Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKE9_LEIBR

TriTrypDb:

LbrM.32.1790 , LBRM2903_320024200

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.586
CLV_C14_Caspase3-7	300	304	PF00656	0.504
CLV_C14_Caspase3-7	734	738	PF00656	0.733
CLV_NRD_NRD_1	133	135	PF00675	0.542
CLV_NRD_NRD_1	233	235	PF00675	0.436
CLV_NRD_NRD_1	328	330	PF00675	0.392
CLV_NRD_NRD_1	633	635	PF00675	0.519
CLV_NRD_NRD_1	640	642	PF00675	0.521
CLV_NRD_NRD_1	718	720	PF00675	0.662
CLV_NRD_NRD_1	725	727	PF00675	0.668
CLV_PCSK_KEX2_1	133	135	PF00082	0.542
CLV_PCSK_KEX2_1	233	235	PF00082	0.436
CLV_PCSK_KEX2_1	237	239	PF00082	0.438
CLV_PCSK_KEX2_1	480	482	PF00082	0.506
CLV_PCSK_KEX2_1	633	635	PF00082	0.524
CLV_PCSK_KEX2_1	640	642	PF00082	0.532
CLV_PCSK_KEX2_1	718	720	PF00082	0.627
CLV_PCSK_KEX2_1	763	765	PF00082	0.569
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.438
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.540
CLV_PCSK_PC1ET2_1	763	765	PF00082	0.569
CLV_PCSK_PC7_1	233	239	PF00082	0.433
CLV_PCSK_SKI1_1	234	238	PF00082	0.439
CLV_PCSK_SKI1_1	265	269	PF00082	0.604
CLV_PCSK_SKI1_1	455	459	PF00082	0.454
CLV_PCSK_SKI1_1	506	510	PF00082	0.454
CLV_PCSK_SKI1_1	533	537	PF00082	0.560
CLV_PCSK_SKI1_1	542	546	PF00082	0.418
CLV_PCSK_SKI1_1	634	638	PF00082	0.364
CLV_Separin_Metazoa	678	682	PF03568	0.486
DEG_APCC_DBOX_1	505	513	PF00400	0.489
DOC_ANK_TNKS_1	328	335	PF00023	0.355
DOC_CYCLIN_RxL_1	503	511	PF00134	0.486
DOC_CYCLIN_RxL_1	530	540	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.600
DOC_MAPK_DCC_7	237	247	PF00069	0.514
DOC_MAPK_DCC_7	592	601	PF00069	0.554
DOC_MAPK_gen_1	233	242	PF00069	0.514
DOC_MAPK_gen_1	25	33	PF00069	0.429
DOC_MAPK_gen_1	263	270	PF00069	0.551
DOC_MAPK_gen_1	633	639	PF00069	0.315
DOC_MAPK_MEF2A_6	238	247	PF00069	0.509
DOC_MAPK_MEF2A_6	592	601	PF00069	0.554
DOC_PP1_RVXF_1	131	138	PF00149	0.475
DOC_PP1_RVXF_1	632	639	PF00149	0.466
DOC_PP2B_LxvP_1	240	243	PF13499	0.507
DOC_PP2B_LxvP_1	31	34	PF13499	0.505
DOC_PP2B_LxvP_1	594	597	PF13499	0.541
DOC_USP7_MATH_1	18	22	PF00917	0.468
DOC_USP7_MATH_1	274	278	PF00917	0.431
DOC_USP7_MATH_1	491	495	PF00917	0.571
DOC_USP7_MATH_1	555	559	PF00917	0.685
DOC_USP7_MATH_1	673	677	PF00917	0.601
DOC_USP7_MATH_1	7	11	PF00917	0.415
DOC_USP7_UBL2_3	723	727	PF12436	0.619
DOC_WW_Pin1_4	111	116	PF00397	0.670
DOC_WW_Pin1_4	306	311	PF00397	0.570
DOC_WW_Pin1_4	352	357	PF00397	0.604
DOC_WW_Pin1_4	79	84	PF00397	0.314
LIG_14-3-3_CanoR_1	189	197	PF00244	0.514
LIG_14-3-3_CanoR_1	209	218	PF00244	0.234
LIG_14-3-3_CanoR_1	233	237	PF00244	0.440
LIG_14-3-3_CanoR_1	390	394	PF00244	0.591
LIG_14-3-3_CanoR_1	608	614	PF00244	0.563
LIG_14-3-3_CanoR_1	718	722	PF00244	0.638
LIG_Actin_WH2_2	440	457	PF00022	0.496
LIG_BRCT_BRCA1_1	471	475	PF00533	0.356
LIG_BRCT_BRCA1_1	509	513	PF00533	0.478
LIG_BRCT_BRCA1_2	471	477	PF00533	0.374
LIG_deltaCOP1_diTrp_1	404	408	PF00928	0.400
LIG_deltaCOP1_diTrp_1	87	95	PF00928	0.401
