Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKE7_LEIBR

TriTrypDb:

LbrM.32.1770 , LBRM2903_320024000

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.583
CLV_C14_Caspase3-7	295	299	PF00656	0.601
CLV_C14_Caspase3-7	376	380	PF00656	0.693
CLV_NRD_NRD_1	138	140	PF00675	0.498
CLV_NRD_NRD_1	33	35	PF00675	0.732
CLV_NRD_NRD_1	377	379	PF00675	0.584
CLV_NRD_NRD_1	402	404	PF00675	0.579
CLV_NRD_NRD_1	484	486	PF00675	0.811
CLV_NRD_NRD_1	511	513	PF00675	0.729
CLV_PCSK_KEX2_1	138	140	PF00082	0.498
CLV_PCSK_KEX2_1	33	35	PF00082	0.732
CLV_PCSK_KEX2_1	377	379	PF00082	0.584
CLV_PCSK_KEX2_1	402	404	PF00082	0.579
CLV_PCSK_KEX2_1	44	46	PF00082	0.490
CLV_PCSK_KEX2_1	470	472	PF00082	0.614
CLV_PCSK_KEX2_1	484	486	PF00082	0.811
CLV_PCSK_KEX2_1	511	513	PF00082	0.729
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.541
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.612
CLV_PCSK_SKI1_1	122	126	PF00082	0.719
CLV_PCSK_SKI1_1	214	218	PF00082	0.609
CLV_PCSK_SKI1_1	281	285	PF00082	0.530
CLV_PCSK_SKI1_1	446	450	PF00082	0.769
CLV_PCSK_SKI1_1	616	620	PF00082	0.659
DEG_APCC_DBOX_1	12	20	PF00400	0.671
DEG_APCC_DBOX_1	621	629	PF00400	0.674
DEG_Nend_UBRbox_3	1	3	PF02207	0.489
DEG_SPOP_SBC_1	366	370	PF00917	0.751
DOC_CKS1_1	192	197	PF01111	0.566
DOC_CKS1_1	215	220	PF01111	0.574
DOC_MAPK_gen_1	377	384	PF00069	0.582
DOC_MAPK_gen_1	481	491	PF00069	0.583
DOC_MAPK_gen_1	558	566	PF00069	0.754
DOC_MAPK_JIP1_4	560	566	PF00069	0.748
DOC_MAPK_MEF2A_6	318	326	PF00069	0.580
DOC_MAPK_MEF2A_6	377	386	PF00069	0.583
DOC_MAPK_MEF2A_6	558	566	PF00069	0.754
DOC_PP4_FxxP_1	210	213	PF00568	0.687
DOC_PP4_FxxP_1	449	452	PF00568	0.747
DOC_PP4_FxxP_1	654	657	PF00568	0.700
DOC_USP7_MATH_1	166	170	PF00917	0.578
DOC_USP7_MATH_1	300	304	PF00917	0.707
DOC_USP7_MATH_1	367	371	PF00917	0.724
DOC_USP7_MATH_1	4	8	PF00917	0.579
DOC_USP7_MATH_1	421	425	PF00917	0.588
DOC_USP7_MATH_1	525	529	PF00917	0.736
DOC_USP7_MATH_1	531	535	PF00917	0.661
DOC_USP7_MATH_1	548	552	PF00917	0.724
DOC_USP7_MATH_2	312	318	PF00917	0.582
DOC_WW_Pin1_4	160	165	PF00397	0.775
DOC_WW_Pin1_4	186	191	PF00397	0.701
DOC_WW_Pin1_4	209	214	PF00397	0.780
DOC_WW_Pin1_4	233	238	PF00397	0.772
DOC_WW_Pin1_4	284	289	PF00397	0.793
DOC_WW_Pin1_4	318	323	PF00397	0.588
