Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKH9_LEIBR

TriTrypDb:

LbrM.32.2090 , LBRM2903_320027400

Length:

606

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.625
CLV_C14_Caspase3-7	127	131	PF00656	0.504
CLV_C14_Caspase3-7	323	327	PF00656	0.550
CLV_C14_Caspase3-7	35	39	PF00656	0.573
CLV_C14_Caspase3-7	401	405	PF00656	0.548
CLV_C14_Caspase3-7	559	563	PF00656	0.596
CLV_NRD_NRD_1	540	542	PF00675	0.694
CLV_NRD_NRD_1	546	548	PF00675	0.592
CLV_NRD_NRD_1	601	603	PF00675	0.545
CLV_PCSK_KEX2_1	540	542	PF00082	0.687
CLV_PCSK_KEX2_1	546	548	PF00082	0.586
CLV_PCSK_KEX2_1	600	602	PF00082	0.615
CLV_PCSK_SKI1_1	17	21	PF00082	0.486
CLV_PCSK_SKI1_1	284	288	PF00082	0.644
CLV_PCSK_SKI1_1	29	33	PF00082	0.482
CLV_PCSK_SKI1_1	37	41	PF00082	0.481
DEG_SCF_FBW7_1	149	156	PF00400	0.649
DEG_SCF_FBW7_2	143	150	PF00400	0.570
DEG_SPOP_SBC_1	100	104	PF00917	0.357
DEG_SPOP_SBC_1	203	207	PF00917	0.542
DEG_SPOP_SBC_1	354	358	PF00917	0.643
DEG_SPOP_SBC_1	500	504	PF00917	0.567
DOC_CYCLIN_yCln2_LP_2	81	87	PF00134	0.382
DOC_PP1_RVXF_1	519	526	PF00149	0.696
DOC_PP2B_LxvP_1	162	165	PF13499	0.534
DOC_PP2B_LxvP_1	232	235	PF13499	0.669
DOC_PP2B_LxvP_1	493	496	PF13499	0.698
DOC_PP2B_PxIxI_1	248	254	PF00149	0.527
DOC_USP7_MATH_1	100	104	PF00917	0.514
DOC_USP7_MATH_1	111	115	PF00917	0.487
DOC_USP7_MATH_1	214	218	PF00917	0.766
DOC_USP7_MATH_1	223	227	PF00917	0.607
DOC_USP7_MATH_1	303	307	PF00917	0.732
DOC_USP7_MATH_1	386	390	PF00917	0.672
DOC_USP7_MATH_1	411	415	PF00917	0.644
DOC_USP7_MATH_1	500	504	PF00917	0.567
DOC_USP7_MATH_1	509	513	PF00917	0.539
DOC_USP7_MATH_1	545	549	PF00917	0.699
DOC_WW_Pin1_4	112	117	PF00397	0.455
DOC_WW_Pin1_4	143	148	PF00397	0.698
DOC_WW_Pin1_4	149	154	PF00397	0.617
DOC_WW_Pin1_4	170	175	PF00397	0.558
DOC_WW_Pin1_4	245	250	PF00397	0.521
DOC_WW_Pin1_4	399	404	PF00397	0.738
DOC_WW_Pin1_4	43	48	PF00397	0.481
DOC_WW_Pin1_4	479	484	PF00397	0.649
DOC_WW_Pin1_4	496	501	PF00397	0.614
LIG_14-3-3_CanoR_1	176	184	PF00244	0.545
LIG_14-3-3_CanoR_1	262	270	PF00244	0.745
LIG_14-3-3_CanoR_1	521	526	PF00244	0.547
LIG_14-3-3_CanoR_1	546	553	PF00244	0.518
LIG_Actin_WH2_2	181	199	PF00022	0.630
LIG_BIR_III_4	70	74	PF00653	0.429
LIG_Clathr_ClatBox_1	250	254	PF01394	0.531
LIG_Clathr_ClatBox_1	65	69	PF01394	0.488
LIG_CtBP_PxDLS_1	495	499	PF00389	0.715
LIG_DLG_GKlike_1	521	529	PF00625	0.541
LIG_eIF4E_1	60	66	PF01652	0.329
LIG_FHA_1	102	108	PF00498	0.431
LIG_FHA_1	134	140	PF00498	0.558
LIG_FHA_1	193	199	PF00498	0.537
LIG_FHA_1	300	306	PF00498	0.652
LIG_FHA_1	361	367	PF00498	0.787
