Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania braziliensis

UniProt:

A4HKE4_LEIBR

TriTrypDb:

LbrM.32.1740 , LBRM2903_320023700

Length:

736

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKE4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	6
GO:0008047	enzyme activator activity	3	6
GO:0030234	enzyme regulator activity	2	6
GO:0030695	GTPase regulator activity	4	6
GO:0060589	nucleoside-triphosphatase regulator activity	3	6
GO:0098772	molecular function regulator activity	1	6
GO:0140677	molecular function activator activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.412
CLV_NRD_NRD_1	396	398	PF00675	0.827
CLV_NRD_NRD_1	399	401	PF00675	0.787
CLV_PCSK_FUR_1	394	398	PF00082	0.819
CLV_PCSK_FUR_1	91	95	PF00082	0.412
CLV_PCSK_KEX2_1	127	129	PF00082	0.412
CLV_PCSK_KEX2_1	16	18	PF00082	0.476
CLV_PCSK_KEX2_1	396	398	PF00082	0.824
CLV_PCSK_KEX2_1	399	401	PF00082	0.784
CLV_PCSK_KEX2_1	664	666	PF00082	0.551
CLV_PCSK_KEX2_1	93	95	PF00082	0.408
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.369
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.735
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.537
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.408
CLV_PCSK_PC7_1	394	400	PF00082	0.707
CLV_PCSK_SKI1_1	115	119	PF00082	0.345
CLV_PCSK_SKI1_1	150	154	PF00082	0.577
CLV_PCSK_SKI1_1	168	172	PF00082	0.498
CLV_PCSK_SKI1_1	17	21	PF00082	0.364
CLV_PCSK_SKI1_1	320	324	PF00082	0.674
CLV_PCSK_SKI1_1	334	338	PF00082	0.565
CLV_PCSK_SKI1_1	400	404	PF00082	0.566
CLV_PCSK_SKI1_1	551	555	PF00082	0.565
CLV_PCSK_SKI1_1	606	610	PF00082	0.623
CLV_PCSK_SKI1_1	622	626	PF00082	0.633
CLV_PCSK_SKI1_1	661	665	PF00082	0.549
CLV_PCSK_SKI1_1	723	727	PF00082	0.640
CLV_PCSK_SKI1_1	93	97	PF00082	0.271
CLV_Separin_Metazoa	477	481	PF03568	0.573
DEG_APCC_DBOX_1	16	24	PF00400	0.324
DEG_SCF_FBW7_1	187	194	PF00400	0.553
DEG_SPOP_SBC_1	206	210	PF00917	0.530
DEG_SPOP_SBC_1	526	530	PF00917	0.711
DOC_CDC14_PxL_1	426	434	PF14671	0.593
DOC_CKS1_1	321	326	PF01111	0.542
DOC_CKS1_1	690	695	PF01111	0.683
DOC_CYCLIN_RxL_1	127	139	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	247	250	PF00134	0.521
DOC_MAPK_DCC_7	174	184	PF00069	0.521
DOC_MAPK_gen_1	127	135	PF00069	0.249
DOC_MAPK_gen_1	16	22	PF00069	0.376
DOC_MAPK_gen_1	67	75	PF00069	0.412
DOC_PP1_RVXF_1	604	611	PF00149	0.528
DOC_PP1_RVXF_1	620	626	PF00149	0.548
DOC_PP1_SILK_1	2	7	PF00149	0.414
DOC_PP2B_LxvP_1	133	136	PF13499	0.477
