Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKG6_LEIBR

TriTrypDb:

LbrM.32.1960 , LBRM2903_320026000

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.560
CLV_NRD_NRD_1	303	305	PF00675	0.387
CLV_NRD_NRD_1	392	394	PF00675	0.261
CLV_NRD_NRD_1	459	461	PF00675	0.303
CLV_NRD_NRD_1	607	609	PF00675	0.600
CLV_PCSK_KEX2_1	118	120	PF00082	0.560
CLV_PCSK_KEX2_1	303	305	PF00082	0.387
CLV_PCSK_KEX2_1	392	394	PF00082	0.261
CLV_PCSK_KEX2_1	458	460	PF00082	0.315
CLV_PCSK_SKI1_1	23	27	PF00082	0.366
CLV_PCSK_SKI1_1	285	289	PF00082	0.461
CLV_PCSK_SKI1_1	448	452	PF00082	0.352
CLV_PCSK_SKI1_1	45	49	PF00082	0.393
CLV_PCSK_SKI1_1	460	464	PF00082	0.325
DEG_APCC_DBOX_1	22	30	PF00400	0.348
DEG_APCC_DBOX_1	481	489	PF00400	0.354
DEG_Kelch_actinfilin_1	368	372	PF01344	0.237
DEG_SCF_FBW7_2	7	12	PF00400	0.397
DEG_SPOP_SBC_1	266	270	PF00917	0.495
DOC_CKS1_1	341	346	PF01111	0.386
DOC_CYCLIN_RxL_1	282	292	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	258	264	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.416
DOC_MAPK_DCC_7	539	549	PF00069	0.378
DOC_MAPK_gen_1	392	399	PF00069	0.276
DOC_MAPK_gen_1	458	465	PF00069	0.342
DOC_MAPK_gen_1	81	90	PF00069	0.375
DOC_MAPK_HePTP_8	184	196	PF00069	0.443
DOC_MAPK_MEF2A_6	187	196	PF00069	0.453
DOC_PP2B_LxvP_1	242	245	PF13499	0.491
DOC_PP2B_LxvP_1	263	266	PF13499	0.765
DOC_PP2B_LxvP_1	31	34	PF13499	0.508
DOC_PP2B_LxvP_1	538	541	PF13499	0.454
DOC_PP4_FxxP_1	110	113	PF00568	0.372
DOC_PP4_FxxP_1	341	344	PF00568	0.361
DOC_USP7_MATH_1	168	172	PF00917	0.549
DOC_USP7_MATH_1	275	279	PF00917	0.677
DOC_USP7_MATH_1	290	294	PF00917	0.418
DOC_USP7_MATH_1	377	381	PF00917	0.347
DOC_USP7_MATH_1	82	86	PF00917	0.262
DOC_WW_Pin1_4	268	273	PF00397	0.750
DOC_WW_Pin1_4	340	345	PF00397	0.372
DOC_WW_Pin1_4	5	10	PF00397	0.621
DOC_WW_Pin1_4	549	554	PF00397	0.577
DOC_WW_Pin1_4	568	573	PF00397	0.420
LIG_14-3-3_CanoR_1	283	288	PF00244	0.526
LIG_14-3-3_CanoR_1	411	421	PF00244	0.387
LIG_14-3-3_CanoR_1	460	466	PF00244	0.373
LIG_14-3-3_CanoR_1	482	486	PF00244	0.347
LIG_Actin_WH2_2	10	25	PF00022	0.277
LIG_ActinCP_TwfCPI_2	110	119	PF01115	0.376
LIG_APCC_ABBA_1	441	446	PF00400	0.354
LIG_APCC_ABBA_1	70	75	PF00400	0.404
LIG_BRCT_BRCA1_1	232	236	PF00533	0.255
LIG_CAP-Gly_1	614	620	PF01302	0.542
LIG_DCNL_PONY_1	1	4	PF03556	0.474
LIG_deltaCOP1_diTrp_1	104	110	PF00928	0.372
LIG_deltaCOP1_diTrp_1	518	525	PF00928	0.496
LIG_FHA_1	145	151	PF00498	0.621
LIG_FHA_1	164	170	PF00498	0.495
LIG_FHA_1	357	363	PF00498	0.428
LIG_FHA_1	412	418	PF00498	0.418
LIG_FHA_2	341	347	PF00498	0.387
LIG_FHA_2	514	520	PF00498	0.573
LIG_FHA_2	574	580	PF00498	0.412
LIG_GBD_Chelix_1	18	26	PF00786	0.382
LIG_LIR_Apic_2	339	344	PF02991	0.352
LIG_LIR_Apic_2	528	532	PF02991	0.518
LIG_LIR_Gen_1	104	115	PF02991	0.405
LIG_LIR_Gen_1	131	140	PF02991	0.370
LIG_LIR_Gen_1	416	426	PF02991	0.269
LIG_LIR_Gen_1	451	461	PF02991	0.388
