MIP-T3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Microtubule-binding protein MIP-T3, putative

Species:

Leishmania braziliensis

UniProt:

A4HKD4_LEIBR

TriTrypDb:

LbrM.32.1630 , LBRM2903_320022400

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKD4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0065007	biological regulation	1	1
GO:0070507	regulation of microtubule cytoskeleton organization	5	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.599
CLV_PCSK_KEX2_1	182	184	PF00082	0.623
CLV_PCSK_KEX2_1	251	253	PF00082	0.567
CLV_PCSK_KEX2_1	31	33	PF00082	0.282
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.567
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.282
CLV_PCSK_SKI1_1	28	32	PF00082	0.282
CLV_PCSK_SKI1_1	85	89	PF00082	0.387
DOC_MAPK_gen_1	69	78	PF00069	0.570
DOC_MAPK_gen_1	85	93	PF00069	0.513
DOC_MAPK_JIP1_4	237	243	PF00069	0.459
DOC_MAPK_MEF2A_6	71	80	PF00069	0.461
DOC_MAPK_MEF2A_6	85	93	PF00069	0.544
DOC_PP2B_LxvP_1	163	166	PF13499	0.710
DOC_PP2B_LxvP_1	18	21	PF13499	0.496
DOC_PP4_FxxP_1	142	145	PF00568	0.508
DOC_USP7_UBL2_3	195	199	PF12436	0.588
DOC_WW_Pin1_4	141	146	PF00397	0.728
DOC_WW_Pin1_4	175	180	PF00397	0.687
DOC_WW_Pin1_4	19	24	PF00397	0.510
DOC_WW_Pin1_4	228	233	PF00397	0.525
LIG_14-3-3_CanoR_1	182	190	PF00244	0.628
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_Clathr_ClatBox_1	86	90	PF01394	0.408
LIG_EVH1_2	33	37	PF00568	0.482
LIG_FHA_1	7	13	PF00498	0.299
LIG_FHA_1	75	81	PF00498	0.482
LIG_LIR_Gen_1	74	83	PF02991	0.408
LIG_LIR_Nem_3	107	113	PF02991	0.562
LIG_LIR_Nem_3	46	52	PF02991	0.535
LIG_LIR_Nem_3	74	78	PF02991	0.408
LIG_SH2_CRK	15	19	PF00017	0.585
LIG_SH2_GRB2like	82	85	PF00017	0.562
LIG_SH2_SRC	52	55	PF00017	0.496
LIG_SH2_STAP1	203	207	PF00017	0.690
LIG_SH2_STAP1	52	56	PF00017	0.496
LIG_SH2_STAT3	120	123	PF00017	0.395
LIG_SH2_STAT5	113	116	PF00017	0.562
LIG_SH2_STAT5	75	78	PF00017	0.482
LIG_SH2_STAT5	82	85	PF00017	0.482
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.408
LIG_TYR_ITIM	73	78	PF00017	0.408
LIG_UBA3_1	79	88	PF00899	0.585
MOD_CDK_SPxxK_3	175	182	PF00069	0.467
MOD_CK1_1	143	149	PF00069	0.652
MOD_CK1_1	185	191	PF00069	0.608
MOD_CK1_1	239	245	PF00069	0.515
MOD_CK2_1	175	181	PF00069	0.565
MOD_CK2_1	97	103	PF00069	0.482
MOD_DYRK1A_RPxSP_1	175	179	PF00069	0.455
MOD_GlcNHglycan	1	4	PF01048	0.617
MOD_GlcNHglycan	130	133	PF01048	0.646
MOD_GlcNHglycan	187	190	PF01048	0.541
MOD_GlcNHglycan	62	65	PF01048	0.361
MOD_GlcNHglycan	99	102	PF01048	0.282
MOD_GSK3_1	140	147	PF00069	0.628
MOD_GSK3_1	150	157	PF00069	0.561
MOD_GSK3_1	171	178	PF00069	0.607
MOD_GSK3_1	19	26	PF00069	0.563
MOD_N-GLC_1	135	140	PF02516	0.663
MOD_N-GLC_1	159	164	PF02516	0.763
MOD_NEK2_1	140	145	PF00069	0.613
MOD_NEK2_1	233	238	PF00069	0.692
MOD_NEK2_1	60	65	PF00069	0.498
MOD_NEK2_2	159	164	PF00069	0.582
MOD_PKA_1	182	188	PF00069	0.602
MOD_PKA_2	182	188	PF00069	0.662
MOD_PKA_2	60	66	PF00069	0.585
MOD_Plk_1	135	141	PF00069	0.518
MOD_Plk_1	159	165	PF00069	0.755
MOD_Plk_2-3	262	268	PF00069	0.545
MOD_Plk_4	218	224	PF00069	0.519
MOD_Plk_4	273	279	PF00069	0.592
MOD_Plk_4	74	80	PF00069	0.483
MOD_ProDKin_1	141	147	PF00069	0.727
MOD_ProDKin_1	175	181	PF00069	0.683
MOD_ProDKin_1	19	25	PF00069	0.510
MOD_ProDKin_1	228	234	PF00069	0.527
MOD_SUMO_for_1	87	90	PF00179	0.585
MOD_SUMO_rev_2	231	239	PF00179	0.595
MOD_SUMO_rev_2	67	73	PF00179	0.485
TRG_ENDOCYTIC_2	15	18	PF00928	0.544
TRG_ENDOCYTIC_2	52	55	PF00928	0.471
TRG_ENDOCYTIC_2	75	78	PF00928	0.521
TRG_NES_CRM1_1	81	92	PF08389	0.585
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAU9	Leptomonas seymouri	59%	100%
A0A1X0NUE7	Trypanosomatidae	47%	98%
A0A3S7X5H3	Leishmania donovani	79%	100%
A0A422NIC4	Trypanosoma rangeli	43%	100%
A4I7W4	Leishmania infantum	79%	100%
D0AA27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B2S2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q5D5	Leishmania major	76%	100%
V5AZG9	Trypanosoma cruzi	47%	92%