Pumilio/PUF RNA binding protein 7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio/PUF RNA binding protein 7, putative

Species:

Leishmania braziliensis

UniProt:

A4HKG2_LEIBR

TriTrypDb:

LbrM.32.1920 , LBRM2903_320025600

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKG2

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.489
CLV_C14_Caspase3-7	243	247	PF00656	0.416
CLV_C14_Caspase3-7	360	364	PF00656	0.428
CLV_C14_Caspase3-7	592	596	PF00656	0.729
CLV_NRD_NRD_1	357	359	PF00675	0.517
CLV_NRD_NRD_1	397	399	PF00675	0.613
CLV_NRD_NRD_1	606	608	PF00675	0.579
CLV_NRD_NRD_1	654	656	PF00675	0.409
CLV_NRD_NRD_1	83	85	PF00675	0.431
CLV_PCSK_KEX2_1	128	130	PF00082	0.400
CLV_PCSK_KEX2_1	402	404	PF00082	0.570
CLV_PCSK_KEX2_1	714	716	PF00082	0.703
CLV_PCSK_KEX2_1	729	731	PF00082	0.437
CLV_PCSK_KEX2_1	762	764	PF00082	0.600
CLV_PCSK_KEX2_1	83	85	PF00082	0.431
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.286
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.570
CLV_PCSK_PC1ET2_1	714	716	PF00082	0.739
CLV_PCSK_PC1ET2_1	729	731	PF00082	0.652
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.600
CLV_PCSK_PC7_1	398	404	PF00082	0.566
CLV_PCSK_PC7_1	725	731	PF00082	0.557
CLV_PCSK_SKI1_1	15	19	PF00082	0.376
CLV_PCSK_SKI1_1	359	363	PF00082	0.531
CLV_PCSK_SKI1_1	434	438	PF00082	0.384
CLV_PCSK_SKI1_1	640	644	PF00082	0.474
CLV_PCSK_SKI1_1	655	659	PF00082	0.463
CLV_PCSK_SKI1_1	677	681	PF00082	0.399
CLV_PCSK_SKI1_1	725	729	PF00082	0.617
CLV_PCSK_SKI1_1	762	766	PF00082	0.636
CLV_PCSK_SKI1_1	84	88	PF00082	0.518
DEG_APCC_DBOX_1	639	647	PF00400	0.273
DEG_APCC_DBOX_1	676	684	PF00400	0.382
DEG_APCC_DBOX_1	82	90	PF00400	0.448
DEG_SCF_FBW7_2	261	268	PF00400	0.445
DEG_SPOP_SBC_1	412	416	PF00917	0.545
DOC_CKS1_1	238	243	PF01111	0.570
DOC_CKS1_1	262	267	PF01111	0.454
DOC_CYCLIN_RxL_1	15	28	PF00134	0.535
DOC_CYCLIN_RxL_1	356	363	PF00134	0.550
DOC_CYCLIN_RxL_1	634	645	PF00134	0.506
DOC_CYCLIN_RxL_1	649	661	PF00134	0.526
DOC_CYCLIN_RxL_1	759	767	PF00134	0.707
DOC_CYCLIN_RxL_1	81	88	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	260	263	PF00134	0.344
DOC_MAPK_gen_1	236	244	PF00069	0.561
DOC_MAPK_gen_1	83	89	PF00069	0.436
DOC_MAPK_MEF2A_6	341	348	PF00069	0.391
DOC_MAPK_MEF2A_6	57	66	PF00069	0.420
DOC_PP1_RVXF_1	160	167	PF00149	0.263
DOC_PP1_RVXF_1	3	9	PF00149	0.482
DOC_PP1_RVXF_1	494	501	PF00149	0.307
