Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKG3_LEIBR

TriTrypDb:

LbrM.32.1930 , LBRM2903_320025700

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.340
CLV_NRD_NRD_1	129	131	PF00675	0.443
CLV_NRD_NRD_1	205	207	PF00675	0.583
CLV_NRD_NRD_1	212	214	PF00675	0.643
CLV_NRD_NRD_1	304	306	PF00675	0.463
CLV_NRD_NRD_1	4	6	PF00675	0.539
CLV_NRD_NRD_1	436	438	PF00675	0.597
CLV_PCSK_FUR_1	2	6	PF00082	0.547
CLV_PCSK_FUR_1	302	306	PF00082	0.469
CLV_PCSK_FUR_1	358	362	PF00082	0.545
CLV_PCSK_KEX2_1	129	131	PF00082	0.502
CLV_PCSK_KEX2_1	205	207	PF00082	0.583
CLV_PCSK_KEX2_1	211	213	PF00082	0.651
CLV_PCSK_KEX2_1	304	306	PF00082	0.531
CLV_PCSK_KEX2_1	360	362	PF00082	0.574
CLV_PCSK_KEX2_1	4	6	PF00082	0.539
CLV_PCSK_KEX2_1	436	438	PF00082	0.540
CLV_PCSK_KEX2_1	505	507	PF00082	0.561
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.574
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.561
CLV_PCSK_PC7_1	125	131	PF00082	0.465
CLV_PCSK_PC7_1	356	362	PF00082	0.537
CLV_PCSK_SKI1_1	205	209	PF00082	0.724
CLV_PCSK_SKI1_1	313	317	PF00082	0.370
CLV_PCSK_SKI1_1	406	410	PF00082	0.532
CLV_PCSK_SKI1_1	498	502	PF00082	0.466
DEG_APCC_DBOX_1	239	247	PF00400	0.704
DEG_COP1_1	439	447	PF00400	0.529
DEG_Nend_UBRbox_1	1	4	PF02207	0.560
DEG_SPOP_SBC_1	264	268	PF00917	0.486
DOC_ANK_TNKS_1	341	348	PF00023	0.471
DOC_ANK_TNKS_1	360	367	PF00023	0.532
DOC_MAPK_gen_1	2	9	PF00069	0.548
DOC_MAPK_gen_1	382	391	PF00069	0.495
DOC_MAPK_MEF2A_6	148	157	PF00069	0.418
DOC_PP2B_LxvP_1	389	392	PF13499	0.458
DOC_PP2B_LxvP_1	42	45	PF13499	0.464
DOC_USP7_MATH_1	10	14	PF00917	0.692
DOC_USP7_MATH_1	27	31	PF00917	0.607
DOC_USP7_MATH_1	331	335	PF00917	0.334
DOC_USP7_MATH_1	354	358	PF00917	0.363
DOC_USP7_MATH_1	78	82	PF00917	0.468
DOC_USP7_UBL2_3	316	320	PF12436	0.371
DOC_USP7_UBL2_3	376	380	PF12436	0.642
DOC_WW_Pin1_4	12	17	PF00397	0.582
DOC_WW_Pin1_4	270	275	PF00397	0.504
DOC_WW_Pin1_4	446	451	PF00397	0.583
DOC_WW_Pin1_4	466	471	PF00397	0.525
LIG_14-3-3_CanoR_1	211	220	PF00244	0.548
LIG_14-3-3_CanoR_1	232	237	PF00244	0.496
LIG_14-3-3_CanoR_1	247	255	PF00244	0.507
LIG_14-3-3_CanoR_1	372	379	PF00244	0.404
LIG_14-3-3_CanoR_1	387	392	PF00244	0.402
LIG_14-3-3_CanoR_1	436	445	PF00244	0.651
LIG_14-3-3_CanoR_1	68	76	PF00244	0.482
LIG_14-3-3_CanoR_1	8	17	PF00244	0.483
LIG_AP2alpha_1	63	67	PF02296	0.366
LIG_BRCT_BRCA1_1	179	183	PF00533	0.339
LIG_BRCT_BRCA1_1	251	255	PF00533	0.566
LIG_BRCT_BRCA1_1	33	37	PF00533	0.616
LIG_Clathr_ClatBox_1	152	156	PF01394	0.480
LIG_FHA_1	147	153	PF00498	0.401
LIG_FHA_1	174	180	PF00498	0.384
LIG_FHA_1	339	345	PF00498	0.329
LIG_FHA_1	439	445	PF00498	0.600
