Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKD7_LEIBR

TriTrypDb:

LbrM.32.1660 , LBRM2903_320022700

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.537
CLV_C14_Caspase3-7	7	11	PF00656	0.499
CLV_NRD_NRD_1	352	354	PF00675	0.436
CLV_NRD_NRD_1	62	64	PF00675	0.566
CLV_PCSK_KEX2_1	352	354	PF00082	0.349
CLV_PCSK_KEX2_1	61	63	PF00082	0.558
CLV_PCSK_SKI1_1	117	121	PF00082	0.552
CLV_PCSK_SKI1_1	137	141	PF00082	0.607
CLV_PCSK_SKI1_1	150	154	PF00082	0.580
CLV_PCSK_SKI1_1	308	312	PF00082	0.335
CLV_PCSK_SKI1_1	51	55	PF00082	0.354
DEG_APCC_DBOX_1	136	144	PF00400	0.570
DEG_APCC_DBOX_1	20	28	PF00400	0.458
DEG_SCF_TRCP1_1	184	190	PF00400	0.517
DOC_ANK_TNKS_1	107	114	PF00023	0.519
DOC_ANK_TNKS_1	170	177	PF00023	0.538
DOC_CKS1_1	322	327	PF01111	0.385
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.518
DOC_MAPK_gen_1	49	57	PF00069	0.354
DOC_MAPK_MEF2A_6	49	57	PF00069	0.354
DOC_PP4_FxxP_1	322	325	PF00568	0.438
DOC_USP7_MATH_1	161	165	PF00917	0.664
DOC_USP7_MATH_1	206	210	PF00917	0.531
DOC_USP7_MATH_2	241	247	PF00917	0.533
DOC_WW_Pin1_4	162	167	PF00397	0.632
DOC_WW_Pin1_4	200	205	PF00397	0.585
DOC_WW_Pin1_4	235	240	PF00397	0.680
DOC_WW_Pin1_4	321	326	PF00397	0.382
DOC_WW_Pin1_4	78	83	PF00397	0.582
LIG_14-3-3_CanoR_1	259	267	PF00244	0.529
LIG_14-3-3_CanoR_1	316	325	PF00244	0.327
LIG_14-3-3_CanoR_1	352	357	PF00244	0.447
LIG_14-3-3_CanoR_1	51	56	PF00244	0.377
LIG_14-3-3_CanoR_1	61	67	PF00244	0.480
LIG_Actin_WH2_2	5	23	PF00022	0.600
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_BIR_III_4	110	114	PF00653	0.541
LIG_BRCT_BRCA1_1	267	271	PF00533	0.424
LIG_BRCT_BRCA1_1	318	322	PF00533	0.477
LIG_Clathr_ClatBox_1	56	60	PF01394	0.359
LIG_CtBP_PxDLS_1	166	170	PF00389	0.508
LIG_DLG_GKlike_1	62	69	PF00625	0.453
LIG_FHA_1	151	157	PF00498	0.568
LIG_FHA_1	289	295	PF00498	0.399
LIG_FHA_1	356	362	PF00498	0.388
LIG_FHA_2	62	68	PF00498	0.558
LIG_FHA_2	85	91	PF00498	0.507
LIG_LIR_Apic_2	319	325	PF02991	0.454
LIG_LIR_Gen_1	270	279	PF02991	0.367
LIG_LIR_Gen_1	339	350	PF02991	0.381
LIG_LIR_Gen_1	64	74	PF02991	0.481
LIG_LIR_Nem_3	270	275	PF02991	0.362
LIG_LIR_Nem_3	339	345	PF02991	0.353
LIG_LIR_Nem_3	64	69	PF02991	0.464
LIG_SH2_CRK	158	162	PF00017	0.507
LIG_SH2_STAT3	351	354	PF00017	0.410
LIG_SH2_STAT5	286	289	PF00017	0.441
LIG_SH2_STAT5	301	304	PF00017	0.439
LIG_SH2_STAT5	323	326	PF00017	0.388
LIG_SH2_STAT5	342	345	PF00017	0.339
LIG_SH3_3	10	16	PF00018	0.552
LIG_SH3_3	160	166	PF00018	0.677
