Putative ATP-dependent zinc metallopeptidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Metalloprotease M41 FtsH, putative

Species:

Leishmania braziliensis

UniProt:

A4HKD8_LEIBR

TriTrypDb:

LbrM.32.1670 , LBRM2903_320022800

Length:

708

Annotations

LeishMANIAdb annotations

Homologous to bacterial FtsH and Eukaryotic AFG3 proteins. Probably involved in mitochondrial protein processing.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	25
GO:0110165	cellular anatomical entity	1	26
GO:0005739	mitochondrion	5	1
GO:0005745	m-AAA complex	4	3
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	3
GO:0098798	mitochondrial protein-containing complex	2	3
GO:0098800	inner mitochondrial membrane protein complex	3	3
GO:1902494	catalytic complex	2	3
GO:1905368	peptidase complex	3	3

Expansion

Sequence features

A4HKD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKD8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	33
GO:0006807	nitrogen compound metabolic process	2	33
GO:0008152	metabolic process	1	33
GO:0019538	protein metabolic process	3	33
GO:0043170	macromolecule metabolic process	3	33
GO:0044238	primary metabolic process	2	33
GO:0071704	organic substance metabolic process	2	33
GO:1901564	organonitrogen compound metabolic process	3	33
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0016485	protein processing	5	3
GO:0022607	cellular component assembly	4	3
GO:0034982	mitochondrial protein processing	6	3
GO:0043933	protein-containing complex organization	4	3
GO:0051604	protein maturation	4	3
GO:0065003	protein-containing complex assembly	5	3
GO:0071840	cellular component organization or biogenesis	2	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	33
GO:0003824	catalytic activity	1	33
GO:0004175	endopeptidase activity	4	33
GO:0004176	ATP-dependent peptidase activity	2	33
GO:0004222	metalloendopeptidase activity	5	33
GO:0005488	binding	1	33
GO:0005524	ATP binding	5	33
GO:0008233	peptidase activity	3	33
GO:0008237	metallopeptidase activity	4	33
GO:0016462	pyrophosphatase activity	5	33
GO:0016787	hydrolase activity	2	33
GO:0016817	hydrolase activity, acting on acid anhydrides	3	33
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	33
GO:0016887	ATP hydrolysis activity	7	33
GO:0017076	purine nucleotide binding	4	33
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	33
GO:0030554	adenyl nucleotide binding	5	33
GO:0032553	ribonucleotide binding	3	33
GO:0032555	purine ribonucleotide binding	4	33
GO:0032559	adenyl ribonucleotide binding	5	33
GO:0035639	purine ribonucleoside triphosphate binding	4	33
GO:0036094	small molecule binding	2	33
GO:0043167	ion binding	2	33
GO:0043168	anion binding	3	33
GO:0097159	organic cyclic compound binding	2	33
GO:0097367	carbohydrate derivative binding	2	33
GO:0140096	catalytic activity, acting on a protein	2	33
GO:0140657	ATP-dependent activity	1	33
GO:1901265	nucleoside phosphate binding	3	33
GO:1901363	heterocyclic compound binding	2	33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.426
CLV_C14_Caspase3-7	634	638	PF00656	0.486
CLV_NRD_NRD_1	147	149	PF00675	0.337
CLV_NRD_NRD_1	366	368	PF00675	0.235
CLV_NRD_NRD_1	435	437	PF00675	0.450
CLV_PCSK_KEX2_1	147	149	PF00082	0.337
CLV_PCSK_KEX2_1	281	283	PF00082	0.230
