LeishMANIAdb
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Cation efflux family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cation efflux family protein
Gene product:
Cation efflux family, putative
Species:
Leishmania braziliensis
UniProt:
A4HKH5_LEIBR
TriTrypDb:
LbrM.32.2050 , LBRM2903_320026900 *
Length:
609

Annotations

LeishMANIAdb annotations

Similar to Zn transporters found in animals.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4HKH5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKH5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0008324 monoatomic cation transmembrane transporter activity 4 2
GO:0015075 monoatomic ion transmembrane transporter activity 3 2
GO:0022857 transmembrane transporter activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 327 331 PF00656 0.514
CLV_NRD_NRD_1 19 21 PF00675 0.479
CLV_NRD_NRD_1 283 285 PF00675 0.719
CLV_NRD_NRD_1 338 340 PF00675 0.659
CLV_NRD_NRD_1 441 443 PF00675 0.760
CLV_NRD_NRD_1 597 599 PF00675 0.777
CLV_PCSK_KEX2_1 19 21 PF00082 0.479
CLV_PCSK_KEX2_1 283 285 PF00082 0.719
CLV_PCSK_KEX2_1 441 443 PF00082 0.754
CLV_PCSK_KEX2_1 597 599 PF00082 0.777
CLV_PCSK_SKI1_1 268 272 PF00082 0.700
CLV_PCSK_SKI1_1 277 281 PF00082 0.520
CLV_PCSK_SKI1_1 293 297 PF00082 0.509
CLV_PCSK_SKI1_1 340 344 PF00082 0.523
DEG_APCC_DBOX_1 267 275 PF00400 0.501
DEG_APCC_DBOX_1 338 346 PF00400 0.492
DEG_MDM2_SWIB_1 28 36 PF02201 0.510
DEG_SCF_FBW7_1 490 495 PF00400 0.493
DEG_SPOP_SBC_1 493 497 PF00917 0.492
DOC_CKS1_1 370 375 PF01111 0.466
DOC_CKS1_1 40 45 PF01111 0.277
DOC_CKS1_1 489 494 PF01111 0.646
DOC_CYCLIN_RxL_1 336 347 PF00134 0.314
DOC_MAPK_DCC_7 573 583 PF00069 0.472
DOC_MAPK_gen_1 287 297 PF00069 0.316
DOC_MAPK_HePTP_8 91 103 PF00069 0.530
DOC_MAPK_MEF2A_6 268 275 PF00069 0.459
DOC_MAPK_MEF2A_6 88 95 PF00069 0.636
DOC_MAPK_NFAT4_5 268 276 PF00069 0.507
DOC_PP2B_LxvP_1 568 571 PF13499 0.541
DOC_PP4_FxxP_1 189 192 PF00568 0.826
DOC_PP4_FxxP_1 489 492 PF00568 0.672
DOC_PP4_FxxP_1 549 552 PF00568 0.470
DOC_PP4_FxxP_1 9 12 PF00568 0.564
DOC_USP7_MATH_1 119 123 PF00917 0.349
DOC_USP7_MATH_1 12 16 PF00917 0.565
DOC_USP7_MATH_1 314 318 PF00917 0.358
DOC_USP7_MATH_1 355 359 PF00917 0.377
DOC_USP7_MATH_1 462 466 PF00917 0.589
DOC_USP7_MATH_1 524 528 PF00917 0.558
DOC_USP7_MATH_1 569 573 PF00917 0.569
DOC_WW_Pin1_4 120 125 PF00397 0.339
DOC_WW_Pin1_4 198 203 PF00397 0.724
DOC_WW_Pin1_4 204 209 PF00397 0.649
DOC_WW_Pin1_4 369 374 PF00397 0.465
DOC_WW_Pin1_4 39 44 PF00397 0.384
DOC_WW_Pin1_4 488 493 PF00397 0.632
DOC_WW_Pin1_4 522 527 PF00397 0.641
DOC_WW_Pin1_4 541 546 PF00397 0.416
LIG_14-3-3_CanoR_1 597 605 PF00244 0.466
LIG_14-3-3_CanoR_1 88 92 PF00244 0.636
LIG_14-3-3_CanoR_1 94 100 PF00244 0.431
LIG_BRCT_BRCA1_1 122 126 PF00533 0.395
