Clu domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translation initiation factor eIF3 subunit 135, putative

Species:

Leishmania braziliensis

UniProt:

A4HKE3_LEIBR

TriTrypDb:

LbrM.32.1730 , LBRM2903_320023500 , LBRM2903_320023600

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HKE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKE3

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003743	translation initiation factor activity	4	2
GO:0005488	binding	1	2
GO:0008135	translation factor activity, RNA binding	3	2
GO:0045182	translation regulator activity	1	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.526
CLV_NRD_NRD_1	27	29	PF00675	0.613
CLV_NRD_NRD_1	318	320	PF00675	0.288
CLV_NRD_NRD_1	447	449	PF00675	0.295
CLV_NRD_NRD_1	643	645	PF00675	0.412
CLV_NRD_NRD_1	74	76	PF00675	0.722
CLV_NRD_NRD_1	800	802	PF00675	0.666
CLV_NRD_NRD_1	846	848	PF00675	0.481
CLV_PCSK_FUR_1	445	449	PF00082	0.295
CLV_PCSK_KEX2_1	27	29	PF00082	0.621
CLV_PCSK_KEX2_1	318	320	PF00082	0.333
CLV_PCSK_KEX2_1	447	449	PF00082	0.252
CLV_PCSK_KEX2_1	528	530	PF00082	0.364
CLV_PCSK_KEX2_1	74	76	PF00082	0.723
CLV_PCSK_KEX2_1	794	796	PF00082	0.574
CLV_PCSK_KEX2_1	800	802	PF00082	0.646
CLV_PCSK_KEX2_1	832	834	PF00082	0.341
CLV_PCSK_KEX2_1	846	848	PF00082	0.454
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.364
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.457
CLV_PCSK_PC1ET2_1	832	834	PF00082	0.341
CLV_PCSK_SKI1_1	115	119	PF00082	0.502
CLV_PCSK_SKI1_1	313	317	PF00082	0.231
CLV_PCSK_SKI1_1	354	358	PF00082	0.245
CLV_PCSK_SKI1_1	413	417	PF00082	0.340
CLV_PCSK_SKI1_1	613	617	PF00082	0.433
CLV_PCSK_SKI1_1	695	699	PF00082	0.295
CLV_PCSK_SKI1_1	706	710	PF00082	0.295
CLV_PCSK_SKI1_1	794	798	PF00082	0.469
CLV_PCSK_SKI1_1	877	881	PF00082	0.540
DEG_APCC_DBOX_1	876	884	PF00400	0.596
DEG_SPOP_SBC_1	247	251	PF00917	0.419
DOC_AGCK_PIF_1	367	372	PF00069	0.488
DOC_CDC14_PxL_1	649	657	PF14671	0.411
DOC_CKS1_1	34	39	PF01111	0.534
DOC_CKS1_1	520	525	PF01111	0.348
DOC_CYCLIN_RxL_1	44	53	PF00134	0.486
DOC_CYCLIN_RxL_1	695	704	PF00134	0.488
DOC_CYCLIN_yClb1_LxF_4	589	595	PF00134	0.328
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	457	460	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	63	69	PF00134	0.704
DOC_MAPK_DCC_7	456	464	PF00069	0.533
DOC_MAPK_FxFP_2	566	569	PF00069	0.336
DOC_MAPK_gen_1	872	881	PF00069	0.518
DOC_MAPK_HePTP_8	766	778	PF00069	0.263
