CBFD_NFYB_HMF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKH6_LEIBR

TriTrypDb:

LbrM.32.2060 , LBRM2903_320027000

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKH6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0046982	protein heterodimerization activity	4	8
GO:0046983	protein dimerization activity	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.545
CLV_NRD_NRD_1	31	33	PF00675	0.623
CLV_PCSK_KEX2_1	154	156	PF00082	0.559
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.552
CLV_PCSK_SKI1_1	101	105	PF00082	0.430
CLV_PCSK_SKI1_1	118	122	PF00082	0.529
CLV_PCSK_SKI1_1	96	100	PF00082	0.449
DOC_MAPK_MEF2A_6	15	23	PF00069	0.477
DOC_USP7_MATH_1	120	124	PF00917	0.582
DOC_USP7_MATH_1	147	151	PF00917	0.526
DOC_USP7_MATH_1	26	30	PF00917	0.530
DOC_USP7_MATH_1	63	67	PF00917	0.543
LIG_14-3-3_CanoR_1	11	19	PF00244	0.472
LIG_14-3-3_CanoR_1	125	129	PF00244	0.445
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_FHA_1	125	131	PF00498	0.514
LIG_FHA_1	18	24	PF00498	0.488
LIG_FHA_2	38	44	PF00498	0.481
LIG_LIR_Nem_3	104	110	PF02991	0.374
LIG_SH2_STAT5	109	112	PF00017	0.427
LIG_SUMO_SIM_par_1	17	24	PF11976	0.479
LIG_UBA3_1	145	154	PF00899	0.529
MOD_CK1_1	10	16	PF00069	0.609
MOD_CK1_1	123	129	PF00069	0.520
MOD_CK1_1	17	23	PF00069	0.595
MOD_CK1_1	57	63	PF00069	0.579
MOD_GlcNHglycan	1	4	PF01048	0.530
MOD_GlcNHglycan	49	52	PF01048	0.612
MOD_GlcNHglycan	60	63	PF01048	0.588
MOD_GSK3_1	10	17	PF00069	0.599
MOD_GSK3_1	114	121	PF00069	0.490
MOD_GSK3_1	54	61	PF00069	0.489
MOD_LATS_1	52	58	PF00433	0.488
MOD_NEK2_1	148	153	PF00069	0.561
MOD_NEK2_1	47	52	PF00069	0.484
MOD_NEK2_2	103	108	PF00069	0.280
MOD_NEK2_2	63	68	PF00069	0.517
MOD_PKA_1	118	124	PF00069	0.533
MOD_PKA_1	32	38	PF00069	0.621
MOD_PKA_2	10	16	PF00069	0.652
MOD_PKA_2	124	130	PF00069	0.457
MOD_Plk_1	17	23	PF00069	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KIL7	Bodo saltans	35%	100%
A0A3S7X5N4	Leishmania donovani	72%	100%
A4I803	Leishmania infantum	72%	100%
D0AA70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B2W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q591	Leishmania major	73%	100%