LIG_BRCT_BRCA1_1 34 38 PF00533 0.530
LIG_BRCT_BRCA1_1 426 430 PF00533 0.644
LIG_BRCT_BRCA1_1 443 447 PF00533 0.465
LIG_BRCT_BRCA1_1 485 489 PF00533 0.526
LIG_BRCT_BRCA1_1 526 530 PF00533 0.470
LIG_BRCT_BRCA1_1 96 100 PF00533 0.390
LIG_EVH1_1 489 493 PF00568 0.673
LIG_FHA_1 105 111 PF00498 0.381
LIG_FHA_1 146 152 PF00498 0.696
LIG_FHA_1 219 225 PF00498 0.481
LIG_FHA_1 229 235 PF00498 0.530
LIG_FHA_1 280 286 PF00498 0.353
LIG_FHA_1 32 38 PF00498 0.429
LIG_FHA_1 40 46 PF00498 0.499
LIG_FHA_1 563 569 PF00498 0.467
LIG_FHA_1 65 71 PF00498 0.506
LIG_FHA_1 96 102 PF00498 0.530
LIG_FHA_2 106 112 PF00498 0.530
LIG_IBAR_NPY_1 536 538 PF08397 0.449
LIG_Integrin_isoDGR_2 266 268 PF01839 0.626
LIG_Integrin_RGD_1 451 453 PF01839 0.695
LIG_LIR_Apic_2 187 192 PF02991 0.824
LIG_LIR_Apic_2 368 373 PF02991 0.513
LIG_LIR_Apic_2 486 492 PF02991 0.494
LIG_LIR_Apic_2 546 552 PF02991 0.473
LIG_LIR_Gen_1 184 192 PF02991 0.639
LIG_LIR_Gen_1 25 36 PF02991 0.285
LIG_LIR_Gen_1 347 356 PF02991 0.496
LIG_LIR_Gen_1 527 538 PF02991 0.472
LIG_LIR_Gen_1 97 106 PF02991 0.530
LIG_LIR_Nem_3 184 189 PF02991 0.636
LIG_LIR_Nem_3 25 31 PF02991 0.466
LIG_LIR_Nem_3 260 264 PF02991 0.295
LIG_LIR_Nem_3 306 312 PF02991 0.481
LIG_LIR_Nem_3 347 351 PF02991 0.489
LIG_LIR_Nem_3 35 41 PF02991 0.429
LIG_LIR_Nem_3 444 450 PF02991 0.672
LIG_LIR_Nem_3 527 533 PF02991 0.636
LIG_LIR_Nem_3 97 103 PF02991 0.530
LIG_Pex14_2 28 32 PF04695 0.530
LIG_SH2_CRK 259 263 PF00017 0.464
LIG_SH2_GRB2like 264 267 PF00017 0.327
LIG_SH2_PTP2 348 351 PF00017 0.484
LIG_SH2_SRC 264 267 PF00017 0.390
LIG_SH2_SRC 348 351 PF00017 0.484
LIG_SH2_STAT5 225 228 PF00017 0.530
LIG_SH2_STAT5 261 264 PF00017 0.479
LIG_SH2_STAT5 348 351 PF00017 0.484
LIG_SH2_STAT5 532 535 PF00017 0.471
LIG_SH3_3 487 493 PF00018 0.671
LIG_SH3_3 572 578 PF00018 0.573
LIG_SUMO_SIM_anti_2 236 244 PF11976 0.471
LIG_SUMO_SIM_anti_2 269 275 PF11976 0.505
LIG_SUMO_SIM_anti_2 299 307 PF11976 0.306
LIG_SUMO_SIM_par_1 236 244 PF11976 0.509
LIG_SUMO_SIM_par_1 299 307 PF11976 0.306
LIG_SUMO_SIM_par_1 51 57 PF11976 0.530
LIG_SUMO_SIM_par_1 64 69 PF11976 0.315
LIG_TRAF2_1 185 188 PF00917 0.637
LIG_TRFH_1 225 229 PF08558 0.530
LIG_TYR_ITIM 257 262 PF00017 0.583
LIG_UBA3_1 270 277 PF00899 0.632
LIG_UBA3_1 8 16 PF00899 0.419
MOD_CK1_1 193 199 PF00069 0.649
MOD_CK1_1 218 224 PF00069 0.485
MOD_CK1_1 365 371 PF00069 0.555
MOD_CK1_1 398 404 PF00069 0.601
MOD_CK1_1 525 531 PF00069 0.758
MOD_CK1_1 544 550 PF00069 0.512
MOD_CK1_1 69 75 PF00069 0.637
MOD_CK2_1 105 111 PF00069 0.530
MOD_CK2_1 181 187 PF00069 0.516
MOD_GlcNHglycan 195 198 PF01048 0.664
MOD_GlcNHglycan 208 211 PF01048 0.505
MOD_GlcNHglycan 218 221 PF01048 0.467
MOD_GlcNHglycan 243 246 PF01048 0.370
MOD_GlcNHglycan 326 329 PF01048 0.566
MOD_GlcNHglycan 357 360 PF01048 0.532
