RNA methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKF8_LEIBR

TriTrypDb:

LbrM.32.1880 , LBRM2903_320025200

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKF8

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.354
CLV_C14_Caspase3-7	196	200	PF00656	0.415
CLV_C14_Caspase3-7	299	303	PF00656	0.586
CLV_NRD_NRD_1	2	4	PF00675	0.726
CLV_NRD_NRD_1	214	216	PF00675	0.508
CLV_NRD_NRD_1	31	33	PF00675	0.553
CLV_NRD_NRD_1	319	321	PF00675	0.592
CLV_NRD_NRD_1	403	405	PF00675	0.388
CLV_NRD_NRD_1	465	467	PF00675	0.410
CLV_NRD_NRD_1	569	571	PF00675	0.542
CLV_PCSK_KEX2_1	2	4	PF00082	0.726
CLV_PCSK_KEX2_1	214	216	PF00082	0.508
CLV_PCSK_KEX2_1	31	33	PF00082	0.563
CLV_PCSK_KEX2_1	319	321	PF00082	0.577
CLV_PCSK_KEX2_1	403	405	PF00082	0.424
CLV_PCSK_KEX2_1	465	467	PF00082	0.498
CLV_PCSK_KEX2_1	569	571	PF00082	0.542
CLV_PCSK_SKI1_1	106	110	PF00082	0.570
CLV_PCSK_SKI1_1	113	117	PF00082	0.529
CLV_PCSK_SKI1_1	162	166	PF00082	0.704
CLV_PCSK_SKI1_1	215	219	PF00082	0.495
CLV_PCSK_SKI1_1	221	225	PF00082	0.626
CLV_PCSK_SKI1_1	354	358	PF00082	0.499
CLV_PCSK_SKI1_1	395	399	PF00082	0.415
CLV_PCSK_SKI1_1	569	573	PF00082	0.565
DEG_Nend_UBRbox_1	1	4	PF02207	0.710
DEG_SPOP_SBC_1	558	562	PF00917	0.465
DOC_CKS1_1	223	228	PF01111	0.475
DOC_CKS1_1	355	360	PF01111	0.684
DOC_CYCLIN_RxL_1	212	222	PF00134	0.554
DOC_CYCLIN_yClb3_PxF_3	152	158	PF00134	0.421
DOC_CYCLIN_yClb3_PxF_3	374	382	PF00134	0.547
DOC_PP1_RVXF_1	111	117	PF00149	0.489
DOC_PP2B_LxvP_1	12	15	PF13499	0.701
DOC_PP2B_LxvP_1	333	336	PF13499	0.657
DOC_PP2B_LxvP_1	597	600	PF13499	0.340
DOC_PP4_FxxP_1	150	153	PF00568	0.363
DOC_PP4_MxPP_1	72	75	PF00568	0.261
DOC_USP7_MATH_1	115	119	PF00917	0.750
DOC_USP7_MATH_1	309	313	PF00917	0.402
DOC_USP7_MATH_1	336	340	PF00917	0.649
DOC_USP7_MATH_1	418	422	PF00917	0.746
DOC_USP7_MATH_1	473	477	PF00917	0.515
DOC_USP7_MATH_1	489	493	PF00917	0.623
DOC_USP7_MATH_1	503	507	PF00917	0.627
DOC_USP7_MATH_1	557	561	PF00917	0.571
DOC_USP7_MATH_1	59	63	PF00917	0.381
DOC_WW_Pin1_4	148	153	PF00397	0.372
DOC_WW_Pin1_4	168	173	PF00397	0.448
DOC_WW_Pin1_4	222	227	PF00397	0.589
DOC_WW_Pin1_4	349	354	PF00397	0.724
DOC_WW_Pin1_4	364	369	PF00397	0.630
DOC_WW_Pin1_4	408	413	PF00397	0.650
DOC_WW_Pin1_4	421	426	PF00397	0.621
DOC_WW_Pin1_4	477	482	PF00397	0.402
DOC_WW_Pin1_4	70	75	PF00397	0.547
LIG_14-3-3_CanoR_1	182	187	PF00244	0.337
LIG_14-3-3_CanoR_1	214	218	PF00244	0.484
LIG_14-3-3_CanoR_1	501	506	PF00244	0.362
LIG_14-3-3_CanoR_1	660	667	PF00244	0.335
LIG_Actin_WH2_2	573	590	PF00022	0.325
LIG_APCC_ABBA_1	141	146	PF00400	0.480
LIG_Clathr_ClatBox_1	173	177	PF01394	0.375
LIG_FHA_1	128	134	PF00498	0.647
LIG_FHA_1	218	224	PF00498	0.608
LIG_FHA_1	260	266	PF00498	0.546
LIG_FHA_1	291	297	PF00498	0.416
LIG_FHA_1	346	352	PF00498	0.728
LIG_FHA_1	355	361	PF00498	0.744
LIG_FHA_1	365	371	PF00498	0.579
LIG_FHA_1	478	484	PF00498	0.419
LIG_FHA_1	491	497	PF00498	0.587
LIG_FHA_1	58	64	PF00498	0.438
