Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKD5_LEIBR

TriTrypDb:

LbrM.32.1640 , LBRM2903_320022500

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HKD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKD5

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	412	418	PF00089	0.629
CLV_NRD_NRD_1	188	190	PF00675	0.351
CLV_NRD_NRD_1	212	214	PF00675	0.444
CLV_NRD_NRD_1	273	275	PF00675	0.401
CLV_NRD_NRD_1	410	412	PF00675	0.559
CLV_NRD_NRD_1	428	430	PF00675	0.437
CLV_NRD_NRD_1	51	53	PF00675	0.511
CLV_PCSK_KEX2_1	190	192	PF00082	0.549
CLV_PCSK_KEX2_1	273	275	PF00082	0.401
CLV_PCSK_KEX2_1	410	412	PF00082	0.561

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICK2	Leptomonas seymouri	84%	71%
A0A0S4J6R5	Bodo saltans	67%	82%
A0A1X0NV16	Trypanosomatidae	74%	86%
A0A3S7X5I1	Leishmania donovani	90%	100%
A0A422NID9	Trypanosoma rangeli	69%	100%
A4I7W5	Leishmania infantum	90%	100%
D0AA28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	86%
E9B2S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	72%
Q4Q5D4	Leishmania major	91%	100%
V5DFT8	Trypanosoma cruzi	72%	90%

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