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.229
CLV_PCSK_SKI1_1	248	252	PF00082	0.226
CLV_PCSK_SKI1_1	284	288	PF00082	0.230
CLV_PCSK_SKI1_1	357	361	PF00082	0.228
CLV_PCSK_SKI1_1	389	393	PF00082	0.281
CLV_PCSK_SKI1_1	615	619	PF00082	0.279
CLV_PCSK_SKI1_1	669	673	PF00082	0.257
CLV_PCSK_SKI1_1	703	707	PF00082	0.339
DEG_Nend_UBRbox_3	1	3	PF02207	0.471
DEG_SCF_FBW7_1	60	66	PF00400	0.337
DOC_CKS1_1	60	65	PF01111	0.336
DOC_CYCLIN_RxL_1	281	289	PF00134	0.440
DOC_CYCLIN_RxL_1	666	676	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.564
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.329
DOC_MAPK_gen_1	291	299	PF00069	0.475
DOC_MAPK_gen_1	361	371	PF00069	0.427
DOC_MAPK_JIP1_4	445	451	PF00069	0.478
DOC_MAPK_MEF2A_6	291	299	PF00069	0.424
DOC_MAPK_MEF2A_6	364	373	PF00069	0.426
DOC_MAPK_MEF2A_6	492	499	PF00069	0.595
DOC_MAPK_MEF2A_6	543	550	PF00069	0.382
DOC_MAPK_NFAT4_5	543	551	PF00069	0.519
DOC_PP2B_LxvP_1	33	36	PF13499	0.395
DOC_PP4_FxxP_1	139	142	PF00568	0.228
DOC_USP7_MATH_1	153	157	PF00917	0.636
DOC_USP7_MATH_1	305	309	PF00917	0.438
DOC_USP7_MATH_1	418	422	PF00917	0.708
DOC_USP7_MATH_1	453	457	PF00917	0.525
DOC_USP7_MATH_1	61	65	PF00917	0.530
DOC_USP7_MATH_1	68	72	PF00917	0.537
DOC_USP7_MATH_1	8	12	PF00917	0.384
DOC_USP7_UBL2_3	211	215	PF12436	0.490
DOC_USP7_UBL2_3	222	226	PF12436	0.451
DOC_USP7_UBL2_3	543	547	PF12436	0.396
DOC_USP7_UBL2_3	631	635	PF12436	0.467
DOC_USP7_UBL2_3	689	693	PF12436	0.418
DOC_WW_Pin1_4	258	263	PF00397	0.463
DOC_WW_Pin1_4	3	8	PF00397	0.535
DOC_WW_Pin1_4	465	470	PF00397	0.497
DOC_WW_Pin1_4	59	64	PF00397	0.336
LIG_14-3-3_CanoR_1	197	202	PF00244	0.606
LIG_14-3-3_CanoR_1	436	440	PF00244	0.548
LIG_14-3-3_CanoR_1	514	522	PF00244	0.335
LIG_14-3-3_CanoR_1	639	645	PF00244	0.463
LIG_Actin_WH2_2	677	694	PF00022	0.329
LIG_BIR_III_2	443	447	PF00653	0.688
LIG_BIR_III_4	304	308	PF00653	0.426
LIG_BRCT_BRCA1_1	259	263	PF00533	0.448
LIG_CaM_IQ_9	602	617	PF13499	0.420
LIG_EVH1_1	33	37	PF00568	0.364
LIG_FHA_1	466	472	PF00498	0.492
LIG_FHA_1	536	542	PF00498	0.481
LIG_FHA_1	558	564	PF00498	0.401
LIG_FHA_2	198	204	PF00498	0.484
LIG_FHA_2	336	342	PF00498	0.454
LIG_FHA_2	426	432	PF00498	0.710
LIG_FHA_2	641	647	PF00498	0.489
LIG_LIR_Apic_2	127	131	PF02991	0.296
LIG_LIR_Gen_1	11	19	PF02991	0.407
LIG_LIR_Gen_1	270	275	PF02991	0.426
LIG_LIR_Gen_1	459	464	PF02991	0.621
LIG_LIR_Gen_1	525	535	PF02991	0.435
LIG_LIR_Gen_1	574	584	PF02991	0.458
LIG_LIR_Nem_3	104	110	PF02991	0.422
LIG_LIR_Nem_3	199	204	PF02991	0.504
LIG_LIR_Nem_3	270	274	PF02991	0.426
LIG_LIR_Nem_3	381	386	PF02991	0.474
LIG_LIR_Nem_3	459	463	PF02991	0.625
LIG_LIR_Nem_3	525	530	PF02991	0.435
LIG_LIR_Nem_3	574	580	PF02991	0.452
LIG_NRBOX	680	686	PF00104	0.422
LIG_PCNA_yPIPBox_3	501	514	PF02747	0.510
LIG_PDZ_Class_2	703	708	PF00595	0.633
LIG_Pex14_2	271	275	PF04695	0.420
LIG_PTB_Apo_2	132	139	PF02174	0.400
LIG_PTB_Apo_2	454	461	PF02174	0.505
LIG_PTB_Phospho_1	454	460	PF10480	0.510
LIG_SH2_CRK	460	464	PF00017	0.442
LIG_SH2_CRK	53	57	PF00017	0.540
LIG_SH2_GRB2like	386	389	PF00017	0.493
LIG_SH2_GRB2like	82	85	PF00017	0.334
LIG_SH2_NCK_1	53	57	PF00017	0.336
LIG_SH2_SRC	97	100	PF00017	0.478
LIG_SH2_STAP1	460	464	PF00017	0.494
LIG_SH2_STAP1	559	563	PF00017	0.439
LIG_SH2_STAP1	82	86	PF00017	0.381
LIG_SH2_STAT3	17	20	PF00017	0.405
LIG_SH2_STAT3	559	562	PF00017	0.420
