Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKF0_LEIBR

TriTrypDb:

LbrM.32.1800 , LBRM2903_320024300

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HKF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.864
CLV_NRD_NRD_1	17	19	PF00675	0.539
CLV_PCSK_KEX2_1	17	19	PF00082	0.539
CLV_PCSK_KEX2_1	172	174	PF00082	0.662
CLV_PCSK_KEX2_1	250	252	PF00082	0.655
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.662
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.655
CLV_PCSK_SKI1_1	17	21	PF00082	0.541
CLV_PCSK_SKI1_1	237	241	PF00082	0.642
DEG_Nend_Nbox_1	1	3	PF02207	0.760
DEG_SCF_FBW7_1	110	115	PF00400	0.849
DEG_SCF_FBW7_2	198	205	PF00400	0.883
DEG_SIAH_1	58	66	PF03145	0.612
DEG_SPOP_SBC_1	185	189	PF00917	0.877
DEG_SPOP_SBC_1	190	194	PF00917	0.813
DEG_SPOP_SBC_1	306	310	PF00917	0.868
DOC_CKS1_1	199	204	PF01111	0.884
DOC_CKS1_1	21	26	PF01111	0.754
DOC_CKS1_1	262	267	PF01111	0.847
DOC_CKS1_1	315	320	PF01111	0.850
DOC_CKS1_1	347	352	PF01111	0.846
DOC_CKS1_1	91	96	PF01111	0.760
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.866
DOC_CYCLIN_yCln2_LP_2	47	50	PF00134	0.738
DOC_MAPK_gen_1	235	242	PF00069	0.843
DOC_MAPK_MEF2A_6	208	217	PF00069	0.871
DOC_MAPK_MEF2A_6	22	30	PF00069	0.650
DOC_MAPK_MEF2A_6	69	77	PF00069	0.449
DOC_MAPK_RevD_3	134	149	PF00069	0.828
DOC_PP2B_LxvP_1	46	49	PF13499	0.734
DOC_USP7_MATH_1	112	116	PF00917	0.847
DOC_USP7_MATH_1	124	128	PF00917	0.674
DOC_USP7_MATH_1	183	187	PF00917	0.879
DOC_USP7_MATH_1	190	194	PF00917	0.788
DOC_USP7_MATH_1	292	296	PF00917	0.867
DOC_USP7_MATH_1	368	372	PF00917	0.847
DOC_USP7_MATH_1	73	77	PF00917	0.549
DOC_USP7_MATH_2	302	308	PF00917	0.867
DOC_USP7_UBL2_3	384	388	PF12436	0.806
DOC_WW_Pin1_4	100	105	PF00397	0.712
DOC_WW_Pin1_4	108	113	PF00397	0.627
DOC_WW_Pin1_4	120	125	PF00397	0.595
DOC_WW_Pin1_4	191	196	PF00397	0.877
DOC_WW_Pin1_4	198	203	PF00397	0.797
DOC_WW_Pin1_4	20	25	PF00397	0.753
DOC_WW_Pin1_4	207	212	PF00397	0.673
DOC_WW_Pin1_4	261	266	PF00397	0.848
DOC_WW_Pin1_4	295	300	PF00397	0.871
DOC_WW_Pin1_4	314	319	PF00397	0.614
DOC_WW_Pin1_4	327	332	PF00397	0.674
DOC_WW_Pin1_4	338	343	PF00397	0.720
DOC_WW_Pin1_4	346	351	PF00397	0.608
DOC_WW_Pin1_4	360	365	PF00397	0.677
DOC_WW_Pin1_4	90	95	PF00397	0.760
LIG_14-3-3_CanoR_1	294	299	PF00244	0.871
LIG_14-3-3_CanoR_1	377	385	PF00244	0.804
LIG_14-3-3_CanoR_1	67	73	PF00244	0.449