LIG_LIR_Gen_1	502	513	PF02991	0.633
LIG_LIR_Gen_1	518	527	PF02991	0.523
LIG_LIR_Nem_3	104	110	PF02991	0.392
LIG_LIR_Nem_3	138	143	PF02991	0.367
LIG_LIR_Nem_3	41	47	PF02991	0.323
LIG_LIR_Nem_3	416	422	PF02991	0.334
LIG_LIR_Nem_3	451	456	PF02991	0.429
LIG_LIR_Nem_3	502	508	PF02991	0.610
LIG_LIR_Nem_3	518	523	PF02991	0.451
LIG_LYPXL_S_1	564	568	PF13949	0.498
LIG_LYPXL_yS_3	565	568	PF13949	0.500
LIG_MYND_1	261	265	PF01753	0.488
LIG_MYND_1	352	356	PF01753	0.385
LIG_NRBOX	484	490	PF00104	0.379
LIG_PCNA_PIPBox_1	221	230	PF02747	0.474
LIG_PCNA_PIPBox_1	391	400	PF02747	0.370
LIG_PCNA_yPIPBox_3	384	398	PF02747	0.366
LIG_PCNA_yPIPBox_3	487	500	PF02747	0.517
LIG_PDZ_Class_3	615	620	PF00595	0.503
LIG_Pex14_1	520	524	PF04695	0.532
LIG_Pex14_2	140	144	PF04695	0.355
LIG_Rb_LxCxE_1	282	300	PF01857	0.329
LIG_SH2_CRK	419	423	PF00017	0.463
LIG_SH2_CRK	453	457	PF00017	0.252
LIG_SH2_CRK	505	509	PF00017	0.686
LIG_SH2_NCK_1	466	470	PF00017	0.242
LIG_SH2_SRC	560	563	PF00017	0.461
LIG_SH2_SRC	73	76	PF00017	0.476
LIG_SH2_STAP1	320	324	PF00017	0.366
LIG_SH2_STAT5	129	132	PF00017	0.329
LIG_SH2_STAT5	404	407	PF00017	0.394
LIG_SH2_STAT5	421	424	PF00017	0.406
LIG_SH2_STAT5	439	442	PF00017	0.249
LIG_SH2_STAT5	560	563	PF00017	0.412
LIG_SH2_STAT5	604	607	PF00017	0.481
LIG_SH2_STAT5	73	76	PF00017	0.482
LIG_SH3_3	147	153	PF00018	0.580
LIG_SH3_3	189	195	PF00018	0.398
LIG_SH3_3	237	243	PF00018	0.263
LIG_SH3_3	253	259	PF00018	0.475
LIG_SH3_3	26	32	PF00018	0.271
LIG_SH3_3	346	352	PF00018	0.400
LIG_SH3_3	44	50	PF00018	0.402
LIG_SH3_3	560	566	PF00018	0.523
LIG_SUMO_SIM_anti_2	359	365	PF11976	0.427
LIG_SUMO_SIM_par_1	334	339	PF11976	0.428
LIG_SUMO_SIM_par_1	358	365	PF11976	0.427
LIG_TRAF2_1	139	142	PF00917	0.529
LIG_TRAF2_1	155	158	PF00917	0.550
LIG_TRAF2_1	516	519	PF00917	0.571
LIG_TRAF2_1	58	61	PF00917	0.581
LIG_TRAF2_1	65	68	PF00917	0.432
LIG_TYR_ITIM	417	422	PF00017	0.338
LIG_TYR_ITIM	563	568	PF00017	0.344
LIG_TYR_ITSM	449	456	PF00017	0.286
LIG_UBA3_1	310	317	PF00899	0.380
LIG_UBA3_1	601	609	PF00899	0.498
LIG_WRC_WIRS_1	130	135	PF05994	0.399
LIG_WRC_WIRS_1	137	142	PF05994	0.308
MOD_CK1_1	268	274	PF00069	0.686
MOD_CK1_1	277	283	PF00069	0.555
MOD_CK1_1	38	44	PF00069	0.367
MOD_CK1_1	478	484	PF00069	0.381
MOD_CK1_1	5	11	PF00069	0.455
MOD_CK1_1	506	512	PF00069	0.430
MOD_CK1_1	59	65	PF00069	0.547
MOD_CK2_1	135	141	PF00069	0.397
MOD_CK2_1	152	158	PF00069	0.453
MOD_CK2_1	290	296	PF00069	0.441
MOD_CK2_1	340	346	PF00069	0.379
MOD_CK2_1	506	512	PF00069	0.570
MOD_CK2_1	513	519	PF00069	0.508
MOD_CK2_1	573	579	PF00069	0.420
MOD_CK2_1	62	68	PF00069	0.484
MOD_GlcNHglycan	232	235	PF01048	0.264
MOD_GlcNHglycan	273	276	PF01048	0.684
MOD_GlcNHglycan	277	280	PF01048	0.538
MOD_GlcNHglycan	291	295	PF01048	0.291
MOD_GlcNHglycan	299	302	PF01048	0.597
MOD_GlcNHglycan	36	40	PF01048	0.358
MOD_GlcNHglycan	364	367	PF01048	0.305
MOD_GlcNHglycan	50	53	PF01048	0.382