DOC_PP2B_LxvP_1	246	249	PF13499	0.553
DOC_PP2B_LxvP_1	270	273	PF13499	0.532
DOC_PP2B_LxvP_1	432	435	PF13499	0.605
DOC_PP4_FxxP_1	240	243	PF00568	0.522
DOC_PP4_FxxP_1	586	589	PF00568	0.710
DOC_PP4_FxxP_1	625	628	PF00568	0.510
DOC_PP4_MxPP_1	582	585	PF00568	0.521
DOC_USP7_MATH_1	186	190	PF00917	0.595
DOC_USP7_MATH_1	193	197	PF00917	0.634
DOC_USP7_MATH_1	254	258	PF00917	0.621
DOC_USP7_MATH_1	273	277	PF00917	0.551
DOC_USP7_MATH_1	304	308	PF00917	0.701
DOC_USP7_MATH_1	356	360	PF00917	0.587
DOC_USP7_MATH_1	418	422	PF00917	0.602
DOC_USP7_MATH_1	446	450	PF00917	0.731
DOC_USP7_MATH_1	507	511	PF00917	0.582
DOC_USP7_MATH_1	594	598	PF00917	0.694
DOC_USP7_MATH_1	667	671	PF00917	0.652
DOC_USP7_MATH_1	82	86	PF00917	0.337
DOC_USP7_UBL2_3	174	178	PF12436	0.525
DOC_WW_Pin1_4	168	173	PF00397	0.702
DOC_WW_Pin1_4	187	192	PF00397	0.498
DOC_WW_Pin1_4	261	266	PF00397	0.660
DOC_WW_Pin1_4	274	279	PF00397	0.570
DOC_WW_Pin1_4	320	325	PF00397	0.543
DOC_WW_Pin1_4	433	438	PF00397	0.716
DOC_WW_Pin1_4	508	513	PF00397	0.565
DOC_WW_Pin1_4	560	565	PF00397	0.571
DOC_WW_Pin1_4	577	582	PF00397	0.690
DOC_WW_Pin1_4	623	628	PF00397	0.615
DOC_WW_Pin1_4	640	645	PF00397	0.604
DOC_WW_Pin1_4	677	682	PF00397	0.575
DOC_WW_Pin1_4	689	694	PF00397	0.612
DOC_WW_Pin1_4	702	707	PF00397	0.539
LIG_14-3-3_CanoR_1	397	403	PF00244	0.680
LIG_14-3-3_CanoR_1	665	674	PF00244	0.604
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BIR_III_2	151	155	PF00653	0.550
LIG_BRCT_BRCA1_1	642	646	PF00533	0.541
LIG_deltaCOP1_diTrp_1	74	83	PF00928	0.412
LIG_EVH1_1	475	479	PF00568	0.564
LIG_FHA_1	162	168	PF00498	0.645
LIG_FHA_1	171	177	PF00498	0.660
LIG_FHA_1	321	327	PF00498	0.576
LIG_FHA_1	355	361	PF00498	0.818
LIG_FHA_1	366	372	PF00498	0.614
LIG_FHA_1	385	391	PF00498	0.587
LIG_FHA_1	439	445	PF00498	0.737
LIG_FHA_1	496	502	PF00498	0.603
LIG_FHA_1	542	548	PF00498	0.604
LIG_FHA_1	554	560	PF00498	0.582
LIG_FHA_1	602	608	PF00498	0.530
LIG_FHA_1	70	76	PF00498	0.412
LIG_FHA_1	703	709	PF00498	0.671
LIG_FHA_2	284	290	PF00498	0.634
LIG_FHA_2	526	532	PF00498	0.629
LIG_FHA_2	536	542	PF00498	0.677
LIG_LIR_Apic_2	103	107	PF02991	0.408
LIG_LIR_Apic_2	238	243	PF02991	0.514
LIG_LIR_Apic_2	631	637	PF02991	0.609
LIG_LIR_Gen_1	40	49	PF02991	0.412
LIG_LIR_LC3C_4	367	372	PF02991	0.535
LIG_LIR_Nem_3	183	187	PF02991	0.525
LIG_LIR_Nem_3	40	44	PF02991	0.519
LIG_MYND_1	487	491	PF01753	0.560
LIG_NRBOX	18	24	PF00104	0.412
LIG_PTAP_UEV_1	411	416	PF05743	0.521