LIG_FHA_1	416	422	PF00498	0.562
LIG_FHA_1	445	451	PF00498	0.625
LIG_FHA_1	460	466	PF00498	0.718
LIG_FHA_1	47	53	PF00498	0.612
LIG_FHA_1	567	573	PF00498	0.517
LIG_FHA_1	72	78	PF00498	0.413
LIG_FHA_2	125	131	PF00498	0.480
LIG_FHA_2	451	457	PF00498	0.659
LIG_LIR_Gen_1	436	445	PF02991	0.518
LIG_LIR_Gen_1	59	68	PF02991	0.457
LIG_LIR_Gen_1	97	106	PF02991	0.453
LIG_LIR_Nem_3	436	440	PF02991	0.572
LIG_LIR_Nem_3	59	63	PF02991	0.479
LIG_LIR_Nem_3	97	101	PF02991	0.436
LIG_MYND_1	496	500	PF01753	0.562
LIG_PCNA_PIPBox_1	471	480	PF02747	0.636
LIG_PCNA_yPIPBox_3	7	17	PF02747	0.378
LIG_SH2_CRK	478	482	PF00017	0.659
LIG_SH2_NCK_1	478	482	PF00017	0.651
LIG_SH2_PTP2	60	63	PF00017	0.344
LIG_SH2_SRC	579	582	PF00017	0.638
LIG_SH2_STAP1	242	246	PF00017	0.523
LIG_SH2_STAT5	478	481	PF00017	0.670
LIG_SH2_STAT5	579	582	PF00017	0.680
LIG_SH2_STAT5	60	63	PF00017	0.344
LIG_SH3_3	250	256	PF00018	0.625
LIG_SH3_3	288	294	PF00018	0.804
LIG_SH3_3	400	406	PF00018	0.729
LIG_SH3_3	477	483	PF00018	0.647
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.677
LIG_SUMO_SIM_anti_2	569	576	PF11976	0.516
LIG_SUMO_SIM_anti_2	584	592	PF11976	0.611
LIG_SUMO_SIM_anti_2	62	67	PF11976	0.468
LIG_SUMO_SIM_anti_2	9	16	PF11976	0.535
LIG_SUMO_SIM_par_1	247	254	PF11976	0.526
LIG_SUMO_SIM_par_1	408	415	PF11976	0.561
LIG_SUMO_SIM_par_1	64	70	PF11976	0.458
LIG_TRAF2_1	534	537	PF00917	0.662
LIG_TYR_ITIM	58	63	PF00017	0.359
MOD_CDC14_SPxK_1	173	176	PF00782	0.539
MOD_CDK_SPxK_1	170	176	PF00069	0.539
MOD_CDK_SPxxK_3	112	119	PF00069	0.400
MOD_CK1_1	102	108	PF00069	0.555
MOD_CK1_1	261	267	PF00069	0.818
MOD_CK1_1	276	282	PF00069	0.546
MOD_CK1_1	358	364	PF00069	0.546
MOD_CK1_1	391	397	PF00069	0.679
MOD_CK1_1	415	421	PF00069	0.611
MOD_CK1_1	499	505	PF00069	0.723
MOD_CK1_1	528	534	PF00069	0.670
MOD_CK1_1	563	569	PF00069	0.668
MOD_CK1_1	586	592	PF00069	0.453
MOD_CK2_1	139	145	PF00069	0.632
MOD_CK2_1	391	397	PF00069	0.636
MOD_CK2_1	45	51	PF00069	0.629
MOD_CK2_1	500	506	PF00069	0.568
MOD_CK2_1	531	537	PF00069	0.666
MOD_CK2_1	77	83	PF00069	0.404
MOD_GlcNHglycan	216	219	PF01048	0.679
MOD_GlcNHglycan	237	240	PF01048	0.551
MOD_GlcNHglycan	295	299	PF01048	0.697
MOD_GlcNHglycan	349	352	PF01048	0.671
MOD_GlcNHglycan	357	360	PF01048	0.629
MOD_GlcNHglycan	363	366	PF01048	0.610
MOD_GlcNHglycan	413	417	PF01048	0.695
MOD_GlcNHglycan	531	534	PF01048	0.786
MOD_GlcNHglycan	562	566	PF01048	0.517
MOD_GlcNHglycan	585	588	PF01048	0.613
MOD_GSK3_1	102	109	PF00069	0.639
MOD_GSK3_1	139	146	PF00069	0.783
MOD_GSK3_1	149	156	PF00069	0.645
