Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKF7_LEIBR

TriTrypDb:

LbrM.32.1870 , LBRM2903_320025100

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.541
CLV_NRD_NRD_1	214	216	PF00675	0.597
CLV_NRD_NRD_1	284	286	PF00675	0.531
CLV_PCSK_KEX2_1	284	286	PF00082	0.618
CLV_PCSK_KEX2_1	405	407	PF00082	0.628
CLV_PCSK_KEX2_1	62	64	PF00082	0.642
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.575
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.642
CLV_PCSK_SKI1_1	178	182	PF00082	0.552
CLV_PCSK_SKI1_1	269	273	PF00082	0.473
CLV_PCSK_SKI1_1	83	87	PF00082	0.535
DEG_APCC_DBOX_1	177	185	PF00400	0.553
DEG_APCC_DBOX_1	82	90	PF00400	0.520
DEG_Nend_Nbox_1	1	3	PF02207	0.537
DOC_CKS1_1	265	270	PF01111	0.485
DOC_CKS1_1	318	323	PF01111	0.560
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.518
DOC_MAPK_JIP1_4	235	241	PF00069	0.537
DOC_PP1_RVXF_1	267	274	PF00149	0.561
DOC_PP2B_LxvP_1	398	401	PF13499	0.565
DOC_PP4_FxxP_1	293	296	PF00568	0.633
DOC_USP7_MATH_1	32	36	PF00917	0.586
DOC_USP7_MATH_1	388	392	PF00917	0.477
DOC_USP7_MATH_1	437	441	PF00917	0.630
DOC_USP7_MATH_1	463	467	PF00917	0.638
DOC_USP7_UBL2_3	62	66	PF12436	0.558
DOC_WW_Pin1_4	20	25	PF00397	0.553
DOC_WW_Pin1_4	242	247	PF00397	0.554
DOC_WW_Pin1_4	264	269	PF00397	0.493
DOC_WW_Pin1_4	300	305	PF00397	0.650
DOC_WW_Pin1_4	317	322	PF00397	0.517
DOC_WW_Pin1_4	352	357	PF00397	0.506
DOC_WW_Pin1_4	361	366	PF00397	0.476
DOC_WW_Pin1_4	427	432	PF00397	0.655
DOC_WW_Pin1_4	43	48	PF00397	0.589
DOC_WW_Pin1_4	442	447	PF00397	0.542
DOC_WW_Pin1_4	461	466	PF00397	0.497
DOC_WW_Pin1_4	67	72	PF00397	0.557
DOC_WW_Pin1_4	9	14	PF00397	0.612
LIG_14-3-3_CanoR_1	125	131	PF00244	0.497
LIG_14-3-3_CanoR_1	199	204	PF00244	0.506
LIG_14-3-3_CanoR_1	235	240	PF00244	0.536
LIG_14-3-3_CanoR_1	269	274	PF00244	0.559
LIG_14-3-3_CanoR_1	287	296	PF00244	0.486
LIG_14-3-3_CanoR_1	325	331	PF00244	0.632
LIG_14-3-3_CanoR_1	387	393	PF00244	0.483
LIG_14-3-3_CanoR_1	472	479	PF00244	0.601
LIG_14-3-3_CanoR_1	499	507	PF00244	0.605
LIG_Actin_WH2_2	271	289	PF00022	0.564
LIG_Actin_WH2_2	338	355	PF00022	0.513
LIG_deltaCOP1_diTrp_1	103	110	PF00928	0.503
LIG_Dynein_DLC8_1	64	70	PF01221	0.560
LIG_EH1_1	452	460	PF00400	0.622
LIG_FHA_1	146	152	PF00498	0.481
LIG_FHA_1	265	271	PF00498	0.515
LIG_FHA_1	392	398	PF00498	0.582
LIG_FHA_1	409	415	PF00498	0.525
LIG_FHA_1	53	59	PF00498	0.533
LIG_FHA_2	127	133	PF00498	0.513
LIG_FHA_2	165	171	PF00498	0.535
LIG_FHA_2	186	192	PF00498	0.582
