WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKF2_LEIBR

TriTrypDb:

LbrM.32.1820 , LBRM2903_320024500

Length:

923

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	7
GO:0008287	protein serine/threonine phosphatase complex	4	7
GO:0032991	protein-containing complex	1	7
GO:1902494	catalytic complex	2	7
GO:1903293	phosphatase complex	3	7
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKF2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	7
GO:0019888	protein phosphatase regulator activity	4	7
GO:0030234	enzyme regulator activity	2	7
GO:0098772	molecular function regulator activity	1	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.776
CLV_C14_Caspase3-7	870	874	PF00656	0.543
CLV_NRD_NRD_1	139	141	PF00675	0.582
CLV_NRD_NRD_1	177	179	PF00675	0.579
CLV_NRD_NRD_1	259	261	PF00675	0.598
CLV_NRD_NRD_1	3	5	PF00675	0.738
CLV_NRD_NRD_1	436	438	PF00675	0.613
CLV_NRD_NRD_1	507	509	PF00675	0.508
CLV_NRD_NRD_1	561	563	PF00675	0.502
CLV_NRD_NRD_1	698	700	PF00675	0.573
CLV_NRD_NRD_1	750	752	PF00675	0.502
CLV_NRD_NRD_1	86	88	PF00675	0.731
CLV_NRD_NRD_1	917	919	PF00675	0.548
CLV_PCSK_KEX2_1	141	143	PF00082	0.727
CLV_PCSK_KEX2_1	177	179	PF00082	0.579
CLV_PCSK_KEX2_1	436	438	PF00082	0.615
CLV_PCSK_KEX2_1	507	509	PF00082	0.480
CLV_PCSK_KEX2_1	561	563	PF00082	0.502
CLV_PCSK_KEX2_1	86	88	PF00082	0.731
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.727
CLV_PCSK_PC7_1	503	509	PF00082	0.556
CLV_PCSK_SKI1_1	161	165	PF00082	0.826
CLV_PCSK_SKI1_1	211	215	PF00082	0.503
CLV_PCSK_SKI1_1	503	507	PF00082	0.574
CLV_PCSK_SKI1_1	531	535	PF00082	0.419
CLV_PCSK_SKI1_1	553	557	PF00082	0.459
CLV_PCSK_SKI1_1	890	894	PF00082	0.467
CLV_Separin_Metazoa	504	508	PF03568	0.558
DEG_APCC_DBOX_1	160	168	PF00400	0.823
DEG_Nend_UBRbox_2	1	3	PF02207	0.727
DEG_SPOP_SBC_1	305	309	PF00917	0.712
DOC_CDC14_PxL_1	403	411	PF14671	0.516
DOC_CKS1_1	331	336	PF01111	0.577
DOC_MAPK_gen_1	751	762	PF00069	0.352
DOC_MAPK_MEF2A_6	740	747	PF00069	0.443
DOC_MAPK_NFAT4_5	740	748	PF00069	0.443
DOC_PP1_RVXF_1	529	536	PF00149	0.462
DOC_PP2B_LxvP_1	649	652	PF13499	0.528
DOC_PP4_FxxP_1	375	378	PF00568	0.823
DOC_PP4_FxxP_1	535	538	PF00568	0.360
DOC_PP4_FxxP_1	731	734	PF00568	0.461
DOC_PP4_FxxP_1	827	830	PF00568	0.582
DOC_USP7_MATH_1	117	121	PF00917	0.740
DOC_USP7_MATH_1	163	167	PF00917	0.769
DOC_USP7_MATH_1	387	391	PF00917	0.556
DOC_USP7_MATH_1	520	524	PF00917	0.541
