LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4HKG9_LEIBR
TriTrypDb:
LbrM.32.1990 , LBRM2903_320026300
Length:
655

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 33
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 15
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 65
NetGPI no yes: 0, no: 65
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HKG9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKG9

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 66
GO:0006793 phosphorus metabolic process 3 66
GO:0006796 phosphate-containing compound metabolic process 4 66
GO:0006807 nitrogen compound metabolic process 2 66
GO:0008152 metabolic process 1 66
GO:0009987 cellular process 1 66
GO:0016310 phosphorylation 5 66
GO:0019538 protein metabolic process 3 66
GO:0036211 protein modification process 4 66
GO:0043170 macromolecule metabolic process 3 66
GO:0043412 macromolecule modification 4 66
GO:0044237 cellular metabolic process 2 66
GO:0044238 primary metabolic process 2 66
GO:0071704 organic substance metabolic process 2 66
GO:1901564 organonitrogen compound metabolic process 3 66
GO:0006996 organelle organization 4 1
GO:0016043 cellular component organization 3 1
GO:0032392 DNA geometric change 7 1
GO:0032508 DNA duplex unwinding 8 1
GO:0051276 chromosome organization 5 1
GO:0071103 DNA conformation change 6 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 66
GO:0003824 catalytic activity 1 66
GO:0004672 protein kinase activity 3 66
GO:0005488 binding 1 66
GO:0005524 ATP binding 5 66
GO:0016301 kinase activity 4 66
GO:0016740 transferase activity 2 66
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 66
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 66
GO:0017076 purine nucleotide binding 4 66
GO:0030554 adenyl nucleotide binding 5 66
GO:0032553 ribonucleotide binding 3 66
GO:0032555 purine ribonucleotide binding 4 66
GO:0032559 adenyl ribonucleotide binding 5 66
GO:0035639 purine ribonucleoside triphosphate binding 4 66
GO:0036094 small molecule binding 2 66
GO:0043167 ion binding 2 66
GO:0043168 anion binding 3 66
GO:0097159 organic cyclic compound binding 2 66
GO:0097367 carbohydrate derivative binding 2 66
GO:0140096 catalytic activity, acting on a protein 2 66
GO:1901265 nucleoside phosphate binding 3 66
GO:1901363 heterocyclic compound binding 2 66
GO:0004674 protein serine/threonine kinase activity 4 39
GO:0003676 nucleic acid binding 3 1
GO:0003677 DNA binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 108 112 PF00656 0.515
CLV_NRD_NRD_1 256 258 PF00675 0.390
CLV_NRD_NRD_1 312 314 PF00675 0.321