LIG_SH2_STAT3	72	75	PF00017	0.477
LIG_SH2_STAT3	85	88	PF00017	0.527
LIG_SH2_STAT5	145	148	PF00017	0.342
LIG_SH2_STAT5	217	220	PF00017	0.471
LIG_SH2_STAT5	386	389	PF00017	0.476
LIG_SH2_STAT5	48	51	PF00017	0.488
LIG_SH2_STAT5	559	562	PF00017	0.433
LIG_SH2_STAT5	664	667	PF00017	0.450
LIG_SH3_3	111	117	PF00018	0.351
LIG_SH3_3	183	189	PF00018	0.616
LIG_SH3_3	26	32	PF00018	0.504
LIG_SH3_3	366	372	PF00018	0.422
LIG_SH3_3	57	63	PF00018	0.408
LIG_SH3_3	88	94	PF00018	0.417
LIG_SH3_4	398	405	PF00018	0.562
LIG_SH3_4	631	638	PF00018	0.519
LIG_Sin3_3	656	663	PF02671	0.379
LIG_SUMO_SIM_anti_2	341	347	PF11976	0.433
LIG_SxIP_EBH_1	547	557	PF03271	0.412
LIG_TRAF2_1	320	323	PF00917	0.438
LIG_TRAF2_1	428	431	PF00917	0.690
LIG_TYR_ITSM	523	530	PF00017	0.276
LIG_UBA3_1	180	188	PF00899	0.483
MOD_CK1_1	124	130	PF00069	0.400
MOD_CK1_1	175	181	PF00069	0.371
MOD_CK1_1	421	427	PF00069	0.542
MOD_CK1_1	465	471	PF00069	0.434
MOD_CK2_1	317	323	PF00069	0.286
MOD_CK2_1	335	341	PF00069	0.238
MOD_CK2_1	425	431	PF00069	0.651
MOD_CK2_1	453	459	PF00069	0.461
MOD_CK2_1	640	646	PF00069	0.349
MOD_CMANNOS	641	644	PF00535	0.400
MOD_Cter_Amidation	509	512	PF01082	0.413
MOD_Cter_Amidation	686	689	PF01082	0.423
MOD_GlcNHglycan	117	120	PF01048	0.482
MOD_GlcNHglycan	155	158	PF01048	0.565
MOD_GlcNHglycan	159	162	PF01048	0.632
MOD_GlcNHglycan	17	20	PF01048	0.639
MOD_GlcNHglycan	177	180	PF01048	0.569
MOD_GlcNHglycan	266	269	PF01048	0.254
MOD_GlcNHglycan	277	280	PF01048	0.293
MOD_GlcNHglycan	414	417	PF01048	0.718
MOD_GlcNHglycan	418	421	PF01048	0.741
MOD_GlcNHglycan	661	664	PF01048	0.326
MOD_GSK3_1	153	160	PF00069	0.572
MOD_GSK3_1	167	174	PF00069	0.624
MOD_GSK3_1	258	265	PF00069	0.263
MOD_GSK3_1	412	419	PF00069	0.526
MOD_GSK3_1	421	428	PF00069	0.571
MOD_GSK3_1	431	438	PF00069	0.542
MOD_GSK3_1	465	472	PF00069	0.357
MOD_GSK3_1	59	66	PF00069	0.700
MOD_N-GLC_1	3	8	PF02516	0.679
MOD_N-GLC_1	323	328	PF02516	0.273
MOD_NEK2_1	264	269	PF00069	0.194
MOD_NEK2_1	275	280	PF00069	0.209
MOD_NEK2_1	517	522	PF00069	0.248
MOD_NEK2_1	535	540	PF00069	0.263
MOD_NEK2_1	575	580	PF00069	0.256
MOD_NEK2_1	621	626	PF00069	0.294
MOD_NEK2_1	659	664	PF00069	0.251
MOD_NEK2_2	8	13	PF00069	0.587
MOD_PIKK_1	27	33	PF00454	0.490
MOD_PIKK_1	557	563	PF00454	0.269
MOD_PIKK_1	575	581	PF00454	0.269
MOD_PK_1	595	601	PF00069	0.400
MOD_PKA_2	115	121	PF00069	0.496
MOD_PKA_2	196	202	PF00069	0.452
MOD_PKA_2	435	441	PF00069	0.735
MOD_PKA_2	515	521	PF00069	0.292
MOD_PKA_2	606	612	PF00069	0.273
MOD_Plk_1	323	329	PF00069	0.269
MOD_Plk_1	595	601	PF00069	0.286
MOD_Plk_1	667	673	PF00069	0.354
MOD_Plk_2-3	569	575	PF00069	0.400
MOD_Plk_4	121	127	PF00069	0.475
MOD_Plk_4	172	178	PF00069	0.532
MOD_Plk_4	246	252	PF00069	0.280
MOD_Plk_4	435	441	PF00069	0.504
MOD_Plk_4	475	481	PF00069	0.345
MOD_Plk_4	546	552	PF00069	0.313
MOD_Plk_4	667	673	PF00069	0.315
MOD_Plk_4	695	701	PF00069	0.314
MOD_Plk_4	8	14	PF00069	0.542
MOD_ProDKin_1	258	264	PF00069	0.321
MOD_ProDKin_1	3	9	PF00069	0.701
MOD_ProDKin_1	465	471	PF00069	0.365
MOD_ProDKin_1	59	65	PF00069	0.427
MOD_SUMO_for_1	444	447	PF00179	0.617
MOD_SUMO_for_1	650	653	PF00179	0.296
MOD_SUMO_rev_2	285	293	PF00179	0.354
MOD_SUMO_rev_2	362	369	PF00179	0.269
MOD_SUMO_rev_2	429	439	PF00179	0.730
MOD_SUMO_rev_2	442	446	PF00179	0.440
TRG_DiLeu_BaEn_1	435	440	PF01217	0.697