LIG_FHA_1	613	619	PF00498	0.426
LIG_FHA_2	194	200	PF00498	0.475
LIG_GBD_Chelix_1	267	275	PF00786	0.407
LIG_HP1_1	172	176	PF01393	0.396
LIG_LIR_Apic_2	146	152	PF02991	0.506
LIG_LIR_Apic_2	476	482	PF02991	0.410
LIG_LIR_Gen_1	518	526	PF02991	0.474
LIG_LIR_Nem_3	428	432	PF02991	0.486
LIG_LIR_Nem_3	458	462	PF02991	0.497
LIG_LIR_Nem_3	518	524	PF02991	0.376
LIG_LIR_Nem_3	81	86	PF02991	0.465
LIG_SH2_CRK	479	483	PF00017	0.419
LIG_SH2_GRB2like	436	439	PF00017	0.357
LIG_SH2_NCK_1	298	302	PF00017	0.461
LIG_SH2_NCK_1	521	525	PF00017	0.299
LIG_SH2_SRC	279	282	PF00017	0.369
LIG_SH2_STAP1	436	440	PF00017	0.408
LIG_SH2_STAP1	521	525	PF00017	0.314
LIG_SH2_STAP1	540	544	PF00017	0.534
LIG_SH2_STAT3	255	258	PF00017	0.362
LIG_SH2_STAT5	149	152	PF00017	0.549
LIG_SH2_STAT5	255	258	PF00017	0.362
LIG_SH2_STAT5	277	280	PF00017	0.383
LIG_SH2_STAT5	380	383	PF00017	0.524
LIG_SH2_STAT5	429	432	PF00017	0.430
LIG_SH2_STAT5	459	462	PF00017	0.347
LIG_SH2_STAT5	479	482	PF00017	0.518
LIG_SH2_STAT5	484	487	PF00017	0.390
LIG_SH2_STAT5	68	71	PF00017	0.447
LIG_SH3_3	12	18	PF00018	0.667
LIG_SH3_3	150	156	PF00018	0.635
LIG_SH3_3	220	226	PF00018	0.448
LIG_SH3_3	251	257	PF00018	0.375
LIG_SH3_3	352	358	PF00018	0.496
LIG_SH3_3	371	377	PF00018	0.431
LIG_SH3_3	661	667	PF00018	0.356
LIG_SUMO_SIM_anti_2	592	599	PF11976	0.342
LIG_SUMO_SIM_par_1	169	177	PF11976	0.507
LIG_SUMO_SIM_par_1	492	497	PF11976	0.473
LIG_TYR_ITIM	275	280	PF00017	0.228
LIG_WW_1	152	155	PF00397	0.402
LIG_WW_1	481	484	PF00397	0.329
LIG_WW_3	151	155	PF00397	0.383
MOD_CDC14_SPxK_1	151	154	PF00782	0.376
MOD_CDK_SPK_2	349	354	PF00069	0.760
MOD_CDK_SPK_2	364	369	PF00069	0.654
MOD_CDK_SPxK_1	148	154	PF00069	0.338
MOD_CK1_1	122	128	PF00069	0.630
MOD_CK1_1	292	298	PF00069	0.485
MOD_CK1_1	338	344	PF00069	0.570
MOD_CK1_1	421	427	PF00069	0.670
MOD_CK1_1	561	567	PF00069	0.560
MOD_CK1_1	583	589	PF00069	0.517
MOD_CK1_1	62	68	PF00069	0.377
MOD_CK1_1	73	79	PF00069	0.368
MOD_CK2_1	308	314	PF00069	0.457
MOD_CK2_1	336	342	PF00069	0.503
MOD_CK2_1	583	589	PF00069	0.467
MOD_Cter_Amidation	463	466	PF01082	0.353
MOD_DYRK1A_RPxSP_1	354	358	PF00069	0.499
MOD_GlcNHglycan	245	248	PF01048	0.640
MOD_GlcNHglycan	3	6	PF01048	0.662
MOD_GlcNHglycan	338	341	PF01048	0.735
MOD_GlcNHglycan	342	345	PF01048	0.746
MOD_GlcNHglycan	38	42	PF01048	0.501
MOD_GlcNHglycan	418	421	PF01048	0.700
MOD_GlcNHglycan	450	453	PF01048	0.415
MOD_GlcNHglycan	501	504	PF01048	0.551
MOD_GlcNHglycan	54	57	PF01048	0.426
MOD_GlcNHglycan	561	564	PF01048	0.323
MOD_GlcNHglycan	653	656	PF01048	0.413
MOD_GlcNHglycan	661	664	PF01048	0.365
MOD_GlcNHglycan	99	102	PF01048	0.748
MOD_GSK3_1	115	122	PF00069	0.673
MOD_GSK3_1	127	134	PF00069	0.680
MOD_GSK3_1	162	169	PF00069	0.461
MOD_GSK3_1	182	189	PF00069	0.399
MOD_GSK3_1	213	220	PF00069	0.431
MOD_GSK3_1	239	246	PF00069	0.530
MOD_GSK3_1	290	297	PF00069	0.561
MOD_GSK3_1	336	343	PF00069	0.686
MOD_GSK3_1	345	352	PF00069	0.745
