Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKD5_LEIBR

TriTrypDb:

LbrM.32.1640 , LBRM2903_320022500

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	412	418	PF00089	0.629
CLV_NRD_NRD_1	188	190	PF00675	0.351
CLV_NRD_NRD_1	212	214	PF00675	0.444
CLV_NRD_NRD_1	273	275	PF00675	0.401
CLV_NRD_NRD_1	410	412	PF00675	0.559
CLV_NRD_NRD_1	428	430	PF00675	0.437
CLV_NRD_NRD_1	51	53	PF00675	0.511
CLV_PCSK_KEX2_1	190	192	PF00082	0.549
CLV_PCSK_KEX2_1	273	275	PF00082	0.401
CLV_PCSK_KEX2_1	410	412	PF00082	0.561
CLV_PCSK_KEX2_1	51	53	PF00082	0.511
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.549
CLV_PCSK_SKI1_1	184	188	PF00082	0.492
CLV_PCSK_SKI1_1	273	277	PF00082	0.426
CLV_PCSK_SKI1_1	278	282	PF00082	0.430
CLV_PCSK_SKI1_1	291	295	PF00082	0.445
CLV_PCSK_SKI1_1	429	433	PF00082	0.528
CLV_PCSK_SKI1_1	435	439	PF00082	0.481
CLV_PCSK_SKI1_1	83	87	PF00082	0.515
CLV_PCSK_SKI1_1	9	13	PF00082	0.641
CLV_PCSK_SKI1_1	95	99	PF00082	0.479
DEG_APCC_DBOX_1	414	422	PF00400	0.618
DEG_APCC_KENBOX_2	354	358	PF00400	0.589
DEG_SPOP_SBC_1	446	450	PF00917	0.658
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.532
DOC_MAPK_gen_1	189	200	PF00069	0.420
DOC_MAPK_gen_1	294	303	PF00069	0.507
DOC_MAPK_gen_1	410	418	PF00069	0.494
DOC_MAPK_MEF2A_6	193	202	PF00069	0.400
DOC_PP1_RVXF_1	136	143	PF00149	0.437
DOC_PP1_RVXF_1	170	177	PF00149	0.367
DOC_PP1_RVXF_1	182	189	PF00149	0.348
DOC_PP1_RVXF_1	44	51	PF00149	0.639
DOC_PP1_RVXF_1	81	87	PF00149	0.511
DOC_PP1_RVXF_1	93	100	PF00149	0.480
DOC_PP2B_LxvP_1	390	393	PF13499	0.516
DOC_PP2B_LxvP_1	422	425	PF13499	0.518
DOC_PP4_FxxP_1	202	205	PF00568	0.467
DOC_PP4_FxxP_1	248	251	PF00568	0.481
DOC_PP4_FxxP_1	283	286	PF00568	0.445
DOC_USP7_UBL2_3	210	214	PF12436	0.479
DOC_USP7_UBL2_3	432	436	PF12436	0.627
DOC_USP7_UBL2_3	91	95	PF12436	0.622
DOC_WW_Pin1_4	319	324	PF00397	0.474
DOC_WW_Pin1_4	455	460	PF00397	0.774
DOC_WW_Pin1_4	90	95	PF00397	0.534
LIG_14-3-3_CanoR_1	191	200	PF00244	0.425
LIG_14-3-3_CanoR_1	415	419	PF00244	0.622
LIG_Actin_WH2_2	49	67	PF00022	0.431
LIG_APCC_ABBA_1	71	76	PF00400	0.519
LIG_BRCT_BRCA1_1	150	154	PF00533	0.422
LIG_BRCT_BRCA1_1	262	266	PF00533	0.539
LIG_BRCT_BRCA1_1	387	391	PF00533	0.524
LIG_deltaCOP1_diTrp_1	329	338	PF00928	0.432
LIG_deltaCOP1_diTrp_1	75	86	PF00928	0.499
LIG_eIF4E_1	284	290	PF01652	0.480