LIG_Dynein_DLC8_1	24	30	PF01221	0.449
LIG_EH1_1	261	269	PF00400	0.643
LIG_eIF4E_1	371	377	PF01652	0.281
LIG_FHA_1	167	173	PF00498	0.480
LIG_FHA_1	26	32	PF00498	0.483
LIG_FHA_1	289	295	PF00498	0.533
LIG_FHA_1	416	422	PF00498	0.424
LIG_FHA_1	557	563	PF00498	0.605
LIG_FHA_1	60	66	PF00498	0.520
LIG_FHA_2	298	304	PF00498	0.580
LIG_FHA_2	396	402	PF00498	0.336
LIG_FHA_2	433	439	PF00498	0.597
LIG_FHA_2	474	480	PF00498	0.592
LIG_FHA_2	585	591	PF00498	0.704
LIG_LIR_Gen_1	200	207	PF02991	0.319
LIG_LIR_Gen_1	35	43	PF02991	0.527
LIG_LIR_Gen_1	370	381	PF02991	0.479
LIG_LIR_Gen_1	404	414	PF02991	0.363
LIG_LIR_Gen_1	418	427	PF02991	0.442
LIG_LIR_Gen_1	658	668	PF02991	0.456
LIG_LIR_Nem_3	127	132	PF02991	0.485
LIG_LIR_Nem_3	200	204	PF02991	0.447
LIG_LIR_Nem_3	35	40	PF02991	0.530
LIG_LIR_Nem_3	368	374	PF02991	0.568
LIG_LIR_Nem_3	404	409	PF02991	0.372
LIG_LIR_Nem_3	658	663	PF02991	0.533
LIG_MAD2	215	223	PF02301	0.336
LIG_Pex14_1	380	384	PF04695	0.401
LIG_Rb_pABgroove_1	507	515	PF01858	0.510
LIG_SH2_CRK	132	136	PF00017	0.517
LIG_SH2_CRK	201	205	PF00017	0.312
LIG_SH2_CRK	459	463	PF00017	0.503
LIG_SH2_CRK	68	72	PF00017	0.476
LIG_SH2_CRK	691	695	PF00017	0.723
LIG_SH2_GRB2like	443	446	PF00017	0.447
LIG_SH2_NCK_1	201	205	PF00017	0.312
LIG_SH2_NCK_1	691	695	PF00017	0.723
LIG_SH2_SRC	153	156	PF00017	0.321
LIG_SH2_SRC	254	257	PF00017	0.574
LIG_SH2_SRC	443	446	PF00017	0.563
LIG_SH2_STAP1	153	157	PF00017	0.319
LIG_SH2_STAT5	23	26	PF00017	0.623
LIG_SH2_STAT5	371	374	PF00017	0.452
LIG_SH2_STAT5	384	387	PF00017	0.373
LIG_SH2_STAT5	443	446	PF00017	0.574
LIG_SH3_1	77	83	PF00018	0.309
LIG_SH3_2	358	363	PF14604	0.487
LIG_SH3_2	80	85	PF14604	0.315
LIG_SH3_3	109	115	PF00018	0.449
LIG_SH3_3	220	226	PF00018	0.600
LIG_SH3_3	242	248	PF00018	0.571
LIG_SH3_3	355	361	PF00018	0.511
LIG_SH3_3	661	667	PF00018	0.552
LIG_SH3_3	680	686	PF00018	0.468
LIG_SH3_3	77	83	PF00018	0.309
LIG_SUMO_SIM_par_1	28	35	PF11976	0.485
LIG_TYR_ITIM	457	462	PF00017	0.324
LIG_UBA3_1	324	330	PF00899	0.494
LIG_UBA3_1	344	352	PF00899	0.272
LIG_WRC_WIRS_1	501	506	PF05994	0.419
LIG_WW_3	310	314	PF00397	0.491
MOD_CDC14_SPxK_1	82	85	PF00782	0.326
MOD_CDK_SPxK_1	79	85	PF00069	0.310
MOD_CDK_SPxxK_3	306	313	PF00069	0.527
MOD_CK1_1	100	106	PF00069	0.624
MOD_CK1_1	110	116	PF00069	0.644
MOD_CK1_1	156	162	PF00069	0.572
MOD_CK1_1	191	197	PF00069	0.527
MOD_CK1_1	32	38	PF00069	0.502
MOD_CK1_1	473	479	PF00069	0.481
MOD_CK1_1	584	590	PF00069	0.674
MOD_CK2_1	432	438	PF00069	0.600
MOD_CK2_1	473	479	PF00069	0.601
MOD_CK2_1	584	590	PF00069	0.686
MOD_CK2_1	672	678	PF00069	0.742
MOD_CMANNOS	657	660	PF00535	0.595
MOD_CMANNOS	86	89	PF00535	0.416
MOD_GlcNHglycan	103	106	PF01048	0.560
MOD_GlcNHglycan	155	158	PF01048	0.425
MOD_GlcNHglycan	190	193	PF01048	0.533
MOD_GlcNHglycan	472	475	PF01048	0.622
MOD_GlcNHglycan	583	586	PF01048	0.691
MOD_GlcNHglycan	609	612	PF01048	0.492
MOD_GlcNHglycan	652	656	PF01048	0.556