LIG_SH2_CRK	130	134	PF00017	0.521
LIG_SH2_PTP2	104	107	PF00017	0.412
LIG_SH2_STAT5	104	107	PF00017	0.412
LIG_SH2_STAT5	124	127	PF00017	0.199
LIG_SH2_STAT5	234	237	PF00017	0.508
LIG_SH3_3	143	149	PF00018	0.573
LIG_SH3_3	173	179	PF00018	0.616
LIG_SH3_3	246	252	PF00018	0.744
LIG_SH3_3	409	415	PF00018	0.669
LIG_SH3_3	432	438	PF00018	0.691
LIG_SH3_3	473	479	PF00018	0.719
LIG_SH3_3	485	491	PF00018	0.613
LIG_SH3_3	509	515	PF00018	0.670
LIG_SH3_3	520	526	PF00018	0.642
LIG_SH3_3	578	584	PF00018	0.610
LIG_SH3_3	633	639	PF00018	0.594
LIG_SH3_3	651	657	PF00018	0.550
LIG_SH3_3	687	693	PF00018	0.584
LIG_Sin3_3	293	300	PF02671	0.552
LIG_SUMO_SIM_par_1	514	520	PF11976	0.537
LIG_UBA3_1	19	24	PF00899	0.324
LIG_WW_3	477	481	PF00397	0.655
MOD_CDK_SPxK_1	168	174	PF00069	0.615
MOD_CDK_SPxxK_3	320	327	PF00069	0.543
MOD_CK1_1	274	280	PF00069	0.597
MOD_CK1_1	433	439	PF00069	0.688
MOD_CK1_1	447	453	PF00069	0.550
MOD_CK1_1	565	571	PF00069	0.677
MOD_CK1_1	611	617	PF00069	0.552
MOD_CK1_1	677	683	PF00069	0.610
MOD_CK2_1	283	289	PF00069	0.565
MOD_CK2_1	373	379	PF00069	0.624
MOD_CK2_1	525	531	PF00069	0.635
MOD_CK2_1	535	541	PF00069	0.679
MOD_CK2_1	644	650	PF00069	0.678
MOD_GlcNHglycan	243	246	PF01048	0.677
MOD_GlcNHglycan	256	259	PF01048	0.573
MOD_GlcNHglycan	273	276	PF01048	0.495
MOD_GlcNHglycan	298	301	PF01048	0.645
MOD_GlcNHglycan	344	347	PF01048	0.671
MOD_GlcNHglycan	412	415	PF01048	0.594
MOD_GlcNHglycan	432	435	PF01048	0.533
MOD_GlcNHglycan	54	57	PF01048	0.412
MOD_GlcNHglycan	570	573	PF01048	0.697
MOD_GlcNHglycan	610	613	PF01048	0.520
MOD_GlcNHglycan	693	696	PF01048	0.633
MOD_GSK3_1	187	194	PF00069	0.546
MOD_GSK3_1	201	208	PF00069	0.497
MOD_GSK3_1	211	218	PF00069	0.482
MOD_GSK3_1	273	280	PF00069	0.615
MOD_GSK3_1	291	298	PF00069	0.508
MOD_GSK3_1	352	359	PF00069	0.649
MOD_GSK3_1	373	380	PF00069	0.651
MOD_GSK3_1	398	405	PF00069	0.567
MOD_GSK3_1	406	413	PF00069	0.588
MOD_GSK3_1	495	502	PF00069	0.594
MOD_GSK3_1	558	565	PF00069	0.650
MOD_GSK3_1	63	70	PF00069	0.424
MOD_GSK3_1	640	647	PF00069	0.702
MOD_GSK3_1	685	692	PF00069	0.645
MOD_GSK3_1	96	103	PF00069	0.407
MOD_N-GLC_1	211	216	PF02516	0.599
MOD_N-GLC_1	260	265	PF02516	0.541
MOD_N-GLC_1	644	649	PF02516	0.546
MOD_N-GLC_1	667	672	PF02516	0.616
MOD_NEK2_1	201	206	PF00069	0.603
MOD_NEK2_1	207	212	PF00069	0.622
MOD_NEK2_1	228	233	PF00069	0.490
MOD_NEK2_1	295	300	PF00069	0.553
MOD_NEK2_1	312	317	PF00069	0.507
MOD_NEK2_1	402	407	PF00069	0.678