LIG_FHA_2	219	225	PF00498	0.542
LIG_FHA_2	247	253	PF00498	0.665
LIG_FHA_2	301	307	PF00498	0.562
LIG_LIR_Apic_2	291	296	PF02991	0.623
LIG_LIR_Gen_1	107	117	PF02991	0.475
LIG_LIR_Gen_1	348	357	PF02991	0.499
LIG_LIR_Gen_1	373	381	PF02991	0.505
LIG_LIR_Nem_3	107	113	PF02991	0.479
LIG_LIR_Nem_3	348	352	PF02991	0.484
LIG_LIR_Nem_3	355	361	PF02991	0.474
LIG_LIR_Nem_3	373	377	PF02991	0.386
LIG_LIR_Nem_3	42	48	PF02991	0.588
LIG_MAD2	457	465	PF02301	0.572
LIG_NRBOX	341	347	PF00104	0.481
LIG_PCNA_yPIPBox_3	339	353	PF02747	0.457
LIG_PDZ_Class_2	504	509	PF00595	0.527
LIG_Pex14_1	110	114	PF04695	0.471
LIG_Pex14_2	194	198	PF04695	0.545
LIG_Pex14_2	370	374	PF04695	0.510
LIG_SH2_CRK	114	118	PF00017	0.465
LIG_SH2_SRC	205	208	PF00017	0.550
LIG_SH2_STAP1	484	488	PF00017	0.535
LIG_SH2_STAT3	453	456	PF00017	0.532
LIG_SH2_STAT3	84	87	PF00017	0.471
LIG_SH2_STAT5	114	117	PF00017	0.468
LIG_SH2_STAT5	205	208	PF00017	0.550
LIG_SH2_STAT5	316	319	PF00017	0.554
LIG_SH2_STAT5	489	492	PF00017	0.539
LIG_SH2_STAT5	84	87	PF00017	0.524
LIG_SH3_3	158	164	PF00018	0.564
LIG_SH3_3	21	27	PF00018	0.623
LIG_SH3_3	230	236	PF00018	0.619
LIG_SH3_3	262	268	PF00018	0.505
LIG_SH3_3	443	449	PF00018	0.626
LIG_SUMO_SIM_par_1	118	127	PF11976	0.458
LIG_SUMO_SIM_par_1	393	399	PF11976	0.581
LIG_SxIP_EBH_1	74	88	PF03271	0.483
LIG_TRAF2_1	101	104	PF00917	0.547
LIG_TRAF2_1	167	170	PF00917	0.532
LIG_TRAF2_1	249	252	PF00917	0.579
LIG_UBA3_1	342	347	PF00899	0.443
LIG_UBA3_1	396	405	PF00899	0.545
LIG_WRC_WIRS_1	270	275	PF05994	0.552
LIG_WRC_WIRS_1	346	351	PF05994	0.498
MOD_CDK_SPK_2	264	269	PF00069	0.493
MOD_CDK_SPxK_1	43	49	PF00069	0.504
MOD_CDK_SPxK_1	442	448	PF00069	0.644
MOD_CK1_1	209	215	PF00069	0.495
MOD_CK1_1	237	243	PF00069	0.620
MOD_CK1_1	391	397	PF00069	0.571
MOD_CK1_1	418	424	PF00069	0.645
MOD_CK1_1	427	433	PF00069	0.591
MOD_CK1_1	466	472	PF00069	0.657
MOD_CK2_1	164	170	PF00069	0.532
MOD_CK2_1	246	252	PF00069	0.658
MOD_CK2_1	300	306	PF00069	0.565
MOD_CK2_1	376	382	PF00069	0.506
MOD_Cter_Amidation	60	63	PF01082	0.553
MOD_GlcNHglycan	211	214	PF01048	0.577
MOD_GlcNHglycan	426	429	PF01048	0.659
MOD_GlcNHglycan	435	438	PF01048	0.603
MOD_GlcNHglycan	465	468	PF01048	0.647
MOD_GlcNHglycan	9	12	PF01048	0.610
MOD_GSK3_1	145	152	PF00069	0.478
MOD_GSK3_1	218	225	PF00069	0.622
MOD_GSK3_1	235	242	PF00069	0.503
MOD_GSK3_1	316	323	PF00069	0.672
MOD_GSK3_1	341	348	PF00069	0.478
MOD_GSK3_1	357	364	PF00069	0.415
MOD_GSK3_1	387	394	PF00069	0.487
MOD_GSK3_1	414	421	PF00069	0.640
