Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKE0_LEIBR

TriTrypDb:

LbrM.32.1700 , LBRM2903_320023200

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HKE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.643
CLV_C14_Caspase3-7	436	440	PF00656	0.494
CLV_NRD_NRD_1	259	261	PF00675	0.689
CLV_NRD_NRD_1	272	274	PF00675	0.604
CLV_NRD_NRD_1	281	283	PF00675	0.582
CLV_NRD_NRD_1	35	37	PF00675	0.483
CLV_NRD_NRD_1	80	82	PF00675	0.536
CLV_PCSK_FUR_1	78	82	PF00082	0.545
CLV_PCSK_KEX2_1	259	261	PF00082	0.689
CLV_PCSK_KEX2_1	281	283	PF00082	0.709
CLV_PCSK_KEX2_1	330	332	PF00082	0.754
CLV_PCSK_KEX2_1	35	37	PF00082	0.483
CLV_PCSK_KEX2_1	429	431	PF00082	0.660
CLV_PCSK_KEX2_1	80	82	PF00082	0.536
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.672
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.644
CLV_PCSK_PC7_1	255	261	PF00082	0.643
CLV_PCSK_PC7_1	326	332	PF00082	0.665
CLV_PCSK_SKI1_1	145	149	PF00082	0.645
CLV_PCSK_SKI1_1	178	182	PF00082	0.672
CLV_PCSK_SKI1_1	410	414	PF00082	0.685
DOC_CDC14_PxL_1	152	160	PF14671	0.390
DOC_CDC14_PxL_1	421	429	PF14671	0.507
DOC_CYCLIN_RxL_1	407	414	PF00134	0.421
DOC_MAPK_gen_1	143	152	PF00069	0.479
DOC_MAPK_gen_1	281	288	PF00069	0.393
DOC_MAPK_gen_1	52	61	PF00069	0.646
DOC_PP2B_LxvP_1	111	114	PF13499	0.520
DOC_PP2B_LxvP_1	362	365	PF13499	0.491
DOC_USP7_MATH_1	112	116	PF00917	0.478
DOC_USP7_MATH_1	121	125	PF00917	0.421
DOC_USP7_MATH_1	395	399	PF00917	0.493
DOC_WW_Pin1_4	192	197	PF00397	0.438
DOC_WW_Pin1_4	388	393	PF00397	0.391
LIG_14-3-3_CanoR_1	178	187	PF00244	0.365
LIG_14-3-3_CanoR_1	397	403	PF00244	0.487
LIG_14-3-3_CanoR_1	410	418	PF00244	0.462
LIG_14-3-3_CanoR_1	430	438	PF00244	0.408
LIG_14-3-3_CanoR_1	445	451	PF00244	0.428
LIG_Actin_WH2_2	177	194	PF00022	0.407
LIG_Actin_WH2_2	381	399	PF00022	0.496
LIG_BRCT_BRCA1_1	27	31	PF00533	0.646
LIG_BRCT_BRCA1_1	356	360	PF00533	0.399
LIG_FHA_1	226	232	PF00498	0.490
LIG_FHA_1	235	241	PF00498	0.412
LIG_FHA_1	433	439	PF00498	0.445
LIG_FHA_2	180	186	PF00498	0.435
LIG_FHA_2	19	25	PF00498	0.653
LIG_FHA_2	399	405	PF00498	0.508
LIG_LIR_Apic_2	154	160	PF02991	0.433
LIG_LIR_Gen_1	238	248	PF02991	0.492
LIG_LIR_Gen_1	372	382	PF02991	0.501
LIG_LIR_Gen_1	420	427	PF02991	0.495
LIG_LIR_Nem_3	102	106	PF02991	0.290
LIG_LIR_Nem_3	238	244	PF02991	0.492
LIG_LIR_Nem_3	368	374	PF02991	0.464
LIG_LIR_Nem_3	420	424	PF02991	0.483
LIG_MYND_1	156	160	PF01753	0.500
LIG_NRBOX	408	414	PF00104	0.480
LIG_PCNA_yPIPBox_3	410	422	PF02747	0.491
LIG_Pex14_1	173	177	PF04695	0.510
LIG_SH2_CRK	177	181	PF00017	0.503
LIG_SH2_CRK	386	390	PF00017	0.454
LIG_SH2_GRB2like	374	377	PF00017	0.407
LIG_SH2_PTP2	374	377	PF00017	0.407
LIG_SH2_SRC	309	312	PF00017	0.454
LIG_SH2_SRC	374	377	PF00017	0.407
LIG_SH2_STAT5	157	160	PF00017	0.497
LIG_SH2_STAT5	226	229	PF00017	0.468
LIG_SH2_STAT5	239	242	PF00017	0.378
LIG_SH2_STAT5	262	265	PF00017	0.440