LIG_FHA_1	135	141	PF00498	0.448
LIG_FHA_1	153	159	PF00498	0.284
LIG_FHA_1	181	187	PF00498	0.351
LIG_FHA_1	193	199	PF00498	0.424
LIG_FHA_1	252	258	PF00498	0.441
LIG_FHA_1	290	296	PF00498	0.525
LIG_FHA_1	302	308	PF00498	0.474
LIG_FHA_1	387	393	PF00498	0.565
LIG_FHA_1	426	432	PF00498	0.503
LIG_FHA_1	452	458	PF00498	0.695
LIG_FHA_2	295	301	PF00498	0.549
LIG_FHA_2	320	326	PF00498	0.445
LIG_FHA_2	436	442	PF00498	0.518
LIG_FHA_2	96	102	PF00498	0.527
LIG_LIR_Apic_2	245	251	PF02991	0.490
LIG_LIR_Apic_2	282	286	PF02991	0.443
LIG_LIR_Gen_1	121	132	PF02991	0.431
LIG_LIR_Gen_1	151	161	PF02991	0.406
LIG_LIR_Gen_1	196	205	PF02991	0.490
LIG_LIR_Gen_1	206	215	PF02991	0.493
LIG_LIR_Gen_1	240	251	PF02991	0.507
LIG_LIR_Gen_1	263	272	PF02991	0.382
LIG_LIR_Gen_1	362	370	PF02991	0.520
LIG_LIR_Nem_3	121	127	PF02991	0.502
LIG_LIR_Nem_3	151	157	PF02991	0.434
LIG_LIR_Nem_3	196	202	PF02991	0.412
LIG_LIR_Nem_3	206	211	PF02991	0.383
LIG_LIR_Nem_3	240	246	PF02991	0.532
LIG_LIR_Nem_3	25	29	PF02991	0.581
LIG_LIR_Nem_3	263	269	PF02991	0.378
LIG_LIR_Nem_3	362	366	PF02991	0.523
LIG_LIR_Nem_3	388	394	PF02991	0.554
LIG_LIR_Nem_3	433	437	PF02991	0.516
LIG_LIR_Nem_3	47	53	PF02991	0.503
LIG_LIR_Nem_3	98	102	PF02991	0.412
LIG_PCNA_yPIPBox_3	354	364	PF02747	0.510
LIG_PCNA_yPIPBox_3	397	411	PF02747	0.568
LIG_Pex14_2	124	128	PF04695	0.334
LIG_Pex14_2	86	90	PF04695	0.512
LIG_SH2_CRK	26	30	PF00017	0.568
LIG_SH2_SRC	255	258	PF00017	0.451
LIG_SH2_STAP1	194	198	PF00017	0.417
LIG_SH2_STAP1	220	224	PF00017	0.448
LIG_SH2_STAP1	255	259	PF00017	0.412
LIG_SH2_STAT5	129	132	PF00017	0.388
LIG_SH2_STAT5	194	197	PF00017	0.431
LIG_SH2_STAT5	199	202	PF00017	0.361
LIG_SH2_STAT5	352	355	PF00017	0.491
LIG_SH3_3	18	24	PF00018	0.585
LIG_SUMO_SIM_par_1	110	117	PF11976	0.474
LIG_TRAF2_1	460	463	PF00917	0.501
LIG_TRAF2_1	73	76	PF00917	0.542
LIG_UBA3_1	60	65	PF00899	0.426
MOD_CDK_SPK_2	90	95	PF00069	0.534
MOD_CK1_1	192	198	PF00069	0.434
MOD_CK1_1	260	266	PF00069	0.386
MOD_CK1_1	362	368	PF00069	0.521
MOD_CK1_1	414	420	PF00069	0.529
MOD_CK1_1	44	50	PF00069	0.644
MOD_CK2_1	146	152	PF00069	0.409
MOD_CK2_1	294	300	PF00069	0.659
MOD_CK2_1	319	325	PF00069	0.473
MOD_CK2_1	33	39	PF00069	0.651
MOD_CK2_1	447	453	PF00069	0.574
MOD_CK2_1	457	463	PF00069	0.617
MOD_CK2_1	95	101	PF00069	0.504
MOD_GlcNHglycan	142	145	PF01048	0.438