MOD_GSK3_1	359	366	PF00069	0.696
MOD_GSK3_1	37	44	PF00069	0.430
MOD_GSK3_1	416	423	PF00069	0.634
MOD_GSK3_1	473	480	PF00069	0.397
MOD_GSK3_1	490	497	PF00069	0.497
MOD_GSK3_1	499	506	PF00069	0.623
MOD_GSK3_1	557	564	PF00069	0.562
MOD_GSK3_1	576	583	PF00069	0.225
MOD_GSK3_1	612	619	PF00069	0.405
MOD_GSK3_1	647	654	PF00069	0.530
MOD_LATS_1	160	166	PF00433	0.474
MOD_N-GLC_1	364	369	PF02516	0.625
MOD_N-GLC_1	416	421	PF02516	0.646
MOD_N-GLC_1	57	62	PF02516	0.434
MOD_NEK2_1	1	6	PF00069	0.689
MOD_NEK2_1	109	114	PF00069	0.562
MOD_NEK2_1	133	138	PF00069	0.654
MOD_NEK2_1	296	301	PF00069	0.608
MOD_NEK2_1	329	334	PF00069	0.374
MOD_NEK2_1	39	44	PF00069	0.609
MOD_NEK2_1	399	404	PF00069	0.496
MOD_NEK2_1	430	435	PF00069	0.353
MOD_NEK2_1	448	453	PF00069	0.446
MOD_NEK2_1	57	62	PF00069	0.394
MOD_NEK2_1	91	96	PF00069	0.524
MOD_NEK2_2	59	64	PF00069	0.360
MOD_PIKK_1	193	199	PF00454	0.601
MOD_PIKK_1	647	653	PF00454	0.446
MOD_PK_1	182	188	PF00069	0.338
MOD_PKA_2	1	7	PF00069	0.776
MOD_PKA_2	122	128	PF00069	0.489
MOD_PKA_2	213	219	PF00069	0.535
MOD_PKA_2	27	33	PF00069	0.473
MOD_PKA_2	399	405	PF00069	0.454
MOD_PKA_2	659	665	PF00069	0.330
MOD_PKA_2	91	97	PF00069	0.559
MOD_Plk_1	489	495	PF00069	0.409
MOD_Plk_1	540	546	PF00069	0.586
MOD_Plk_1	583	589	PF00069	0.423
MOD_Plk_4	182	188	PF00069	0.400
MOD_Plk_4	425	431	PF00069	0.458
MOD_Plk_4	616	622	PF00069	0.363
MOD_Plk_4	73	79	PF00069	0.351
MOD_Plk_4	94	100	PF00069	0.633
MOD_ProDKin_1	148	154	PF00069	0.388
MOD_ProDKin_1	168	174	PF00069	0.434
MOD_ProDKin_1	222	228	PF00069	0.592
MOD_ProDKin_1	349	355	PF00069	0.724
MOD_ProDKin_1	364	370	PF00069	0.627
MOD_ProDKin_1	408	414	PF00069	0.652
MOD_ProDKin_1	421	427	PF00069	0.606
MOD_ProDKin_1	477	483	PF00069	0.404
MOD_ProDKin_1	70	76	PF00069	0.543
MOD_SUMO_for_1	515	518	PF00179	0.285
MOD_SUMO_rev_2	118	122	PF00179	0.491
MOD_SUMO_rev_2	242	247	PF00179	0.433
TRG_ENDOCYTIC_2	155	158	PF00928	0.439
TRG_ENDOCYTIC_2	277	280	PF00928	0.398
TRG_ENDOCYTIC_2	325	328	PF00928	0.441
TRG_ENDOCYTIC_2	429	432	PF00928	0.502
TRG_ENDOCYTIC_2	521	524	PF00928	0.308
TRG_ER_diArg_1	1	3	PF00400	0.734
TRG_ER_diArg_1	187	190	PF00400	0.504
TRG_ER_diArg_1	213	215	PF00400	0.494
TRG_ER_diArg_1	31	33	PF00400	0.544
TRG_ER_diArg_1	318	320	PF00400	0.550
TRG_ER_diArg_1	45	48	PF00400	0.363
TRG_ER_diArg_1	568	570	PF00400	0.509
TRG_NES_CRM1_1	38	51	PF08389	0.424
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	578	582	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	646	651	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P977	Leptomonas seymouri	47%	98%
A0A0S4IV62	Bodo saltans	35%	100%
A0A1X0NUB8	Trypanosomatidae	34%	100%
A0A3Q8IFH0	Leishmania donovani	72%	100%
A0A3R7KBD3	Trypanosoma rangeli	36%	100%
A4I7Y6	Leishmania infantum	72%	100%
D0AA55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B2U7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q5A9	Leishmania major	71%	100%
V5BF12	Trypanosoma cruzi	37%	100%