DOC_USP7_MATH_1	57	61	PF00917	0.766
DOC_USP7_MATH_1	670	674	PF00917	0.488
DOC_USP7_MATH_1	702	706	PF00917	0.537
DOC_USP7_MATH_1	808	812	PF00917	0.624
DOC_USP7_MATH_1	89	93	PF00917	0.680
DOC_USP7_MATH_2	111	117	PF00917	0.839
DOC_USP7_UBL2_3	5	9	PF12436	0.746
DOC_USP7_UBL2_3	512	516	PF12436	0.505
DOC_WW_Pin1_4	12	17	PF00397	0.749
DOC_WW_Pin1_4	140	145	PF00397	0.726
DOC_WW_Pin1_4	261	266	PF00397	0.749
DOC_WW_Pin1_4	283	288	PF00397	0.714
DOC_WW_Pin1_4	312	317	PF00397	0.609
DOC_WW_Pin1_4	330	335	PF00397	0.717
DOC_WW_Pin1_4	341	346	PF00397	0.722
DOC_WW_Pin1_4	478	483	PF00397	0.726
DOC_WW_Pin1_4	538	543	PF00397	0.563
DOC_WW_Pin1_4	563	568	PF00397	0.537
DOC_WW_Pin1_4	77	82	PF00397	0.720
LIG_14-3-3_CanoR_1	190	196	PF00244	0.793
LIG_14-3-3_CanoR_1	211	220	PF00244	0.649
LIG_14-3-3_CanoR_1	275	283	PF00244	0.636
LIG_14-3-3_CanoR_1	35	44	PF00244	0.626
LIG_14-3-3_CanoR_1	436	442	PF00244	0.680
LIG_14-3-3_CanoR_1	451	457	PF00244	0.717
LIG_14-3-3_CanoR_1	507	515	PF00244	0.443
LIG_14-3-3_CanoR_1	902	908	PF00244	0.453
LIG_AP2alpha_2	825	827	PF02296	0.571
LIG_BRCT_BRCA1_1	345	349	PF00533	0.715
LIG_BRCT_BRCA1_1	50	54	PF00533	0.716
LIG_BRCT_BRCA1_1	584	588	PF00533	0.564
LIG_BRCT_BRCA1_1	672	676	PF00533	0.476
LIG_CaM_NSCaTE_8	852	859	PF13499	0.405
LIG_EH_1	711	715	PF12763	0.647
LIG_eIF4E_1	907	913	PF01652	0.509
LIG_FHA_1	275	281	PF00498	0.573
LIG_FHA_1	491	497	PF00498	0.625
LIG_FHA_1	605	611	PF00498	0.466
LIG_FHA_1	886	892	PF00498	0.502
LIG_FHA_2	241	247	PF00498	0.811
LIG_FHA_2	274	280	PF00498	0.610
LIG_FHA_2	396	402	PF00498	0.431
LIG_FHA_2	547	553	PF00498	0.454
LIG_FHA_2	770	776	PF00498	0.336
LIG_FHA_2	83	89	PF00498	0.822
LIG_FHA_2	838	844	PF00498	0.395
LIG_Integrin_isoDGR_2	909	911	PF01839	0.521
LIG_LIR_Apic_2	372	378	PF02991	0.818
LIG_LIR_Apic_2	534	538	PF02991	0.353
LIG_LIR_Apic_2	730	734	PF02991	0.469
LIG_LIR_Apic_2	825	830	PF02991	0.574
LIG_LIR_Gen_1	356	364	PF02991	0.538
LIG_LIR_Gen_1	566	574	PF02991	0.552
LIG_LIR_Gen_1	585	596	PF02991	0.566
LIG_LIR_Gen_1	620	630	PF02991	0.444
LIG_LIR_Gen_1	739	750	PF02991	0.444
LIG_LIR_Gen_1	777	787	PF02991	0.476
LIG_LIR_Nem_3	214	220	PF02991	0.641
LIG_LIR_Nem_3	356	361	PF02991	0.537
LIG_LIR_Nem_3	421	425	PF02991	0.474
LIG_LIR_Nem_3	563	568	PF02991	0.537
LIG_LIR_Nem_3	585	591	PF02991	0.572
LIG_LIR_Nem_3	602	606	PF02991	0.489
LIG_LIR_Nem_3	620	625	PF02991	0.447
LIG_LIR_Nem_3	739	745	PF02991	0.440
LIG_LIR_Nem_3	777	783	PF02991	0.482
