LeishMANIAdb
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PPM-type phosphatase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PPM-type phosphatase domain-containing protein
Gene product:
protein phosphatase 2C, putative
Species:
Leishmania braziliensis
UniProt:
A4HKF6_LEIBR
TriTrypDb:
LbrM.32.1860 , LBRM2903_320025000 *
Length:
566

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) no yes: 1
Forrest at al. (procyclic) no yes: 1
Silverman et al. no yes: 1
Pissara et al. no yes: 7
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 9
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 3
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1

Expansion

Sequence features

A4HKF6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKF6

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 15
GO:0006793 phosphorus metabolic process 3 15
GO:0006796 phosphate-containing compound metabolic process 4 15
GO:0006807 nitrogen compound metabolic process 2 15
GO:0008152 metabolic process 1 15
GO:0009987 cellular process 1 15
GO:0016311 dephosphorylation 5 15
GO:0019538 protein metabolic process 3 15
GO:0036211 protein modification process 4 15
GO:0043170 macromolecule metabolic process 3 15
GO:0043412 macromolecule modification 4 15
GO:0044237 cellular metabolic process 2 15
GO:0044238 primary metabolic process 2 15
GO:0071704 organic substance metabolic process 2 15
GO:1901564 organonitrogen compound metabolic process 3 15
GO:0035970 peptidyl-threonine dephosphorylation 6 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 18
GO:0004721 phosphoprotein phosphatase activity 3 18
GO:0004722 protein serine/threonine phosphatase activity 4 18
GO:0016787 hydrolase activity 2 18
GO:0016788 hydrolase activity, acting on ester bonds 3 18
GO:0016791 phosphatase activity 5 18
GO:0042578 phosphoric ester hydrolase activity 4 18
GO:0140096 catalytic activity, acting on a protein 2 18
GO:0005488 binding 1 3
GO:0043167 ion binding 2 3
GO:0043169 cation binding 3 3
GO:0046872 metal ion binding 4 3
GO:0017018 myosin phosphatase activity 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 366 370 PF00656 0.270
CLV_NRD_NRD_1 10 12 PF00675 0.600
CLV_NRD_NRD_1 112 114 PF00675 0.365
CLV_NRD_NRD_1 145 147 PF00675 0.223
CLV_NRD_NRD_1 281 283 PF00675 0.222
CLV_NRD_NRD_1 45 47 PF00675 0.465
CLV_PCSK_FUR_1 43 47 PF00082 0.409
CLV_PCSK_KEX2_1 10 12 PF00082 0.618
CLV_PCSK_KEX2_1 112 114 PF00082 0.369
CLV_PCSK_KEX2_1 145 147 PF00082 0.222
CLV_PCSK_KEX2_1 281 283 PF00082 0.224
CLV_PCSK_KEX2_1 392 394 PF00082 0.402
CLV_PCSK_KEX2_1 45 47 PF00082 0.412
CLV_PCSK_KEX2_1 5 7 PF00082 0.570
CLV_PCSK_PC1ET2_1 392 394 PF00082 0.402
CLV_PCSK_PC1ET2_1 5 7 PF00082 0.552
CLV_PCSK_PC7_1 6 12 PF00082 0.507
CLV_PCSK_SKI1_1 261 265 PF00082 0.238
CLV_PCSK_SKI1_1 51 55 PF00082 0.349
CLV_Separin_Metazoa 109 113 PF03568 0.383
DEG_APCC_DBOX_1 356 364 PF00400 0.266
DEG_APCC_DBOX_1 50 58 PF00400 0.346
DEG_SPOP_SBC_1 549 553 PF00917 0.510
DOC_MAPK_gen_1 281 289 PF00069 0.222
DOC_MAPK_gen_1 351 360 PF00069 0.251
DOC_MAPK_MEF2A_6 51 59 PF00069 0.576
DOC_PP2B_LxvP_1 415 418 PF13499 0.416
DOC_PP4_FxxP_1 349 352 PF00568 0.275
DOC_USP7_MATH_1 240 244 PF00917 0.222
DOC_USP7_MATH_1 310 314 PF00917 0.298
DOC_USP7_MATH_1 402 406 PF00917 0.539
DOC_USP7_MATH_1 410 414 PF00917 0.605
DOC_USP7_MATH_1 418 422 PF00917 0.531
DOC_USP7_MATH_1 533 537 PF00917 0.562
DOC_USP7_MATH_2 447 453 PF00917 0.465
DOC_USP7_UBL2_3 190 194 PF12436 0.236
DOC_WW_Pin1_4 16 21 PF00397 0.411
DOC_WW_Pin1_4 370 375 PF00397 0.261
DOC_WW_Pin1_4 406 411 PF00397 0.566
DOC_WW_Pin1_4 436 441 PF00397 0.540
DOC_WW_Pin1_4 487 492 PF00397 0.570
DOC_WW_Pin1_4 536 541 PF00397 0.509
DOC_WW_Pin1_4 552 557 PF00397 0.499
LIG_14-3-3_CanoR_1 145 149 PF00244 0.318
LIG_14-3-3_CanoR_1 45 49 PF00244 0.405
LIG_14-3-3_CanoR_1 507 511 PF00244 0.465
LIG_APCC_ABBA_1 226 231 PF00400 0.266
LIG_Clathr_ClatBox_1 154 158 PF01394 0.266
LIG_CtBP_PxDLS_1 556 560 PF00389 0.459
LIG_DCNL_PONY_1 1 4 PF03556 0.514
LIG_FHA_1 151 157 PF00498 0.282
LIG_FHA_1 45 51 PF00498 0.438
LIG_FHA_1 509 515 PF00498 0.538
LIG_FHA_1 56 62 PF00498 0.431
LIG_FHA_1 75 81 PF00498 0.295