DOC_WW_Pin1_4	330	335	PF00397	0.833
DOC_WW_Pin1_4	345	350	PF00397	0.623
DOC_WW_Pin1_4	360	365	PF00397	0.654
DOC_WW_Pin1_4	469	474	PF00397	0.675
DOC_WW_Pin1_4	62	67	PF00397	0.753
LIG_14-3-3_CanoR_1	33	37	PF00244	0.580
LIG_14-3-3_CanoR_1	340	350	PF00244	0.601
LIG_14-3-3_CanoR_1	433	442	PF00244	0.588
LIG_14-3-3_CanoR_1	547	557	PF00244	0.797
LIG_14-3-3_CanoR_1	622	626	PF00244	0.685
LIG_14-3-3_CanoR_1	642	646	PF00244	0.478
LIG_14-3-3_CanoR_1	73	82	PF00244	0.824
LIG_14-3-3_CanoR_1	8	16	PF00244	0.680
LIG_14-3-3_CanoR_1	84	92	PF00244	0.651
LIG_BIR_III_4	447	451	PF00653	0.574
LIG_BRCT_BRCA1_1	202	206	PF00533	0.797
LIG_BRCT_BRCA1_1	316	320	PF00533	0.585
LIG_CtBP_PxDLS_1	486	490	PF00389	0.572
LIG_FHA_1	150	156	PF00498	0.793
LIG_FHA_1	393	399	PF00498	0.615
LIG_FHA_2	148	154	PF00498	0.574
LIG_FHA_2	246	252	PF00498	0.730
LIG_FHA_2	257	263	PF00498	0.527
LIG_FHA_2	340	346	PF00498	0.830
LIG_FHA_2	470	476	PF00498	0.743
LIG_FHA_2	573	579	PF00498	0.593
LIG_FHA_2	609	615	PF00498	0.622
LIG_LIR_Apic_2	208	213	PF02991	0.691
LIG_LIR_Apic_2	236	241	PF02991	0.581
LIG_LIR_Apic_2	447	452	PF02991	0.570
LIG_LIR_Apic_2	480	486	PF02991	0.595
LIG_LIR_Apic_2	595	601	PF02991	0.727
LIG_LIR_Apic_2	653	657	PF02991	0.704
LIG_LIR_Gen_1	265	272	PF02991	0.693
LIG_LIR_Gen_1	578	588	PF02991	0.620
LIG_LIR_Gen_1	639	647	PF02991	0.756
LIG_LIR_Gen_1	661	666	PF02991	0.537
LIG_LIR_Nem_3	265	269	PF02991	0.708
LIG_LIR_Nem_3	578	583	PF02991	0.588
LIG_LIR_Nem_3	639	643	PF02991	0.762
LIG_LIR_Nem_3	661	666	PF02991	0.537
LIG_NRBOX	578	584	PF00104	0.596
LIG_Pex14_2	206	210	PF04695	0.695
LIG_Pex14_2	408	412	PF04695	0.660
LIG_PTAP_UEV_1	513	518	PF05743	0.581
LIG_SH2_CRK	238	242	PF00017	0.591
LIG_SH2_CRK	483	487	PF00017	0.585
LIG_SH2_CRK	598	602	PF00017	0.734
LIG_SH2_CRK	640	644	PF00017	0.676
LIG_SH2_CRK	96	100	PF00017	0.580
LIG_SH2_STAT3	204	207	PF00017	0.568
LIG_SH2_STAT5	40	43	PF00017	0.769
LIG_SH2_STAT5	609	612	PF00017	0.630
LIG_SH3_1	511	517	PF00018	0.589
LIG_SH3_3	167	173	PF00018	0.790
LIG_SH3_3	189	195	PF00018	0.724
LIG_SH3_3	333	339	PF00018	0.836
LIG_SH3_3	361	367	PF00018	0.725
LIG_SH3_3	511	517	PF00018	0.589
LIG_SH3_3	632	638	PF00018	0.531
LIG_SH3_3	653	659	PF00018	0.740
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.800