MOD_GlcNHglycan	501	504	PF01048	0.480
MOD_GlcNHglycan	505	508	PF01048	0.544
MOD_GSK3_1	267	274	PF00069	0.734
MOD_GSK3_1	275	282	PF00069	0.422
MOD_GSK3_1	407	414	PF00069	0.291
MOD_GSK3_1	477	484	PF00069	0.413
MOD_GSK3_1	499	506	PF00069	0.459
MOD_GSK3_1	545	552	PF00069	0.621
MOD_GSK3_1	573	580	PF00069	0.461
MOD_GSK3_1	59	66	PF00069	0.476
MOD_N-GLC_1	230	235	PF02516	0.320
MOD_N-GLC_1	275	280	PF02516	0.614
MOD_N-GLC_2	330	332	PF02516	0.419
MOD_NEK2_1	102	107	PF00069	0.289
MOD_NEK2_1	128	133	PF00069	0.425
MOD_NEK2_1	144	149	PF00069	0.389
MOD_NEK2_1	18	23	PF00069	0.406
MOD_NEK2_1	2	7	PF00069	0.570
MOD_NEK2_1	267	272	PF00069	0.487
MOD_NEK2_1	35	40	PF00069	0.361
MOD_NEK2_1	477	482	PF00069	0.457
MOD_NEK2_2	129	134	PF00069	0.319
MOD_NEK2_2	309	314	PF00069	0.246
MOD_NEK2_2	461	466	PF00069	0.333
MOD_PIKK_1	152	158	PF00454	0.439
MOD_PIKK_1	217	223	PF00454	0.348
MOD_PIKK_1	24	30	PF00454	0.448
MOD_PIKK_1	56	62	PF00454	0.512
MOD_PKA_1	392	398	PF00069	0.392
MOD_PKA_2	392	398	PF00069	0.423
MOD_PKA_2	407	413	PF00069	0.538
MOD_PKA_2	481	487	PF00069	0.335
MOD_PKA_2	80	86	PF00069	0.457
MOD_Plk_1	2	8	PF00069	0.487
MOD_Plk_1	35	41	PF00069	0.382
MOD_Plk_1	400	406	PF00069	0.329
MOD_Plk_1	427	433	PF00069	0.407
MOD_Plk_1	448	454	PF00069	0.516
MOD_Plk_1	581	587	PF00069	0.589
MOD_Plk_2-3	577	583	PF00069	0.535
MOD_Plk_4	214	220	PF00069	0.349
MOD_Plk_4	309	315	PF00069	0.491
MOD_Plk_4	400	406	PF00069	0.451
MOD_Plk_4	413	419	PF00069	0.431
MOD_Plk_4	427	433	PF00069	0.398
MOD_Plk_4	461	467	PF00069	0.312
MOD_Plk_4	59	65	PF00069	0.432
MOD_ProDKin_1	268	274	PF00069	0.749
MOD_ProDKin_1	340	346	PF00069	0.379
MOD_ProDKin_1	5	11	PF00069	0.608
MOD_ProDKin_1	549	555	PF00069	0.571
MOD_ProDKin_1	568	574	PF00069	0.416
MOD_SUMO_rev_2	445	450	PF00179	0.290
MOD_SUMO_rev_2	590	598	PF00179	0.578
TRG_DiLeu_BaEn_4	177	183	PF01217	0.436
TRG_DiLeu_BaEn_4	67	73	PF01217	0.272
TRG_DiLeu_BaLyEn_6	484	489	PF01217	0.427
TRG_ENDOCYTIC_2	320	323	PF00928	0.347
TRG_ENDOCYTIC_2	419	422	PF00928	0.345
TRG_ENDOCYTIC_2	453	456	PF00928	0.318
TRG_ENDOCYTIC_2	505	508	PF00928	0.678
TRG_ENDOCYTIC_2	524	527	PF00928	0.419
TRG_ENDOCYTIC_2	560	563	PF00928	0.461
TRG_ENDOCYTIC_2	565	568	PF00928	0.509
TRG_ENDOCYTIC_2	588	591	PF00928	0.425
TRG_ER_diArg_1	117	119	PF00400	0.543
TRG_ER_diArg_1	302	304	PF00400	0.403
TRG_ER_diArg_1	392	394	PF00400	0.261
TRG_ER_diArg_1	457	460	PF00400	0.316
TRG_ER_diArg_1	605	608	PF00400	0.536
TRG_NES_CRM1_1	12	24	PF08389	0.265
TRG_Pf-PMV_PEXEL_1	100	104	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G9	Leptomonas seymouri	62%	98%
A0A0S4IM38	Bodo saltans	38%	100%
A0A1X0NUS4	Trypanosomatidae	43%	100%
A0A3Q8ID57	Leishmania donovani	81%	100%
A0A422NH67	Trypanosoma rangeli	44%	100%
D0AA61	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B2V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q5A1	Leishmania major	81%	100%