DOC_PP1_RVXF_1	694	701	PF00149	0.464
DOC_PP2B_LxvP_1	260	263	PF13499	0.344
DOC_USP7_MATH_1	217	221	PF00917	0.515
DOC_USP7_MATH_1	391	395	PF00917	0.643
DOC_USP7_MATH_1	412	416	PF00917	0.808
DOC_USP7_MATH_1	421	425	PF00917	0.532
DOC_USP7_MATH_1	432	436	PF00917	0.206
DOC_USP7_MATH_1	465	469	PF00917	0.554
DOC_USP7_MATH_1	507	511	PF00917	0.460
DOC_USP7_MATH_1	547	551	PF00917	0.298
DOC_USP7_UBL2_3	395	399	PF12436	0.798
DOC_USP7_UBL2_3	41	45	PF12436	0.406
DOC_USP7_UBL2_3	604	608	PF12436	0.641
DOC_WW_Pin1_4	237	242	PF00397	0.536
DOC_WW_Pin1_4	261	266	PF00397	0.596
DOC_WW_Pin1_4	298	303	PF00397	0.547
DOC_WW_Pin1_4	370	375	PF00397	0.738
DOC_WW_Pin1_4	468	473	PF00397	0.413
DOC_WW_Pin1_4	517	522	PF00397	0.323
DOC_WW_Pin1_4	669	674	PF00397	0.413
DOC_WW_Pin1_4	89	94	PF00397	0.344
LIG_14-3-3_CanoR_1	223	231	PF00244	0.294
LIG_14-3-3_CanoR_1	358	362	PF00244	0.293
LIG_14-3-3_CanoR_1	715	721	PF00244	0.601
LIG_14-3-3_CanoR_1	763	769	PF00244	0.509
LIG_Actin_WH2_2	40	58	PF00022	0.486
LIG_Actin_WH2_2	483	498	PF00022	0.446
LIG_BRCT_BRCA1_1	162	166	PF00533	0.268
LIG_BRCT_BRCA1_1	496	500	PF00533	0.571
LIG_EH1_1	636	644	PF00400	0.383
LIG_eIF4E_1	255	261	PF01652	0.300
LIG_eIF4E_1	637	643	PF01652	0.419
LIG_EVH1_1	261	265	PF00568	0.408
LIG_FHA_1	230	236	PF00498	0.486
LIG_FHA_1	428	434	PF00498	0.432
LIG_FHA_1	452	458	PF00498	0.575
LIG_FHA_1	499	505	PF00498	0.493
LIG_FHA_1	57	63	PF00498	0.441
LIG_FHA_1	592	598	PF00498	0.507
LIG_FHA_1	646	652	PF00498	0.539
LIG_FHA_2	238	244	PF00498	0.500
LIG_FHA_2	327	333	PF00498	0.554
LIG_FHA_2	358	364	PF00498	0.372
LIG_FHA_2	405	411	PF00498	0.809
LIG_FHA_2	438	444	PF00498	0.501
LIG_FHA_2	446	452	PF00498	0.530
LIG_FHA_2	63	69	PF00498	0.445
LIG_LIR_Apic_2	258	262	PF02991	0.489
LIG_LIR_Apic_2	278	284	PF02991	0.619
LIG_LIR_Gen_1	322	331	PF02991	0.434
LIG_LIR_Gen_1	440	449	PF02991	0.303
LIG_LIR_Gen_1	497	508	PF02991	0.539
LIG_LIR_Gen_1	616	627	PF02991	0.355
LIG_LIR_Nem_3	124	130	PF02991	0.433
LIG_LIR_Nem_3	163	169	PF02991	0.314
LIG_LIR_Nem_3	190	196	PF02991	0.441
LIG_LIR_Nem_3	285	289	PF02991	0.569
LIG_LIR_Nem_3	322	327	PF02991	0.430
LIG_LIR_Nem_3	440	444	PF02991	0.290
LIG_LIR_Nem_3	497	503	PF02991	0.552
LIG_LIR_Nem_3	616	622	PF02991	0.399
LIG_NRBOX	230	236	PF00104	0.413
LIG_NRBOX	361	367	PF00104	0.302
LIG_NRBOX	490	496	PF00104	0.491
LIG_NRBOX	62	68	PF00104	0.437
LIG_PCNA_yPIPBox_3	96	109	PF02747	0.336
LIG_PTB_Apo_2	694	701	PF02174	0.423
LIG_SH2_CRK	308	312	PF00017	0.542
LIG_SH2_CRK	33	37	PF00017	0.500
LIG_SH2_NCK_1	196	200	PF00017	0.579
LIG_SH2_SRC	177	180	PF00017	0.457
LIG_SH2_SRC	196	199	PF00017	0.379
LIG_SH2_STAP1	255	259	PF00017	0.377
LIG_SH2_STAT5	177	180	PF00017	0.483
LIG_SH2_STAT5	259	262	PF00017	0.439
LIG_SH2_STAT5	308	311	PF00017	0.363
LIG_SH2_STAT5	637	640	PF00017	0.421
LIG_SH3_1	259	265	PF00018	0.372
LIG_SH3_3	149	155	PF00018	0.473
LIG_SH3_3	259	265	PF00018	0.372
LIG_SH3_3	466	472	PF00018	0.419
LIG_SH3_3	501	507	PF00018	0.540
LIG_SH3_3	521	527	PF00018	0.218
LIG_SH3_4	395	402	PF00018	0.558
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.342
LIG_SUMO_SIM_anti_2	562	568	PF11976	0.223
LIG_SUMO_SIM_par_1	240	246	PF11976	0.490
LIG_SUMO_SIM_par_1	423	431	PF11976	0.533
LIG_SUMO_SIM_par_1	62	68	PF11976	0.465
LIG_TRAF2_1	265	268	PF00917	0.650
LIG_TRAF2_1	577	580	PF00917	0.470
LIG_TRFH_1	259	263	PF08558	0.333
LIG_UBA3_1	102	111	PF00899	0.264
LIG_UBA3_1	333	341	PF00899	0.426
LIG_UBA3_1	490	496	PF00899	0.302
LIG_UBA3_1	658	663	PF00899	0.415
LIG_WRC_WIRS_1	438	443	PF05994	0.283
LIG_WW_3	395	399	PF00397	0.553
MOD_CK1_1	225	231	PF00069	0.499
MOD_CK1_1	383	389	PF00069	0.741
MOD_CK1_1	401	407	PF00069	0.681
MOD_CK1_1	468	474	PF00069	0.498
MOD_CK1_1	708	714	PF00069	0.635
MOD_CK1_1	741	747	PF00069	0.673
MOD_CK2_1	192	198	PF00069	0.549
MOD_CK2_1	237	243	PF00069	0.538
MOD_CK2_1	437	443	PF00069	0.337
MOD_CK2_1	445	451	PF00069	0.394
MOD_CK2_1	603	609	PF00069	0.624
MOD_CK2_1	746	752	PF00069	0.769
MOD_GlcNHglycan	291	294	PF01048	0.706
MOD_GlcNHglycan	367	370	PF01048	0.565
MOD_GlcNHglycan	385	388	PF01048	0.555
MOD_GlcNHglycan	487	490	PF01048	0.492
MOD_GlcNHglycan	687	690	PF01048	0.470
MOD_GlcNHglycan	748	751	PF01048	0.787
MOD_GSK3_1	225	232	PF00069	0.468
MOD_GSK3_1	296	303	PF00069	0.408
MOD_GSK3_1	365	372	PF00069	0.542
MOD_GSK3_1	377	384	PF00069	0.736
MOD_GSK3_1	387	394	PF00069	0.679
MOD_GSK3_1	398	405	PF00069	0.636
MOD_GSK3_1	413	420	PF00069	0.462
MOD_GSK3_1	447	454	PF00069	0.488
MOD_GSK3_1	494	501	PF00069	0.566
MOD_GSK3_1	51	58	PF00069	0.426
MOD_GSK3_1	561	568	PF00069	0.432
MOD_GSK3_1	716	723	PF00069	0.531
MOD_GSK3_1	741	748	PF00069	0.676
MOD_LATS_1	160	166	PF00433	0.262
MOD_N-GLC_1	377	382	PF02516	0.773
MOD_N-GLC_1	55	60	PF02516	0.488
MOD_N-GLC_1	589	594	PF02516	0.481
MOD_N-GLC_1	613	618	PF02516	0.442