DOC_MAPK_MEF2A_6	354	361	PF00069	0.495
DOC_MAPK_MEF2A_6	456	464	PF00069	0.533
DOC_MAPK_MEF2A_6	769	778	PF00069	0.370
DOC_PP1_RVXF_1	875	882	PF00149	0.511
DOC_PP2B_LxvP_1	350	353	PF13499	0.450
DOC_PP2B_LxvP_1	357	360	PF13499	0.479
DOC_PP2B_LxvP_1	457	460	PF13499	0.495
DOC_PP2B_LxvP_1	513	516	PF13499	0.279
DOC_PP2B_LxvP_1	650	653	PF13499	0.401
DOC_PP4_FxxP_1	566	569	PF00568	0.490
DOC_PP4_FxxP_1	65	68	PF00568	0.505
DOC_PP4_FxxP_1	841	844	PF00568	0.572
DOC_SPAK_OSR1_1	593	597	PF12202	0.310
DOC_USP7_MATH_1	168	172	PF00917	0.612
DOC_USP7_MATH_1	17	21	PF00917	0.608
DOC_USP7_MATH_1	174	178	PF00917	0.687
DOC_USP7_MATH_1	247	251	PF00917	0.472
DOC_USP7_MATH_1	274	278	PF00917	0.488
DOC_USP7_MATH_1	395	399	PF00917	0.484
DOC_USP7_MATH_1	415	419	PF00917	0.488
DOC_USP7_MATH_1	535	539	PF00917	0.561
DOC_USP7_MATH_1	542	546	PF00917	0.477
DOC_USP7_MATH_1	59	63	PF00917	0.697
DOC_USP7_MATH_1	73	77	PF00917	0.489
DOC_USP7_MATH_1	744	748	PF00917	0.462
DOC_USP7_MATH_1	853	857	PF00917	0.730
DOC_WW_Pin1_4	161	166	PF00397	0.669
DOC_WW_Pin1_4	33	38	PF00397	0.831
DOC_WW_Pin1_4	41	46	PF00397	0.783
DOC_WW_Pin1_4	473	478	PF00397	0.683
DOC_WW_Pin1_4	519	524	PF00397	0.446
DOC_WW_Pin1_4	57	62	PF00397	0.508
DOC_WW_Pin1_4	707	712	PF00397	0.488
DOC_WW_Pin1_4	75	80	PF00397	0.676
DOC_WW_Pin1_4	847	852	PF00397	0.729
DOC_WW_Pin1_4	883	888	PF00397	0.558
LIG_14-3-3_CanoR_1	222	226	PF00244	0.443
LIG_14-3-3_CanoR_1	27	35	PF00244	0.581
LIG_14-3-3_CanoR_1	448	458	PF00244	0.591
LIG_14-3-3_CanoR_1	675	684	PF00244	0.512
LIG_14-3-3_CanoR_1	706	711	PF00244	0.482
LIG_14-3-3_CanoR_1	757	761	PF00244	0.388
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_BIR_III_2	173	177	PF00653	0.411
LIG_BIR_III_4	823	827	PF00653	0.398
LIG_BRCT_BRCA1_1	14	18	PF00533	0.673
LIG_BRCT_BRCA1_1	542	546	PF00533	0.293
LIG_BRCT_BRCA1_1	61	65	PF00533	0.490
LIG_BRCT_BRCA1_1	732	736	PF00533	0.531
LIG_Clathr_ClatBox_1	574	578	PF01394	0.441
LIG_deltaCOP1_diTrp_1	226	229	PF00928	0.533
LIG_EH1_1	872	880	PF00400	0.363
LIG_eIF4E_1	380	386	PF01652	0.533
LIG_eIF4E_1	898	904	PF01652	0.409
LIG_EVH1_1	65	69	PF00568	0.505
LIG_FHA_1	102	108	PF00498	0.604
LIG_FHA_1	11	17	PF00498	0.579
LIG_FHA_1	380	386	PF00498	0.396
LIG_FHA_1	397	403	PF00498	0.370
LIG_FHA_1	452	458	PF00498	0.456
LIG_FHA_1	596	602	PF00498	0.509
LIG_FHA_1	610	616	PF00498	0.263
LIG_FHA_1	707	713	PF00498	0.489
LIG_FHA_2	123	129	PF00498	0.517
LIG_FHA_2	188	194	PF00498	0.351
LIG_FHA_2	221	227	PF00498	0.420