LIG_SH2_STAT5	374	377	PF00017	0.446
LIG_SH2_STAT5	53	56	PF00017	0.684
LIG_SH3_3	386	392	PF00018	0.387
LIG_SUMO_SIM_par_1	131	136	PF11976	0.446
LIG_SUMO_SIM_par_1	215	221	PF11976	0.481
LIG_TYR_ITIM	175	180	PF00017	0.571
LIG_TYR_ITIM	384	389	PF00017	0.611
LIG_WRC_WIRS_1	100	105	PF05994	0.247
LIG_WRC_WIRS_1	418	423	PF05994	0.608
MOD_CK1_1	124	130	PF00069	0.528
MOD_CK1_1	179	185	PF00069	0.422
MOD_CK1_1	246	252	PF00069	0.512
MOD_CK1_1	335	341	PF00069	0.648
MOD_CK1_1	398	404	PF00069	0.480
MOD_CK1_1	432	438	PF00069	0.542
MOD_CK2_1	135	141	PF00069	0.491
MOD_CK2_1	18	24	PF00069	0.565
MOD_CK2_1	269	275	PF00069	0.519
MOD_CK2_1	398	404	PF00069	0.649
MOD_GlcNHglycan	114	117	PF01048	0.603
MOD_GlcNHglycan	206	209	PF01048	0.622
MOD_GlcNHglycan	245	248	PF01048	0.743
MOD_GlcNHglycan	27	30	PF01048	0.622
MOD_GlcNHglycan	327	330	PF01048	0.683
MOD_GlcNHglycan	334	337	PF01048	0.705
MOD_GlcNHglycan	397	400	PF01048	0.671
MOD_GlcNHglycan	431	434	PF01048	0.582
MOD_GlcNHglycan	442	445	PF01048	0.556
MOD_GSK3_1	120	127	PF00069	0.638
MOD_GSK3_1	131	138	PF00069	0.703
MOD_GSK3_1	14	21	PF00069	0.623
MOD_GSK3_1	192	199	PF00069	0.624
MOD_GSK3_1	235	242	PF00069	0.623
MOD_GSK3_1	265	272	PF00069	0.651
MOD_GSK3_1	325	332	PF00069	0.755
MOD_GSK3_1	335	342	PF00069	0.703
MOD_GSK3_1	345	352	PF00069	0.586
MOD_GSK3_1	425	432	PF00069	0.547
MOD_GSK3_1	47	54	PF00069	0.637
MOD_N-GLC_1	192	197	PF02516	0.580
MOD_N-GLC_1	369	374	PF02516	0.640
MOD_NEK2_1	135	140	PF00069	0.686
MOD_NEK2_1	176	181	PF00069	0.571
MOD_NEK2_1	204	209	PF00069	0.574
MOD_NEK2_1	234	239	PF00069	0.508
MOD_NEK2_1	369	374	PF00069	0.667
MOD_NEK2_2	265	270	PF00069	0.523
MOD_PIKK_1	411	417	PF00454	0.445
MOD_PIKK_1	47	53	PF00454	0.559
MOD_PK_1	6	12	PF00069	0.551
MOD_PKA_1	429	435	PF00069	0.531
MOD_PKA_2	325	331	PF00069	0.570
MOD_PKA_2	429	435	PF00069	0.531
MOD_PKA_2	446	452	PF00069	0.515
MOD_Plk_1	369	375	PF00069	0.660
MOD_Plk_1	6	12	PF00069	0.551
MOD_Plk_4	197	203	PF00069	0.564
MOD_Plk_4	235	241	PF00069	0.586
MOD_Plk_4	265	271	PF00069	0.532
MOD_Plk_4	27	33	PF00069	0.547
MOD_Plk_4	417	423	PF00069	0.615
MOD_Plk_4	99	105	PF00069	0.247
MOD_ProDKin_1	192	198	PF00069	0.536
MOD_ProDKin_1	388	394	PF00069	0.468
MOD_SUMO_for_1	208	211	PF00179	0.516
MOD_SUMO_for_1	83	86	PF00179	0.609
TRG_DiLeu_BaEn_3	164	170	PF01217	0.421
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.408
TRG_ENDOCYTIC_2	177	180	PF00928	0.657
TRG_ENDOCYTIC_2	374	377	PF00928	0.545
TRG_ENDOCYTIC_2	386	389	PF00928	0.488
TRG_ER_diArg_1	258	260	PF00400	0.613
TRG_ER_diArg_1	77	80	PF00400	0.697
TRG_Pf-PMV_PEXEL_1	178	183	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	410	415	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5J8	Leishmania donovani	53%	88%
A4I7W8	Leishmania infantum	50%	77%
E9B2S8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	86%
Q4Q5C9	Leishmania major	52%	100%