MOD_NEK2_1	229	234	PF00069	0.317
MOD_NEK2_1	288	293	PF00069	0.488
MOD_NEK2_1	365	370	PF00069	0.537
MOD_NEK2_1	437	442	PF00069	0.346
MOD_NEK2_1	512	517	PF00069	0.454
MOD_NEK2_1	55	60	PF00069	0.407
MOD_NEK2_1	613	618	PF00069	0.442
MOD_NEK2_1	764	769	PF00069	0.629
MOD_NEK2_2	217	222	PF00069	0.279
MOD_PIKK_1	451	457	PF00454	0.521
MOD_PIKK_1	743	749	PF00454	0.532
MOD_PKA_1	398	404	PF00069	0.820
MOD_PKA_1	714	720	PF00069	0.503
MOD_PKA_2	222	228	PF00069	0.469
MOD_PKA_2	357	363	PF00069	0.293
MOD_PKA_2	402	408	PF00069	0.834
MOD_PKA_2	445	451	PF00069	0.553
MOD_PKA_2	714	720	PF00069	0.609
MOD_Plk_1	225	231	PF00069	0.391
MOD_Plk_1	561	567	PF00069	0.413
MOD_Plk_4	217	223	PF00069	0.456
MOD_Plk_4	225	231	PF00069	0.419
MOD_Plk_4	357	363	PF00069	0.468
MOD_Plk_4	421	427	PF00069	0.568
MOD_Plk_4	507	513	PF00069	0.336
MOD_Plk_4	561	567	PF00069	0.359
MOD_Plk_4	62	68	PF00069	0.379
MOD_Plk_4	94	100	PF00069	0.449
MOD_ProDKin_1	237	243	PF00069	0.539
MOD_ProDKin_1	261	267	PF00069	0.609
MOD_ProDKin_1	298	304	PF00069	0.533
MOD_ProDKin_1	370	376	PF00069	0.743
MOD_ProDKin_1	468	474	PF00069	0.410
MOD_ProDKin_1	517	523	PF00069	0.330
MOD_ProDKin_1	669	675	PF00069	0.407
MOD_ProDKin_1	89	95	PF00069	0.344
MOD_SUMO_for_1	577	580	PF00179	0.343
MOD_SUMO_rev_2	123	130	PF00179	0.379
MOD_SUMO_rev_2	652	658	PF00179	0.516
MOD_SUMO_rev_2	734	744	PF00179	0.655
MOD_SUMO_rev_2	748	756	PF00179	0.765
TRG_DiLeu_BaEn_1	499	504	PF01217	0.453
TRG_DiLeu_BaEn_1	654	659	PF01217	0.524
TRG_DiLeu_BaEn_4	226	232	PF01217	0.505
TRG_DiLeu_BaEn_4	278	284	PF01217	0.511
TRG_ENDOCYTIC_2	308	311	PF00928	0.420
TRG_ENDOCYTIC_2	619	622	PF00928	0.598
TRG_ER_diArg_1	646	649	PF00400	0.465
TRG_ER_diArg_1	82	84	PF00400	0.411
TRG_NLS_MonoCore_2	759	764	PF00514	0.741
TRG_NLS_MonoExtN_4	757	764	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	640	645	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	649	654	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICI6	Leptomonas seymouri	66%	100%
A0A0S4JFA8	Bodo saltans	40%	100%
A0A1X0NUE8	Trypanosomatidae	42%	100%
A0A3Q8IJA2	Leishmania donovani	80%	99%
A0A422NH58	Trypanosoma rangeli	44%	100%
A4I7Z0	Leishmania infantum	80%	99%
D0AA57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B2V1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4Q5A5	Leishmania major	79%	100%
V5DFW5	Trypanosoma cruzi	44%	100%