CLV_NRD_NRD_1 529 531 PF00675 0.579
CLV_PCSK_FUR_1 581 585 PF00082 0.372
CLV_PCSK_KEX2_1 256 258 PF00082 0.440
CLV_PCSK_KEX2_1 312 314 PF00082 0.325
CLV_PCSK_KEX2_1 371 373 PF00082 0.296
CLV_PCSK_KEX2_1 456 458 PF00082 0.353
CLV_PCSK_KEX2_1 529 531 PF00082 0.606
CLV_PCSK_KEX2_1 583 585 PF00082 0.364
CLV_PCSK_PC1ET2_1 371 373 PF00082 0.350
CLV_PCSK_PC1ET2_1 456 458 PF00082 0.329
CLV_PCSK_PC1ET2_1 583 585 PF00082 0.372
CLV_PCSK_PC7_1 252 258 PF00082 0.367
CLV_PCSK_SKI1_1 143 147 PF00082 0.383
CLV_PCSK_SKI1_1 266 270 PF00082 0.371
CLV_PCSK_SKI1_1 287 291 PF00082 0.255
CLV_PCSK_SKI1_1 317 321 PF00082 0.318
CLV_PCSK_SKI1_1 329 333 PF00082 0.313
CLV_PCSK_SKI1_1 443 447 PF00082 0.304
DEG_APCC_DBOX_1 442 450 PF00400 0.292
DEG_APCC_DBOX_1 583 591 PF00400 0.293
DEG_SPOP_SBC_1 68 72 PF00917 0.705
DOC_CKS1_1 357 362 PF01111 0.364
DOC_CYCLIN_RxL_1 553 563 PF00134 0.287
DOC_CYCLIN_yCln2_LP_2 357 363 PF00134 0.392
DOC_MAPK_gen_1 317 326 PF00069 0.324
DOC_MAPK_gen_1 581 589 PF00069 0.300
DOC_MAPK_MEF2A_6 581 589 PF00069 0.334
DOC_MAPK_RevD_3 300 313 PF00069 0.340
DOC_PP1_RVXF_1 499 505 PF00149 0.279
DOC_PP4_FxxP_1 414 417 PF00568 0.366
DOC_PP4_FxxP_1 504 507 PF00568 0.520
DOC_PP4_FxxP_1 633 636 PF00568 0.440
DOC_USP7_MATH_1 13 17 PF00917 0.651
DOC_USP7_MATH_1 203 207 PF00917 0.431
DOC_USP7_MATH_1 46 50 PF00917 0.660
DOC_USP7_MATH_1 525 529 PF00917 0.541
DOC_USP7_MATH_1 56 60 PF00917 0.538
DOC_USP7_MATH_1 611 615 PF00917 0.314
DOC_USP7_MATH_1 624 628 PF00917 0.477
DOC_USP7_MATH_1 94 98 PF00917 0.731
DOC_USP7_MATH_2 396 402 PF00917 0.307
DOC_USP7_UBL2_3 28 32 PF12436 0.445
DOC_USP7_UBL2_3 371 375 PF12436 0.276
DOC_USP7_UBL2_3 452 456 PF12436 0.199
DOC_WW_Pin1_4 111 116 PF00397 0.632
DOC_WW_Pin1_4 356 361 PF00397 0.334
DOC_WW_Pin1_4 450 455 PF00397 0.314
DOC_WW_Pin1_4 591 596 PF00397 0.361
DOC_WW_Pin1_4 89 94 PF00397 0.578
LIG_14-3-3_CanoR_1 202 211 PF00244 0.398
LIG_14-3-3_CanoR_1 256 260 PF00244 0.299
LIG_14-3-3_CanoR_1 529 538 PF00244 0.536
LIG_14-3-3_CanoR_1 584 590 PF00244 0.395
LIG_Actin_RPEL_3 306 325 PF02755 0.423
LIG_Actin_WH2_2 242 258 PF00022 0.167
LIG_APCC_ABBA_1 265 270 PF00400 0.199
LIG_APCC_ABBAyCdc20_2 312 318 PF00400 0.316
LIG_BRCT_BRCA1_1 327 331 PF00533 0.337
LIG_BRCT_BRCA1_1 629 633 PF00533 0.385
LIG_BRCT_BRCA1_2 327 333 PF00533 0.337
LIG_Clathr_ClatBox_1 473 477 PF01394 0.348
LIG_EH1_1 297 305 PF00400 0.293
LIG_eIF4E_1 298 304 PF01652 0.327
LIG_EVH1_2 617 621 PF00568 0.423
LIG_FHA_1 101 107 PF00498 0.832
LIG_FHA_1 295 301 PF00498 0.415
LIG_FHA_1 564 570 PF00498 0.303
LIG_FHA_1 626 632 PF00498 0.468
LIG_FHA_1 68 74 PF00498 0.738