TRG_DiLeu_BaEn_1	655	660	PF01217	0.279
TRG_ENDOCYTIC_2	107	110	PF00928	0.527
TRG_ENDOCYTIC_2	217	220	PF00928	0.332
TRG_ENDOCYTIC_2	460	463	PF00928	0.538
TRG_ENDOCYTIC_2	527	530	PF00928	0.276
TRG_ER_diArg_1	146	148	PF00400	0.426
TRG_ER_diArg_1	514	517	PF00400	0.451
TRG_ER_diArg_1	552	555	PF00400	0.261
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	657	661	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A5	Leptomonas seymouri	46%	100%
A0A0N1HUW7	Leptomonas seymouri	32%	100%
A0A0N1I6C1	Leptomonas seymouri	35%	91%
A0A0N1IMN9	Leptomonas seymouri	78%	100%
A0A0N1PBB9	Leptomonas seymouri	47%	100%
A0A0N1PGD9	Leptomonas seymouri	33%	71%
A0A0S4J3N2	Bodo saltans	70%	100%
A0A0S4JAH0	Bodo saltans	49%	100%
A0A0S4JGG9	Bodo saltans	49%	100%
A0A0S4JTL4	Bodo saltans	34%	84%
A0A1X0NKD8	Trypanosomatidae	32%	100%
A0A1X0NW32	Trypanosomatidae	76%	100%
A0A1X0P749	Trypanosomatidae	50%	100%
A0A1X0P7E6	Trypanosomatidae	50%	100%
A0A1X0P9F5	Trypanosomatidae	34%	98%
A0A3Q8IFG3	Leishmania donovani	86%	99%
A0A3Q8IJP7	Leishmania donovani	51%	100%
A0A3R7KKD0	Trypanosoma rangeli	46%	100%
A0A3R7L0P7	Trypanosoma rangeli	75%	100%
A0A3R7REN1	Trypanosoma rangeli	33%	100%
A0A3S5H775	Leishmania donovani	47%	100%
A0A422N673	Trypanosoma rangeli	34%	100%
A0A422NJ44	Trypanosoma rangeli	48%	100%
A0L4S0	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	35%	100%
A0LN68	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)	33%	100%
A0LR74	Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B)	34%	100%
A0PXM8	Clostridium novyi (strain NT)	37%	100%
A2ZVG7	Oryza sativa subsp. japonica	34%	90%
A4H9H1	Leishmania braziliensis	48%	100%
A4HAA8	Leishmania braziliensis	46%	100%
A4HPD5	Leishmania braziliensis	34%	100%
A4HXT7	Leishmania infantum	51%	100%
A4HYI8	Leishmania infantum	47%	100%
A4I809	Leishmania infantum	85%	99%
A5U8T5	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	32%	93%
A5W382	Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)	35%	100%
A6LD25	Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)	36%	100%
A6QBN8	Sulfurovum sp. (strain NBC37-1)	33%	100%
A6TWP7	Alkaliphilus metalliredigens (strain QYMF)	38%	100%
A8F7F7	Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO)	38%	100%
A8ZNZ4	Acaryochloris marina (strain MBIC 11017)	33%	100%
A9BFL9	Petrotoga mobilis (strain DSM 10674 / SJ95)	34%	100%
A9EXK6	Sorangium cellulosum (strain So ce56)	34%	100%
A9GAW6	Sorangium cellulosum (strain So ce56)	36%	100%
A9GRC9	Sorangium cellulosum (strain So ce56)	34%	100%
A9NE17	Acholeplasma laidlawii (strain PG-8A)	35%	100%
B0B970	Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)	36%	78%
B0K5A3	Thermoanaerobacter sp. (strain X514)	37%	100%
B0K657	Thermoanaerobacter sp. (strain X514)	35%	100%
B1AI94	Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)	32%	98%
B1GZK7	Endomicrobium trichonymphae	37%	100%
B1ZMG6	Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)	33%	100%
B2A3Q4	Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)	35%	100%
B2JVU2	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	35%	100%
B2UE66	Ralstonia pickettii (strain 12J)	35%	99%
B2UMY1	Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013 / CIP 107961 / Muc)	32%	87%
B2XTF7	Heterosigma akashiwo (strain NIES-293 / 8280G21-1)	34%	100%