MOD_GlcNHglycan	675	678	PF01048	0.715
MOD_GlcNHglycan	737	740	PF01048	0.706
MOD_GlcNHglycan	74	77	PF01048	0.510
MOD_GlcNHglycan	9	12	PF01048	0.507
MOD_GSK3_1	107	114	PF00069	0.674
MOD_GSK3_1	25	32	PF00069	0.512
MOD_GSK3_1	275	282	PF00069	0.509
MOD_GSK3_1	380	387	PF00069	0.550
MOD_GSK3_1	391	398	PF00069	0.561
MOD_GSK3_1	469	476	PF00069	0.548
MOD_GSK3_1	727	734	PF00069	0.573
MOD_GSK3_1	97	104	PF00069	0.626
MOD_N-GLC_1	365	370	PF02516	0.474
MOD_NEK2_1	124	129	PF00069	0.505
MOD_NEK2_1	227	232	PF00069	0.325
MOD_NEK2_1	324	329	PF00069	0.439
MOD_NEK2_1	365	370	PF00069	0.474
MOD_NEK2_1	513	518	PF00069	0.540
MOD_NEK2_1	545	550	PF00069	0.505
MOD_NEK2_1	643	648	PF00069	0.424
MOD_PIKK_1	25	31	PF00454	0.551
MOD_PIKK_1	312	318	PF00454	0.431
MOD_PIKK_1	365	371	PF00454	0.496
MOD_PIKK_1	59	65	PF00454	0.447
MOD_PK_1	662	668	PF00069	0.365
MOD_PKA_1	25	31	PF00069	0.439
MOD_PKA_1	726	732	PF00069	0.653
MOD_PKA_2	188	194	PF00069	0.536
MOD_PKA_2	232	238	PF00069	0.418
MOD_PKA_2	312	318	PF00069	0.578
MOD_PKA_2	389	395	PF00069	0.570
MOD_PKA_2	607	613	PF00069	0.559
MOD_PKA_2	699	705	PF00069	0.720
MOD_PKA_2	717	723	PF00069	0.467
MOD_Plk_1	97	103	PF00069	0.670
MOD_Plk_4	124	130	PF00069	0.545
MOD_Plk_4	156	162	PF00069	0.564
MOD_Plk_4	227	233	PF00069	0.411
MOD_Plk_4	275	281	PF00069	0.526
MOD_Plk_4	32	38	PF00069	0.547
MOD_Plk_4	367	373	PF00069	0.486
MOD_Plk_4	380	386	PF00069	0.469
MOD_Plk_4	457	463	PF00069	0.485
MOD_Plk_4	491	497	PF00069	0.481
MOD_Plk_4	547	553	PF00069	0.601
MOD_Plk_4	741	747	PF00069	0.519
MOD_ProDKin_1	111	117	PF00069	0.655
MOD_ProDKin_1	306	312	PF00069	0.568
MOD_ProDKin_1	352	358	PF00069	0.611
MOD_ProDKin_1	79	85	PF00069	0.310
MOD_SUMO_rev_2	255	264	PF00179	0.591
MOD_SUMO_rev_2	538	544	PF00179	0.499
TRG_DiLeu_BaEn_1	12	17	PF01217	0.310
TRG_DiLeu_BaEn_1	659	664	PF01217	0.552
TRG_DiLeu_BaEn_2	332	338	PF01217	0.331
TRG_ENDOCYTIC_2	128	131	PF00928	0.486
TRG_ENDOCYTIC_2	132	135	PF00928	0.486
TRG_ENDOCYTIC_2	201	204	PF00928	0.486
TRG_ENDOCYTIC_2	37	40	PF00928	0.551
TRG_ENDOCYTIC_2	371	374	PF00928	0.490
TRG_ENDOCYTIC_2	459	462	PF00928	0.332
TRG_ENDOCYTIC_2	546	549	PF00928	0.524
TRG_ENDOCYTIC_2	68	71	PF00928	0.397
TRG_ER_diArg_1	132	134	PF00400	0.545
TRG_ER_diArg_1	232	234	PF00400	0.445
TRG_ER_diArg_1	632	634	PF00400	0.528
TRG_ER_diArg_1	639	641	PF00400	0.519
TRG_NES_CRM1_1	540	553	PF08389	0.531
TRG_NES_CRM1_1	560	574	PF08389	0.271
TRG_NLS_MonoExtC_3	762	768	PF00514	0.616
TRG_NLS_MonoExtN_4	761	767	PF00514	0.763
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	506	511	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	533	538	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P980	Leptomonas seymouri	42%	100%
A0A1X0NUC5	Trypanosomatidae	25%	100%
A0A3Q8IG63	Leishmania donovani	71%	100%
A4I7X7	Leishmania infantum	71%	100%
E9B2T8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q5B9	Leishmania major	71%	100%
V5AZI4	Trypanosoma cruzi	27%	100%