MOD_GSK3_1	426	433	PF00069	0.569
MOD_GSK3_1	457	464	PF00069	0.624
MOD_GSK3_1	466	473	PF00069	0.593
MOD_GSK3_1	65	72	PF00069	0.562
MOD_N-GLC_1	32	37	PF02516	0.703
MOD_N-GLC_1	421	426	PF02516	0.597
MOD_NEK2_1	184	189	PF00069	0.590
MOD_NEK2_1	239	244	PF00069	0.623
MOD_NEK2_1	298	303	PF00069	0.572
MOD_NEK2_1	345	350	PF00069	0.470
MOD_NEK2_1	357	362	PF00069	0.472
MOD_NEK2_1	392	397	PF00069	0.521
MOD_NEK2_1	498	503	PF00069	0.537
MOD_NEK2_2	437	442	PF00069	0.629
MOD_NEK2_2	484	489	PF00069	0.538
MOD_PIKK_1	288	294	PF00454	0.608
MOD_PIKK_1	400	406	PF00454	0.555
MOD_PIKK_1	467	473	PF00454	0.639
MOD_PIKK_1	498	504	PF00454	0.536
MOD_PIKK_1	65	71	PF00454	0.649
MOD_PK_1	415	421	PF00069	0.641
MOD_PKA_2	124	130	PF00069	0.491
MOD_PKA_2	198	204	PF00069	0.510
MOD_PKA_2	234	240	PF00069	0.551
MOD_PKA_2	324	330	PF00069	0.630
MOD_PKA_2	386	392	PF00069	0.478
MOD_PKA_2	414	420	PF00069	0.639
MOD_PKA_2	471	477	PF00069	0.641
MOD_PKA_2	498	504	PF00069	0.536
MOD_Plk_1	157	163	PF00069	0.589
MOD_Plk_1	164	170	PF00069	0.547
MOD_Plk_1	32	38	PF00069	0.622
MOD_Plk_1	392	398	PF00069	0.524
MOD_Plk_1	415	421	PF00069	0.611
MOD_Plk_2-3	376	382	PF00069	0.419
MOD_Plk_4	112	118	PF00069	0.547
MOD_Plk_4	218	224	PF00069	0.540
MOD_Plk_4	269	275	PF00069	0.557
MOD_Plk_4	32	38	PF00069	0.570
MOD_Plk_4	341	347	PF00069	0.534
MOD_Plk_4	392	398	PF00069	0.552
MOD_Plk_4	484	490	PF00069	0.536
MOD_Plk_4	76	82	PF00069	0.579
MOD_ProDKin_1	20	26	PF00069	0.548
MOD_ProDKin_1	242	248	PF00069	0.555
MOD_ProDKin_1	264	270	PF00069	0.488
MOD_ProDKin_1	300	306	PF00069	0.652
MOD_ProDKin_1	317	323	PF00069	0.515
MOD_ProDKin_1	352	358	PF00069	0.502
MOD_ProDKin_1	361	367	PF00069	0.473
MOD_ProDKin_1	427	433	PF00069	0.654
MOD_ProDKin_1	43	49	PF00069	0.592
MOD_ProDKin_1	442	448	PF00069	0.539
MOD_ProDKin_1	461	467	PF00069	0.498
MOD_ProDKin_1	67	73	PF00069	0.555
MOD_ProDKin_1	9	15	PF00069	0.613
TRG_DiLeu_BaEn_1	179	184	PF01217	0.589
TRG_DiLeu_BaEn_1	380	385	PF01217	0.439
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.412
TRG_DiLeu_BaLyEn_6	266	271	PF01217	0.512
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.521
TRG_DiLeu_LyEn_5	380	385	PF01217	0.439
TRG_ENDOCYTIC_2	114	117	PF00928	0.468
TRG_ENDOCYTIC_2	2	5	PF00928	0.539
TRG_ER_diArg_1	284	287	PF00400	0.587
TRG_ER_diArg_1	350	353	PF00400	0.478
TRG_NES_CRM1_1	119	132	PF08389	0.413
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7S0	Leishmania donovani	68%	98%
Q4Q5B0	Leishmania major	67%	100%