B3DV46	Methylacidiphilum infernorum (isolate V4)	34%	100%
B3DY14	Methylacidiphilum infernorum (isolate V4)	34%	100%
B3PNH3	Metamycoplasma arthritidis (strain 158L3-1)	32%	95%
B3QZS3	Phytoplasma mali (strain AT)	33%	100%
B3R057	Phytoplasma mali (strain AT)	34%	100%
B3R0R7	Phytoplasma mali (strain AT)	34%	100%
B4SCV5	Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)	35%	100%
B4U7U4	Hydrogenobaculum sp. (strain Y04AAS1)	34%	100%
B7J0N5	Borreliella burgdorferi (strain ZS7)	35%	100%
B7T1V0	Vaucheria litorea	34%	100%
B8D065	Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)	35%	100%
B8G4Q6	Chloroflexus aggregans (strain MD-66 / DSM 9485)	35%	100%
B8H444	Caulobacter vibrioides (strain NA1000 / CB15N)	33%	100%
B8I4B9	Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)	34%	100%
B8J992	Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)	34%	100%
B9KXV3	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)	36%	100%
B9L3S8	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)	38%	100%
B9MPK5	Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320)	35%	100%
C0ZPK5	Rhodococcus erythropolis (strain PR4 / NBRC 100887)	35%	83%
C1F8X6	Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)	34%	100%
C5CES8	Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)	32%	100%
C5J6A7	Mesomycoplasma conjunctivae (strain ATCC 25834 / NCTC 10147 / HRC/581)	30%	94%
C6V4R9	Neorickettsia risticii (strain Illinois)	32%	100%
C6VKW6	Lactiplantibacillus plantarum (strain JDM1)	38%	95%
C7M0M0	Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)	34%	100%
C7MC16	Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / JCM 11609 / LMG 19847 / NBRC 14762 / NCIMB 9860 / 6-10)	33%	100%
C7N1I1	Slackia heliotrinireducens (strain ATCC 29202 / DSM 20476 / NCTC 11029 / RHS 1)	35%	90%
C7N914	Leptotrichia buccalis (strain ATCC 14201 / DSM 1135 / JCM 12969 / NCTC 10249 / C-1013-b)	35%	92%
C8W731	Lancefieldella parvula (strain ATCC 33793 / DSM 20469 / CCUG 32760 / JCM 10300 / KCTC 3663 / VPI 0546 / 1246)	33%	100%
C8WEG0	Zymomonas mobilis subsp. mobilis (strain NCIMB 11163 / B70)	36%	100%
C9ZZX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
D0A0W3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0A3J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0AA32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
D0LWB8	Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2)	38%	100%
D0MGU8	Rhodothermus marinus (strain ATCC 43812 / DSM 4252 / R-10)	36%	100%
D1AXT4	Streptobacillus moniliformis (strain ATCC 14647 / DSM 12112 / NCTC 10651 / 9901)	36%	100%
D1BLD0	Veillonella parvula (strain ATCC 10790 / DSM 2008 / CCUG 5123 / JCM 12972 / NCTC 11810 / Te3)	35%	100%
D1C1U7	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	35%	100%
D1C2C6	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	35%	100%
D1C8C0	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)	33%	100%
D2NQQ7	Rothia mucilaginosa (strain DY-18)	37%	94%
D3EZK2	Conexibacter woesei (strain DSM 14684 / CIP 108061 / JCM 11494 / NBRC 100937 / ID131577)	37%	95%
D3F124	Conexibacter woesei (strain DSM 14684 / CIP 108061 / JCM 11494 / NBRC 100937 / ID131577)	34%	100%
D3FA80	Conexibacter woesei (strain DSM 14684 / CIP 108061 / JCM 11494 / NBRC 100937 / ID131577)	33%	100%
D3FFN2	Mycoplasma gallisepticum (strain R(high / passage 156))	34%	93%
D4HA34	Cutibacterium acnes (strain SK137)	36%	99%
D5D8E3	Sulcia muelleri (strain DMIN)	34%	100%
D5H7Z5	Salinibacter ruber (strain M8)	36%	100%
D5HA94	Salinibacter ruber (strain M8)	32%	100%
E9ARJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9ASB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9B1M1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	80%
E9B2S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
O19922	Cyanidium caldarium	35%	100%
O32617	Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)	34%	100%
O67077	Aquifex aeolicus (strain VF5)	34%	100%
O69076	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	37%	100%
O78516	Guillardia theta	32%	100%
O80860	Arabidopsis thaliana	34%	100%
O80983	Arabidopsis thaliana	37%	99%
O82150	Nicotiana tabacum	37%	99%
O83746	Treponema pallidum (strain Nichols)	31%	100%
O88967	Mus musculus	36%	99%
P0A4V9	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	93%
P0AAI3	Escherichia coli (strain K12)	33%	100%
P0AAI4	Shigella flexneri	33%	100%
P32795	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	95%
P37476	Bacillus subtilis (strain 168)	35%	100%
P39925	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	93%
P40341	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	86%
P46469	Lactococcus lactis subsp. lactis (strain IL1403)	34%	100%
P51327	Porphyra purpurea	33%	100%
P57462	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	32%	100%
P59652	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	37%	100%
P63343	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	100%
P63344	Salmonella typhi	33%	100%
P71377	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	33%	100%
P71408	Helicobacter pylori (strain ATCC 700392 / 26695)	33%	100%
P72991	Synechocystis sp. (strain PCC 6803 / Kazusa)	33%	100%
P73179	Synechocystis sp. (strain PCC 6803 / Kazusa)	37%	100%
P75120	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	34%	100%
P94304	Alkalihalophilus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4)	35%	100%
P9WQN2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	93%
P9WQN3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	93%
Q03Z46	Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y)	36%	100%
Q04Q03	Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)	35%	100%
Q0DHL4	Oryza sativa subsp. japonica	38%	86%
Q0TTK8	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	35%	99%
Q10ZF7	Trichodesmium erythraeum (strain IMS101)	36%	100%
Q1AV13	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1)	36%	100%
Q1D491	Myxococcus xanthus (strain DK1622)	34%	100%
Q1LLA9	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)	33%	100%
Q1PDW5	Arabidopsis thaliana	36%	100%
Q1RGP0	Rickettsia bellii (strain RML369-C)	32%	100%
Q1XDF9	Neopyropia yezoensis	35%	100%
Q2JNP0	Synechococcus sp. (strain JA-2-3B'a(2-13))	36%	100%
Q2KJI7	Bos taurus	35%	88%
Q2LUQ1	Syntrophus aciditrophicus (strain SB)	33%	96%
Q2NIN5	Aster yellows witches'-broom phytoplasma (strain AYWB)	36%	100%
Q2SF13	Hahella chejuensis (strain KCTC 2396)	30%	100%
Q39102	Arabidopsis thaliana	36%	99%
Q39444	Capsicum annuum	37%	100%
Q3A579	Syntrophotalea carbinolica (strain DSM 2380 / NBRC 103641 / GraBd1)	32%	100%