LIG_FHA_2 145 151 PF00498 0.246
LIG_LIR_Apic_2 348 352 PF02991 0.275
LIG_LIR_Gen_1 180 191 PF02991 0.278
LIG_LIR_Gen_1 203 212 PF02991 0.268
LIG_LIR_Gen_1 327 337 PF02991 0.315
LIG_LIR_Nem_3 130 136 PF02991 0.296
LIG_LIR_Nem_3 180 186 PF02991 0.278
LIG_LIR_Nem_3 203 208 PF02991 0.268
LIG_LIR_Nem_3 327 332 PF02991 0.315
LIG_LIR_Nem_3 63 68 PF02991 0.345
LIG_MAD2 548 556 PF02301 0.479
LIG_PCNA_yPIPBox_3 273 287 PF02747 0.266
LIG_PCNA_yPIPBox_3 31 45 PF02747 0.418
LIG_SH2_CRK 70 74 PF00017 0.354
LIG_SH2_SRC 229 232 PF00017 0.362
LIG_SH2_SRC 416 419 PF00017 0.415
LIG_SH2_SRC 68 71 PF00017 0.261
LIG_SH2_STAT3 181 184 PF00017 0.266
LIG_SH2_STAT3 26 29 PF00017 0.406
LIG_SH2_STAT5 177 180 PF00017 0.351
LIG_SH2_STAT5 211 214 PF00017 0.280
LIG_SH2_STAT5 229 232 PF00017 0.317
LIG_SH2_STAT5 236 239 PF00017 0.229
LIG_SH2_STAT5 26 29 PF00017 0.432
LIG_SH2_STAT5 277 280 PF00017 0.234
LIG_SH2_STAT5 416 419 PF00017 0.415
LIG_SH2_STAT5 48 51 PF00017 0.384
LIG_SH2_STAT5 68 71 PF00017 0.246
LIG_SH3_1 6 12 PF00018 0.479
LIG_SH3_2 17 22 PF14604 0.405
LIG_SH3_3 14 20 PF00018 0.471
LIG_SH3_3 259 265 PF00018 0.263
LIG_SH3_3 485 491 PF00018 0.514
LIG_SH3_3 6 12 PF00018 0.497
LIG_SUMO_SIM_anti_2 153 158 PF11976 0.228
LIG_SUMO_SIM_anti_2 385 390 PF11976 0.308
LIG_SUMO_SIM_anti_2 58 63 PF11976 0.293
LIG_SUMO_SIM_par_1 152 158 PF11976 0.266
LIG_SUMO_SIM_par_1 285 290 PF11976 0.266
LIG_SUMO_SIM_par_1 555 560 PF11976 0.460
LIG_SUMO_SIM_par_1 57 63 PF11976 0.475
LIG_SUMO_SIM_par_1 72 77 PF11976 0.270
LIG_UBA3_1 1 5 PF00899 0.514
LIG_UBA3_1 154 159 PF00899 0.266
LIG_WW_3 7 11 PF00397 0.496
MOD_CDC14_SPxK_1 19 22 PF00782 0.391
MOD_CDK_SPK_2 487 492 PF00069 0.519
MOD_CDK_SPxK_1 16 22 PF00069 0.404
MOD_CK1_1 405 411 PF00069 0.467
MOD_CK1_1 422 428 PF00069 0.501
MOD_CK1_1 438 444 PF00069 0.546
MOD_CK1_1 490 496 PF00069 0.521
MOD_CK1_1 506 512 PF00069 0.520
MOD_CK1_1 536 542 PF00069 0.472
MOD_CK2_1 310 316 PF00069 0.297
MOD_GlcNHglycan 127 130 PF01048 0.373
MOD_GlcNHglycan 169 172 PF01048 0.303
MOD_GlcNHglycan 312 315 PF01048 0.302
MOD_GlcNHglycan 404 407 PF01048 0.557
MOD_GlcNHglycan 429 432 PF01048 0.524
MOD_GlcNHglycan 440 443 PF01048 0.524
MOD_GlcNHglycan 461 464 PF01048 0.495
MOD_GlcNHglycan 470 473 PF01048 0.541
MOD_GlcNHglycan 497 500 PF01048 0.576
MOD_GlcNHglycan 528 531 PF01048 0.560
MOD_GSK3_1 167 174 PF00069 0.333
MOD_GSK3_1 398 405 PF00069 0.553
MOD_GSK3_1 406 413 PF00069 0.536
MOD_GSK3_1 418 425 PF00069 0.513
MOD_GSK3_1 434 441 PF00069 0.553
MOD_GSK3_1 483 490 PF00069 0.744
MOD_GSK3_1 506 513 PF00069 0.467
MOD_GSK3_1 548 555 PF00069 0.544
MOD_LATS_1 546 552 PF00433 0.480
MOD_N-GLC_1 249 254 PF02516 0.236
MOD_N-GLC_1 299 304 PF02516 0.222
MOD_N-GLC_1 382 387 PF02516 0.352
MOD_N-GLC_1 427 432 PF02516 0.622
MOD_N-GLC_1 536 541 PF02516 0.531
MOD_NEK2_1 287 292 PF00069 0.323
MOD_NEK2_1 541 546 PF00069 0.523
MOD_NEK2_1 55 60 PF00069 0.327
MOD_NEK2_1 550 555 PF00069 0.497
MOD_PIKK_1 115 121 PF00454 0.368
MOD_PIKK_1 25 31 PF00454 0.396
MOD_PIKK_1 299 305 PF00454 0.299
MOD_PK_1 249 255 PF00069 0.236
MOD_PKA_2 144 150 PF00069 0.351
MOD_PKA_2 317 323 PF00069 0.274
MOD_PKA_2 44 50 PF00069 0.441
MOD_PKA_2 506 512 PF00069 0.491
MOD_Plk_1 299 305 PF00069 0.235
MOD_Plk_1 382 388 PF00069 0.352
MOD_Plk_1 427 433 PF00069 0.647
MOD_Plk_1 557 563 PF00069 0.468
MOD_Plk_4 150 156 PF00069 0.264
MOD_Plk_4 382 388 PF00069 0.301
MOD_Plk_4 410 416 PF00069 0.525
MOD_Plk_4 57 63 PF00069 0.324
MOD_Plk_4 74 80 PF00069 0.490
MOD_ProDKin_1 16 22 PF00069 0.409
MOD_ProDKin_1 370 376 PF00069 0.261
MOD_ProDKin_1 406 412 PF00069 0.563
MOD_ProDKin_1 436 442 PF00069 0.542
MOD_ProDKin_1 487 493 PF00069 0.569
MOD_ProDKin_1 536 542 PF00069 0.511
MOD_ProDKin_1 552 558 PF00069 0.498
MOD_SUMO_for_1 193 196 PF00179 0.236
MOD_SUMO_rev_2 254 263 PF00179 0.315
MOD_SUMO_rev_2 476 486 PF00179 0.581
TRG_ENDOCYTIC_2 202 205 PF00928 0.223
TRG_ENDOCYTIC_2 70 73 PF00928 0.357
TRG_ER_diArg_1 111 113 PF00400 0.343
TRG_ER_diArg_1 144 146 PF00400 0.225
TRG_ER_diArg_1 281 283 PF00400 0.238
TRG_ER_diArg_1 350 353 PF00400 0.239
TRG_ER_diArg_1 9 11 PF00400 0.550
TRG_Pf-PMV_PEXEL_1 291 295 PF00026 0.222
TRG_Pf-PMV_PEXEL_1 36 40 PF00026 0.462

