Phosphatidylethanolamine-binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylethanolamine-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKG4_LEIBR

TriTrypDb:

LbrM.32.1940 , LBRM2903_320025800

Length:

513

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKG4

PDB structure(s): 7aih_X , 7ane_X

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.558
CLV_NRD_NRD_1	148	150	PF00675	0.370
CLV_NRD_NRD_1	2	4	PF00675	0.560
CLV_NRD_NRD_1	382	384	PF00675	0.553
CLV_NRD_NRD_1	48	50	PF00675	0.463
CLV_NRD_NRD_1	498	500	PF00675	0.449
CLV_PCSK_KEX2_1	2	4	PF00082	0.560
CLV_PCSK_KEX2_1	498	500	PF00082	0.449
CLV_PCSK_SKI1_1	2	6	PF00082	0.688
CLV_PCSK_SKI1_1	283	287	PF00082	0.366
CLV_PCSK_SKI1_1	352	356	PF00082	0.549
CLV_PCSK_SKI1_1	383	387	PF00082	0.540
CLV_PCSK_SKI1_1	72	76	PF00082	0.371
DEG_APCC_DBOX_1	382	390	PF00400	0.445
DEG_MDM2_SWIB_1	414	422	PF02201	0.327
DEG_Nend_UBRbox_1	1	4	PF02207	0.559
DOC_ANK_TNKS_1	460	467	PF00023	0.413
DOC_CKS1_1	89	94	PF01111	0.339
DOC_CYCLIN_yCln2_LP_2	431	437	PF00134	0.457
DOC_MAPK_FxFP_2	66	69	PF00069	0.397
DOC_MAPK_FxFP_2	80	83	PF00069	0.381
DOC_PP1_RVXF_1	490	497	PF00149	0.517
DOC_PP2B_LxvP_1	294	297	PF13499	0.420
DOC_PP2B_LxvP_1	429	432	PF13499	0.327
DOC_PP2B_LxvP_1	97	100	PF13499	0.473
DOC_PP4_FxxP_1	377	380	PF00568	0.439
DOC_PP4_FxxP_1	66	69	PF00568	0.397
DOC_PP4_FxxP_1	80	83	PF00568	0.381
DOC_USP7_MATH_1	21	25	PF00917	0.442
DOC_USP7_MATH_1	232	236	PF00917	0.561
DOC_USP7_MATH_1	366	370	PF00917	0.431
DOC_USP7_MATH_1	387	391	PF00917	0.663
DOC_USP7_MATH_1	406	410	PF00917	0.333
DOC_USP7_MATH_1	464	468	PF00917	0.466
DOC_USP7_UBL2_3	249	253	PF12436	0.629
DOC_WW_Pin1_4	128	133	PF00397	0.584
DOC_WW_Pin1_4	196	201	PF00397	0.539
DOC_WW_Pin1_4	262	267	PF00397	0.298
DOC_WW_Pin1_4	88	93	PF00397	0.334
DOC_WW_Pin1_4	95	100	PF00397	0.379
LIG_14-3-3_CanoR_1	3	12	PF00244	0.474
LIG_14-3-3_CanoR_1	372	378	PF00244	0.540
LIG_14-3-3_CanoR_1	499	509	PF00244	0.532
LIG_APCC_ABBA_1	224	229	PF00400	0.338
LIG_BRCT_BRCA1_1	167	171	PF00533	0.307
LIG_EH1_1	288	296	PF00400	0.231
LIG_eIF4E_1	289	295	PF01652	0.228
LIG_EVH1_1	117	121	PF00568	0.404
LIG_EVH1_2	221	225	PF00568	0.364
LIG_EVH1_2	99	103	PF00568	0.399
LIG_FHA_1	133	139	PF00498	0.298
LIG_FHA_1	241	247	PF00498	0.567
LIG_FHA_1	308	314	PF00498	0.490
LIG_FHA_1	333	339	PF00498	0.352
LIG_FHA_1	343	349	PF00498	0.231
LIG_FHA_1	89	95	PF00498	0.345
LIG_FHA_2	300	306	PF00498	0.446