LIG_LIR_Nem_3	88	93	PF02991	0.695
LIG_MAD2	890	898	PF02301	0.483
LIG_MLH1_MIPbox_1	584	588	PF16413	0.564
LIG_MYND_1	12	16	PF01753	0.750
LIG_PCNA_yPIPBox_3	551	562	PF02747	0.466
LIG_Pex14_2	354	358	PF04695	0.679
LIG_Pex14_2	631	635	PF04695	0.460
LIG_Rb_pABgroove_1	793	801	PF01858	0.441
LIG_SH2_CRK	207	211	PF00017	0.667
LIG_SH2_CRK	220	224	PF00017	0.666
LIG_SH2_GRB2like	774	777	PF00017	0.509
LIG_SH2_NCK_1	318	322	PF00017	0.554
LIG_SH2_SRC	109	112	PF00017	0.591
LIG_SH2_SRC	701	704	PF00017	0.649
LIG_SH2_SRC	719	722	PF00017	0.318
LIG_SH2_STAP1	318	322	PF00017	0.554
LIG_SH2_STAP1	719	723	PF00017	0.481
LIG_SH2_STAT5	422	425	PF00017	0.474
LIG_SH2_STAT5	529	532	PF00017	0.460
LIG_SH2_STAT5	547	550	PF00017	0.213
LIG_SH2_STAT5	587	590	PF00017	0.578
LIG_SH2_STAT5	742	745	PF00017	0.445
LIG_SH2_STAT5	765	768	PF00017	0.474
LIG_SH2_STAT5	769	772	PF00017	0.476
LIG_SH2_STAT5	905	908	PF00017	0.414
LIG_SH2_STAT5	914	917	PF00017	0.443
LIG_SH3_3	15	21	PF00018	0.744
LIG_SH3_3	589	595	PF00018	0.570
LIG_SH3_3	802	808	PF00018	0.451
LIG_SH3_CIN85_PxpxPR_1	263	268	PF14604	0.749
LIG_SUMO_SIM_anti_2	390	395	PF11976	0.486
LIG_SUMO_SIM_par_1	783	789	PF11976	0.467
LIG_SUMO_SIM_par_1	837	843	PF11976	0.436
LIG_TRAF2_1	111	114	PF00917	0.583
LIG_TRAF2_1	840	843	PF00917	0.379
LIG_TYR_ITIM	420	425	PF00017	0.470
LIG_UBA3_1	597	601	PF00899	0.509
LIG_UBA3_1	759	768	PF00899	0.476
MOD_CDK_SPK_2	343	348	PF00069	0.575
MOD_CDK_SPxK_1	140	146	PF00069	0.728
MOD_CDK_SPxxK_3	261	268	PF00069	0.750
MOD_CDK_SPxxK_3	283	290	PF00069	0.571
MOD_CDK_SPxxK_3	341	348	PF00069	0.578
MOD_CK1_1	116	122	PF00069	0.738
MOD_CK1_1	157	163	PF00069	0.823
MOD_CK1_1	253	259	PF00069	0.612
MOD_CK1_1	271	277	PF00069	0.504
MOD_CK1_1	294	300	PF00069	0.737
MOD_CK1_1	30	36	PF00069	0.744
MOD_CK1_1	314	320	PF00069	0.698
MOD_CK1_1	341	347	PF00069	0.832
MOD_CK1_1	357	363	PF00069	0.691
MOD_CK1_1	48	54	PF00069	0.741
MOD_CK1_1	487	493	PF00069	0.686
MOD_CK1_1	543	549	PF00069	0.494
MOD_CK1_1	705	711	PF00069	0.508
MOD_CK1_1	727	733	PF00069	0.449
MOD_CK1_1	80	86	PF00069	0.833
MOD_CK1_1	811	817	PF00069	0.659
MOD_CK1_1	862	868	PF00069	0.777
MOD_CK2_1	117	123	PF00069	0.690
MOD_CK2_1	191	197	PF00069	0.681
MOD_CK2_1	273	279	PF00069	0.613
MOD_CK2_1	360	366	PF00069	0.711
MOD_CK2_1	546	552	PF00069	0.453
MOD_CK2_1	769	775	PF00069	0.482
MOD_CK2_1	837	843	PF00069	0.404
MOD_GlcNHglycan	113	118	PF01048	0.745
MOD_GlcNHglycan	173	176	PF01048	0.833