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PET0 Leptomonas seymouri 63% 97%
A0A3Q8IFG7 Leishmania donovani 30% 100%
A0A3Q8IGS1 Leishmania donovani 78% 100%
A0A3Q8IL63 Leishmania donovani 28% 100%
A0A3S7WTA2 Leishmania donovani 35% 100%
A0A3S7WZ14 Leishmania donovani 31% 100%
A4H7Y6 Leishmania braziliensis 35% 100%
A4HAW5 Leishmania braziliensis 29% 100%
A4HE10 Leishmania braziliensis 30% 100%
A4HHY5 Leishmania braziliensis 28% 100%
A4HWB4 Leishmania infantum 36% 100%
A4I1B7 Leishmania infantum 31% 100%
A4I565 Leishmania infantum 30% 100%
A4I7Y4 Leishmania infantum 78% 100%
A4IA25 Leishmania infantum 28% 100%
D0AA51 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9AQ14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AXF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B0G2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B2U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
E9B540 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q2U6 Leishmania major 28% 100%
Q4Q5B1 Leishmania major 77% 99%
Q4Q7S1 Leishmania major 31% 100%
Q4QA19 Leishmania major 31% 100%
Q4QFG7 Leishmania major 35% 100%
Q4QFP5 Leishmania major 25% 66%
Q6K1U0 Oryza sativa subsp. japonica 30% 77%
Q6K1U4 Oryza sativa subsp. japonica 29% 100%
Q6K5I0 Oryza sativa subsp. japonica 30% 100%
Q9CAJ0 Arabidopsis thaliana 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS