Coatomer subunit epsilon

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

coatomer subunit epsilon

Species:

Leishmania braziliensis

UniProt:

A4HKG0_LEIBR

TriTrypDb:

LbrM.32.1900 , LBRM2903_320025400

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	11
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	11
GO:0031410	cytoplasmic vesicle	6	11
GO:0031982	vesicle	4	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0097708	intracellular vesicle	5	11
GO:0098588	bounding membrane of organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005794	Golgi apparatus	5	2
GO:0030117	membrane coat	3	1
GO:0030120	vesicle coat	4	1
GO:0030126	COPI vesicle coat	5	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4HKG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKG0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	12
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0048193	Golgi vesicle transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0046907	intracellular transport	3	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.582
CLV_C14_Caspase3-7	255	259	PF00656	0.514
CLV_C14_Caspase3-7	300	304	PF00656	0.422
CLV_NRD_NRD_1	76	78	PF00675	0.205
CLV_PCSK_KEX2_1	182	184	PF00082	0.381
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.383
CLV_PCSK_SKI1_1	117	121	PF00082	0.446
CLV_PCSK_SKI1_1	179	183	PF00082	0.414
CLV_PCSK_SKI1_1	254	258	PF00082	0.263
CLV_PCSK_SKI1_1	44	48	PF00082	0.246
CLV_PCSK_SKI1_1	9	13	PF00082	0.276
DEG_APCC_DBOX_1	253	261	PF00400	0.474
DOC_CYCLIN_RxL_1	251	261	PF00134	0.474
DOC_USP7_MATH_1	22	26	PF00917	0.474
DOC_USP7_MATH_1	252	256	PF00917	0.480
DOC_USP7_MATH_1	29	33	PF00917	0.517
DOC_USP7_MATH_1	35	39	PF00917	0.405
LIG_14-3-3_CanoR_1	155	159	PF00244	0.404
LIG_14-3-3_CanoR_1	228	234	PF00244	0.414
LIG_14-3-3_CanoR_1	28	37	PF00244	0.530
LIG_FHA_1	121	127	PF00498	0.409
LIG_FHA_1	155	161	PF00498	0.447
LIG_FHA_1	98	104	PF00498	0.529
LIG_FHA_2	298	304	PF00498	0.422
LIG_LIR_Nem_3	194	200	PF02991	0.536
LIG_LIR_Nem_3	220	225	PF02991	0.532
LIG_LIR_Nem_3	88	92	PF02991	0.516
LIG_Pex14_1	301	305	PF04695	0.463
LIG_SH2_CRK	116	120	PF00017	0.468
LIG_SH2_CRK	197	201	PF00017	0.530
LIG_SH2_NCK_1	249	253	PF00017	0.530
LIG_SH2_STAP1	156	160	PF00017	0.376
LIG_SH2_STAT3	290	293	PF00017	0.474
LIG_SH2_STAT5	156	159	PF00017	0.453
LIG_SH2_STAT5	290	293	PF00017	0.481
LIG_SUMO_SIM_par_1	67	75	PF11976	0.537
LIG_TYR_ITIM	195	200	PF00017	0.530
LIG_UBA3_1	72	78	PF00899	0.405
MOD_CK1_1	217	223	PF00069	0.607
MOD_CK2_1	261	267	PF00069	0.543
MOD_CK2_1	95	101	PF00069	0.506
MOD_GlcNHglycan	197	200	PF01048	0.288
MOD_GlcNHglycan	216	219	PF01048	0.300
MOD_GlcNHglycan	316	319	PF01048	0.381
MOD_GlcNHglycan	36	40	PF01048	0.238
MOD_GlcNHglycan	97	100	PF01048	0.347
MOD_GSK3_1	191	198	PF00069	0.474
MOD_GSK3_1	229	236	PF00069	0.551
MOD_GSK3_1	293	300	PF00069	0.495
MOD_GSK3_1	35	42	PF00069	0.485
MOD_GSK3_1	60	67	PF00069	0.531
MOD_NEK2_1	120	125	PF00069	0.386
MOD_NEK2_1	195	200	PF00069	0.484
MOD_NEK2_1	72	77	PF00069	0.553
MOD_PIKK_1	60	66	PF00454	0.506
MOD_PKA_2	154	160	PF00069	0.423
MOD_Plk_1	252	258	PF00069	0.486
MOD_Plk_1	266	272	PF00069	0.529
MOD_Plk_1	35	41	PF00069	0.521
MOD_Plk_4	191	197	PF00069	0.494
MOD_Plk_4	229	235	PF00069	0.463
MOD_Plk_4	57	63	PF00069	0.505
MOD_SUMO_rev_2	175	184	PF00179	0.507
TRG_DiLeu_BaEn_1	43	48	PF01217	0.414
TRG_DiLeu_LyEn_5	68	73	PF01217	0.565
TRG_ENDOCYTIC_2	116	119	PF00928	0.469
TRG_ENDOCYTIC_2	197	200	PF00928	0.535
TRG_ENDOCYTIC_2	89	92	PF00928	0.585
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9J3	Leptomonas seymouri	71%	100%
A0A0S4JK00	Bodo saltans	41%	100%
A0A1X0NVS2	Trypanosomatidae	49%	97%
A0A3Q8IFX8	Leishmania donovani	85%	100%
A0A3R7RKY5	Trypanosoma rangeli	46%	100%
A2XY73	Oryza sativa subsp. indica	27%	100%
A4I7Y8	Leishmania infantum	85%	100%
D0AA50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B2U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O14579	Homo sapiens	27%	100%
O62246	Caenorhabditis elegans	25%	100%
O89079	Mus musculus	25%	100%
P0C541	Oryza sativa subsp. japonica	27%	100%
Q28104	Bos taurus	26%	100%
Q4Q5A7	Leishmania major	84%	100%
Q5RFR8	Pongo abelii	27%	100%
Q5ZIK9	Gallus gallus	26%	100%
Q60445	Cricetulus griseus	26%	100%
Q9MAX6	Oryza sativa subsp. japonica	24%	100%
Q9SA78	Arabidopsis thaliana	24%	100%
V5BJL5	Trypanosoma cruzi	48%	100%