MOD_GlcNHglycan	295	299	PF01048	0.773
MOD_GlcNHglycan	302	305	PF01048	0.747
MOD_GlcNHglycan	309	312	PF01048	0.696
MOD_GlcNHglycan	319	322	PF01048	0.662
MOD_GlcNHglycan	365	369	PF01048	0.697
MOD_GlcNHglycan	384	388	PF01048	0.638
MOD_GlcNHglycan	403	406	PF01048	0.552
MOD_GlcNHglycan	415	419	PF01048	0.478
MOD_GlcNHglycan	489	492	PF01048	0.570
MOD_GlcNHglycan	50	53	PF01048	0.756
MOD_GlcNHglycan	59	62	PF01048	0.692
MOD_GlcNHglycan	615	618	PF01048	0.471
MOD_GlcNHglycan	652	655	PF01048	0.549
MOD_GlcNHglycan	681	684	PF01048	0.467
MOD_GlcNHglycan	726	729	PF01048	0.548
MOD_GlcNHglycan	788	793	PF01048	0.452
MOD_GlcNHglycan	82	85	PF01048	0.826
MOD_GlcNHglycan	834	837	PF01048	0.441
MOD_GlcNHglycan	856	859	PF01048	0.471
MOD_GlcNHglycan	873	876	PF01048	0.522
MOD_GSK3_1	109	116	PF00069	0.752
MOD_GSK3_1	117	124	PF00069	0.783
MOD_GSK3_1	132	139	PF00069	0.781
MOD_GSK3_1	140	147	PF00069	0.716
MOD_GSK3_1	152	159	PF00069	0.744
MOD_GSK3_1	27	34	PF00069	0.746
MOD_GSK3_1	271	278	PF00069	0.622
MOD_GSK3_1	279	286	PF00069	0.588
MOD_GSK3_1	293	300	PF00069	0.814
MOD_GSK3_1	307	314	PF00069	0.702
MOD_GSK3_1	339	346	PF00069	0.842
MOD_GSK3_1	35	42	PF00069	0.748
MOD_GSK3_1	353	360	PF00069	0.681
MOD_GSK3_1	383	390	PF00069	0.669
MOD_GSK3_1	423	430	PF00069	0.634
MOD_GSK3_1	431	438	PF00069	0.739
MOD_GSK3_1	464	471	PF00069	0.748
MOD_GSK3_1	490	497	PF00069	0.685
MOD_GSK3_1	57	64	PF00069	0.766
MOD_GSK3_1	578	585	PF00069	0.556
MOD_GSK3_1	631	638	PF00069	0.510
MOD_GSK3_1	664	671	PF00069	0.463
MOD_GSK3_1	701	708	PF00069	0.635
MOD_GSK3_1	808	815	PF00069	0.518
MOD_GSK3_1	850	857	PF00069	0.545
MOD_GSK3_1	859	866	PF00069	0.701
MOD_GSK3_1	89	96	PF00069	0.648
MOD_N-GLC_1	157	162	PF02516	0.608
MOD_N-GLC_1	431	436	PF02516	0.753
MOD_N-GLC_1	494	499	PF02516	0.756
MOD_N-GLC_1	775	780	PF02516	0.492
MOD_N-GLC_1	871	876	PF02516	0.544
MOD_N-GLC_2	483	485	PF02516	0.817
MOD_NEK2_1	152	157	PF00069	0.806
MOD_NEK2_1	206	211	PF00069	0.660
MOD_NEK2_1	250	255	PF00069	0.567
MOD_NEK2_1	281	286	PF00069	0.712
MOD_NEK2_1	31	36	PF00069	0.744
MOD_NEK2_1	354	359	PF00069	0.755
MOD_NEK2_1	371	376	PF00069	0.650
MOD_NEK2_1	423	428	PF00069	0.509
MOD_NEK2_1	514	519	PF00069	0.465
MOD_NEK2_1	582	587	PF00069	0.568
MOD_NEK2_1	676	681	PF00069	0.445
MOD_NEK2_1	809	814	PF00069	0.511
MOD_NEK2_1	844	849	PF00069	0.488
MOD_NEK2_1	856	861	PF00069	0.602
MOD_NEK2_1	903	908	PF00069	0.463
MOD_NEK2_2	163	168	PF00069	0.815