Q3B6R3	Chlorobium luteolum (strain DSM 273 / BCRC 81028 / 2530)	36%	100%
Q3JEE4	Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)	36%	100%
Q3ULF4	Mus musculus	35%	91%
Q4A5F0	Mycoplasmopsis synoviae (strain 53)	29%	100%
Q4L3G8	Staphylococcus haemolyticus (strain JCSC1435)	36%	97%
Q4Q5D1	Leishmania major	86%	100%
Q4QD50	Leishmania major	46%	99%
Q4QDY0	Leishmania major	47%	98%
Q4UN68	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	35%	100%
Q55700	Synechocystis sp. (strain PCC 6803 / Kazusa)	33%	100%
Q5SI82	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	36%	100%
Q5Z974	Oryza sativa subsp. japonica	36%	100%
Q60AK1	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	34%	100%
Q655S1	Oryza sativa subsp. japonica	36%	100%
Q67JH0	Symbiobacterium thermophilum (strain T / IAM 14863)	38%	100%
Q67LC0	Symbiobacterium thermophilum (strain T / IAM 14863)	34%	100%
Q67T82	Symbiobacterium thermophilum (strain T / IAM 14863)	37%	100%
Q67WJ2	Oryza sativa subsp. japonica	35%	100%
Q68XR9	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	35%	100%
Q6H6R9	Oryza sativa subsp. japonica	33%	86%
Q6KHA4	Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)	33%	100%
Q6LUJ8	Photobacterium profundum (strain SS9)	36%	100%
Q6M2F0	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	34%	83%
Q6MDI5	Protochlamydia amoebophila (strain UWE25)	38%	77%
Q6MJV1	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	34%	100%
Q6MLS7	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	36%	100%
Q7TT47	Rattus norvegicus	35%	91%
Q7URM7	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	35%	97%
Q7UUZ7	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	37%	100%
Q83FV7	Tropheryma whipplei (strain Twist)	34%	100%
Q83XX3	Oenococcus oeni	33%	99%
Q84WU8	Arabidopsis thaliana	38%	88%
Q88Z31	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	38%	95%
Q89AF2	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	34%	100%
Q8EUA6	Malacoplasma penetrans (strain HF-2)	33%	86%
Q8JZQ2	Mus musculus	34%	88%
Q8K9G8	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	32%	100%
Q8LQJ8	Oryza sativa subsp. japonica	38%	99%
Q8LQJ9	Oryza sativa subsp. japonica	37%	100%
Q8S2A7	Oryza sativa subsp. japonica	37%	88%
Q8VZI8	Arabidopsis thaliana	38%	87%
Q8W585	Arabidopsis thaliana	35%	100%
Q8X9L0	Escherichia coli O157:H7	33%	100%
Q8YMZ8	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	35%	100%
Q920A7	Mus musculus	37%	90%
Q925S8	Rattus norvegicus	36%	99%
Q92JJ9	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	35%	100%
Q96TA2	Homo sapiens	36%	92%
Q98PE4	Mycoplasmopsis pulmonis (strain UAB CTIP)	33%	98%
Q9BAE0	Medicago sativa	36%	100%
Q9FH02	Arabidopsis thaliana	37%	100%
Q9HGM3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	92%
Q9N3T5	Caenorhabditis elegans	36%	91%
Q9TJ83	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	34%	100%
Q9UQ90	Homo sapiens	35%	89%
Q9WZ49	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	34%	100%
Q9Y4W6	Homo sapiens	34%	89%
Q9ZEA2	Rickettsia prowazekii (strain Madrid E)	35%	100%
Q9ZM66	Helicobacter pylori (strain J99 / ATCC 700824)	34%	100%
V5B092	Trypanosoma cruzi	34%	100%
V5B4C8	Trypanosoma cruzi	47%	100%
V5BEV9	Trypanosoma cruzi	35%	99%
V5BP04	Trypanosoma cruzi	69%	100%