LIG_Actin_WH2_2	235	252	PF00022	0.848
LIG_BRCT_BRCA1_1	347	351	PF00533	0.845
LIG_BRCT_BRCA1_1	378	382	PF00533	0.800
LIG_BRCT_BRCA1_2	378	384	PF00533	0.802
LIG_EH1_1	1	9	PF00400	0.738
LIG_eIF4E_1	2	8	PF01652	0.735
LIG_FHA_1	21	27	PF00498	0.523
LIG_FHA_1	214	220	PF00498	0.866
LIG_FHA_1	3	9	PF00498	0.728
LIG_FHA_1	311	317	PF00498	0.863
LIG_FHA_2	307	313	PF00498	0.872
LIG_FHA_2	315	321	PF00498	0.748
LIG_LIR_Apic_2	281	287	PF02991	0.852
LIG_LIR_Gen_1	320	331	PF02991	0.842
LIG_LIR_Gen_1	379	386	PF02991	0.802
LIG_LIR_Gen_1	42	53	PF02991	0.732
LIG_LIR_Nem_3	320	326	PF02991	0.846
LIG_LIR_Nem_3	36	41	PF02991	0.549
LIG_LIR_Nem_3	42	48	PF02991	0.444
LIG_LIR_Nem_3	51	55	PF02991	0.405
LIG_MLH1_MIPbox_1	378	382	PF16413	0.800
LIG_NRBOX	7	13	PF00104	0.719
LIG_NRP_CendR_1	388	389	PF00754	0.619
LIG_PCNA_PIPBox_1	375	384	PF02747	0.806
LIG_PCNA_yPIPBox_3	373	382	PF02747	0.812
LIG_Pex14_1	85	89	PF04695	0.549
LIG_Pex14_2	52	56	PF04695	0.600
LIG_Pex14_2	81	85	PF04695	0.549
LIG_REV1ctd_RIR_1	379	388	PF16727	0.802
LIG_SH2_CRK	284	288	PF00017	0.850
LIG_SH2_GRB2like	27	30	PF00017	0.549
LIG_SH2_PTP2	27	30	PF00017	0.549
LIG_SH2_SRC	27	30	PF00017	0.549
LIG_SH2_STAT5	27	30	PF00017	0.549
LIG_SH2_STAT5	284	287	PF00017	0.849
LIG_SH2_STAT5	33	36	PF00017	0.444
LIG_SH3_1	148	154	PF00018	0.859
LIG_SH3_1	18	24	PF00018	0.749
LIG_SH3_1	208	214	PF00018	0.872
LIG_SH3_3	148	154	PF00018	0.859
LIG_SH3_3	18	24	PF00018	0.749
LIG_SH3_3	196	202	PF00018	0.885
LIG_SH3_3	208	214	PF00018	0.722
LIG_SH3_3	296	302	PF00018	0.866
LIG_SH3_3	344	350	PF00018	0.847
LIG_SH3_3	88	94	PF00018	0.549
LIG_SUMO_SIM_anti_2	130	135	PF11976	0.816
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.727
LIG_SUMO_SIM_par_1	238	243	PF11976	0.842
LIG_SUMO_SIM_par_1	73	79	PF11976	0.549
LIG_TRAF2_1	317	320	PF00917	0.846
LIG_TRFH_1	45	49	PF08558	0.549
LIG_TRFH_1	90	94	PF08558	0.549
LIG_TYR_ITIM	25	30	PF00017	0.549
LIG_WRC_WIRS_1	35	40	PF05994	0.549
MOD_CDK_SPxK_1	198	204	PF00069	0.878
MOD_CDK_SPxxK_3	314	321	PF00069	0.830
MOD_CDK_SPxxK_3	338	345	PF00069	0.841
MOD_CK1_1	100	106	PF00069	0.815
MOD_CK1_1	108	114	PF00069	0.690
MOD_CK1_1	115	121	PF00069	0.567
MOD_CK1_1	127	133	PF00069	0.451
MOD_CK1_1	186	192	PF00069	0.866
MOD_CK1_1	193	199	PF00069	0.750
MOD_CK1_1	207	213	PF00069	0.618
MOD_CK1_1	252	258	PF00069	0.831
MOD_CK1_1	295	301	PF00069	0.855
MOD_CK1_1	307	313	PF00069	0.651
MOD_CK1_1	346	352	PF00069	0.825
