Putative chromosomal passenger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chromosomal passenger complex 2

Species:

Leishmania braziliensis

UniProt:

A4HKF1_LEIBR

TriTrypDb:

LbrM.32.1810 , LBRM2903_320024400

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0005876	spindle microtubule	7	1
GO:0032133	chromosome passenger complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKF1

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007051	spindle organization	3	1
GO:0007059	chromosome segregation	2	1
GO:0009987	cellular process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0033044	regulation of chromosome organization	6	1
GO:0033045	regulation of sister chromatid segregation	5	1
GO:0033047	regulation of mitotic sister chromatid segregation	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051225	spindle assembly	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0051983	regulation of chromosome segregation	4	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0065007	biological regulation	1	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140694	non-membrane-bounded organelle assembly	6	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.669
CLV_NRD_NRD_1	147	149	PF00675	0.456
CLV_NRD_NRD_1	193	195	PF00675	0.663
CLV_PCSK_KEX2_1	147	149	PF00082	0.456
CLV_PCSK_KEX2_1	78	80	PF00082	0.573
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.457
CLV_PCSK_SKI1_1	148	152	PF00082	0.521
CLV_PCSK_SKI1_1	68	72	PF00082	0.424
CLV_PCSK_SKI1_1	75	79	PF00082	0.431
DEG_APCC_DBOX_1	24	32	PF00400	0.617
DOC_CKS1_1	156	161	PF01111	0.660
DOC_CKS1_1	203	208	PF01111	0.536
DOC_MAPK_gen_1	147	155	PF00069	0.694
DOC_MAPK_gen_1	75	85	PF00069	0.595
DOC_MAPK_MEF2A_6	147	155	PF00069	0.422
DOC_PP4_FxxP_1	203	206	PF00568	0.539
DOC_USP7_MATH_1	154	158	PF00917	0.569
DOC_USP7_MATH_1	175	179	PF00917	0.674
DOC_USP7_MATH_1	188	192	PF00917	0.558
DOC_USP7_MATH_1	52	56	PF00917	0.601
DOC_WW_Pin1_4	108	113	PF00397	0.689
DOC_WW_Pin1_4	117	122	PF00397	0.615
DOC_WW_Pin1_4	155	160	PF00397	0.593
DOC_WW_Pin1_4	202	207	PF00397	0.537
DOC_WW_Pin1_4	210	215	PF00397	0.534
LIG_14-3-3_CanoR_1	79	84	PF00244	0.707
LIG_14-3-3_CanoR_1	89	96	PF00244	0.646
LIG_AP2alpha_2	9	11	PF02296	0.593
LIG_APCC_ABBA_1	8	13	PF00400	0.603
LIG_BIR_II_1	1	5	PF00653	0.520
LIG_BRCT_BRCA1_1	199	203	PF00533	0.669
LIG_BRCT_BRCA1_1	54	58	PF00533	0.551
LIG_FHA_1	126	132	PF00498	0.750
LIG_FHA_1	184	190	PF00498	0.568
LIG_FHA_1	61	67	PF00498	0.385
LIG_FHA_1	80	86	PF00498	0.592
LIG_FHA_2	117	123	PF00498	0.672
LIG_FHA_2	203	209	PF00498	0.544
LIG_LIR_Apic_2	200	206	PF02991	0.544
LIG_LIR_Gen_1	55	66	PF02991	0.592
LIG_LIR_Nem_3	208	212	PF02991	0.522
LIG_LIR_Nem_3	55	61	PF02991	0.510
LIG_LIR_Nem_3	9	14	PF02991	0.491
LIG_SH2_STAP1	81	85	PF00017	0.670
LIG_SH2_STAT5	39	42	PF00017	0.543
LIG_SH2_STAT5	62	65	PF00017	0.382
LIG_SH2_STAT5	81	84	PF00017	0.610
MOD_CK1_1	157	163	PF00069	0.708
MOD_CK1_1	178	184	PF00069	0.767
MOD_CK2_1	116	122	PF00069	0.661
MOD_CK2_1	127	133	PF00069	0.617
MOD_CK2_1	202	208	PF00069	0.593
MOD_GlcNHglycan	1	4	PF01048	0.537
MOD_GlcNHglycan	177	180	PF01048	0.557
MOD_GlcNHglycan	91	94	PF01048	0.640
MOD_GSK3_1	127	134	PF00069	0.676
MOD_GSK3_1	154	161	PF00069	0.601
MOD_GSK3_1	178	185	PF00069	0.553
MOD_GSK3_1	197	204	PF00069	0.718
MOD_NEK2_1	131	136	PF00069	0.645
MOD_NEK2_1	201	206	PF00069	0.641
MOD_NEK2_1	88	93	PF00069	0.636
MOD_PIKK_1	158	164	PF00454	0.672
MOD_PKA_2	88	94	PF00069	0.617
MOD_Plk_4	127	133	PF00069	0.664
MOD_Plk_4	197	203	PF00069	0.657
MOD_ProDKin_1	108	114	PF00069	0.689
MOD_ProDKin_1	117	123	PF00069	0.613
MOD_ProDKin_1	155	161	PF00069	0.589
MOD_ProDKin_1	202	208	PF00069	0.538
MOD_SUMO_rev_2	120	128	PF00179	0.634
TRG_Pf-PMV_PEXEL_1	15	20	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P979	Leptomonas seymouri	60%	96%
A0A1X0NUE6	Trypanosomatidae	29%	91%
A0A3S7X5K6	Leishmania donovani	77%	97%
A0A422NL93	Trypanosoma rangeli	33%	93%
A4I7X9	Leishmania infantum	78%	97%
E9B2U0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	97%
Q4Q5B6	Leishmania major	76%	100%
V5BJL0	Trypanosoma cruzi	32%	73%