LIG_FHA_2	353	359	PF00498	0.454
LIG_FHA_2	414	420	PF00498	0.332
LIG_FHA_2	85	91	PF00498	0.427
LIG_LIR_Apic_2	23	28	PF02991	0.653
LIG_LIR_Apic_2	267	273	PF02991	0.370
LIG_LIR_Apic_2	375	380	PF02991	0.418
LIG_LIR_Apic_2	65	69	PF02991	0.395
LIG_LIR_Apic_2	77	83	PF02991	0.384
LIG_LIR_Gen_1	260	269	PF02991	0.370
LIG_LIR_Gen_1	424	434	PF02991	0.511
LIG_LIR_Gen_1	447	456	PF02991	0.475
LIG_LIR_Nem_3	102	106	PF02991	0.383
LIG_LIR_Nem_3	115	120	PF02991	0.389
LIG_LIR_Nem_3	260	264	PF02991	0.368
LIG_LIR_Nem_3	424	429	PF02991	0.499
LIG_LIR_Nem_3	81	85	PF02991	0.523
LIG_LYPXL_yS_3	117	120	PF13949	0.386
LIG_PCNA_yPIPBox_3	283	295	PF02747	0.236
LIG_Pex14_2	103	107	PF04695	0.387
LIG_Pex14_2	414	418	PF04695	0.329
LIG_REV1ctd_RIR_1	411	421	PF16727	0.344
LIG_SH2_CRK	25	29	PF00017	0.575
LIG_SH2_CRK	259	263	PF00017	0.299
LIG_SH2_CRK	270	274	PF00017	0.377
LIG_SH2_GRB2like	106	109	PF00017	0.385
LIG_SH2_PTP2	212	215	PF00017	0.225
LIG_SH2_PTP2	323	326	PF00017	0.356
LIG_SH2_SRC	157	160	PF00017	0.391
LIG_SH2_SRC	347	350	PF00017	0.298
LIG_SH2_STAP1	175	179	PF00017	0.295
LIG_SH2_STAP1	259	263	PF00017	0.299
LIG_SH2_STAP1	70	74	PF00017	0.383
LIG_SH2_STAP1	85	89	PF00017	0.361
LIG_SH2_STAT5	147	150	PF00017	0.336
LIG_SH2_STAT5	157	160	PF00017	0.357
LIG_SH2_STAT5	212	215	PF00017	0.225
LIG_SH2_STAT5	259	262	PF00017	0.301
LIG_SH2_STAT5	323	326	PF00017	0.341
LIG_SH2_STAT5	347	350	PF00017	0.409
LIG_SH3_1	188	194	PF00018	0.418
LIG_SH3_1	402	408	PF00018	0.469
LIG_SH3_2	266	271	PF14604	0.336
LIG_SH3_3	115	121	PF00018	0.424
LIG_SH3_3	126	132	PF00018	0.379
LIG_SH3_3	166	172	PF00018	0.324
LIG_SH3_3	187	193	PF00018	0.472
LIG_SH3_3	263	269	PF00018	0.308
LIG_SH3_3	316	322	PF00018	0.374
LIG_SH3_3	402	408	PF00018	0.375
LIG_SH3_3	431	437	PF00018	0.399
LIG_SH3_3	506	512	PF00018	0.534
LIG_TRAF2_1	356	359	PF00917	0.516
LIG_TRFH_1	95	99	PF08558	0.474
LIG_TYR_ITSM	113	120	PF00017	0.485
LIG_UBA3_1	144	150	PF00899	0.474
LIG_WRC_WIRS_1	258	263	PF05994	0.380
MOD_CDK_SPK_2	196	201	PF00069	0.539
MOD_CK1_1	131	137	PF00069	0.505
MOD_CK1_1	235	241	PF00069	0.571
MOD_CK1_1	375	381	PF00069	0.664
MOD_CK1_1	409	415	PF00069	0.357
MOD_CK1_1	497	503	PF00069	0.509
MOD_CK2_1	107	113	PF00069	0.415
MOD_CK2_1	17	23	PF00069	0.440
MOD_CK2_1	352	358	PF00069	0.564
MOD_CK2_1	75	81	PF00069	0.526
MOD_GlcNHglycan	19	22	PF01048	0.586
MOD_GlcNHglycan	228	233	PF01048	0.577
MOD_GlcNHglycan	389	392	PF01048	0.430
