD_GSK3_1	380	387	PF00069	0.616
MOD_GSK3_1	395	402	PF00069	0.536
MOD_GSK3_1	489	496	PF00069	0.576
MOD_GSK3_1	498	505	PF00069	0.578
MOD_N-GLC_2	252	254	PF02516	0.426
MOD_NEK2_1	153	158	PF00069	0.353
MOD_NEK2_1	194	199	PF00069	0.389
MOD_NEK2_1	294	299	PF00069	0.559
MOD_PIKK_1	296	302	PF00454	0.572
MOD_PK_1	84	90	PF00069	0.405
MOD_PKA_1	83	89	PF00069	0.555
MOD_PKA_2	158	164	PF00069	0.365
MOD_PKA_2	232	238	PF00069	0.382
MOD_PKA_2	266	272	PF00069	0.486
MOD_PKA_2	315	321	PF00069	0.564
MOD_PKA_2	323	329	PF00069	0.575
MOD_Plk_1	367	373	PF00069	0.568
MOD_Plk_1	84	90	PF00069	0.405
MOD_Plk_4	232	238	PF00069	0.412
MOD_Plk_4	266	272	PF00069	0.489
MOD_Plk_4	386	392	PF00069	0.705
MOD_Plk_4	432	438	PF00069	0.656
MOD_Plk_4	84	90	PF00069	0.405
MOD_ProDKin_1	200	206	PF00069	0.444
MOD_ProDKin_1	370	376	PF00069	0.673
MOD_ProDKin_1	412	418	PF00069	0.684
MOD_ProDKin_1	429	435	PF00069	0.576
MOD_ProDKin_1	437	443	PF00069	0.566
MOD_ProDKin_1	502	508	PF00069	0.524
MOD_ProDKin_1	525	531	PF00069	0.518
MOD_SUMO_rev_2	33	40	PF00179	0.536
TRG_ENDOCYTIC_2	111	114	PF00928	0.389
TRG_ENDOCYTIC_2	12	15	PF00928	0.537
TRG_ENDOCYTIC_2	191	194	PF00928	0.522
TRG_ENDOCYTIC_2	22	25	PF00928	0.430
TRG_ENDOCYTIC_2	467	470	PF00928	0.491
TRG_ENDOCYTIC_2	514	517	PF00928	0.510
TRG_ER_diArg_1	133	136	PF00400	0.538
TRG_ER_diArg_1	164	167	PF00400	0.537
TRG_ER_diArg_1	315	317	PF00400	0.588
TRG_ER_diArg_1	43	46	PF00400	0.382
TRG_ER_diArg_1	73	76	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5P1	Leishmania donovani	63%	100%
A4I812	Leishmania infantum	63%	100%
E9B2W9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	73%
Q4Q587	Leishmania major	63%	100%