LIG_FHA_1 83 89 PF00498 0.564
LIG_FHA_2 529 535 PF00498 0.546
LIG_FHA_2 635 641 PF00498 0.367
LIG_Integrin_isoDGR_2 120 122 PF01839 0.432
LIG_Integrin_RGD_1 252 254 PF01839 0.172
LIG_Integrin_RGD_1 61 63 PF01839 0.463
LIG_LIR_Apic_2 359 365 PF02991 0.321
LIG_LIR_Apic_2 411 417 PF02991 0.375
LIG_LIR_Apic_2 612 618 PF02991 0.356
LIG_LIR_Apic_2 630 636 PF02991 0.479
LIG_LIR_Gen_1 142 150 PF02991 0.514
LIG_LIR_Gen_1 157 167 PF02991 0.373
LIG_LIR_Gen_1 222 231 PF02991 0.324
LIG_LIR_Gen_1 297 306 PF02991 0.317
LIG_LIR_Gen_1 328 339 PF02991 0.285
LIG_LIR_Gen_1 555 565 PF02991 0.322
LIG_LIR_Gen_1 642 652 PF02991 0.372
LIG_LIR_Nem_3 142 147 PF02991 0.494
LIG_LIR_Nem_3 222 228 PF02991 0.300
LIG_LIR_Nem_3 297 302 PF02991 0.320
LIG_LIR_Nem_3 328 334 PF02991 0.284
LIG_LIR_Nem_3 555 560 PF02991 0.207
LIG_LIR_Nem_3 642 647 PF02991 0.419
LIG_LYPXL_SIV_4 23 31 PF13949 0.451
LIG_MAD2 408 416 PF02301 0.237
LIG_Pex14_1 553 557 PF04695 0.319
LIG_PTB_Apo_2 161 168 PF02174 0.391
LIG_PTB_Phospho_1 161 167 PF10480 0.384
LIG_SH2_CRK 615 619 PF00017 0.423
LIG_SH2_NCK_1 167 171 PF00017 0.537
LIG_SH2_PTP2 144 147 PF00017 0.550
LIG_SH2_STAP1 231 235 PF00017 0.328
LIG_SH2_STAP1 343 347 PF00017 0.312
LIG_SH2_STAP1 387 391 PF00017 0.323
LIG_SH2_STAP1 619 623 PF00017 0.372
LIG_SH2_STAT3 298 301 PF00017 0.319
LIG_SH2_STAT5 128 131 PF00017 0.503
LIG_SH2_STAT5 144 147 PF00017 0.408
LIG_SH2_STAT5 159 162 PF00017 0.362
LIG_SH2_STAT5 194 197 PF00017 0.467
LIG_SH2_STAT5 234 237 PF00017 0.368
LIG_SH2_STAT5 298 301 PF00017 0.295
LIG_SH2_STAT5 362 365 PF00017 0.324
LIG_SH2_STAT5 472 475 PF00017 0.379
LIG_SH2_STAT5 479 482 PF00017 0.402
LIG_SH2_STAT5 503 506 PF00017 0.436
LIG_SH2_STAT5 557 560 PF00017 0.334
LIG_SH3_3 184 190 PF00018 0.553
LIG_SH3_3 414 420 PF00018 0.237
LIG_SH3_3 70 76 PF00018 0.613
LIG_SUMO_SIM_par_1 237 248 PF11976 0.308
LIG_SUMO_SIM_par_1 563 568 PF11976 0.402
LIG_TRAF2_1 459 462 PF00917 0.436
LIG_TRAF2_1 637 640 PF00917 0.258
LIG_TRFH_1 361 365 PF08558 0.305
LIG_TYR_ITIM 126 131 PF00017 0.575
LIG_TYR_ITIM 385 390 PF00017 0.352
LIG_UBA3_1 445 452 PF00899 0.294
MOD_CDC14_SPxK_1 453 456 PF00782 0.167
MOD_CDC14_SPxK_1 92 95 PF00782 0.480
MOD_CDK_SPxK_1 450 456 PF00069 0.167
MOD_CDK_SPxK_1 89 95 PF00069 0.480
MOD_CDK_SPxxK_3 450 457 PF00069 0.473
MOD_CK1_1 104 110 PF00069 0.739
MOD_CK1_1 345 351 PF00069 0.336
MOD_CK1_1 482 488 PF00069 0.468
MOD_CK1_1 528 534 PF00069 0.555
MOD_CK1_1 563 569 PF00069 0.352
MOD_CK1_1 627 633 PF00069 0.417
MOD_CK1_1 67 73 PF00069 0.679
MOD_CK2_1 209 215 PF00069 0.268
MOD_CK2_1 235 241 PF00069 0.423
MOD_CK2_1 288 294 PF00069 0.348
