Putative zinc finger protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HKG1_LEIBR

TriTrypDb:

LbrM.32.1910 , LBRM2903_320025500

Length:

127

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HKG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKG1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	19
GO:0043167	ion binding	2	19
GO:0043169	cation binding	3	19
GO:0046872	metal ion binding	4	19
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.433
CLV_NRD_NRD_1	73	75	PF00675	0.596
CLV_PCSK_FUR_1	71	75	PF00082	0.621
CLV_PCSK_KEX2_1	12	14	PF00082	0.433
CLV_PCSK_KEX2_1	73	75	PF00082	0.596
DEG_Nend_UBRbox_3	1	3	PF02207	0.587
DEG_SCF_FBW7_2	31	38	PF00400	0.440
DOC_MAPK_gen_1	80	89	PF00069	0.487
DOC_PP4_MxPP_1	18	21	PF00568	0.716
DOC_PP4_MxPP_1	59	62	PF00568	0.414
DOC_USP7_MATH_1	104	108	PF00917	0.363
DOC_USP7_MATH_1	119	123	PF00917	0.519
DOC_USP7_MATH_1	62	66	PF00917	0.539
DOC_USP7_UBL2_3	80	84	PF12436	0.499
DOC_WW_Pin1_4	31	36	PF00397	0.440
LIG_14-3-3_CanoR_1	47	54	PF00244	0.363
LIG_KLC1_Yacidic_2	38	43	PF13176	0.363
LIG_LIR_Apic_2	48	54	PF02991	0.335
LIG_LIR_Apic_2	65	69	PF02991	0.400
LIG_Pex14_1	29	33	PF04695	0.347
LIG_SH2_CRK	66	70	PF00017	0.584
LIG_SH2_SRC	41	44	PF00017	0.360
LIG_SH2_STAT3	57	60	PF00017	0.626
LIG_SH2_STAT5	33	36	PF00017	0.397
LIG_SH2_STAT5	4	7	PF00017	0.619
LIG_SH2_STAT5	41	44	PF00017	0.316
LIG_SH3_3	14	20	PF00018	0.593
LIG_TRAF2_1	106	109	PF00917	0.536
MOD_CK1_1	96	102	PF00069	0.357
MOD_CK2_1	103	109	PF00069	0.363
MOD_CK2_1	24	30	PF00069	0.363
MOD_GlcNHglycan	121	124	PF01048	0.675
MOD_GlcNHglycan	26	29	PF01048	0.253
MOD_GSK3_1	104	111	PF00069	0.534
MOD_GSK3_1	76	83	PF00069	0.582
MOD_PKA_2	46	52	PF00069	0.363
MOD_Plk_1	55	61	PF00069	0.663
MOD_ProDKin_1	31	37	PF00069	0.440
TRG_ENDOCYTIC_2	15	18	PF00928	0.562
TRG_ER_diArg_1	71	74	PF00400	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E5	Leptomonas seymouri	46%	100%
A0A0N0P975	Leptomonas seymouri	80%	99%
A0A0S4IT37	Bodo saltans	43%	88%
A0A1X0NLL7	Trypanosomatidae	46%	97%
A0A3R7NZE2	Trypanosoma rangeli	40%	88%
A0A3S7X0B7	Leishmania donovani	46%	84%
A0A3S7X5L3	Leishmania donovani	87%	98%
A0A422NH81	Trypanosoma rangeli	63%	73%
A4HFD2	Leishmania braziliensis	43%	100%
A4I363	Leishmania infantum	46%	84%
A4I7Y9	Leishmania infantum	87%	98%
C9ZKV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	98%
D0AA56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	91%
E9ACZ0	Leishmania major	46%	100%
E9AYR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B2V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q4Q5A6	Leishmania major	88%	100%