NYN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKE8_LEIBR

TriTrypDb:

LbrM.32.1780 , LBRM2903_320024100

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.504
CLV_C14_Caspase3-7	284	288	PF00656	0.555
CLV_C14_Caspase3-7	29	33	PF00656	0.487
CLV_C14_Caspase3-7	56	60	PF00656	0.641
CLV_NRD_NRD_1	231	233	PF00675	0.466
CLV_NRD_NRD_1	292	294	PF00675	0.726
CLV_PCSK_FUR_1	229	233	PF00082	0.541
CLV_PCSK_KEX2_1	173	175	PF00082	0.406
CLV_PCSK_KEX2_1	231	233	PF00082	0.433
CLV_PCSK_KEX2_1	260	262	PF00082	0.385
CLV_PCSK_KEX2_1	292	294	PF00082	0.726
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.474
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.391
CLV_PCSK_SKI1_1	231	235	PF00082	0.507
CLV_PCSK_SKI1_1	58	62	PF00082	0.423
CLV_PCSK_SKI1_1	98	102	PF00082	0.295
DEG_Nend_Nbox_1	1	3	PF02207	0.539
DOC_CKS1_1	187	192	PF01111	0.487
DOC_MAPK_gen_1	173	181	PF00069	0.432
DOC_MAPK_MEF2A_6	98	107	PF00069	0.249
DOC_PP1_RVXF_1	1	8	PF00149	0.578
DOC_PP4_FxxP_1	187	190	PF00568	0.472
DOC_PP4_FxxP_1	40	43	PF00568	0.536
DOC_USP7_MATH_1	148	152	PF00917	0.542
DOC_USP7_MATH_1	71	75	PF00917	0.584
DOC_WW_Pin1_4	186	191	PF00397	0.349
LIG_14-3-3_CanoR_1	162	167	PF00244	0.543
LIG_14-3-3_CanoR_1	249	253	PF00244	0.366
LIG_APCC_ABBA_1	120	125	PF00400	0.490
LIG_Clathr_ClatBox_1	106	110	PF01394	0.308
LIG_EH1_1	100	108	PF00400	0.313
LIG_eIF4E_1	228	234	PF01652	0.490
LIG_FHA_1	212	218	PF00498	0.446
LIG_FHA_1	82	88	PF00498	0.389
LIG_FHA_2	152	158	PF00498	0.528
LIG_FHA_2	21	27	PF00498	0.579
LIG_LIR_Gen_1	175	181	PF02991	0.371
LIG_LIR_Gen_1	4	15	PF02991	0.636
LIG_LIR_Gen_1	45	54	PF02991	0.492
LIG_LIR_Gen_1	89	96	PF02991	0.479
LIG_LIR_Nem_3	175	180	PF02991	0.326
LIG_LIR_Nem_3	259	265	PF02991	0.510
LIG_LIR_Nem_3	4	10	PF02991	0.568
LIG_LIR_Nem_3	45	51	PF02991	0.488
LIG_NRP_CendR_1	293	296	PF00754	0.498
LIG_Pex14_2	138	142	PF04695	0.381
LIG_Pex14_2	262	266	PF04695	0.362
LIG_PTB_Apo_2	108	115	PF02174	0.368
LIG_PTB_Apo_2	222	229	PF02174	0.382
LIG_PTB_Phospho_1	222	228	PF10480	0.376
LIG_SH2_CRK	203	207	PF00017	0.396
LIG_SH2_SRC	123	126	PF00017	0.376
LIG_SH3_3	10	16	PF00018	0.434
LIG_SH3_3	152	158	PF00018	0.524
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.416
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.432
LIG_SUMO_SIM_par_1	102	108	PF11976	0.298
LIG_TRAF2_1	43	46	PF00917	0.694
LIG_TYR_ITIM	201	206	PF00017	0.386
LIG_UBA3_1	233	237	PF00899	0.541
MOD_CK1_1	140	146	PF00069	0.435
MOD_CK1_1	151	157	PF00069	0.416
MOD_CK1_1	89	95	PF00069	0.460
MOD_CK2_1	151	157	PF00069	0.440
MOD_CK2_1	172	178	PF00069	0.447
MOD_GlcNHglycan	150	153	PF01048	0.367
MOD_GlcNHglycan	283	286	PF01048	0.556
MOD_GlcNHglycan	67	70	PF01048	0.543
MOD_GSK3_1	168	175	PF00069	0.585
MOD_GSK3_1	211	218	PF00069	0.439
MOD_NEK2_1	137	142	PF00069	0.347
MOD_OFUCOSY	136	141	PF10250	0.284
MOD_PK_1	162	168	PF00069	0.585
MOD_PKA_2	20	26	PF00069	0.542
MOD_PKA_2	248	254	PF00069	0.388
MOD_PKA_2	89	95	PF00069	0.366
MOD_Plk_4	248	254	PF00069	0.519
MOD_ProDKin_1	186	192	PF00069	0.359
MOD_SUMO_rev_2	119	129	PF00179	0.276
TRG_DiLeu_BaEn_3	45	51	PF01217	0.549
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.495
TRG_ENDOCYTIC_2	123	126	PF00928	0.451
TRG_ENDOCYTIC_2	203	206	PF00928	0.391
TRG_ENDOCYTIC_2	91	94	PF00928	0.505
TRG_ER_diArg_1	228	231	PF00400	0.436
TRG_ER_diArg_1	292	295	PF00400	0.767
TRG_NES_CRM1_1	207	220	PF08389	0.418
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMW3	Leptomonas seymouri	64%	99%
A0A1X0NUU9	Trypanosomatidae	46%	95%
A0A3S7X5I4	Leishmania donovani	80%	100%
A0A422NL68	Trypanosoma rangeli	40%	100%
A4I7X6	Leishmania infantum	80%	100%
D0AA41	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
E9B2T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q5C0	Leishmania major	79%	100%
V5BF01	Trypanosoma cruzi	41%	100%