MOD_CK2_1 398 404 PF00069 0.355
MOD_CK2_1 456 462 PF00069 0.386
MOD_CK2_1 528 534 PF00069 0.555
MOD_CK2_1 574 580 PF00069 0.366
MOD_CK2_1 591 597 PF00069 0.383
MOD_CK2_1 634 640 PF00069 0.293
MOD_Cter_Amidation 369 372 PF01082 0.290
MOD_Cter_Amidation 373 376 PF01082 0.266
MOD_GlcNHglycan 15 18 PF01048 0.582
MOD_GlcNHglycan 2 5 PF01048 0.545
MOD_GlcNHglycan 309 312 PF01048 0.381
MOD_GlcNHglycan 320 323 PF01048 0.345
MOD_GlcNHglycan 44 47 PF01048 0.671
MOD_GlcNHglycan 458 461 PF01048 0.272
MOD_GlcNHglycan 48 51 PF01048 0.699
MOD_GlcNHglycan 484 487 PF01048 0.402
MOD_GlcNHglycan 534 537 PF01048 0.523
MOD_GlcNHglycan 576 579 PF01048 0.329
MOD_GSK3_1 22 29 PF00069 0.725
MOD_GSK3_1 342 349 PF00069 0.326
MOD_GSK3_1 352 359 PF00069 0.323
MOD_GSK3_1 415 422 PF00069 0.459
MOD_GSK3_1 42 49 PF00069 0.641
MOD_GSK3_1 528 535 PF00069 0.608
MOD_GSK3_1 563 570 PF00069 0.333
MOD_GSK3_1 585 592 PF00069 0.329
MOD_GSK3_1 64 71 PF00069 0.610
MOD_GSK3_1 82 89 PF00069 0.548
MOD_GSK3_1 96 103 PF00069 0.697
MOD_LATS_1 602 608 PF00433 0.168
MOD_N-GLC_1 260 265 PF02516 0.451
MOD_N-GLC_1 283 288 PF02516 0.182
MOD_NEK2_1 219 224 PF00069 0.364
MOD_NEK2_1 255 260 PF00069 0.260
MOD_NEK2_1 325 330 PF00069 0.315
MOD_NEK2_1 337 342 PF00069 0.307
MOD_NEK2_1 445 450 PF00069 0.208
MOD_NEK2_1 463 468 PF00069 0.331
MOD_NEK2_1 5 10 PF00069 0.748
MOD_NEK2_1 545 550 PF00069 0.439
MOD_NEK2_1 560 565 PF00069 0.294
MOD_NEK2_1 589 594 PF00069 0.377
MOD_NEK2_1 625 630 PF00069 0.308
MOD_NMyristoyl 1 7 PF02799 0.594
MOD_PIKK_1 185 191 PF00454 0.531
MOD_PIKK_1 203 209 PF00454 0.213
MOD_PIKK_1 337 343 PF00454 0.315
MOD_PIKK_1 545 551 PF00454 0.335
MOD_PK_1 146 152 PF00069 0.543
MOD_PKA_1 456 462 PF00069 0.333
MOD_PKA_2 185 191 PF00069 0.293
MOD_PKA_2 255 261 PF00069 0.167
MOD_PKA_2 456 462 PF00069 0.319
MOD_PKA_2 528 534 PF00069 0.595
MOD_Plk_1 101 107 PF00069 0.629
MOD_Plk_1 260 266 PF00069 0.434
MOD_Plk_1 343 349 PF00069 0.281
MOD_Plk_2-3 398 404 PF00069 0.342
MOD_Plk_4 294 300 PF00069 0.391
MOD_Plk_4 352 358 PF00069 0.312
MOD_Plk_4 445 451 PF00069 0.325
MOD_Plk_4 464 470 PF00069 0.390
MOD_Plk_4 479 485 PF00069 0.392
MOD_Plk_4 560 566 PF00069 0.372
MOD_Plk_4 585 591 PF00069 0.331
MOD_Plk_4 627 633 PF00069 0.330
MOD_Plk_4 69 75 PF00069 0.543
MOD_ProDKin_1 111 117 PF00069 0.631
MOD_ProDKin_1 356 362 PF00069 0.334
MOD_ProDKin_1 450 456 PF00069 0.314
MOD_ProDKin_1 591 597 PF00069 0.361
MOD_ProDKin_1 89 95 PF00069 0.581
MOD_SUMO_rev_2 25 33 PF00179 0.450
TRG_ENDOCYTIC_2 128 131 PF00928 0.549
TRG_ENDOCYTIC_2 144 147 PF00928 0.505
TRG_ENDOCYTIC_2 159 162 PF00928 0.448
TRG_ENDOCYTIC_2 387 390 PF00928 0.330
TRG_ENDOCYTIC_2 472 475 PF00928 0.367
TRG_ENDOCYTIC_2 540 543 PF00928 0.264
TRG_ENDOCYTIC_2 557 560 PF00928 0.325
TRG_ER_diArg_1 255 257 PF00400 0.402
TRG_ER_diArg_1 312 314 PF00400 0.310
TRG_ER_diArg_1 405 408 PF00400 0.318
TRG_NES_CRM1_1 643 655 PF08389 0.243
TRG_Pf-PMV_PEXEL_1 287 292 PF00026 0.385
TRG_Pf-PMV_PEXEL_1 408 412 PF00026 0.299
TRG_Pf-PMV_PEXEL_1 530 534 PF00026 0.642
TRG_Pf-PMV_PEXEL_1 556 561 PF00026 0.377
TRG_Pf-PMV_PEXEL_1 650 655 PF00026 0.577

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P953 Leptomonas seymouri 30% 100%
A0A0N1I9A0 Leptomonas seymouri 68% 100%
A0A0N1PD05 Leptomonas seymouri 34% 100%
A0A0S4IMB7 Bodo saltans 34% 100%
A0A0S4IRZ7 Bodo saltans 39% 100%
A0A0S4J804 Bodo saltans 30% 100%
A0A0S4JPZ1 Bodo saltans 28% 100%
A0A1X0NIX2 Trypanosomatidae 28% 100%
A0A1X0NUB2 Trypanosomatidae 47% 100%
A0A1X0P527 Trypanosomatidae 32% 100%
A0A1X0P549 Trypanosomatidae 30% 100%
A0A1X0P863 Trypanosomatidae 29% 100%
A0A1X0P8W3 Trypanosomatidae 24% 88%
A0A1X0P994 Trypanosomatidae 29% 100%
A0A3Q8IFK8 Leishmania donovani 26% 100%
A0A3Q8IHH8 Leishmania donovani 33% 100%
A0A3Q8IIH5 Leishmania donovani 27% 100%
A0A3Q8IJM9 Leishmania donovani 30% 100%
A0A3R7MKG5 Trypanosoma rangeli 28% 100%
A0A3S7X5M4 Leishmania donovani 74% 100%
A0A3S7X6T8 Leishmania donovani 32% 100%
A0A3S7XAL3 Leishmania donovani 30% 100%
A0A3S7XAT9 Leishmania donovani 31% 100%
A0A422NCP0 Trypanosoma rangeli 30% 100%
A0A422NH41 Trypanosoma rangeli 46% 100%
A4HHQ5 Leishmania braziliensis 34% 100%
A4HJT5 Leishmania braziliensis 27% 85%
A4HLR0 Leishmania braziliensis 32% 100%
A4HNI1 Leishmania braziliensis 29% 100%
A4HP12 Leishmania braziliensis 30% 100%
A4HP13 Leishmania braziliensis 29% 100%
A4HW88 Leishmania infantum 27% 100%
A4I4X0 Leishmania infantum 33% 100%
A4I7A1 Leishmania infantum 26% 100%
A4I7Z6 Leishmania infantum 74% 100%
A4I960 Leishmania infantum 32% 100%
A4IC37 Leishmania infantum 29% 100%
A4IDC1 Leishmania infantum 30% 100%
A4IDC2 Leishmania infantum 31% 100%
C9ZMH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AEB9 Leishmania major 33% 100%
E9AFZ2 Leishmania major 30% 100%
E9ALG7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
Q4Q1S3 Leishmania major 29% 98%
Q4Q1S4 Leishmania major 30% 100%
Q4Q3Y9 Leishmania major 32% 85%
Q4Q598 Leishmania major 72% 100%
Q4Q5W2 Leishmania major 26% 81%
Q4QFJ2 Leishmania major 27% 100%
V5BC28 Trypanosoma cruzi 28% 100%
V5BPJ0 Trypanosoma cruzi 31% 100%
V5D7G4 Trypanosoma cruzi 31% 79%
V5DFW9 Trypanosoma cruzi 46% 100%
V5DKY9 Trypanosoma cruzi 25% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS