DNA methylase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

DNA methylase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKG5_LEIBR

TriTrypDb:

LbrM.32.1950 , LBRM2903_320025900

Length:

177

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.500
CLV_NRD_NRD_1	56	58	PF00675	0.642
CLV_PCSK_KEX2_1	56	58	PF00082	0.640
CLV_PCSK_PC7_1	52	58	PF00082	0.611
CLV_PCSK_SKI1_1	125	129	PF00082	0.512
CLV_PCSK_SKI1_1	164	168	PF00082	0.621
CLV_PCSK_SKI1_1	173	177	PF00082	0.610
DOC_USP7_MATH_1	169	173	PF00917	0.647
DOC_USP7_UBL2_3	170	174	PF12436	0.720
DOC_WW_Pin1_4	34	39	PF00397	0.550
LIG_14-3-3_CanoR_1	116	124	PF00244	0.612
LIG_14-3-3_CanoR_1	13	22	PF00244	0.532
LIG_14-3-3_CanoR_1	140	145	PF00244	0.513
LIG_14-3-3_CanoR_1	28	35	PF00244	0.467
LIG_deltaCOP1_diTrp_1	119	129	PF00928	0.616
LIG_FHA_1	119	125	PF00498	0.461
LIG_FHA_1	71	77	PF00498	0.462
LIG_FHA_2	126	132	PF00498	0.638
LIG_FHA_2	34	40	PF00498	0.749
LIG_FHA_2	48	54	PF00498	0.635
LIG_LIR_Gen_1	29	40	PF02991	0.514
LIG_LIR_Nem_3	29	35	PF02991	0.440
LIG_LIR_Nem_3	9	15	PF02991	0.634
LIG_REV1ctd_RIR_1	165	175	PF16727	0.606
LIG_SH2_CRK	12	16	PF00017	0.495
LIG_SH2_CRK	88	92	PF00017	0.684
LIG_SH2_STAT5	100	103	PF00017	0.645
LIG_SH2_STAT5	117	120	PF00017	0.611
LIG_SH3_3	153	159	PF00018	0.522
LIG_SH3_3	16	22	PF00018	0.576
LIG_SH3_3	35	41	PF00018	0.449
LIG_TRAF2_1	152	155	PF00917	0.524
MOD_CK2_1	131	137	PF00069	0.694
MOD_CK2_1	149	155	PF00069	0.577
MOD_CK2_1	33	39	PF00069	0.753
MOD_CK2_1	47	53	PF00069	0.480
MOD_CK2_1	63	69	PF00069	0.362
MOD_GlcNHglycan	151	154	PF01048	0.615
MOD_GSK3_1	169	176	PF00069	0.523
MOD_GSK3_1	22	29	PF00069	0.574
MOD_LATS_1	92	98	PF00433	0.712
MOD_N-GLC_1	57	62	PF02516	0.479
MOD_NEK2_1	70	75	PF00069	0.523
MOD_PK_1	140	146	PF00069	0.517
MOD_PKA_2	107	113	PF00069	0.624
MOD_PKA_2	115	121	PF00069	0.601
MOD_PKA_2	27	33	PF00069	0.522
MOD_PKA_2	62	68	PF00069	0.683
MOD_Plk_1	63	69	PF00069	0.677
MOD_Plk_2-3	78	84	PF00069	0.568
MOD_Plk_4	125	131	PF00069	0.600
MOD_Plk_4	86	92	PF00069	0.692
MOD_ProDKin_1	34	40	PF00069	0.548
TRG_ENDOCYTIC_2	12	15	PF00928	0.646
TRG_ENDOCYTIC_2	88	91	PF00928	0.640
TRG_ER_diLys_1	173	177	PF00400	0.737
TRG_NLS_MonoExtC_3	169	174	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN5	Leptomonas seymouri	41%	97%
A0A3S7X5J7	Leishmania donovani	67%	99%
A4I7Z3	Leishmania infantum	66%	99%
E9B2V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%
Q4Q5A2	Leishmania major	66%	100%