LIG_FHA_1	93	99	PF00498	0.419
LIG_FHA_2	319	325	PF00498	0.344
LIG_FHA_2	441	447	PF00498	0.709
LIG_FHA_2	467	473	PF00498	0.739
LIG_FHA_2	502	508	PF00498	0.566
LIG_FHA_2	53	59	PF00498	0.490
LIG_LIR_Gen_1	156	165	PF02991	0.529
LIG_LIR_Gen_1	334	345	PF02991	0.443
LIG_LIR_Gen_1	472	482	PF02991	0.574
LIG_LIR_Gen_1	60	69	PF02991	0.529
LIG_LIR_Gen_1	91	102	PF02991	0.472
LIG_LIR_Nem_3	156	160	PF02991	0.542
LIG_LIR_Nem_3	186	192	PF02991	0.360
LIG_LIR_Nem_3	334	340	PF02991	0.441
LIG_LIR_Nem_3	472	477	PF02991	0.618
LIG_LIR_Nem_3	60	66	PF02991	0.541
LIG_LIR_Nem_3	91	97	PF02991	0.474
LIG_LYPXL_SIV_4	473	481	PF13949	0.495
LIG_Pex14_1	185	189	PF04695	0.339
LIG_Pex14_2	63	67	PF04695	0.523
LIG_Rb_LxCxE_1	169	188	PF01857	0.339
LIG_REV1ctd_RIR_1	64	72	PF16727	0.487
LIG_RPA_C_Fungi	118	130	PF08784	0.341
LIG_SH2_CRK	189	193	PF00017	0.371
LIG_SH2_PTP2	474	477	PF00017	0.512
LIG_SH2_STAT3	242	245	PF00017	0.592
LIG_SH2_STAT3	349	352	PF00017	0.504
LIG_SH2_STAT5	242	245	PF00017	0.576
LIG_SH2_STAT5	474	477	PF00017	0.520
LIG_SH2_STAT5	75	78	PF00017	0.403
LIG_SH3_2	45	50	PF14604	0.542
LIG_SH3_3	16	22	PF00018	0.576
LIG_SH3_3	214	220	PF00018	0.564
LIG_SH3_3	42	48	PF00018	0.524
LIG_SH3_3	444	450	PF00018	0.568
LIG_Sin3_3	115	122	PF02671	0.499
LIG_SUMO_SIM_par_1	15	20	PF11976	0.478
LIG_SUMO_SIM_par_1	151	156	PF11976	0.434
LIG_TRAF2_1	350	353	PF00917	0.626
LIG_TRAF2_1	412	415	PF00917	0.663
LIG_TRAF2_1	77	80	PF00917	0.530
LIG_TRAF2_1	88	91	PF00917	0.396
LIG_UBA3_1	132	138	PF00899	0.495
MOD_CDC14_SPxK_1	20	23	PF00782	0.487
MOD_CDK_SPxK_1	17	23	PF00069	0.485
MOD_CK1_1	235	241	PF00069	0.548
MOD_CK1_1	250	256	PF00069	0.686
MOD_CK1_1	38	44	PF00069	0.475
MOD_CK1_1	439	445	PF00069	0.604
MOD_CK1_1	449	455	PF00069	0.592
MOD_CK1_1	466	472	PF00069	0.674
MOD_CK1_1	81	87	PF00069	0.336
MOD_CK2_1	235	241	PF00069	0.501
MOD_CK2_1	409	415	PF00069	0.815
MOD_CK2_1	466	472	PF00069	0.716
MOD_CK2_1	501	507	PF00069	0.547
MOD_CK2_1	52	58	PF00069	0.503
MOD_CK2_1	74	80	PF00069	0.489
MOD_Cter_Amidation	2	5	PF01082	0.546
MOD_GlcNHglycan	208	211	PF01048	0.504
MOD_GlcNHglycan	229	232	PF01048	0.562
MOD_GlcNHglycan	24	27	PF01048	0.597
MOD_GlcNHglycan	249	252	PF01048	0.541
MOD_GlcNHglycan	255	258	PF01048	0.587
MOD_GlcNHglycan	29	32	PF01048	0.557
MOD_GlcNHglycan	37	40	PF01048	0.525
MOD_GlcNHglycan	428	431	PF01048	0.560
MOD_GlcNHglycan	451	454	PF01048	0.691
MOD_GlcNHglycan	459	462	PF01048	0.815
MOD_GlcNHglycan	76	79	PF01048	0.460
MOD_GSK3_1	173	180	PF00069	0.329
MOD_GSK3_1	232	239	PF00069	0.646
MOD_GSK3_1	249	256	PF00069	0.563
MOD_GSK3_1	27	34	PF00069	0.592