MOD_NEK2_2	431	436	PF00069	0.753
MOD_NEK2_2	769	774	PF00069	0.476
MOD_PIKK_1	702	708	PF00454	0.635
MOD_PIKK_1	850	856	PF00454	0.572
MOD_PIKK_1	859	865	PF00454	0.602
MOD_PKA_1	507	513	PF00069	0.502
MOD_PKA_2	117	123	PF00069	0.727
MOD_PKA_2	274	280	PF00069	0.634
MOD_PKA_2	31	37	PF00069	0.744
MOD_PKA_2	435	441	PF00069	0.675
MOD_PKA_2	450	456	PF00069	0.714
MOD_PKA_2	464	470	PF00069	0.798
MOD_PKA_2	507	513	PF00069	0.502
MOD_PKA_2	62	68	PF00069	0.742
MOD_PKA_2	679	685	PF00069	0.459
MOD_PKA_2	917	923	PF00069	0.606
MOD_PKA_2	93	99	PF00069	0.611
MOD_Plk_1	240	246	PF00069	0.564
MOD_Plk_1	383	389	PF00069	0.639
MOD_Plk_1	431	437	PF00069	0.759
MOD_Plk_1	775	781	PF00069	0.481
MOD_Plk_1	844	850	PF00069	0.494
MOD_Plk_2-3	240	246	PF00069	0.817
MOD_Plk_2-3	775	781	PF00069	0.489
MOD_Plk_4	132	138	PF00069	0.584
MOD_Plk_4	147	153	PF00069	0.511
MOD_Plk_4	389	395	PF00069	0.500
MOD_Plk_4	437	443	PF00069	0.686
MOD_Plk_4	531	537	PF00069	0.474
MOD_Plk_4	540	546	PF00069	0.526
MOD_Plk_4	578	584	PF00069	0.409
MOD_Plk_4	618	624	PF00069	0.459
MOD_Plk_4	671	677	PF00069	0.475
MOD_Plk_4	727	733	PF00069	0.449
MOD_Plk_4	769	775	PF00069	0.482
MOD_Plk_4	790	796	PF00069	0.464
MOD_Plk_4	815	821	PF00069	0.628
MOD_ProDKin_1	12	18	PF00069	0.748
MOD_ProDKin_1	140	146	PF00069	0.728
MOD_ProDKin_1	261	267	PF00069	0.747
MOD_ProDKin_1	283	289	PF00069	0.716
MOD_ProDKin_1	312	318	PF00069	0.612
MOD_ProDKin_1	330	336	PF00069	0.720
MOD_ProDKin_1	341	347	PF00069	0.719
MOD_ProDKin_1	478	484	PF00069	0.725
MOD_ProDKin_1	538	544	PF00069	0.557
MOD_ProDKin_1	563	569	PF00069	0.537
MOD_ProDKin_1	77	83	PF00069	0.718
MOD_SUMO_rev_2	240	250	PF00179	0.762
MOD_SUMO_rev_2	253	263	PF00179	0.717
TRG_DiLeu_BaEn_1	658	663	PF01217	0.522
TRG_ENDOCYTIC_2	207	210	PF00928	0.657
TRG_ENDOCYTIC_2	220	223	PF00928	0.663
TRG_ENDOCYTIC_2	422	425	PF00928	0.474
TRG_ENDOCYTIC_2	719	722	PF00928	0.492
TRG_ENDOCYTIC_2	742	745	PF00928	0.445
TRG_ER_diArg_1	177	180	PF00400	0.579
TRG_ER_diArg_1	435	437	PF00400	0.606
TRG_ER_diArg_1	500	503	PF00400	0.627
TRG_ER_diArg_1	506	508	PF00400	0.534
TRG_ER_diArg_1	536	539	PF00400	0.541
TRG_ER_diArg_1	560	562	PF00400	0.475
TRG_NLS_MonoExtC_3	139	144	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN7	Leptomonas seymouri	69%	99%
A0A3S7X5H5	Leishmania donovani	82%	100%
A4I7Y0	Leishmania infantum	82%	100%
E9B2U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q5B5	Leishmania major	81%	100%