MOD_CK1_1	362	368	PF00069	0.559
MOD_CK1_1	371	377	PF00069	0.641
MOD_CK1_1	76	82	PF00069	0.549
MOD_CK2_1	185	191	PF00069	0.866
MOD_CK2_1	306	312	PF00069	0.858
MOD_CK2_1	314	320	PF00069	0.692
MOD_GlcNHglycan	118	121	PF01048	0.501
MOD_GlcNHglycan	188	191	PF01048	0.863
MOD_GlcNHglycan	251	254	PF01048	0.830
MOD_GlcNHglycan	271	274	PF01048	0.489
MOD_GlcNHglycan	290	293	PF01048	0.509
MOD_GlcNHglycan	338	341	PF01048	0.855
MOD_GlcNHglycan	70	73	PF01048	0.549
MOD_GlcNHglycan	99	102	PF01048	0.805
MOD_GSK3_1	108	115	PF00069	0.567
MOD_GSK3_1	116	123	PF00069	0.690
MOD_GSK3_1	181	188	PF00069	0.869
MOD_GSK3_1	189	196	PF00069	0.726
MOD_GSK3_1	229	236	PF00069	0.808
MOD_GSK3_1	245	252	PF00069	0.554
MOD_GSK3_1	282	289	PF00069	0.833
MOD_GSK3_1	306	313	PF00069	0.858
MOD_GSK3_1	334	341	PF00069	0.846
MOD_GSK3_1	351	358	PF00069	0.535
MOD_GSK3_1	359	366	PF00069	0.693
MOD_GSK3_1	369	376	PF00069	0.494
MOD_GSK3_1	93	100	PF00069	0.778
MOD_N-GLC_1	282	287	PF02516	0.831
MOD_NEK2_1	144	149	PF00069	0.824
MOD_NEK2_1	233	238	PF00069	0.815
MOD_NEK2_1	311	316	PF00069	0.852
MOD_NEK2_2	245	250	PF00069	0.834
MOD_NEK2_2	355	360	PF00069	0.828
MOD_OFUCOSY	99	106	PF10250	0.812
MOD_PIKK_1	282	288	PF00454	0.832
MOD_PIKK_1	366	372	PF00454	0.832
MOD_PIKK_1	93	99	PF00454	0.775
MOD_PKA_2	181	187	PF00069	0.870
MOD_PKA_2	376	382	PF00069	0.766
MOD_PKA_2	68	74	PF00069	0.549
MOD_Plk_1	204	210	PF00069	0.868
MOD_Plk_1	311	317	PF00069	0.849
MOD_Plk_1	319	325	PF00069	0.683
MOD_Plk_1	355	361	PF00069	0.828
MOD_Plk_4	194	200	PF00069	0.874
MOD_Plk_4	311	317	PF00069	0.849
MOD_Plk_4	355	361	PF00069	0.828
MOD_Plk_4	48	54	PF00069	0.744
MOD_Plk_4	73	79	PF00069	0.549
MOD_ProDKin_1	100	106	PF00069	0.640
MOD_ProDKin_1	108	114	PF00069	0.515
MOD_ProDKin_1	120	126	PF00069	0.468
MOD_ProDKin_1	191	197	PF00069	0.870
MOD_ProDKin_1	198	204	PF00069	0.755
MOD_ProDKin_1	20	26	PF00069	0.691
MOD_ProDKin_1	207	213	PF00069	0.583
MOD_ProDKin_1	261	267	PF00069	0.826
MOD_ProDKin_1	295	301	PF00069	0.855
MOD_ProDKin_1	314	320	PF00069	0.500
MOD_ProDKin_1	327	333	PF00069	0.586
MOD_ProDKin_1	338	344	PF00069	0.647
MOD_ProDKin_1	346	352	PF00069	0.492
MOD_ProDKin_1	360	366	PF00069	0.589
MOD_ProDKin_1	90	96	PF00069	0.761
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.651
TRG_ENDOCYTIC_2	27	30	PF00928	0.549
TRG_ER_diArg_1	16	18	PF00400	0.655
TRG_ER_diArg_1	66	69	PF00400	0.784