LIG_FHA_2	520	526	PF00498	0.546
LIG_FHA_2	652	658	PF00498	0.344
LIG_FHA_2	708	714	PF00498	0.495
LIG_FHA_2	775	781	PF00498	0.575
LIG_FHA_2	852	858	PF00498	0.510
LIG_GBD_Chelix_1	416	424	PF00786	0.288
LIG_LIR_Apic_2	563	569	PF02991	0.378
LIG_LIR_Apic_2	62	68	PF02991	0.498
LIG_LIR_Apic_2	838	844	PF02991	0.523
LIG_LIR_Gen_1	230	237	PF02991	0.404
LIG_LIR_Gen_1	491	502	PF02991	0.544
LIG_LIR_Gen_1	685	694	PF02991	0.496
LIG_LIR_Gen_1	825	836	PF02991	0.337
LIG_LIR_LC3C_4	382	387	PF02991	0.377
LIG_LIR_Nem_3	112	117	PF02991	0.447
LIG_LIR_Nem_3	131	137	PF02991	0.252
LIG_LIR_Nem_3	208	213	PF02991	0.384
LIG_LIR_Nem_3	230	234	PF02991	0.389
LIG_LIR_Nem_3	366	370	PF02991	0.470
LIG_LIR_Nem_3	438	442	PF02991	0.514
LIG_LIR_Nem_3	491	497	PF02991	0.545
LIG_LIR_Nem_3	685	690	PF02991	0.496
LIG_LIR_Nem_3	825	831	PF02991	0.341
LIG_MYND_1	41	45	PF01753	0.505
LIG_Pex14_1	155	159	PF04695	0.415
LIG_Pex14_1	227	231	PF04695	0.439
LIG_Pex14_2	118	122	PF04695	0.370
LIG_REV1ctd_RIR_1	505	513	PF16727	0.308
LIG_SH2_CRK	231	235	PF00017	0.389
LIG_SH2_CRK	494	498	PF00017	0.566
LIG_SH2_CRK	611	615	PF00017	0.461
LIG_SH2_CRK	91	95	PF00017	0.412
LIG_SH2_STAP1	159	163	PF00017	0.543
LIG_SH2_STAP1	210	214	PF00017	0.422
LIG_SH2_STAP1	494	498	PF00017	0.455
LIG_SH2_STAP1	611	615	PF00017	0.347
LIG_SH2_STAT3	342	345	PF00017	0.488
LIG_SH2_STAT3	450	453	PF00017	0.488
LIG_SH2_STAT5	310	313	PF00017	0.488
LIG_SH2_STAT5	364	367	PF00017	0.449
LIG_SH2_STAT5	450	453	PF00017	0.436
LIG_SH2_STAT5	500	503	PF00017	0.292
LIG_SH2_STAT5	611	614	PF00017	0.375
LIG_SH2_STAT5	668	671	PF00017	0.479
LIG_SH2_STAT5	885	888	PF00017	0.634
LIG_SH2_STAT5	898	901	PF00017	0.548
LIG_SH3_2	19	24	PF14604	0.491
LIG_SH3_2	66	71	PF14604	0.502
LIG_SH3_3	16	22	PF00018	0.647
LIG_SH3_3	213	219	PF00018	0.297
LIG_SH3_3	241	247	PF00018	0.481
LIG_SH3_3	258	264	PF00018	0.475
LIG_SH3_3	288	294	PF00018	0.422
LIG_SH3_3	297	303	PF00018	0.459
LIG_SH3_3	31	37	PF00018	0.676
LIG_SH3_3	457	463	PF00018	0.474
LIG_SH3_3	517	523	PF00018	0.447
LIG_SH3_3	567	573	PF00018	0.383
LIG_SH3_3	58	64	PF00018	0.631
LIG_SH3_3	622	628	PF00018	0.384
LIG_SH3_3	66	72	PF00018	0.713
LIG_SH3_3	845	851	PF00018	0.719
LIG_SUMO_SIM_anti_2	346	352	PF11976	0.488
LIG_SUMO_SIM_anti_2	784	790	PF11976	0.406
LIG_SUMO_SIM_par_1	104	110	PF11976	0.305
LIG_TRAF2_1	863	866	PF00917	0.633
LIG_WRC_WIRS_1	364	369	PF05994	0.408
LIG_WW_3	21	25	PF00397	0.636
LIG_WW_3	71	75	PF00397	0.492