LIG_TRAF2_1	241	244	PF00917	0.777
LIG_TRAF2_1	611	614	PF00917	0.626
LIG_TRFH_1	598	602	PF08558	0.734
LIG_WRC_WIRS_1	263	268	PF05994	0.477
LIG_WRC_WIRS_1	59	64	PF05994	0.569
LIG_WW_3	337	341	PF00397	0.594
MOD_CDK_SPK_2	209	214	PF00069	0.780
MOD_CDK_SPK_2	332	337	PF00069	0.807
MOD_CDK_SPxK_1	345	351	PF00069	0.829
MOD_CDK_SPxxK_3	330	337	PF00069	0.808
MOD_CK1_1	146	152	PF00069	0.618
MOD_CK1_1	17	23	PF00069	0.428
MOD_CK1_1	287	293	PF00069	0.807
MOD_CK1_1	303	309	PF00069	0.700
MOD_CK1_1	332	338	PF00069	0.803
MOD_CK1_1	360	366	PF00069	0.839
MOD_CK1_1	424	430	PF00069	0.622
MOD_CK1_1	469	475	PF00069	0.606
MOD_CK1_1	502	508	PF00069	0.788
MOD_CK1_1	527	533	PF00069	0.828
MOD_CK1_1	534	540	PF00069	0.711
MOD_CK1_1	541	547	PF00069	0.634
MOD_CK1_1	58	64	PF00069	0.737
MOD_CK1_1	624	630	PF00069	0.692
MOD_CK1_1	65	71	PF00069	0.683
MOD_CK1_1	7	13	PF00069	0.422
MOD_CK1_1	72	78	PF00069	0.649
MOD_CK2_1	141	147	PF00069	0.733
MOD_CK2_1	256	262	PF00069	0.558
MOD_CK2_1	324	330	PF00069	0.618
MOD_CK2_1	339	345	PF00069	0.825
MOD_CK2_1	349	355	PF00069	0.693
MOD_CK2_1	469	475	PF00069	0.746
MOD_CK2_1	572	578	PF00069	0.590
MOD_CK2_1	608	614	PF00069	0.627
MOD_GlcNHglycan	127	130	PF01048	0.612
MOD_GlcNHglycan	219	222	PF01048	0.579
MOD_GlcNHglycan	289	292	PF01048	0.612
MOD_GlcNHglycan	302	305	PF01048	0.624
MOD_GlcNHglycan	389	392	PF01048	0.621
MOD_GlcNHglycan	455	458	PF01048	0.607
MOD_GlcNHglycan	464	467	PF01048	0.598
MOD_GlcNHglycan	514	517	PF01048	0.649
MOD_GlcNHglycan	529	532	PF01048	0.589
MOD_GlcNHglycan	534	537	PF01048	0.516
MOD_GlcNHglycan	539	543	PF01048	0.552
MOD_GlcNHglycan	645	648	PF01048	0.752
MOD_GlcNHglycan	67	70	PF01048	0.599
MOD_GSK3_1	139	146	PF00069	0.755
MOD_GSK3_1	149	156	PF00069	0.666
MOD_GSK3_1	182	189	PF00069	0.686
MOD_GSK3_1	283	290	PF00069	0.746
MOD_GSK3_1	303	310	PF00069	0.843
MOD_GSK3_1	314	321	PF00069	0.647
MOD_GSK3_1	339	346	PF00069	0.826
MOD_GSK3_1	362	369	PF00069	0.692
MOD_GSK3_1	392	399	PF00069	0.780
MOD_GSK3_1	462	469	PF00069	0.768
MOD_GSK3_1	499	506	PF00069	0.789
MOD_GSK3_1	523	530	PF00069	0.719
MOD_GSK3_1	534	541	PF00069	0.784
MOD_GSK3_1	57	64	PF00069	0.742
MOD_GSK3_1	588	595	PF00069	0.708
MOD_GSK3_1	65	72	PF00069	0.675
MOD_N-GLC_1	166	171	PF02516	0.578
MOD_N-GLC_1	17	22	PF02516	0.463