MOD_GlcNHglycan	502	505	PF01048	0.501
MOD_GSK3_1	128	135	PF00069	0.403
MOD_GSK3_1	17	24	PF00069	0.550
MOD_GSK3_1	228	235	PF00069	0.428
MOD_GSK3_1	29	36	PF00069	0.547
MOD_GSK3_1	299	306	PF00069	0.334
MOD_GSK3_1	409	416	PF00069	0.338
MOD_GSK3_1	84	91	PF00069	0.451
MOD_LATS_1	350	356	PF00433	0.394
MOD_N-GLC_1	107	112	PF02516	0.362
MOD_N-GLC_1	165	170	PF02516	0.308
MOD_N-GLC_1	196	201	PF02516	0.314
MOD_N-GLC_1	95	100	PF02516	0.445
MOD_NEK2_1	112	117	PF00069	0.403
MOD_NEK2_1	203	208	PF00069	0.306
MOD_NEK2_1	342	347	PF00069	0.407
MOD_NEK2_1	373	378	PF00069	0.539
MOD_NEK2_1	413	418	PF00069	0.343
MOD_NEK2_1	486	491	PF00069	0.445
MOD_NEK2_1	494	499	PF00069	0.485
MOD_NEK2_1	5	10	PF00069	0.448
MOD_NEK2_1	75	80	PF00069	0.415
MOD_NEK2_2	393	398	PF00069	0.458
MOD_PIKK_1	272	278	PF00454	0.480
MOD_PIKK_1	29	35	PF00454	0.670
MOD_PKA_2	497	503	PF00069	0.447
MOD_PKA_2	5	11	PF00069	0.498
MOD_Plk_1	112	118	PF00069	0.398
MOD_Plk_1	165	171	PF00069	0.308
MOD_Plk_1	235	241	PF00069	0.533
MOD_Plk_1	70	76	PF00069	0.377
MOD_Plk_4	165	171	PF00069	0.317
MOD_Plk_4	220	226	PF00069	0.332
MOD_Plk_4	257	263	PF00069	0.315
MOD_Plk_4	303	309	PF00069	0.332
MOD_Plk_4	343	349	PF00069	0.367
MOD_Plk_4	409	415	PF00069	0.338
MOD_Plk_4	70	76	PF00069	0.382
MOD_ProDKin_1	128	134	PF00069	0.578
MOD_ProDKin_1	196	202	PF00069	0.529
MOD_ProDKin_1	262	268	PF00069	0.302
MOD_ProDKin_1	88	94	PF00069	0.340
MOD_ProDKin_1	95	101	PF00069	0.381
MOD_SUMO_rev_2	43	51	PF00179	0.463
TRG_DiLeu_BaEn_1	441	446	PF01217	0.552
TRG_DiLeu_BaEn_3	122	128	PF01217	0.312
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.321
TRG_ENDOCYTIC_2	117	120	PF00928	0.413
TRG_ENDOCYTIC_2	212	215	PF00928	0.312
TRG_ENDOCYTIC_2	258	261	PF00928	0.312
TRG_ENDOCYTIC_2	426	429	PF00928	0.511
TRG_ER_diArg_1	1	3	PF00400	0.554
TRG_ER_diArg_1	141	144	PF00400	0.354
TRG_ER_diArg_1	178	181	PF00400	0.423
TRG_ER_diArg_1	456	459	PF00400	0.463
TRG_ER_diArg_1	461	464	PF00400	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF7	Leptomonas seymouri	72%	100%
A0A0S4JIJ2	Bodo saltans	47%	100%
A0A1X0NW02	Trypanosomatidae	61%	100%
A0A3Q8ITB2	Leishmania donovani	86%	100%
A0A422NH53	Trypanosoma rangeli	60%	100%
A4I7Z2	Leishmania infantum	85%	100%
D0AA60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B2V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5A3	Leishmania major	84%	100%
V5BP31	Trypanosoma cruzi	59%	100%