MOD_GlcNHglycan 364 367 PF01048 0.527
MOD_GlcNHglycan 432 435 PF01048 0.614
MOD_GlcNHglycan 464 467 PF01048 0.608
MOD_GlcNHglycan 496 499 PF01048 0.829
MOD_GSK3_1 105 112 PF00069 0.530
MOD_GSK3_1 145 152 PF00069 0.609
MOD_GSK3_1 211 218 PF00069 0.616
MOD_GSK3_1 22 29 PF00069 0.302
MOD_GSK3_1 275 282 PF00069 0.402
MOD_GSK3_1 362 369 PF00069 0.797
MOD_GSK3_1 430 437 PF00069 0.585
MOD_GSK3_1 488 495 PF00069 0.624
MOD_GSK3_1 524 531 PF00069 0.652
MOD_GSK3_1 596 603 PF00069 0.577
MOD_GSK3_1 69 76 PF00069 0.633
MOD_N-GLC_1 216 221 PF02516 0.549
MOD_N-GLC_1 275 280 PF02516 0.401
MOD_N-GLC_1 312 317 PF02516 0.564
MOD_N-GLC_1 517 522 PF02516 0.641
MOD_NEK2_1 126 131 PF00069 0.277
MOD_NEK2_1 275 280 PF00069 0.401
MOD_NEK2_1 303 308 PF00069 0.515
MOD_NEK2_1 31 36 PF00069 0.443
MOD_NEK2_1 362 367 PF00069 0.795
MOD_NEK2_1 45 50 PF00069 0.407
MOD_NEK2_1 54 59 PF00069 0.291
MOD_NEK2_1 564 569 PF00069 0.574
MOD_NEK2_1 95 100 PF00069 0.530
MOD_PIKK_1 134 140 PF00454 0.530
MOD_PIKK_1 73 79 PF00454 0.631
MOD_PKA_1 441 447 PF00069 0.706
MOD_PKA_1 597 603 PF00069 0.573
MOD_PKA_2 145 151 PF00069 0.492
MOD_PKA_2 441 447 PF00069 0.733
MOD_PKA_2 596 602 PF00069 0.580
MOD_PKA_2 87 93 PF00069 0.530
MOD_PKB_1 322 330 PF00069 0.574
MOD_Plk_1 275 281 PF00069 0.401
MOD_Plk_1 434 440 PF00069 0.737
MOD_Plk_2-3 182 188 PF00069 0.523
MOD_Plk_2-3 483 489 PF00069 0.610
MOD_Plk_4 105 111 PF00069 0.232
MOD_Plk_4 218 224 PF00069 0.314
MOD_Plk_4 22 28 PF00069 0.302
MOD_Plk_4 233 239 PF00069 0.510
MOD_Plk_4 257 263 PF00069 0.458
MOD_Plk_4 304 310 PF00069 0.593
MOD_Plk_4 314 320 PF00069 0.427
MOD_Plk_4 32 38 PF00069 0.390
MOD_Plk_4 344 350 PF00069 0.611
MOD_Plk_4 57 63 PF00069 0.315
MOD_Plk_4 577 583 PF00069 0.586
MOD_Plk_4 600 606 PF00069 0.565
MOD_Plk_4 87 93 PF00069 0.530
MOD_Plk_4 95 101 PF00069 0.398
MOD_ProDKin_1 120 126 PF00069 0.394
MOD_ProDKin_1 198 204 PF00069 0.651
MOD_ProDKin_1 369 375 PF00069 0.572
MOD_ProDKin_1 39 45 PF00069 0.384
MOD_ProDKin_1 488 494 PF00069 0.805
MOD_ProDKin_1 522 528 PF00069 0.820
MOD_ProDKin_1 541 547 PF00069 0.504
TRG_DiLeu_BaEn_1 316 321 PF01217 0.574
TRG_DiLeu_BaEn_2 504 510 PF01217 0.588
TRG_ENDOCYTIC_2 259 262 PF00928 0.574
TRG_ENDOCYTIC_2 348 351 PF00928 0.597
TRG_ER_diArg_1 283 285 PF00400 0.635
TRG_ER_diArg_1 321 324 PF00400 0.538
TRG_ER_diArg_1 506 509 PF00400 0.593
TRG_ER_diArg_1 596 598 PF00400 0.735
TRG_NES_CRM1_1 341 352 PF08389 0.606
TRG_Pf-PMV_PEXEL_1 340 344 PF00026 0.586
TRG_Pf-PMV_PEXEL_1 508 512 PF00026 0.593

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X5K5 Leishmania donovani 58% 97%
A4I802 Leishmania infantum 57% 97%
E9B2W4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 97%
Q4Q592 Leishmania major 60% 99%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS