F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKG8_LEIBR

TriTrypDb:

LbrM.32.1980 , LBRM2903_320026200

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.538
CLV_NRD_NRD_1	154	156	PF00675	0.586
CLV_NRD_NRD_1	5	7	PF00675	0.648
CLV_PCSK_KEX2_1	152	154	PF00082	0.544
CLV_PCSK_KEX2_1	156	158	PF00082	0.574
CLV_PCSK_KEX2_1	5	7	PF00082	0.648
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.552
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.558
CLV_PCSK_SKI1_1	13	17	PF00082	0.674
DOC_USP7_MATH_1	101	105	PF00917	0.743
DOC_USP7_MATH_1	4	8	PF00917	0.646
DOC_USP7_MATH_1	86	90	PF00917	0.662
DOC_USP7_UBL2_3	152	156	PF12436	0.601
LIG_14-3-3_CanoR_1	102	112	PF00244	0.658
LIG_APCC_ABBA_1	34	39	PF00400	0.543
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_BRCT_BRCA1_1	112	116	PF00533	0.590
LIG_FHA_2	48	54	PF00498	0.736
LIG_FHA_2	62	68	PF00498	0.619
LIG_FHA_2	92	98	PF00498	0.496
LIG_LIR_Nem_3	113	119	PF02991	0.622
LIG_NRP_CendR_1	156	159	PF00754	0.669
LIG_PCNA_PIPBox_1	127	136	PF02747	0.476
LIG_Pex14_1	28	32	PF04695	0.561
LIG_PTB_Apo_2	132	139	PF02174	0.474
LIG_SH2_NCK_1	20	24	PF00017	0.633
LIG_SH2_STAT5	32	35	PF00017	0.569
LIG_SH3_3	95	101	PF00018	0.632
LIG_WRC_WIRS_1	130	135	PF05994	0.529
MOD_CK1_1	106	112	PF00069	0.757
MOD_CK1_1	60	66	PF00069	0.617
MOD_CK1_1	85	91	PF00069	0.616
MOD_CK2_1	61	67	PF00069	0.694
MOD_GlcNHglycan	105	108	PF01048	0.594
MOD_GlcNHglycan	84	87	PF01048	0.630
MOD_GlcNHglycan	88	91	PF01048	0.621
MOD_GSK3_1	102	109	PF00069	0.630
MOD_GSK3_1	57	64	PF00069	0.604
MOD_GSK3_1	80	87	PF00069	0.630
MOD_NEK2_1	129	134	PF00069	0.507
MOD_NEK2_1	16	21	PF00069	0.678
MOD_PKA_1	151	157	PF00069	0.545
MOD_PKA_2	101	107	PF00069	0.650
MOD_PKA_2	4	10	PF00069	0.635
MOD_PKA_2	80	86	PF00069	0.508
MOD_Plk_1	57	63	PF00069	0.651
MOD_Plk_4	129	135	PF00069	0.535
MOD_Plk_4	57	63	PF00069	0.616
TRG_DiLeu_BaEn_2	138	144	PF01217	0.509
TRG_ER_diArg_1	5	8	PF00400	0.680
TRG_NLS_MonoExtC_3	150	155	PF00514	0.605
TRG_NLS_MonoExtN_4	151	156	PF00514	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P974	Leptomonas seymouri	46%	100%
A0A1X0NT35	Trypanosomatidae	33%	94%
A0A3S7X5K4	Leishmania donovani	74%	100%
A0A422NH51	Trypanosoma rangeli	33%	99%
A4I7Z5	Leishmania infantum	74%	100%
D0AA62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B2V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q599	Leishmania major	69%	96%