MOD_N-GLC_1	256	261	PF02516	0.534
MOD_N-GLC_1	360	365	PF02516	0.597
MOD_N-GLC_1	396	401	PF02516	0.773
MOD_NEK2_1	118	123	PF00069	0.698
MOD_NEK2_1	283	288	PF00069	0.713
MOD_NEK2_1	329	334	PF00069	0.581
MOD_NEK2_1	529	534	PF00069	0.618
MOD_NEK2_1	621	626	PF00069	0.664
MOD_NEK2_2	367	372	PF00069	0.629
MOD_PIKK_1	424	430	PF00454	0.587
MOD_PIKK_1	434	440	PF00454	0.543
MOD_PIKK_1	76	82	PF00454	0.826
MOD_PK_1	139	145	PF00069	0.524
MOD_PKA_1	402	408	PF00069	0.573
MOD_PKA_2	14	20	PF00069	0.577
MOD_PKA_2	312	318	PF00069	0.587
MOD_PKA_2	32	38	PF00069	0.609
MOD_PKA_2	339	345	PF00069	0.597
MOD_PKA_2	402	408	PF00069	0.601
MOD_PKA_2	503	509	PF00069	0.809
MOD_PKA_2	517	523	PF00069	0.651
MOD_PKA_2	532	538	PF00069	0.587
MOD_PKA_2	549	555	PF00069	0.663
MOD_PKA_2	621	627	PF00069	0.681
MOD_PKA_2	641	647	PF00069	0.479
MOD_PKA_2	69	75	PF00069	0.613
MOD_PKA_2	7	13	PF00069	0.650
MOD_PKB_1	521	529	PF00069	0.582
MOD_Plk_1	166	172	PF00069	0.586
MOD_Plk_1	378	384	PF00069	0.721
MOD_Plk_2-3	262	268	PF00069	0.712
MOD_Plk_2-3	592	598	PF00069	0.643
MOD_ProDKin_1	160	166	PF00069	0.772
MOD_ProDKin_1	186	192	PF00069	0.697
MOD_ProDKin_1	209	215	PF00069	0.783
MOD_ProDKin_1	233	239	PF00069	0.774
MOD_ProDKin_1	284	290	PF00069	0.799
MOD_ProDKin_1	318	324	PF00069	0.589
MOD_ProDKin_1	330	336	PF00069	0.834
MOD_ProDKin_1	345	351	PF00069	0.623
MOD_ProDKin_1	360	366	PF00069	0.650
MOD_ProDKin_1	469	475	PF00069	0.674
MOD_ProDKin_1	62	68	PF00069	0.754
MOD_SUMO_rev_2	153	163	PF00179	0.582
MOD_SUMO_rev_2	250	254	PF00179	0.600
TRG_DiLeu_BaEn_1	578	583	PF01217	0.588
TRG_DiLeu_BaEn_4	613	619	PF01217	0.618
TRG_ENDOCYTIC_2	640	643	PF00928	0.768
TRG_ENDOCYTIC_2	663	666	PF00928	0.673
TRG_ER_diArg_1	12	15	PF00400	0.658
TRG_ER_diArg_1	402	404	PF00400	0.579
TRG_ER_diArg_1	483	485	PF00400	0.789
TRG_ER_diArg_1	511	513	PF00400	0.738
TRG_ER_diArg_1	521	524	PF00400	0.698
TRG_ER_diArg_1	583	586	PF00400	0.667
TRG_NES_CRM1_1	274	289	PF08389	0.484
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	586	590	PF00026	0.706
TRG_Pf-PMV_PEXEL_1	626	631	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJ88	Leishmania donovani	59%	100%
A4I7X5	Leishmania infantum	59%	100%
E9B2T6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4Q5C1	Leishmania major	59%	100%