MOD_CDC14_SPxK_1	44	47	PF00782	0.495
MOD_CDC14_SPxK_1	476	479	PF00782	0.464
MOD_CDK_SPK_2	33	38	PF00069	0.532
MOD_CDK_SPxK_1	41	47	PF00069	0.503
MOD_CDK_SPxK_1	473	479	PF00069	0.465
MOD_CDK_SPxxK_3	33	40	PF00069	0.680
MOD_CDK_SPxxK_3	41	48	PF00069	0.548
MOD_CK1_1	138	144	PF00069	0.668
MOD_CK1_1	250	256	PF00069	0.539
MOD_CK1_1	3	9	PF00069	0.792
MOD_CK1_1	398	404	PF00069	0.489
MOD_CK1_1	409	415	PF00069	0.547
MOD_CK1_1	475	481	PF00069	0.714
MOD_CK1_1	488	494	PF00069	0.293
MOD_CK1_1	781	787	PF00069	0.395
MOD_CK1_1	815	821	PF00069	0.520
MOD_CK1_1	852	858	PF00069	0.510
MOD_CK2_1	202	208	PF00069	0.324
MOD_CK2_1	274	280	PF00069	0.583
MOD_CK2_1	519	525	PF00069	0.533
MOD_CK2_1	651	657	PF00069	0.344
MOD_CK2_1	707	713	PF00069	0.470
MOD_CK2_1	774	780	PF00069	0.501
MOD_CK2_1	799	805	PF00069	0.656
MOD_CK2_1	851	857	PF00069	0.509
MOD_Cter_Amidation	798	801	PF01082	0.503
MOD_DYRK1A_RPxSP_1	75	79	PF00069	0.531
MOD_DYRK1A_RPxSP_1	847	851	PF00069	0.491
MOD_GlcNHglycan	170	173	PF01048	0.572
MOD_GlcNHglycan	256	259	PF01048	0.292
MOD_GlcNHglycan	402	405	PF01048	0.384
MOD_GlcNHglycan	531	534	PF01048	0.484
MOD_GlcNHglycan	728	731	PF01048	0.347
MOD_GSK3_1	242	249	PF00069	0.491
MOD_GSK3_1	250	257	PF00069	0.469
MOD_GSK3_1	29	36	PF00069	0.677
MOD_GSK3_1	368	375	PF00069	0.481
MOD_GSK3_1	389	396	PF00069	0.445
MOD_GSK3_1	405	412	PF00069	0.568
MOD_GSK3_1	415	422	PF00069	0.520
MOD_GSK3_1	467	474	PF00069	0.558
MOD_GSK3_1	485	492	PF00069	0.625
MOD_GSK3_1	524	531	PF00069	0.484
MOD_GSK3_1	53	60	PF00069	0.639
MOD_GSK3_1	547	554	PF00069	0.522
MOD_GSK3_1	707	714	PF00069	0.425
MOD_GSK3_1	726	733	PF00069	0.651
MOD_GSK3_1	774	781	PF00069	0.432
MOD_GSK3_1	790	797	PF00069	0.427
MOD_GSK3_1	799	806	PF00069	0.599
MOD_GSK3_1	815	822	PF00069	0.710
MOD_GSK3_1	847	854	PF00069	0.773
MOD_GSK3_1	899	906	PF00069	0.496
MOD_LATS_1	465	471	PF00433	0.417
MOD_N-GLC_1	467	472	PF02516	0.571
MOD_N-GLC_2	517	519	PF02516	0.519
MOD_N-GLC_2	581	583	PF02516	0.468
MOD_NEK2_1	109	114	PF00069	0.496
MOD_NEK2_1	372	377	PF00069	0.502
MOD_NEK2_1	393	398	PF00069	0.377
MOD_NEK2_1	449	454	PF00069	0.467
MOD_NEK2_1	469	474	PF00069	0.414
MOD_NEK2_1	493	498	PF00069	0.518
MOD_NEK2_1	721	726	PF00069	0.534
MOD_NEK2_1	736	741	PF00069	0.326
MOD_NEK2_1	756	761	PF00069	0.348
MOD_NEK2_1	778	783	PF00069	0.539
MOD_NEK2_1	789	794	PF00069	0.434
MOD_NEK2_1	899	904	PF00069	0.589
MOD_NEK2_2	489	494	PF00069	0.445
MOD_PIKK_1	449	455	PF00454	0.488
MOD_PIKK_1	540	546	PF00454	0.394