MOD_GlcNHglycan	259	262	PF01048	0.399
MOD_GSK3_1	148	155	PF00069	0.300
MOD_GSK3_1	180	187	PF00069	0.390
MOD_GSK3_1	189	196	PF00069	0.416
MOD_GSK3_1	29	36	PF00069	0.638
MOD_GSK3_1	392	399	PF00069	0.563
MOD_GSK3_1	441	448	PF00069	0.633
MOD_GSK3_1	451	458	PF00069	0.631
MOD_N-GLC_1	396	401	PF02516	0.588
MOD_NEK2_1	140	145	PF00069	0.513
MOD_NEK2_1	289	294	PF00069	0.505
MOD_NEK2_1	29	34	PF00069	0.622
MOD_NEK2_1	41	46	PF00069	0.573
MOD_NEK2_2	386	391	PF00069	0.538
MOD_PIKK_1	284	290	PF00454	0.465
MOD_PIKK_1	458	464	PF00454	0.538
MOD_PKA_1	189	195	PF00069	0.426
MOD_PKA_1	435	441	PF00069	0.416
MOD_PKA_2	192	198	PF00069	0.425
MOD_PKA_2	284	290	PF00069	0.465
MOD_PKA_2	29	35	PF00069	0.551
MOD_PKA_2	414	420	PF00069	0.622
MOD_PKA_2	441	447	PF00069	0.565
MOD_PKA_2	451	457	PF00069	0.614
MOD_PKB_1	191	199	PF00069	0.568
MOD_Plk_1	146	152	PF00069	0.488
MOD_Plk_1	184	190	PF00069	0.373
MOD_Plk_1	396	402	PF00069	0.559
MOD_Plk_4	227	233	PF00069	0.518
MOD_Plk_4	234	240	PF00069	0.511
MOD_Plk_4	359	365	PF00069	0.571
MOD_Plk_4	386	392	PF00069	0.537
MOD_ProDKin_1	319	325	PF00069	0.473
MOD_ProDKin_1	455	461	PF00069	0.765
MOD_ProDKin_1	90	96	PF00069	0.532
MOD_SUMO_for_1	295	298	PF00179	0.568
MOD_SUMO_for_1	353	356	PF00179	0.592
MOD_SUMO_rev_2	242	251	PF00179	0.633
MOD_SUMO_rev_2	38	47	PF00179	0.542
MOD_SUMO_rev_2	427	437	PF00179	0.542
MOD_SUMO_rev_2	6	14	PF00179	0.491
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.392
TRG_ENDOCYTIC_2	129	132	PF00928	0.281
TRG_ENDOCYTIC_2	199	202	PF00928	0.474
TRG_ENDOCYTIC_2	208	211	PF00928	0.491
TRG_ENDOCYTIC_2	26	29	PF00928	0.570
TRG_ER_diArg_1	188	191	PF00400	0.518
TRG_ER_diArg_1	272	274	PF00400	0.400
TRG_ER_diArg_1	410	412	PF00400	0.561
TRG_ER_diArg_1	50	52	PF00400	0.511
TRG_NLS_MonoExtC_3	188	193	PF00514	0.493
TRG_NLS_MonoExtN_4	189	194	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	100	104	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICK2	Leptomonas seymouri	84%	71%
A0A0S4J6R5	Bodo saltans	67%	82%
A0A1X0NV16	Trypanosomatidae	74%	86%
A0A3S7X5I1	Leishmania donovani	90%	100%
A0A422NID9	Trypanosoma rangeli	69%	100%
A4I7W5	Leishmania infantum	90%	100%
D0AA28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	86%
E9B2S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	72%
Q4Q5D4	Leishmania major	91%	100%
V5DFT8	Trypanosoma cruzi	72%	90%