MOD_GSK3_1	278	285	PF00069	0.569
MOD_GSK3_1	387	394	PF00069	0.443
MOD_GSK3_1	406	413	PF00069	0.745
MOD_GSK3_1	436	443	PF00069	0.606
MOD_GSK3_1	501	508	PF00069	0.589
MOD_GSK3_1	74	81	PF00069	0.387
MOD_N-GLC_1	456	461	PF02516	0.689
MOD_N-GLC_2	495	497	PF02516	0.423
MOD_NEK2_1	263	268	PF00069	0.545
MOD_NEK2_1	278	283	PF00069	0.688
MOD_NEK2_1	318	323	PF00069	0.349
MOD_NEK2_1	338	343	PF00069	0.442
MOD_NEK2_1	35	40	PF00069	0.565
MOD_NEK2_1	67	72	PF00069	0.602
MOD_NEK2_2	78	83	PF00069	0.333
MOD_PIKK_1	371	377	PF00454	0.647
MOD_PIKK_1	67	73	PF00454	0.349
MOD_PK_1	232	238	PF00069	0.466
MOD_PK_1	387	393	PF00069	0.439
MOD_PKA_1	205	211	PF00069	0.634
MOD_PKA_1	212	218	PF00069	0.649
MOD_PKA_1	436	442	PF00069	0.587
MOD_PKA_1	505	511	PF00069	0.473
MOD_PKA_2	205	211	PF00069	0.641
MOD_PKA_2	212	218	PF00069	0.638
MOD_PKA_2	227	233	PF00069	0.674
MOD_PKA_2	236	242	PF00069	0.528
MOD_PKA_2	253	259	PF00069	0.652
MOD_PKA_2	371	377	PF00069	0.647
MOD_PKA_2	409	415	PF00069	0.659
MOD_PKA_2	436	442	PF00069	0.673
MOD_PKA_2	505	511	PF00069	0.473
MOD_PKA_2	67	73	PF00069	0.349
MOD_PKB_1	385	393	PF00069	0.431
MOD_Plk_1	31	37	PF00069	0.548
MOD_Plk_1	332	338	PF00069	0.331
MOD_Plk_1	498	504	PF00069	0.527
MOD_Plk_1	78	84	PF00069	0.358
MOD_Plk_2-3	400	406	PF00069	0.523
MOD_Plk_2-3	54	60	PF00069	0.447
MOD_Plk_4	278	284	PF00069	0.596
MOD_Plk_4	31	37	PF00069	0.532
MOD_Plk_4	38	44	PF00069	0.467
MOD_Plk_4	451	457	PF00069	0.574
MOD_ProDKin_1	12	18	PF00069	0.580
MOD_ProDKin_1	270	276	PF00069	0.504
MOD_ProDKin_1	446	452	PF00069	0.584
MOD_ProDKin_1	466	472	PF00069	0.528
TRG_DiLeu_BaEn_1	113	118	PF01217	0.555
TRG_DiLeu_BaEn_1	156	161	PF01217	0.484
TRG_DiLeu_BaEn_4	174	180	PF01217	0.376
TRG_DiLeu_BaEn_4	414	420	PF01217	0.535
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.614
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.331
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.503
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.489
TRG_ENDOCYTIC_2	189	192	PF00928	0.366
TRG_ENDOCYTIC_2	474	477	PF00928	0.549
TRG_ER_diArg_1	1	4	PF00400	0.553
TRG_ER_diArg_1	129	131	PF00400	0.447
TRG_ER_diArg_1	205	207	PF00400	0.468
TRG_ER_diArg_1	211	213	PF00400	0.521
TRG_ER_diArg_1	295	298	PF00400	0.547
TRG_ER_diArg_1	302	305	PF00400	0.529
TRG_ER_diArg_1	384	387	PF00400	0.607
TRG_ER_diArg_1	435	437	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW1	Leptomonas seymouri	42%	89%
A0A3Q8IG72	Leishmania donovani	62%	100%
A0A3R7MFC1	Trypanosoma rangeli	25%	87%
A4I7Z1	Leishmania infantum	62%	100%
E9B2V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q5A4	Leishmania major	59%	98%