MOD_NEK2_1	534	539	PF00069	0.564
MOD_NEK2_1	553	558	PF00069	0.599
MOD_NEK2_1	617	622	PF00069	0.684
MOD_NEK2_1	96	101	PF00069	0.274
MOD_NEK2_2	356	361	PF00069	0.567
MOD_PIKK_1	339	345	PF00454	0.566
MOD_PIKK_1	481	487	PF00454	0.848
MOD_PIKK_1	517	523	PF00454	0.538
MOD_PIKK_1	553	559	PF00454	0.534
MOD_PIKK_1	594	600	PF00454	0.540
MOD_PIKK_1	617	623	PF00454	0.524
MOD_PIKK_1	711	717	PF00454	0.408
MOD_PK_1	373	379	PF00069	0.561
MOD_PKA_1	398	404	PF00069	0.568
MOD_PKA_2	398	404	PF00069	0.568
MOD_PKA_2	5	11	PF00069	0.569
MOD_PKA_2	52	58	PF00069	0.412
MOD_PKA_2	674	680	PF00069	0.630
MOD_Plk_1	110	116	PF00069	0.263
MOD_Plk_1	334	340	PF00069	0.558
MOD_Plk_1	644	650	PF00069	0.546
MOD_Plk_1	667	673	PF00069	0.628
MOD_Plk_1	96	102	PF00069	0.412
MOD_Plk_4	100	106	PF00069	0.412
MOD_Plk_4	202	208	PF00069	0.607
MOD_Plk_4	291	297	PF00069	0.602
MOD_Plk_4	373	379	PF00069	0.625
MOD_Plk_4	424	430	PF00069	0.522
MOD_Plk_4	495	501	PF00069	0.591
MOD_Plk_4	535	541	PF00069	0.542
MOD_Plk_4	674	680	PF00069	0.755
MOD_ProDKin_1	168	174	PF00069	0.701
MOD_ProDKin_1	187	193	PF00069	0.498
MOD_ProDKin_1	261	267	PF00069	0.663
MOD_ProDKin_1	274	280	PF00069	0.573
MOD_ProDKin_1	320	326	PF00069	0.543
MOD_ProDKin_1	433	439	PF00069	0.720
MOD_ProDKin_1	508	514	PF00069	0.566
MOD_ProDKin_1	560	566	PF00069	0.575
MOD_ProDKin_1	577	583	PF00069	0.691
MOD_ProDKin_1	623	629	PF00069	0.615
MOD_ProDKin_1	640	646	PF00069	0.607
MOD_ProDKin_1	677	683	PF00069	0.575
MOD_ProDKin_1	689	695	PF00069	0.616
MOD_ProDKin_1	702	708	PF00069	0.532
MOD_SUMO_for_1	152	155	PF00179	0.551
MOD_SUMO_rev_2	147	154	PF00179	0.635
MOD_SUMO_rev_2	363	371	PF00179	0.632
TRG_DiLeu_BaEn_2	78	84	PF01217	0.412
TRG_DiLeu_BaLyEn_6	512	517	PF01217	0.577
TRG_ENDOCYTIC_2	130	133	PF00928	0.486
TRG_ER_diArg_1	127	129	PF00400	0.412
TRG_ER_diArg_1	394	397	PF00400	0.807
TRG_ER_diArg_1	652	655	PF00400	0.533
TRG_ER_diArg_1	721	724	PF00400	0.504
TRG_ER_diArg_1	729	732	PF00400	0.447
TRG_NLS_MonoCore_2	396	401	PF00514	0.574
TRG_NLS_MonoExtN_4	394	401	PF00514	0.732
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	480	485	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	716	720	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	723	727	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5J1	Leishmania donovani	48%	100%
A4I7X2	Leishmania infantum	48%	100%
E9B2T3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
Q4Q5C4	Leishmania major	49%	99%