Putative NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HKE1_LEIBR

TriTrypDb:

LbrM.32.1710 , LBRM2903_320023300

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HKE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKE1

Function

Biological processes
Term	Name	Level	Count
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	8	2
GO:0000956	nuclear-transcribed mRNA catabolic process	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006401	RNA catabolic process	5	2
GO:0006402	mRNA catabolic process	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010629	negative regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0048519	negative regulation of biological process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0110154	RNA decapping	6	2
GO:0110156	methylguanosine-cap decapping	7	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	23
GO:0016787	hydrolase activity	2	23
GO:0016462	pyrophosphatase activity	5	17
GO:0016817	hydrolase activity, acting on acid anhydrides	3	17
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	17
GO:0050072	obsolete m7G(5')pppN diphosphatase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	1	3	PF00675	0.669
CLV_NRD_NRD_1	30	32	PF00675	0.268
CLV_NRD_NRD_1	76	78	PF00675	0.396
CLV_PCSK_KEX2_1	30	32	PF00082	0.315
CLV_PCSK_KEX2_1	76	78	PF00082	0.339
CLV_PCSK_SKI1_1	125	129	PF00082	0.190
CLV_PCSK_SKI1_1	174	178	PF00082	0.289
CLV_PCSK_SKI1_1	89	93	PF00082	0.443
DEG_Nend_UBRbox_1	1	4	PF02207	0.457
DOC_MAPK_gen_1	13	21	PF00069	0.566
DOC_MAPK_gen_1	30	37	PF00069	0.265
DOC_MAPK_MEF2A_6	30	37	PF00069	0.341
DOC_PP1_RVXF_1	172	179	PF00149	0.425
DOC_USP7_MATH_1	206	210	PF00917	0.568
DOC_USP7_UBL2_3	13	17	PF12436	0.446
DOC_USP7_UBL2_3	133	137	PF12436	0.272
DOC_USP7_UBL2_3	193	197	PF12436	0.652
DOC_WW_Pin1_4	67	72	PF00397	0.366
LIG_BRCT_BRCA1_1	40	44	PF00533	0.194
LIG_FHA_1	216	222	PF00498	0.482
LIG_FHA_2	111	117	PF00498	0.473
LIG_FHA_2	223	229	PF00498	0.457
LIG_FHA_2	77	83	PF00498	0.417
LIG_LIR_Gen_1	78	87	PF02991	0.316
LIG_LIR_Nem_3	144	149	PF02991	0.326
LIG_LIR_Nem_3	172	176	PF02991	0.325
LIG_LIR_Nem_3	78	83	PF02991	0.321
LIG_LYPXL_S_1	145	149	PF13949	0.300
LIG_LYPXL_yS_3	146	149	PF13949	0.300
LIG_PDZ_Class_2	227	232	PF00595	0.467
LIG_SH2_STAT5	150	153	PF00017	0.301
LIG_SH3_3	94	100	PF00018	0.449
LIG_TRAF2_1	225	228	PF00917	0.457
LIG_TRAF2_1	70	73	PF00917	0.447
LIG_TRAF2_1	79	82	PF00917	0.432
LIG_UBA3_1	148	156	PF00899	0.216
LIG_UBA3_1	180	187	PF00899	0.181
MOD_CK1_1	198	204	PF00069	0.407
MOD_CK1_1	213	219	PF00069	0.426
MOD_CK2_1	110	116	PF00069	0.471
MOD_CK2_1	206	212	PF00069	0.635
MOD_CK2_1	222	228	PF00069	0.719
MOD_CK2_1	62	68	PF00069	0.287
MOD_CK2_1	76	82	PF00069	0.375
MOD_GlcNHglycan	125	128	PF01048	0.397
MOD_GlcNHglycan	200	203	PF01048	0.498
MOD_GlcNHglycan	40	43	PF01048	0.181
MOD_GSK3_1	119	126	PF00069	0.211
MOD_GSK3_1	206	213	PF00069	0.671
MOD_GSK3_1	67	74	PF00069	0.322
MOD_N-GLC_1	222	227	PF02516	0.454
MOD_N-GLC_1	38	43	PF02516	0.194
MOD_NEK2_1	210	215	PF00069	0.470
MOD_NEK2_1	57	62	PF00069	0.386
MOD_PKA_1	76	82	PF00069	0.181
MOD_PKA_2	29	35	PF00069	0.296
MOD_PKA_2	76	82	PF00069	0.349
MOD_Plk_1	6	12	PF00069	0.441
MOD_Plk_1	89	95	PF00069	0.469
MOD_Plk_4	206	212	PF00069	0.481
MOD_Plk_4	89	95	PF00069	0.428
MOD_ProDKin_1	67	73	PF00069	0.366
MOD_SUMO_rev_2	183	189	PF00179	0.317
TRG_DiLeu_BaEn_2	39	45	PF01217	0.350
TRG_DiLeu_LyEn_5	144	149	PF01217	0.233
TRG_ENDOCYTIC_2	146	149	PF00928	0.316
TRG_ER_diArg_1	29	31	PF00400	0.315
TRG_Pf-PMV_PEXEL_1	2	7	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P0	Leptomonas seymouri	28%	100%
A0A0N0P9K0	Leptomonas seymouri	50%	99%
A0A1X0P292	Trypanosomatidae	41%	76%
A0A1X0P2U2	Trypanosomatidae	28%	100%
A0A3Q8IFW7	Leishmania donovani	48%	95%
A0A3Q8IL17	Leishmania donovani	63%	89%
A0A3S5H5F7	Leishmania donovani	30%	100%
A0A422NYC4	Trypanosoma rangeli	26%	100%
A0A422P4Y4	Trypanosoma rangeli	36%	97%
A4H455	Leishmania braziliensis	31%	100%
A4HSD8	Leishmania infantum	30%	100%
A4I7W9	Leishmania infantum	48%	95%
C9ZPX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZQT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	77%
E9AKB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B2T0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	95%
Q4Q5C7	Leishmania major	47%	100%
Q4Q5C8	Leishmania major	70%	100%
Q4QJJ4	Leishmania major	32%	100%
V5BU70	Trypanosoma cruzi	42%	90%
V5DQQ5	Trypanosoma cruzi	41%	90%