LIG_TRFH_1	342	346	PF08558	0.347
LIG_WRC_WIRS_1	207	212	PF05994	0.504
MOD_CDK_SPK_2	235	240	PF00069	0.535
MOD_CK1_1	165	171	PF00069	0.632
MOD_CK1_1	263	269	PF00069	0.563
MOD_CK1_1	29	35	PF00069	0.492
MOD_CK1_1	39	45	PF00069	0.612
MOD_CK1_1	65	71	PF00069	0.580
MOD_CK1_1	81	87	PF00069	0.620
MOD_CK2_1	167	173	PF00069	0.566
MOD_CK2_1	208	214	PF00069	0.589
MOD_CK2_1	34	40	PF00069	0.540
MOD_CK2_1	84	90	PF00069	0.624
MOD_GlcNHglycan	103	106	PF01048	0.647
MOD_GlcNHglycan	184	187	PF01048	0.543
MOD_GlcNHglycan	216	219	PF01048	0.518
MOD_GlcNHglycan	249	252	PF01048	0.641
MOD_GlcNHglycan	28	31	PF01048	0.482
MOD_GlcNHglycan	282	285	PF01048	0.528
MOD_GlcNHglycan	3	6	PF01048	0.636
MOD_GlcNHglycan	33	36	PF01048	0.551
MOD_GlcNHglycan	83	86	PF01048	0.609
MOD_GSK3_1	161	168	PF00069	0.629
MOD_GSK3_1	243	250	PF00069	0.548
MOD_GSK3_1	263	270	PF00069	0.629
MOD_GSK3_1	280	287	PF00069	0.410
MOD_GSK3_1	61	68	PF00069	0.489
MOD_GSK3_1	81	88	PF00069	0.589
MOD_NEK2_1	1	6	PF00069	0.655
MOD_NEK2_1	144	149	PF00069	0.549
MOD_NEK2_1	69	74	PF00069	0.569
MOD_PIKK_1	142	148	PF00454	0.459
MOD_PIKK_1	252	258	PF00454	0.483
MOD_PIKK_1	284	290	PF00454	0.388
MOD_PKA_1	352	358	PF00069	0.450
MOD_PKA_1	61	67	PF00069	0.493
MOD_PKA_2	20	26	PF00069	0.472
MOD_PKA_2	229	235	PF00069	0.540
MOD_PKA_2	352	358	PF00069	0.322
MOD_PKA_2	61	67	PF00069	0.500
MOD_PKA_2	99	105	PF00069	0.545
MOD_PKB_1	49	57	PF00069	0.356
MOD_Plk_1	263	269	PF00069	0.433
MOD_Plk_1	69	75	PF00069	0.500
MOD_Plk_1	85	91	PF00069	0.479
MOD_Plk_4	332	338	PF00069	0.366
MOD_Plk_4	51	57	PF00069	0.368
MOD_Plk_4	75	81	PF00069	0.671
MOD_ProDKin_1	162	168	PF00069	0.633
MOD_ProDKin_1	200	206	PF00069	0.585
MOD_ProDKin_1	235	241	PF00069	0.680
MOD_ProDKin_1	321	327	PF00069	0.384
MOD_ProDKin_1	78	84	PF00069	0.582
MOD_SUMO_rev_2	122	126	PF00179	0.512
TRG_DiLeu_BaEn_1	339	344	PF01217	0.353
TRG_DiLeu_BaEn_4	40	46	PF01217	0.559
TRG_ENDOCYTIC_2	299	302	PF00928	0.403
TRG_ENDOCYTIC_2	342	345	PF00928	0.339
TRG_ER_diArg_1	295	298	PF00400	0.467
TRG_ER_diArg_1	351	353	PF00400	0.324
TRG_ER_diArg_1	49	52	PF00400	0.445
TRG_ER_diArg_1	61	63	PF00400	0.513
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	43	48	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGP1	Leptomonas seymouri	33%	100%
A0A3S7X5J3	Leishmania donovani	61%	100%
A4I808	Leishmania infantum	61%	100%
E9B2S5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	99%
Q4Q5D2	Leishmania major	59%	100%