MOD_PKA_1	47	53	PF00069	0.571
MOD_PKA_1	528	534	PF00069	0.371
MOD_PKA_1	794	800	PF00069	0.595
MOD_PKA_2	221	227	PF00069	0.463
MOD_PKA_2	26	32	PF00069	0.721
MOD_PKA_2	39	45	PF00069	0.530
MOD_PKA_2	528	534	PF00069	0.563
MOD_PKA_2	73	79	PF00069	0.604
MOD_PKA_2	756	762	PF00069	0.388
MOD_PKA_2	794	800	PF00069	0.595
MOD_PKA_2	803	809	PF00069	0.608
MOD_Plk_1	109	115	PF00069	0.477
MOD_Plk_1	220	226	PF00069	0.349
MOD_Plk_1	279	285	PF00069	0.377
MOD_Plk_1	899	905	PF00069	0.505
MOD_Plk_2-3	221	227	PF00069	0.334
MOD_Plk_4	103	109	PF00069	0.402
MOD_Plk_4	267	273	PF00069	0.468
MOD_Plk_4	47	53	PF00069	0.482
MOD_Plk_4	489	495	PF00069	0.474
MOD_Plk_4	547	553	PF00069	0.493
MOD_Plk_4	645	651	PF00069	0.372
MOD_Plk_4	721	727	PF00069	0.544
MOD_Plk_4	784	790	PF00069	0.411
MOD_Plk_4	812	818	PF00069	0.470
MOD_Plk_4	899	905	PF00069	0.600
MOD_ProDKin_1	161	167	PF00069	0.673
MOD_ProDKin_1	33	39	PF00069	0.831
MOD_ProDKin_1	41	47	PF00069	0.782
MOD_ProDKin_1	473	479	PF00069	0.684
MOD_ProDKin_1	519	525	PF00069	0.446
MOD_ProDKin_1	57	63	PF00069	0.512
MOD_ProDKin_1	707	713	PF00069	0.488
MOD_ProDKin_1	75	81	PF00069	0.662
MOD_ProDKin_1	847	853	PF00069	0.732
MOD_ProDKin_1	883	889	PF00069	0.565
MOD_SUMO_rev_2	44	50	PF00179	0.492
TRG_DiLeu_BaEn_1	230	235	PF01217	0.389
TRG_DiLeu_BaEn_1	346	351	PF01217	0.377
TRG_DiLeu_BaEn_1	812	817	PF01217	0.473
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.495
TRG_DiLeu_BaLyEn_6	570	575	PF01217	0.344
TRG_DiLeu_BaLyEn_6	874	879	PF01217	0.519
TRG_ENDOCYTIC_2	114	117	PF00928	0.428
TRG_ENDOCYTIC_2	213	216	PF00928	0.292
TRG_ENDOCYTIC_2	231	234	PF00928	0.383
TRG_ENDOCYTIC_2	364	367	PF00928	0.492
TRG_ENDOCYTIC_2	494	497	PF00928	0.518
TRG_ENDOCYTIC_2	611	614	PF00928	0.464
TRG_ER_diArg_1	26	28	PF00400	0.612
TRG_ER_diArg_1	317	319	PF00400	0.488
TRG_ER_diArg_1	37	40	PF00400	0.689
TRG_ER_diArg_1	447	449	PF00400	0.495
TRG_ER_diArg_1	73	75	PF00400	0.710
TRG_ER_diArg_1	737	740	PF00400	0.532
TRG_ER_diArg_1	846	848	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.237

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B5	Leptomonas seymouri	44%	100%
A0A0S4IN68	Bodo saltans	28%	100%
A0A1X0NUD8	Trypanosomatidae	26%	100%
A0A3S7X5I2	Leishmania donovani	70%	100%
A0A422NLC9	Trypanosoma rangeli	28%	100%
A4I7X1	Leishmania infantum	70%	100%
E9B2T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	99%
Q4Q5C5	Leishmania major	70%	100%
V5BP08	Trypanosoma cruzi	30%	100%