MOD_GSK3_1	192	199	PF00069	0.630
MOD_GSK3_1	202	209	PF00069	0.735
MOD_GSK3_1	240	247	PF00069	0.520
MOD_GSK3_1	254	261	PF00069	0.742
MOD_GSK3_1	269	276	PF00069	0.584
MOD_GSK3_1	299	306	PF00069	0.657
MOD_GSK3_1	354	361	PF00069	0.625
MOD_GSK3_1	37	44	PF00069	0.545
MOD_GSK3_1	386	393	PF00069	0.715
MOD_GSK3_1	411	418	PF00069	0.580
MOD_GSK3_1	425	432	PF00069	0.558
MOD_GSK3_1	494	501	PF00069	0.558
MOD_GSK3_1	521	528	PF00069	0.613
MOD_GSK3_1	563	570	PF00069	0.758
MOD_N-GLC_1	177	182	PF02516	0.546
MOD_N-GLC_2	322	324	PF02516	0.561
MOD_NEK2_1	101	106	PF00069	0.436
MOD_NEK2_1	158	163	PF00069	0.749
MOD_NEK2_1	177	182	PF00069	0.704
MOD_NEK2_1	196	201	PF00069	0.509
MOD_NEK2_1	213	218	PF00069	0.562
MOD_NEK2_1	287	292	PF00069	0.544
MOD_NEK2_1	32	37	PF00069	0.552
MOD_NEK2_1	398	403	PF00069	0.621
MOD_NEK2_1	41	46	PF00069	0.501
MOD_NEK2_1	450	455	PF00069	0.607
MOD_NEK2_1	525	530	PF00069	0.610
MOD_NEK2_1	567	572	PF00069	0.519
MOD_PIKK_1	177	183	PF00454	0.616
MOD_PIKK_1	313	319	PF00454	0.626
MOD_PIKK_1	32	38	PF00454	0.396
MOD_PIKK_1	459	465	PF00454	0.638
MOD_PIKK_1	71	77	PF00454	0.422
MOD_PKA_2	258	264	PF00069	0.796
MOD_PKA_2	303	309	PF00069	0.721
MOD_PKA_2	347	353	PF00069	0.644
MOD_PKA_2	545	551	PF00069	0.495
MOD_PKA_2	560	566	PF00069	0.463
MOD_PKB_1	519	527	PF00069	0.614
MOD_Plk_1	139	145	PF00069	0.650
MOD_Plk_1	264	270	PF00069	0.538
MOD_Plk_1	273	279	PF00069	0.492
MOD_Plk_1	287	293	PF00069	0.526
MOD_Plk_1	37	43	PF00069	0.420
MOD_Plk_1	77	83	PF00069	0.386
MOD_Plk_4	102	108	PF00069	0.425
MOD_Plk_4	276	282	PF00069	0.721
MOD_Plk_4	405	411	PF00069	0.561
MOD_Plk_4	563	569	PF00069	0.515
MOD_Plk_4	586	592	PF00069	0.453
MOD_Plk_4	9	15	PF00069	0.534
MOD_ProDKin_1	112	118	PF00069	0.441
MOD_ProDKin_1	143	149	PF00069	0.696
MOD_ProDKin_1	153	159	PF00069	0.567
MOD_ProDKin_1	170	176	PF00069	0.561
MOD_ProDKin_1	245	251	PF00069	0.522
MOD_ProDKin_1	399	405	PF00069	0.739
MOD_ProDKin_1	43	49	PF00069	0.482
MOD_ProDKin_1	479	485	PF00069	0.644
MOD_ProDKin_1	496	502	PF00069	0.616
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.524
TRG_DiLeu_BaLyEn_6	599	604	PF01217	0.457
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.546
TRG_ENDOCYTIC_2	60	63	PF00928	0.344
TRG_ER_diArg_1	519	522	PF00400	0.620
TRG_ER_diArg_1	539	541	PF00400	0.638
TRG_ER_diArg_1	599	602	PF00400	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5N2	Leishmania donovani	63%	100%
A4I811	Leishmania infantum	62%	100%
E9B2W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q588	Leishmania major	63%	100%